KR20170003189A - Multi ceramide lamellar structure comprising fatty acid and neutralizing agent - Google Patents

Abstract

The present invention relates to a multi ceramide lamellar structure. More particularly, the multi ceramide lamellar structure comprises: at least one from fatty acids and fatty alcohol; and a neutralizing agent thereof. The molar ratio between at least one from fatty acids and fatty alcohol and the neutralizing agent is 9:1 to 1.2:1. A composition comprising the lamellar structure for external skin has excellent phase stability with respect to the stabilization of ceramide using the multi lamellar liquid crystal.

Description

[0001] The present invention relates to a multi-layered ceramide lamella structure comprising a fatty acid and a neutralizing agent,

The present disclosure relates to multilayer ceramide lamellar structures comprising fatty acids and neutralizing agents.

The surface of the human skin consists of keratinocytes in which the mature keratinocytes are differentiated from the basal layer and degenerated. These keratinocytes are bound by ceramide double stranded lamellar structure, which is present in the stratum corneum, to maintain a smooth and elastic skin. Ceramides have two adjacent alkyl chains in the form of rods and have alcohol (-OH) and carbonyl (C = O) functional groups to form α-crystals which can constitute a lamellar structure. However, since this alpha crystal phase is in a metastable state, it is easily transferred to gamma-crystal. Further, since it is difficult to dissolve in most oils, it is difficult to be stably trapped in the inside of the O / W emulsion. Therefore, there is a limitation in using cosmetics in large amounts in cosmetic formulations.

KR10-0439932 B KR10-2013-0037899A

In order to solve this problem, one aspect of the present invention is to provide a lipid-containing ceramide-containing lamellar formulation which is more stable and convenient due to the effect of facilitating the formation of lipids constituting a lamellar structure by using a fatty acid salt or the like and facilitating charge- And to provide a manufacturing method thereof.

Another aspect of the present invention is to provide a ceramide-containing lamellar structure having a structure similar to that of a skin horny layer capable of retaining a large amount of water and a useful active material, and having a superior degree of appearance.

 Another aspect of the present invention is to provide a multilayer ceramide lamellar structure exhibiting excellent skin moisturizing effect and skin barrier function recovery effect when applied to skin, and a composition for external application for skin comprising the same.

One aspect of the present invention provides a multilayer ceramide lamellar structure including a solid fatty acid salt in which a fatty acid and a neutralizing agent are mixed at a molar ratio of 9: 1 to 1.2: 1.

In one aspect of the present invention, the multilayer ceramide lamellar structure provides a multilayer ceramide lamellar structure further comprising a fatty alcohol.

In one aspect of the present invention, the fatty acid provides a multilayer ceramide lamellar structure having 12 to 22 carbon atoms.

In one aspect of the present invention, the fatty acid is selected from the group consisting of lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, and behenic acid; The fatty alcohol may be selected from the group consisting of lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, arachidyl alcohol and behenyl alcohol. ≪ / RTI > Thereby providing a multilayer ceramide lamellar structure.

One aspect of the present invention provides a multilayer ceramide lamellar structure wherein the neutralizing agent is a neutralizing agent comprising at least one of tromethamine, triethanolamine, sodium hydroxide, potassium hydroxide, aminomethyl propanol, aminomethyl propanediol, and arginine.

One aspect of the present invention provides a multilayer ceramide lamellar structure wherein the fatty acid is stearic acid and the neutralizing agent is tromethamine.

Another aspect of the present invention provides a multilayer ceramide lamellar structure wherein the molar ratio of fatty acid to neutralizing agent is from 7: 1 to 1.5: 1.

Another aspect of the present invention provides a multilayer ceramide lamella structure wherein the ceramide is at least one of a natural ceramide and a similar ceramide.

Another aspect of the present invention provides the underwater type make-up cosmetic composition wherein the natural ceramide is at least one of ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7 and ceramide 8.

Another aspect of the present invention provides the underwater type make-up cosmetic composition wherein the pseudoceramide is at least one of the compounds represented by the following formulas (1) to (6).

However,

Wherein R is a C9-C21 saturated or unsaturated aliphatic chain.

[Figure 2]

Wherein n is 1 or 2 and R and R 'are C9-C21 saturated or unsaturated aliphatic chains.

