KR20160126502A - Non Invasive Glucose Meter Using NIR Spectroscopy - Google Patents

Non Invasive Glucose Meter Using NIR Spectroscopy Download PDF

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KR20160126502A
KR20160126502A KR1020150057576A KR20150057576A KR20160126502A KR 20160126502 A KR20160126502 A KR 20160126502A KR 1020150057576 A KR1020150057576 A KR 1020150057576A KR 20150057576 A KR20150057576 A KR 20150057576A KR 20160126502 A KR20160126502 A KR 20160126502A
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light
glucose meter
blood glucose
wet
light emitting
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KR1020150057576A
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Korean (ko)
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홍충식
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홍충식
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1477—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means non-invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters

Abstract

The present invention relates to a non invasive glucose meter using NIR spectroscopy. The present invention includes a light emitting unit having two or more light sources and red light sources and a light receiving unit configured to measure light quantity of the NIR between 1300 nm and 1800 nm and the red light. Accordingly, the present invention can improve measurement error by using a transmissive light by being measured on an earlobe.

Description

근적외선을 이용한 비채혈식 혈당측정기{Non Invasive Glucose Meter Using NIR Spectroscopy}TECHNICAL FIELD [0001] The present invention relates to a non-blood-circulating blood glucose meter using NIR spectroscopy,

채혈이 필요없는 혈당측정기Blood sugar meter without blood collection

[문헌 1] 출원특허 1020090130819 근적외선과 부압을 이용한 비침습형 자가 혈당 측정기 [Patent Document 1] Patent Application No. 1020090130819 Non-invasive blood glucose meter using near-infrared and negative pressure

[문헌 2] 등록특허 1007756690000 팔목 휴대용 무채혈 혈당측정 장치[Patent Document 2] Registered Patent No. 1007756690000 Portable bloodless blood sugar measuring device for cuff

현대화 사회에서 당뇨환자가 급증하고 있으나 당뇨 지수를 측정하기 위해 채혈을 하게 됨으로써 많은 당뇨환자들이 감염의 위험에 처해 있으며 또한 채혈을 위한 장치의 사용으로 환자들이 고통을 느끼고 채혈의 공포를 느끼게 된다. 이러한 문제점을 해결하고자 [문헌1] 과 [문헌2]와 같은 시도가 있었다. 그러나 [문헌1]과 같이 실제적인 해결 수단을 만들지 못하거나 [문헌2]와 같이 과제 해결에 접근은 하였으나 실제적으로 그 측정 정확도를 만들어 내지 못해 아직까지 많은 당뇨 환자들이 고통을 받고 있다. 본 발명은 이러한 문제를 해결하고자 한다.Although diabetic patients are rapidly increasing in modern society, many diabetic patients are at risk of infection due to blood collection to measure the diabetic index. In addition, the use of devices for blood collection causes sufferers to feel pain and fear of blood collection. In order to solve such problems, there have been attempts such as [Document 1] and [Document 2]. However, as in [1], it is not possible to make a practical solution or to approach the solution of the problem as in [2]. However, many diabetic patients suffer from the fact that they can not produce the measurement accuracy. The present invention aims to solve such a problem.

[문헌2]와 같이 두개 이상의 근적외선 광원을 사용하나 본 발명에서는 적색 가시광선을 추가로 사용하여 측정장치의 결합 정도에따른 측정 오차를 개선한다.As described in [2], two or more near-infrared light sources are used, but in the present invention, a red visible light is additionally used to improve the measurement error according to the degree of coupling of the measuring apparatus.

[문헌2]에서는 손목에 착용하여 산란광을 이용하나 본발명은 귓볼에서 측정하여 투과광을 이용함으로써 측정 오차를 개선한다.In [Document 2], scattered light is worn on the wrist, but the present invention improves the measurement error by measuring in the earlobes and using transmitted light.

본발명은 정확하고 채혈이 필요없는 자가혈당기를 제공함으로써 당뇨환자들을 감염의 위험과 채혈의 고통에서 벋어나서 혈당관리를 할수있도록 하는 효과를 갖는다.The present invention has the effect of providing diabetic patients with blood glucose control while avoiding the risk of infection and suffering from blood collection by providing a self-contained blood glucose meter that is accurate and does not require blood collection.

