KR20160140252A - Integrated Biobank Management System - Google Patents

Integrated Biobank Management System Download PDF

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Publication number
KR20160140252A
KR20160140252A KR1020150076652A KR20150076652A KR20160140252A KR 20160140252 A KR20160140252 A KR 20160140252A KR 1020150076652 A KR1020150076652 A KR 1020150076652A KR 20150076652 A KR20150076652 A KR 20150076652A KR 20160140252 A KR20160140252 A KR 20160140252A
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South Korea
Prior art keywords
resources
bio
resource management
managing
temperature
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KR1020150076652A
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Korean (ko)
Inventor
서성보
송제민
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(주)터보소프트
서성보
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Priority to KR1020150076652A priority Critical patent/KR20160140252A/en
Publication of KR20160140252A publication Critical patent/KR20160140252A/en

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    • G06F19/363
    • GPHYSICS
    • G05CONTROLLING; REGULATING
    • G05DSYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D23/00Control of temperature
    • G05D23/19Control of temperature characterised by the use of electric means
    • G05D23/1927Control of temperature characterised by the use of electric means using a plurality of sensors
    • G06F19/366

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Automation & Control Theory (AREA)
  • Medical Treatment And Welfare Office Work (AREA)

Abstract

The present invention relates to a biological resource management system for receiving and managing laboratory animal resources such as human blood, plasma, biological tissue or the like, which is generated from human or laboratory animals, and provides information on providing the biological resources to the providers And a resource management unit for storing the provided bio-resources and managing the provided bio-resources to use the provided bio-resources.

Description

[0002] Integrated Biobank Management System [

The present invention relates to a management system capable of integrally managing biological resources.

Biological resources (human resources and laboratory animal resources) are of interest as important national resources that are expected to create high added value as a material of future bio-industry. In order to systematically collect and secure such biological resources, it is required to promote the securing of necessary resources from a long-term perspective and to establish a systematic system for efficient management and distribution.

Developed countries such as Europe, USA, and Japan recognize the importance of bio-resource information, and collect and manage the system efficiently with UK Biobank IT system (UK), caHUB (USA), caBIG (USA), dbGaP (United States).

However, all of these systems are systems that meet the specific needs of each country, and the overall functions for registering and distributing resources are not clearly established yet.

1) UK Biobank IT system: [http://www.ukbiobank.ac.uk] 2) caHUB (Cancer Human Biobank): [http://cahub.cancer.gov] 3) caBIG (Cancer Biomedical Informatics Grid): [http://www.cabig.nci.nih.gov] 4) dbGaP (Database of Genotype and Phenotype): [http://www.ncbi.nlm.nih.gov/gap]

Accordingly, the present invention provides a system for managing biological resources and information thereof, information on providers providing biological resources, sale of resources, resources to be branched, and the information thereof as a whole.

A bio-resource management system for receiving and managing bio-resources according to the present invention, the bio-resource management system comprising: a provider management unit for providing information on providing the bio-resources to the providers and managing the providers; And a resource management unit for managing the resources to be used.

Also, the provider management unit includes a registration unit for registering and managing information on the providers, a clinical information management unit for preparing and generating clinical questionnaires for the providers, and managing the inputted clinical questionnaire results.

Also, the resource management unit may include a storage unit for storing the bio-resources, a temperature management unit for managing the temperature of the storage unit, and a management unit for managing information about the bio-resources stored in the storage unit, And an information management unit that performs distribution, cultivation, extraction, and quality control of living resources.

The temperature management unit may include a first temperature measurement unit for measuring a temperature inside the storage unit, and a plurality of temperature measurement units disposed at one or more points where the refrigerant is circulated outside the storage unit, The temperature measuring unit, and the plurality of temperature measuring units, respectively, and monitors the temperature in real time.

Meanwhile, the biological resource management network system according to the present invention includes a provider management unit for providing information on providing bio-resources and providing the bio-resource to the providers, and for storing the provided bio-resources and managing them A plurality of biological resource management systems including a plurality of biological resource management systems including a plurality of biological resource management systems, and a network connecting the plurality of biological resource management systems, It is configured to access the data in the resource management system and to know registration and sale information about living resources.

The present invention according to the above-mentioned means can effectively manage biological resources, and can easily recognize the effect of tracking and utilizing the history even when the biological resource is used for sale.

1 is a view showing a concept of a biological resource management system according to the present invention.
2 is a diagram illustrating a configuration of a temperature control unit used in the biological resource management system of the present invention.
FIG. 3 is a diagram showing a bio-resource management system according to the present invention applied to a wide area by a network.

Hereinafter, the present invention will be described in detail with reference to the drawings.