[Figure 3]

(Wherein,

m and n are the same or different and are an integer of 1 to 3;

k and l are the same or different and are 1 or 2;

j is 0 or 1;

R and R 'are C1-C31 linear or branched, saturated or unsaturated alkyl groups, which are the same or different, and contain or do not contain a hydroxyl group;

A ¹ , A ² and A ³ are the same or different and are hydrogen or any substituent of the following structure, provided that A ¹ , A ² and A ³ are simultaneously hydrogen:

Wherein M, M ¹ and M ² are selected from the group consisting of alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium- L is selected from the group consisting of polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, and L is a calcitic metal)

[Figure 4]

(Wherein R, R and R 'are the same or different, which does not contain or contains a hydroxy group, C ₁₀ -C ₃₂ linear or branched and saturated or unsaturated alkyl group;

R ³ and R ⁴ are the same or different and are hydrogen or a C 1 -C 4 alkyl or hydroxyalkyl group;

R < ⁵ > is -A or -CH2CH2OA, wherein A is any one of the substituents of the following structures.

Wherein M, M ¹ and M ² are selected from the group consisting of alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium- L is selected from the group consisting of polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, and L is an alkaline earth metal)

[Figure 5]

(Wherein m and n are the same or different and are an integer of 1 to 4; R and R 'are the same or different and are a C1-C31 linear or branched saturated or unsaturated alkyl group containing or not having a hydroxy group ; A1 and A2 are the same or different and are either hydrogen or a substituent of the following structure;

Wherein M, M ¹ and M ² are selected from the group consisting of alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium- L is selected from the group consisting of polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, and L is an alkaline earth metal)

[6]

(Wherein m and n are the same or different and are an integer of 1 to 3;

k and l are the same or different and are 1 or 2;

j is 0 or 1;

A ¹ , A ² and A ³ are the same or different and are each hydrogen or a substituent having the following structure;

Wherein M < ¹ > and M < ² > are an alkali metal or an organic base containing nitrogen and L is an alkaline earth metal;

R is a substituent having the structure:

Wherein B is a methyl group at 5-, 7- or 8-position of tocopherol, m is an integer of 1 to 3, and D is -CH2 (CH3) -CH- or -CH (CH3) = C- .])

Another aspect of the present invention provides an underwater-type cosmetic composition comprising the multilayer ceramide lamella structure.

Another aspect of the present invention relates to an oil-in-water solution containing ceramides; Aqueous solution; And a solid fatty acid salt in which a fatty acid and a neutralizing agent are mixed at a molar ratio of 9: 1 to 1.2: 1, to prepare a multilayer ceramide lamellar structure.

An underwater type cosmetic composition comprising a lamellar structure according to one aspect of the present invention has a superior degree of appearance according to stabilization of ceramides using a multilayer lamellar liquid crystal.

An underwater-type cosmetic composition comprising a lamellar structure according to one aspect of the present invention can stably contain more ceramides.

 An underwater type cosmetic composition comprising a lamellar structure according to one aspect of the present invention has excellent skin moisturizing effect and barrier function recovery effect when applied to skin.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a photograph of a gel formulation containing a ceramide lamellar structure having a molar ratio of fatty acid to neutralizing agent of 4: 1 according to the present invention. FIG.
2 is a graph showing SAXS experimental results in order to confirm whether Embodiment 1 of the present invention forms a lamellar structure.
Fig. 3 is a photograph showing the precipitation state in the gel-like form while varying the molar ratio of the fatty acid and the neutralizing agent.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily carry out the present invention.

One aspect of the present invention provides a multilayer ceramide lamellar structure including a solid fatty acid salt in which a fatty acid and a neutralizing agent are mixed at a molar ratio of 9: 1 to 1.2: 1.

In one aspect of the present invention, the multilayer ceramide lamellar structure provides a multilayer ceramide lamellar structure further comprising a fatty alcohol.

In one aspect of the present invention, the fatty acid provides a multilayer ceramide lamellar structure having 12 to 22 carbon atoms.