제 1 도 블록도
제 2 도 흐름도First Block Diagram
2,

제 1 도는 본 발명에 따라 구현된 시스템의 블록도를 나타낸다.Figure 1 shows a block diagram of a system implemented in accordance with the present invention.

본 발명에의한 혈당계는 귀(100)의 귓볼부분을 측정한다. 수광부(210)은 파장 1800nm ~ 1300nm 사이의 근적외선 (Near Infra Red, NIR)의 광량을 측정할수 있고 또한 적색광의 광량을 측정할수 있는 광센서로 구성되어 있다. 수광부(210)에서 측정된 광량은 ADC(220)에서 디지탈 데이터로 변환되어 MCU(230)으로 전달된다. MCU(230)은 측정 데이터를 이용해 혈당지수를 계산하며 표시부(240), 메모리부(250), 무선부(260)및 발광부(280)등을 제어 한다. 발광부(280)을 제어하기 위해서 디지탈 데이터를 아날로그 출력으로 변환하는 DAC(270)을 사용하며 DAC(270)출력은 발광부(280)으로 전달된다. 발광부는 1800nm ~ 1300nm 사이의 근적외선 파장중 2개이상의 파장을 만들어내는 발광소자와 적색광을 만들어 내는 발광소자로 구성되어 있다.The blood glucose meter according to the present invention measures the earlob portion of the ear 100. The light receiving unit 210 is composed of an optical sensor capable of measuring the amount of near infra red (NIR) light having a wavelength of 1800 nm to 1300 nm and measuring the amount of red light. The amount of light measured at the light receiving unit 210 is converted into digital data at the ADC 220 and transmitted to the MCU 230. The MCU 230 calculates the blood glucose index using the measurement data and controls the display unit 240, the memory unit 250, the radio unit 260, the light emitting unit 280, and the like. In order to control the light emitting unit 280, a DAC 270 that converts digital data to an analog output is used, and an output of the DAC 270 is transmitted to a light emitting unit 280. The light emitting portion is composed of a light emitting element that emits two or more wavelengths of near infrared rays having a wavelength between 1800 nm and 1300 nm and a light emitting element that emits red light.

측정을 위해서 수광부(210)을 광차폐시키고 발광부(280)의 발광소자를 순차적으로 동작시키는 암광량측정(10)을 수행한다. 이후 발광부(280)의 적색광을 동작시키고 그 광량을 측정(20)하는데 이때 LPF 를 사용하고 일정시간(T0)동안 수행한다. 이후 발광부(280)의 NIR1을 동작시키고 그 광량을 측정(30)하는데 이때 LPF 를 사용하고 일정시간(T1)동안 수행한다. 이후 발광부(280)의 NIR2을 동작시키고 그 광량을 측정(40)하는데 이때 LPF 를 사용하고 일정시간(T2)동안 수행한다. 각각의 발광소자를 동작시키고 각각 정해진 일정시간(T0, T1, T2)동안 측정하는 이유는 광발열에 의한 혈당분자의 이동효과를 이용하기 위함이다.The light amount measuring unit 10 performs light amount measurement 10 for optically shielding the light receiving unit 210 and sequentially operating the light emitting units of the light emitting unit 280 for measurement. Then, the red light of the light emitting unit 280 is operated and the light amount thereof is measured (20). At this time, the LPF is used and performed for a predetermined time T0. Then, NIR1 of the light emitting unit 280 is operated and the amount of light thereof is measured (30). At this time, the LPF is used and performed for a predetermined time T1. Then, the NIR2 of the light emitting unit 280 is operated and the light amount thereof is measured (40). At this time, the LPF is used and performed for a predetermined time T2. The reason that each light emitting element is operated and measured for a predetermined period of time (T0, T1, T2) is to utilize the effect of the movement of the glucose molecule due to light generation.