In the present specification, the term "living organism" refers to all the medical, physical / chemical byproducts, such as human skin, blood, plasma, tissue, organ, etc., Physical / chemical by-products generated from experimental animals such as cows, pigs, monkeys, and the like, all of which can be stored and judged to be worth saving.

1 is an overall configuration diagram of a biological resource management system according to the present invention.

The provider management unit 110 provides medical, legal, and procedural information (when providing human resources) to the providers providing the living resources, or provides legal and procedural information on the experimental animals A resource manager 120 manages the provided content and the history of providers providing the bio resources after receiving the information, and the resource manager 120 manages the provided bio resources It is a module that provides the function of storing it in physical space and managing it so that it can be used, classified, and sold.

Let's take a closer look at these components.

First, the provider management unit includes a registration unit 111 for registering and managing information on bio-resources provided with the bio-resource providers, a clinical information management unit for preparing and generating clinical questionnaires for the bio-resource providers, (112).

All the bio-resources received or registered by the system are given a tag or bar code for management. In the registration unit, the resource is received through the provision of a bar code (or tag) for the bio-resource , And perform basic checks (various tests) on the received resources. Meanwhile, the registration unit may provide information on bio resources to potential providers and provide a serial number to the provider in order to provide bio-resources smoothly. The clinical information management unit generates clinical questionnaires and inputs them from providers And to provide continuing medical care for providers and preparation for disease.

The resource management unit 120 includes a storage unit 121 for physically storing the provided bio-resources, a temperature management unit 122 for maintaining the usefulness of the bio-resources by adjusting the temperature of the storage unit, And an information management unit 123 configured to perform search, verification, and distribution, distribution, cultivation, extraction, and quality control of living resources.

In the information management unit, if the sale of biological resources is performed, the information about the sale is also managed, and a sale processing unit (not shown) for performing the post-process necessary for sale can also be included in the information management unit.

The temperature management unit manages the temperature of the storage unit and is configured to monitor the temperature status of the storage unit in a wired or wireless manner at a near or remote location. The temperature management unit is configured to monitor the abnormal temperature of the storage unit, power off, , The technique for such a configuration is possible with any type of technology currently known.

2 is a conceptual diagram of the temperature management unit of the present invention. The temperature management unit according to the present invention may include a plurality of temperature measurement devices 262, 263, and 264 (not shown) in a refrigerant pipe located inside the storage unit 261 as well as the storage unit for maintaining the temperature of the living body in the storage unit in an optimum state. , 265). Accordingly, the refrigerant pipe from the evaporator 260 to the primary compressor 220 has a low-pressure gaseous refrigerant and gradually becomes a high-pressure refrigerant after passing through the condenser 250. Therefore, the temperature management unit according to the present invention monitors the temperature of the refrigerant pipe exposed to the outside rather than merely monitoring the temperature inside the storage unit, thereby maximizing the temperature maintenance effect according to the external temperature change.

On the other hand, when the temperature of the storage unit or the approach of an unauthorized person is detected, a text message may be automatically transmitted to the management personnel or a message recorded by telephone may be transmitted.

The information management unit is a module for managing all the information about the biological resources stored in the storage unit, and may have a database (DB) for managing information therein. Let's take a closer look at the functions of the information management department.

First, a search for stored biological resources can be given. In order to satisfy various search requests, a dynamic search function can be performed so that any data existing in the database can be searched. At this time, all the data on the database must have meta data set, and the metadata has the same meaning as the metadata in the database technology.

Also, it can have an information deviation search function, which is a method that can detect the presence of data that is incorrectly inputted by a user mistake or logic error in the database. That is, the metadata object and the attribute of the database described above are selected and all the data corresponding to the attribute are retrieved. Through this process, it is possible to find out data in which an object or an attribute is erroneously inputted.

On the other hand, the information management unit may perform verification of the currently stored biological resource, in which case the verification determines whether the same resource is actually stored in the same position as the managed information. That is, it means checking whether or not the resource on the data actually exists. At this time, when the resources actually stored in the storage unit of the storage unit is different from the position on the data stored in the information management unit, the operation of automatically changing the storage unit of the storage unit to the position on the data unit of the information management unit is automatically or manually performed by the user can do.

In addition, the information management unit may have the function of distributing, distributing, cultivating, extracting, and managing the quality of stored biological resources. Especially, in the case of pre-sale, A function for such pre-sale processing can also be provided.

At this time, the information about the sold bio resources and the usage history are all managed by a database (not shown) of the information management unit and can be utilized if necessary.

On the other hand, a registration unit in which information about providers is registered and registered information is managed includes a database (not shown), can input / output various information about providers, and automatically registers necessary clinical questionnaires And storing the input of the generated questionnaire in the database.