In one aspect of the present invention, the fatty acid is selected from the group consisting of lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, and behenic acid; The fatty alcohol may be selected from the group consisting of lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, arachidyl alcohol and behenyl alcohol. ≪ / RTI > Thereby providing a multilayer ceramide lamellar structure.

One aspect of the present invention provides a multilayer ceramide lamellar structure wherein the neutralizing agent is a neutralizing agent comprising at least one of tromethamine, triethanolamine, sodium hydroxide, potassium hydroxide, aminomethyl propanol, aminomethyl propanediol, and arginine.

One aspect of the present invention provides a multilayer ceramide lamellar structure wherein the fatty acid is stearic acid and the neutralizing agent is tromethamine.

Another aspect of the present invention provides a multilayer ceramide lamella structure wherein the ceramide is at least one of a natural ceramide and a similar ceramide.

Another aspect of the present invention provides the underwater type make-up cosmetic composition wherein the natural ceramide is at least one of ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7 and ceramide 8.

Another aspect of the present invention provides the underwater type make-up cosmetic composition wherein the pseudoceramide is at least one of the compounds represented by the following formulas (1) to (6).

However,

Wherein R is a C9-C21 saturated or unsaturated aliphatic chain.

[Figure 2]

Wherein n is 1 or 2 and R and R 'are C9-C21 saturated or unsaturated aliphatic chains.

[Figure 3]

(Wherein,

m and n are the same or different and are an integer of 1 to 3;

k and l are the same or different and are 1 or 2;

j is 0 or 1;

R and R 'are C1-C31 linear or branched, saturated or unsaturated alkyl groups, which are the same or different, and contain or do not contain a hydroxyl group;

A ¹ , A ² and A ³ are the same or different and are hydrogen or any substituent of the following structure, provided that A ¹ , A ² and A ³ are simultaneously hydrogen:

Wherein M, M ¹ and M ² are selected from the group consisting of alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium- L is selected from the group consisting of polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, and L is a calcitic metal)

[Figure 4]

(Wherein R, R and R 'are the same or different, which does not contain or contains a hydroxy group, C ₁₀ -C ₃₂ linear or branched and saturated or unsaturated alkyl group;

R ³ and R ⁴ are the same or different and are hydrogen or a C 1 -C 4 alkyl or hydroxyalkyl group;

R < ⁵ > is -A or -CH2CH2OA, wherein A is any one of the substituents of the following structures.

Wherein M, M ¹ and M ² are selected from the group consisting of alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium- L is selected from the group consisting of polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, and L is an alkaline earth metal)

[Figure 5]

(Wherein m and n are the same or different and are an integer of 1 to 4; R and R 'are the same or different and are a C1-C31 linear or branched saturated or unsaturated alkyl group containing or not having a hydroxy group ; A1 and A2 are the same or different and are either hydrogen or a substituent of the following structure;

Wherein M, M ¹ and M ² are selected from the group consisting of alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium- L is selected from the group consisting of polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, and L is an alkaline earth metal)

[6]

(Wherein m and n are the same or different and are an integer of 1 to 3;

k and l are the same or different and are 1 or 2;

j is 0 or 1;

A ¹ , A ² and A ³ are the same or different and are each hydrogen or a substituent having the following structure;

Wherein M < ¹ > and M < ² > are an alkali metal or an organic base containing nitrogen and L is an alkaline earth metal;

R is a substituent having the structure:

Wherein B is a methyl group at 5-, 7- or 8-position of tocopherol, m is an integer of 1 to 3, and D is -CH2 (CH3) -CH- or -CH (CH3) = C- .])

Another aspect of the present invention provides a water-in-oil type cosmetic composition comprising the multilayer ceramide lamellar structure.

Specifically, the water-in-oil type cosmetic composition may be gel-like. In addition, the water-in-oil type cosmetic composition may be a cream or a lotion by forming an oil drop inside the gel by appropriately adding oil.

