KR20100054357A - System for signal detection of specimen using magnetic resistance sensor - Google Patents

Abstract

PURPOSE: A system for detecting the signal of a specimen is provided to detect the variation of a magnetic component in the specimen using a magnetic resistance sensor and an external magnetic field application device. CONSTITUTION: A fixing unit(120) fixes a specimen which is combined to a magnetic particle. An external magnetic field application device(110) applies an external magnetic field to the specimen. A magnetic resistance sensor(130) detects the magnetic component of the specimen which is combined to the magnetic particle based on the external magnetic field.

Description

System for signal detection of specimen using magnetic resistance sensor

The present invention relates to a diagnostic device using a magnetoresistive sensor. Specifically, the magnetic component is separated into an electrical component by detecting a change in a magnetic component on a sample (inspection object) coupled with magnetic particles using a magnetoresistive sensor and an external magnetic field applying device. And a detection system that can be analyzed.

In general, a magnetic sensor cartridge (magnetic sensor) is a sensor cartridge for measuring the size and direction of the magnetic field or the line of magnetic force, the magnetic field is measured by changing the properties of various materials due to the influence of the magnetic field. Hall elements or magnetoresistive (MR) elements are made using the Hall effect, magnetoresistance effect, etc., and they are also used to manufacture VTRs (Video Tape Recorders) and tape recorders.

Meanwhile, a giant magnetoresistive sensor cartridge and a sensing cell array using the same (Korean Patent Publication No. 2004-55387) have been disclosed as blood component analysis means.

1 is a conceptual diagram of a conventional giant magnetoresistive sensor cartridge and a sensing cell array using the same.

Thus, a plurality of giant magnetoresistive sensor cartridges are placed in a sensing cell array consisting of N columns and M rows, and a biosensor cartridge chip consisting of the sensing cell array is prepared at the package or wafer level.

Component measurement data consisting of surrounding materials are then exposed to each large magnetoresistive sensor cartridge. Then, the respective component measurement data are measured in the sensing cell array of the giant magnetoresistive sensor cartridge, and the component data measured by the blood component analyzer is electrically analyzed.

The existing invention relates to a giant magnetoresistive sensor cartridge and a sensing cell array using the same. A technology for sensing and analyzing components of peripheral materials each consisting of a plurality of components according to the detection of different magnetic fields to separate and analyze them into electrical components Started.

Existing invention has a large magnetoresistive sensor comprising a sensing cell array GMR (Giant Magneto Resistance) element, a switching element and a magnetic material (or forcing word line) to have a plurality of row and column types on a biosensor cartridge chip. Arranged in a sensing cell array, the magnetic susceptibility of each of the peripheral materials having different characteristics is sensed, and the electrical components of the peripheral materials are analyzed.

Alternatively, the peripheral material composed of a plurality of different components may be separated and analyzed into electrical components according to susceptibility or permittivity.

Magnetized pair sensing sensor with MTJ (Magnetic Tunnel Junction) or GMR element, magnetoresistive sensor with MTJ element and magnetic material, dielectric constant sensor with sensing capacitor switching element, MTJ element or GMR element, current line, variable ferromagnetic layer and Magnetization Hall sensing sensors with switching elements, or large magnetoresistive sensors consisting of GMR elements, switching elements and magnetic materials are arranged in the sensing cell array having a plurality of row and column shapes at the biosensor tip, and each of them has different characteristics. Depending on the component of the surrounding material and the size of the component, the different susceptibility or dielectric constant is sensed, and the components of the peripheral material to be analyzed are separated into electrical components.

The existing technology described the use of sensors as arrays and the sensing mechanism between sensors and bio-contents. The emphasis was placed on circuit configuration in relation to array types. However, the sensor configuration of the existing technology is based on a complicated memory structure and has a big problem in producing a simple sensing kit (Kit). In addition, there is a cost disadvantage in that the sensor and circuit stages using a semiconductor process such as an MRAM (Magnetic Random Access Memory) structure have to be composed of a Complementary Metal Oxide Semiconductor (CMOS) switching circuit. In addition, in the case of the existing technology, the sensitivity itself can be improved by 1: 1 contact, but the control of the amount of the detector by the limited volume of the device is limited, and each device requires a separate CMOS circuit. There is this difficult problem.

In addition, in the magnetoresistive sensor, when applying an external magnetic field, there is a technical problem that the sensor is unstable due to a change in external conditions during measurement, and a problem that the detection of the magnetoresistive sensor occurs due to the strengthening of the magnetization value of the magnetic particles. Occurred.

The present invention has been made to solve the above-mentioned problems, an object of the present invention is to mount a sample containing a bio-material such as antigen, and to perform a stable magnetic field in the external magnetic field application device and at the same time magnetic in the magnetic sensor The present invention provides a detection system that detects a magnetic signal for a sample in which components are combined, separates them into electrical components, and analyzes them.

The present invention is a configuration for solving the above problems, a sample fixing unit is fixed to the sample bonded to the magnetic particles; an external magnetic field applying device for applying an external magnetic field to the sample; detecting the magnetic component of the sample according to the external magnetic field It provides a signal detection system of the specimen using a magnetoresistive sensor comprising a; magnetoresistance (MR) sensor.