암광량 측정(10)의 결과와 각 발광소자의 광량 측정(20, 30, 40)를 비교하여 암광량대비 광량비를 측정한다. 이 결과가 각각 vRed, vNIR1, vNIR2 이다.The results of the dark light intensity measurement 10 and the light intensity measurements 20, 30, and 40 of the respective light emitting devices are compared and the light intensity ratio to the dark light intensity is measured. These results are vRed, vNIR1, vNIR2, respectively.

vNIR1과 vNIR2 를 vRed 와 대비하여 vrNIR1과 vrNIR2 를 산출하고 vNIR1과 vNIR2 의 비인 RNIR 을 계산한다.vNIR1 and vNIR2 are compared with vRed to calculate vRNIR1 and vRNIR2, and the RNIR, which is the ratio between vNIR1 and vNIR2, is calculated.

혈당량 = a/vrNIR1 + b/vrNIR2 - c*RNIRBlood glucose level = a / vrNIR1 + b / vrNIR2 - c * RNIR

공식을 이용하여 혈당량을 계산하고 그 결과를 표시부(240)에 표시하고 메모리부(250)에 저장하며 무선부(260)을 통하여 연계기기에 전송한다.And displays the result on the display unit 240. The result is stored in the memory unit 250 and transmitted to the linking device through the wireless unit 260. [

10 암광량 측정
20 적색광량 측정
30 NIR1 광량측정
40 NIR2 광량측정
50 혈당지수 계산
100 귀
210 수광부
220 ADC
230 MCU
240 표시부
250 메모리부
260 무선부
270 DAC
280 발광부10 Dark light measurement
20 Red light measurement
30 NIR1 light measurement
40 NIR2 light measurement
50 Glycemic index calculation
100 ears
210 Photoreceptor
220 ADC
230 MCU
240 display unit
250 memory unit
260 wireless unit
270 DAC
280 Light-

Claims (6)

1300nm ~ 1800nm 사이의 근적외선 구간에서 2개이상의 광원과 적색광원을 포함한 발광부와 1300nm ~ 1800nm 사이의 근적외선과 적색광의 광량을 측정할수 있는 수광부, 이를 디지탈데이터로 변환하는 ADC, 제어하는 MCU등으로 구성된 비침습식혈당측정기A light emitting part including two or more light sources and a red light source in a near infrared ray section between 1300 nm and 1800 nm and a light receiving part capable of measuring a light amount of near infrared rays and red light between 1300 nm and 1800 nm and an ADC for converting the light into digital data, Non-wetting blood glucose meter 청구항 1에서 적색광을 기준으로 근적외선 광량을 계산 이용하는 비칩습식 혈당측정기Claim 1 is a non-chip wet blood glucose meter for calculating and using a near-infrared light amount based on red light 청구항 1에서 두개이상의 근적외선 측정값의 비율을 이용하여 혈당지수를 계산하는 비침습식 혈당측정기Claim 1 is a non-wet type blood glucose meter for calculating a blood glucose index using a ratio of two or more near- 청구항 1에서 무선부를 통하여 연동기기에 데이터를 전송하는 기능을 갖는 비침습식 혈당 측정기A non-wet-type blood glucose meter having a function of transmitting data to an interlocking device through a wireless unit 청구항 1에서 메모리부에 측정 결과값을 저장하는 기능을 갖는 비침습식 혈당측정기The non-wet-type blood glucose meter according to claim 1, wherein the non- 청구항 1에서 표시부에 결과값을 표시하는 기능을 갖는 비침습식 혈당측정기
A non-wet-type blood glucose meter having a function of displaying a result on a display unit
KR1020150057576A 2015-04-23 2015-04-23 Non Invasive Glucose Meter Using NIR Spectroscopy KR20160126502A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11020027B2 (en) 2017-09-18 2021-06-01 Samsung Electronics Co., Ltd. Apparatus and method for estimating glucose exposure and generating glucose exposure estimation model

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11020027B2 (en) 2017-09-18 2021-06-01 Samsung Electronics Co., Ltd. Apparatus and method for estimating glucose exposure and generating glucose exposure estimation model
US11642050B2 (en) 2017-09-18 2023-05-09 Samsung Electronics Co., Ltd. Apparatus and method for estimating glucose exposure and generating glucose exposure estimation model

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