Another aspect of the present invention is that the molar ratio of fatty acid to neutralizing agent is in the range of from 9: 1 to 8: 1, up to 7.5: 1, up to 7.4: 1, up to 7.3: 1, up to 7.2: Or less, 6.9: 1 or less, 6.8: 1 or less, 6.7: 1 or less, 6.6: 1 or less, 6.5: 1 or less, 6.4: 1 or less, 6.3: 1 or less, 6.2: 1 or less, 5: 1 or less, 4.5: 1 or less, 4: 1 or less, 3.5: 1 or less, 1 or less, 2: 1 or less, 1.9: 1 or less, 1.8: 1 or less, 1.7: 1 or less Or less, 1.5: 1 or less, 1.4: 1 or less, 1.3: 1 or less, or 1.2: 1 or less.

The molar ratio of the fatty acid to the neutralizing agent is in the range of 1.2: 1 to 1.3: 1, 1.5: 1 to 1.6: 1, 1.7: 1 to 1.8: 1, 1 or more, 2.2: 1 or more, 2.3: 1 or more, 2.4: 1 or more, 2.5: 1 or more, 3: 1 or more, 4: 1 or more, 1 or more, 8.5: 1 or more, or 9: 1 or more.

When the molar ratio of the fatty acid and the neutralizing agent is within the above range, a stable lamellar structure containing ceramides can be obtained. In the case of a formulation using only a nonionic emulsifier, the hydrogen bonding between the hydrophilic part and the water-based part of the emulsifier is weakened at a high temperature and the fluidity of the lipid is low at a low temperature, so that it is a technical hassle to induce formation of a lamellar structure . When a neutralized fatty acid is used as a surfactant, the charge of the fatty acid is increased so that the interaction with the water phase becomes stronger, and a lamellar structure is formed stably even after rapid cooling after the preparation of the formulation. The charge of the neutralized fatty acid causes a repulsive force between the lamellar layers so as to stably maintain the arrangement of the lamellar phase-water phase-lamellar layer. Also, charged fatty acids increase the stability of the lamella itself by inducing ion-dipole interactions with the hydrophilic portions of other fatty acids and amphiphiles in the lamellar layer.

Another aspect of the present invention provides a multilayer ceramide lamella structure wherein the ceramide is at least one of a natural ceramide and a similar ceramide.

Another aspect of the present invention provides a composition for external application for skin comprising the multilayer ceramide lamellar structure. Specifically, the composition for external application for skin may be a cosmetic composition.

In one aspect of the present invention, the multilayer ceramide lamellar structure may further include at least one member selected from the group consisting of alcohol, vegetable wax, synthetic wax, ozokerite, cetyl palmitate, beeswax, lipid and lipid peptide . Further, in one aspect of the present invention, the multilayer ceramide lamellar structure may further include an oil, and the oil may be an ester oil or a hydrocarbon oil, though it is not limited as long as it is a general oil. Specific examples of the ester oil include isopropyl myristate, isopropyl palmitate, octyl-dodecyl myristate, cetyl octanoate, cetyl 2-ethylhexanoate, C14-18 alkyl ethyl hexanoate, coco- Caproate and decyl cocoate, and the di-ester oil may be selected from the group consisting of butylene glycol dicaprylate, dicaprate, diisostearyl malate, di-C 12-13 alkyl malate, neopentyl glycol diheptanoate, Decyl stearate, neopentyl glycol dicaprylate / dicaprate, tridecyl trimellitate, and dicaprylyl carbonate. Hydrocarbon oils may be hydrogenated polyisobutene, hydrogenated polyisobutene, hydrogenated polydecenes, and squalane.

In the present specification, the ceramide may be at least one selected from the group consisting of natural ceramides and pseudo ceramides. The natural ceramides are ceramides present in nature and include ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7, ceramide 8 and the like. The pseudo ceramide contains ceramide 104 and ceramide 102 and the like. In the present invention, pseudoceramide is a compound having a double-chain lamellar structure which is a structure of natural ceramide.

Another aspect of the present invention provides a composition for external application for skin comprising the multilayer ceramide lamellar structure. In the composition for external application for skin, the ceramide is preferably contained in an amount of 0.01 to 20% by weight based on the total weight of the composition. More preferably 0.05 to 10% by weight. When the above range is satisfied, the degree of appearance is very good and a large amount of moisture can be retained, which is very effective for moisturizing the skin and restoring the barrier function. When the content is less than 0.01%, it is difficult to induce the desired moisture and moisturizing power. When the content is more than 20%, it is difficult to maintain the stability, so that the above range is preferably maintained.