The databases referred to in the above description may be installed separately or managed integrally using a single database.

The biological resource management system according to the present invention has been described above with reference to FIGS. 1 and 2. FIG. FIG. 3 shows another example (biological resource management network system) of the biological resource management system according to the present invention.

A to E in FIG. 3 denote the bio-resource management systems described above. A to E each include a provider management unit and a resource management unit, and in most cases, A to E cover a large area.

  As shown in FIG. 3, each of the bio-resource management systems connected to each other through a network (a LAN, a WAN, a broadband network, or the like can be any type of network) The user can access all of the information related to the living resources, the provider, and the sale in other locations.

A detailed description thereof can be easily understood by referring to the above description.

One example according to the present invention will be described.

In a laboratory located in one place, bio-resources for dementia patients are collected and stored in a bio-resource storage unit maintained at a cryogenic temperature by sorting according to a bar code. The stored resources are monitored in real time using the temperature management unit. The clinical information (basic information, family history, medical information, etc.) is stored in the database together with the dementia information of the providers, and the clinical information is managed by the clinical information management unit.

In another laboratory located elsewhere, laboratory animal resources (cattle, rats, monkeys, etc.) are collected and stored in a cryogenic repository through classification according to the barcode. The stored resources are monitored in real time using the temperature management unit. The clinical information (basic information, medical information, household information, etc.) is stored in the database together with the information of the providers and the clinical information is managed by the clinical information management unit.

Therefore, in the above case, for the study of human dementia, it is possible to provide an environment in which biomaterials corresponding to the history of monkeys stored in another place (information about the state similar to dementia) can be used together.

On the other hand, the stored resources and the information thereon are managed through the database, and it is possible to output what kind of resources are stored in which storage, and where the resources satisfying the conditions (smoking power, drinking power, etc.) If you want to distribute the resources stored in the storage area of another area in the research institute, you can use the information management department to search the storage part of the research institute (or hospital) It can be sold.

In the case of the bio-resource management system described above, it is obvious that the scope of the right should be construed to be extended not only to the scope described in the present specification but also to a range obvious to the ordinary artisan.

Claims (5)

A biological resource management system for receiving and managing biological resources,
A provider management unit for providing information on providing the bio resources to the providers and managing the providers; And
And a resource management unit for storing the provided bio-resources and managing the provided bio-resources so that they can be used.
The method according to claim 1,
The provider management unit,
A registration unit for registering and managing information on the providers; And
And a clinical information management unit for preparing a clinical questionnaire for the providers, generating the questionnaire, and managing the results of the inputted clinical questionnaire.
The method according to claim 1,
The resource management unit,
A storage unit for storing the bio-resources;
A temperature management unit for managing the temperature of the storage unit; And
And an information management unit for managing information on the bio-resources stored in the storage unit, performing search and verification on the bio-resources, and distributing, distributing, culturing, extracting, and managing quality of the stored bio-resources. Resource management system.
The method of claim 3,
The temperature management unit includes:
A first temperature measuring unit for measuring a temperature inside the storage unit; And
And a plurality of temperature measurement units disposed at one or more points where the refrigerant is circulated outside the storage unit,
Wherein the predetermined temperature range is set for each of the first temperature measuring unit and the plurality of temperature measuring units,
A biological resource management system having a configuration for monitoring temperature in real time.
In a biological resource management network system,
A plurality of biological resource management systems according to any one of claims 1 to 4; And
And a network connecting the plurality of biological resource management systems,
And a bio-resource management system for accessing data in the other bio-resource management system by the network, wherein one of the plurality of bio-resource management systems accesses data in the other bio- system.
KR1020150076652A 2015-05-29 2015-05-29 Integrated Biobank Management System KR20160140252A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210012474A (en) 2019-07-25 2021-02-03 주식회사 코쿤 Bio-resource management server and bio-resource management method using the same
KR20220106267A (en) * 2021-01-21 2022-07-29 주식회사 턱스 System and method for monitoring biobank

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
[http://cahub.cancer.gov]
[http://www.cabig.nci.nih.gov]
[http://www.ncbi.nlm.nih.gov/gap]
[http://www.ukbiobank.ac.uk]
1) UK Biobank IT 시스템:
2) caHUB(Cancer Human Biobank):
3) caBIG(Cancer Biomedical Informatics Grid):
4) dbGaP(Database of Genotype and Phenotype):

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210012474A (en) 2019-07-25 2021-02-03 주식회사 코쿤 Bio-resource management server and bio-resource management method using the same
KR20220106267A (en) * 2021-01-21 2022-07-29 주식회사 턱스 System and method for monitoring biobank

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