The composition according to one aspect of the present invention may contain a certain amount of a poorly soluble substance in the composition, which is usually ceramide 3B or the like, due to the characteristic of the lamellar structure having a double layer structure.

The composition for external application for skin according to one aspect of the present invention may be a composition for external application for skin moisturizing or skin elasticity enhancement. As described above, the moisture content of the multilayer lamellar liquid crystal formed by the ceramide is increased and the skin barrier effect is improved, so that it can be excellently used for skin moisturizing and skin elasticity enhancement.

In one aspect of the present invention, an oil solution containing ceramides; Aqueous solution; And a solid fatty acid salt in which a fatty acid and a neutralizing agent are mixed at a molar ratio of 9: 1 to 1.2: 1, to prepare a multilayer ceramide lamellar structure.

In addition, the composition for external application for skin according to one aspect of the present invention may be prepared by a method for producing a multilayer ceramide lamella structure comprising mixing an emulsion containing an ceramide, an aqueous solution and a neutral fatty acid with a neutral fatty acid have.

The multi-layered ceramide lamellar structure can be formed by a solid fatty acid and a neutralizing agent.

The external preparation for skin according to the present invention may be, for example, a pharmaceutical composition or a cosmetic composition.

The pharmaceutical composition may further contain a preservative, a stabilizer, a wetting agent or an emulsifying accelerator, a pharmaceutical adjuvant such as a salt and / or a buffer for controlling osmotic pressure, and other therapeutically useful substances, May be formulated into oral administration forms. Parenteral dosage forms, and may be, for example, but not limited to lotions, ointments, gels, creams, patches or spray formulations. The dosage of the active ingredient is within the level of those skilled in the art, and the daily dose of the drug depends on various factors such as the degree of progress of the subject to be administered, the age of onset, age, health condition, As a standard, it is generally possible to administer the composition at a dose of 1 / / kg to 200 mg / kg, preferably 50 / / kg to 50 mg / kg, once or twice a day, Are not intended to limit the scope of the present invention.

The formulation of the cosmetic composition is not particularly limited and may be appropriately selected according to the purpose. For example, it can be applied to softeners (skin lotion and milk lotion), nutrition lotion, essence, nutrition cream, massage cream, pack, gel, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, A body lotion, a body cream, a body oil, and a body essence, but the present invention is not limited thereto. The content of the active ingredient is not particularly limited, but may be 0.01 to 10% by weight based on the total weight of the composition. When the active ingredient satisfies the above content, it can exhibit excellent efficacy without side effects. The cosmetic composition may also comprise a cosmetically acceptable excipient which acts as a diluent, dispersant or carrier so as to facilitate distribution of the composition when applied to the skin. Preferably, the composition is an oil-in-water (O / W) emulsion, and the emulsion preferably comprises at least 70 wt% of water-containing water. However, the present invention is not limited thereto, and any known excipient for cosmetics may be used. The cosmetic composition may also contain cosmetic auxiliaries commonly used in the field of the present invention such as lipids, organic solvents, silicones, thickeners, softeners, supplemental sunscreens, foam inhibitors, moisturizers, perfumes, preservatives, Pigments or nanopigments (in particular, ultraviolet radiation may be applied physically or chemically) to the surface of the substrate, such as, but not limited to, water, a total charge, a sequestering agent, a blocking agent, a cationic, anionic, nonionic or ampholytic polymers or mixtures thereof, propellants, To provide a photoprotective effect supplementarily), or various other ingredients commonly used in cosmetics, especially those used in the manufacture of sunscreen compositions. Among the organic solvents, lower alcohols and polyols, such as ethanol, isopropanol, propylene glycol, glycerol, sorbitol and the like can be mentioned. The fatty material may comprise oil or wax or mixtures thereof, fatty acids, fatty acid esters, fatty alcohols, petrolatum, paraffin, lanolin, hydrogenated lanolin or acetylated lanolin. Oils may be selected from animal, vegetable, mineral or synthetic oils, especially hydrogenated palm oil, hydrogenated castor oil, liquid petrolatum, liquid paraffin, purcellin oil, volatile or nonvolatile silicone oil and isoparaffin.

When the cosmetic composition is a sunscreen composition for protecting the epidermis of a human body from ultraviolet rays, it may take the form of a suspension or dispersion of a solvent or a fatty substance, or alternatively may be in the form of an emulsion such as a cream or an emulsion (o / w) or water-in-oil, but preferably O / W, or vesicle dispersion, or in the form of ointments, gels, solid sticks or aerosols It can take the form of foam. The emulsion may further comprise anionic, nonionic, cationic or amphoteric surfactants.

When the cosmetic composition is used for protecting hair, it may be used in the form of a composition for shampoo, lotion, gel or rinse, before, after, after, or after bleaching or before or after bleaching or straight perming And can be in the form of a composition for dyeing or bleaching hair, a lotion or gel for styling or treatment, a lotion or gel for hairdryer or hair setter, a hair lacquer or a composition for wave or straight permanent hair, There is a number.

When the cosmetic composition is used as a makeup product for eyelashes, eyebrows, skin or hair, such as skin care creams, foundation creams, lipsticks, eye creams, lotions, eyeliners, mascaras or coloring gels , Solid or paste-like and water-free or water-based, such as oil-in-water or water-in-oil emulsions, suspensions or gels.

The present invention also relates to a skin disease treatment agent comprising the composition for external application for skin, wherein the skin disease is not particularly limited, but can be, for example, acne, psoriasis, hair loss or keratin deficiency. Further, the present invention relates to an external preparation for skin comprising the composition for external application for skin, wherein the external preparation for skin is a generic term including any applied outside the skin, and cosmetics and medicines of various formulations may be included. The external preparation for skin is not particularly limited, but may be, for example, a skin external preparation for preventing skin aging or improving skin wrinkles.

The present invention will be described in more detail through the following examples. However, the examples are for illustrating the present invention, and the scope of the present invention is not limited thereto.

Example  One

ingredient Content (% by weight) Paid Ceramide PC-102 3.50 Ceramide PC-104 4.00 Cholesterol 2.50 Stearic acid 7.50 Cetearyl alcohol 5.00 Behenyl alcohol 2.00 Awards Butylene Glycol 10.00 Glycerin 5.00 Capryl Glycol 0.10 Tromethamine 0.80 Water To 100.00

The raw materials were mixed in the composition shown in Table 1 to prepare a gel-forming system. Stearic acid and tromethamine were prepared in a molar ratio of 4: 1. The oil phase was heated to 80 占 폚 according to the composition shown in Table 1, and the water phase was dissolved in a separate vessel by heating to 70 占 폚. Then, the water phase was mixed with the oil phase and stirred with a homomixer. The stirred contents were cooled to 30 DEG C after bubbles were removed.

As a result, the resulting composition formed a stable gel as shown in Fig.

Experimental Example  One- Lamella Structure formation

A SAXS (Small-angle X-ray scattering) experiment was conducted to examine whether the resultant composition of Example 1 formed a stable lamellar structure. The lamellar structure was judged to form a lamellar structure when the reciprocal of the distance of each peak showing significant scattering intensity after SAXS experiment was about 1: 2: 3 ratio. As a result of the SAXS experiment with the composition of Example 1, a main peak with a ratio of the inverse of the distance of about 1: 2: 3 was found (FIG. 2). Therefore, the formation of the lamellar structure was confirmed in the composition of Example 1 of the present invention.

Experimental Example  2- Precipitation experiment

A gel formulation was prepared in the same manner as in Example 1 except that the molar ratio of stearic acid and tromethamine in the composition ratio of Example 1 was changed as shown in Table 2 below.

Comparative Example 1 Comparative Example 2 Example 2 Example 1 Example 3 Example 4 Stearic acid: tromethamine
Mole ratio 12: 0 12: 1 6: 1 4: 1 2: 1 1.3: 1

The appearance of the gel formulations of Comparative Examples 1 to 2 and Examples 1 to 4 is shown in FIG. When the molar ratio of fatty acid to neutralizing agent was 12: 0 to 12: 1, it was confirmed that the gel was not formed and the wax was precipitated while the gel was formed at a weight of 6: 1 or more.

Claims (14)

Wherein the fatty acid and neutralizing agent are mixed in a molar ratio of 9.0: 1 to 1.2: 1. The method according to claim 1,
Wherein the multilayer ceramide lamellar structure further comprises a fatty alcohol. The method according to claim 1,
Wherein the fatty acid is a C12-C22 multilayer ceramide lamellar structure. The method of claim 3,
The fatty acid may be selected from the group consisting of lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid and behenic acid. One or more; The fatty alcohol may be selected from the group consisting of lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, arachidyl alcohol and behenyl alcohol. ≪ / RTI > Multilayer ceramide lamellar structure. The method according to claim 1,
Wherein the neutralizing agent is a neutralizing agent comprising at least one of tromethamine, triethanolamine, sodium hydroxide, potassium hydroxide, aminomethyl propanol, aminomethyl propane diol and arginine. The method according to claim 1,
Wherein the fatty acid is stearic acid and the neutralizing agent is tromethamine. The method according to claim 1,
Wherein the molar ratio of the fatty acid to the neutralizing agent is 7.0: 1 to 1.5: 1. The method according to claim 1,
Wherein the ceramide is at least one of a natural ceramide and a similar ceramide. 9. The method of claim 8,
Wherein the natural ceramide is at least one of ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7 and ceramide 8. 9. The method of claim 8,
Wherein said pseudoceramide is at least one of the compounds represented by the following formulas (1) to (6).
However,

Wherein R is a C9-C21 saturated or unsaturated aliphatic chain.
[Figure 2]

Wherein n is 1 or 2 and R and R 'are C9-C21 saturated or unsaturated aliphatic chains.
[Figure 3]

(Wherein,
m and n are the same or different and are an integer of 1 to 3;
k and l are the same or different and are 1 or 2;
j is 0 or 1;
R and R 'are C1-C31 linear or branched, saturated or unsaturated alkyl groups, which are the same or different, and contain or do not contain a hydroxyl group;
A ¹ , A ² and A ³ are the same or different and are hydrogen or any substituent of the following structure, provided that A ¹ , A ² and A ³ are simultaneously hydrogen:

Wherein M, M ¹ and M ² are selected from the group consisting of alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium- L is selected from the group consisting of polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, and L is a calcitic metal)
[Figure 4]

(Wherein R, R and R 'are the same or different, which does not contain or contains a hydroxy group, C ₁₀ -C ₃₂ linear or branched and saturated or unsaturated alkyl group;
R ³ and R ⁴ are the same or different and are hydrogen or a C 1 -C 4 alkyl or hydroxyalkyl group;
R < ⁵ > is -A or -CH2CH2OA, wherein A is any one of the substituents of the following structures.

Wherein M, M ¹ and M ² are selected from the group consisting of alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium- L is selected from the group consisting of polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, and L is an alkaline earth metal)
[Figure 5]

(Wherein m and n are the same or different and are an integer of 1 to 4; R and R 'are the same or different and are a C1-C31 linear or branched saturated or unsaturated alkyl group containing or not having a hydroxy group ; A1 and A2 are the same or different and are either hydrogen or a substituent of the following structure;

Wherein M, M ¹ and M ² are selected from the group consisting of alkali metals, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium- L is selected from the group consisting of polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, and L is an alkaline earth metal)
[6]

(Wherein m and n are the same or different and are an integer of 1 to 3;
k and l are the same or different and are 1 or 2;
j is 0 or 1;
A ¹ , A ² and A ³ are the same or different and are each hydrogen or a substituent having the following structure;

Wherein M < ¹ > and M < ² > are an alkali metal or an organic base containing nitrogen and L is an alkaline earth metal;
R is a substituent having the structure:

Wherein B is a methyl group at 5-, 7- or 8-position of tocopherol, m is an integer of 1 to 3, and D is -CH2 (CH3) -CH- or -CH (CH3) = C- .]) 11. An underwater type cosmetic composition comprising the ceramide lamella structure according to any one of claims 1 to 10. 12. The method of claim 11,
Wherein the composition is gel-like. 12. The method of claim 11,
Wherein the composition is a cream or lotion. An oil solution containing ceramides; Aqueous solution; And a solid fatty acid salt obtained by mixing a fatty acid and a neutralizing agent in a molar ratio of 9: 1 to 1.2: 1.

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