In particular, the external magnetic field applying device is characterized in that any one of a solenoid, an electromagnet, a magnet yoke.

In the present invention, the magnetoresistive sensor may be configured as at least one large magnetoresistive (GMR) device.

In addition, the magnetoresistive sensor of the present invention may be made of a bar chip form or a package form.

In particular, the sample fixing unit to which the sample is fixed may be formed as a measuring cartridge or a membrane.

In addition, the signal detection system using a magnetic sensor according to the present invention, the detection of the magnetic component by using a measuring cartridge or a membrane to detect the magnetic signal of the sample in a non-contact manner, or by mounting a sample on the magnetoresistive sensor The magnetic signal can be detected by the direct contact between the sensor and the specimen.

In addition, the above-described signal detection system according to the present invention may further comprise a scan unit for scanning the magnetic signal detected by the magnetic sensor.

In this case, the scan unit may be formed in a structure in which a specimen support unit for supporting the specimen and a measurement loader for fixing the specimen fixing unit are further provided.

In addition, the sample fixing unit may be fixed to the above-described measurement loader, and signal detection may be implemented by applying a constant frequency.

In addition, the present invention may further include a measurement value processing unit for separating and analyzing the magnetic signal sensed by the above-described system into an electrical component and outputting a result.

In addition, the present invention may be configured to further include a drive unit driven to reciprocate the specimen support unit or the magnetic sensor by a predetermined frequency in configuring the entire system.

The sample in the present invention may be a biomaterial including an antigen.

In addition, the magnetic particles bound to the sample in the present invention may be formed to have a magnetization value of 10 ~ 100emu / g, the magnetoresistance sensor is preferably to have a maximum sensitivity at 0 ~ 150Gauss.

According to the present invention, there is provided a signal detection system of a sample using a magnetoresistive sensor, but after mounting the sample on the sample fixing unit and applying an external magnetic field through an external magnetic field applying device, for a sample coupled with the magnetic component in the magnetic sensor It detects magnetic signals and allows them to be separated and analyzed into electrical components.

In particular, while applying an external magnetic field value using any one of the solenoid, electromagnet, magnet yoke, it maximizes the magnetization value of the magnetic particles, it has the effect of maximizing the detection efficiency by minimizing the effect on the magnetic sensor.

In addition, the present invention is to combine the giant magneto-resistance cartridge (Giant Magneto Resistance Cartridge) of the cartridge type for the biosensor cartridge with the measurement processing unit to detect and sense the sample combined with the magnetic component to be separated and analyzed as an electrical component When applying a large magnetoresistive device manufactured by the existing semiconductor unit process as a biosensor, quantitative analysis by improving the sensitivity of the small amount of the detector by non-contacting the sensing element and the sample This can be done smoothly.

In addition, the present invention can be used as a non-contact giant magneto-resistance sensor (Giant Magneto Resistance) to perform a bio-diagnosis through the sensing of the detector. Therefore, the membrane used for the point of care testing (POCT) can be installed in the specimen diagnostic kit to develop a measuring instrument for effective membrane measurement.

Furthermore, the present invention can overcome the detection range limited only to the size of the sensing element, and can distinguish noise between frequencies by a dynamic scanning method, thereby enabling quantitative measurement analysis.

Hereinafter, with reference to the accompanying drawings, it will be described a specific configuration and operation according to the present invention.

2 is a conceptual diagram illustrating a sensing principle of a magnetoresistive sensor used in the present invention. However, for convenience of description, the sensing principle using the Giant Magneto Resistance (GMR) of the magnetoresistive sensor will be described as an example.

This shows a spin-valve type Giant Magneto Resistance (GMR) device. As shown, the magnetoresistive sensor has a nonmagnetic metal layer sandwiched between two ferromagnetic metal layers. The magnetic force of the ferromagnetic metal layer of the first layer is fixed, and the magnetic force of the ferromagnetic material of the second layer is variably adjusted. When the first layer and the magnetic force are parallel, the principle that only electrons spin-oriented in a specific direction passes through the conductor. That is, according to the alignment of the magnetization directions of the two ferromagnetic layers, a difference in electrical resistance, or a potential difference, induced inside the material is generated and recognized as a digital signal. The case where an interlayer material is a conductor corresponds to a GMR device.

Referring to Figure 3 will be described the configuration of the basic detection system according to the present invention.

The basic configuration of the present invention includes a sample to be detected and a sample fixing unit 120 for fixing the sample, an external magnetic field applying device 110 for applying a magnetic field to the sample from outside, and a magnetoresistive sensor 130. Is done.

Mounting the sample to the sample fixing unit 120 using this basic structure, applying an external magnetic field from the external magnetic field applying device 110, combined with a magnetic component (magnetic particles) in the magnetoresistance sensor 130 It detects the magnetic signal on the sample and separates and analyzes it into electrical components. In particular, the sample may include a biomaterial such as an antigen, and may also include a non-biomaterial. Mounting (mounting) means that the sample is coupled to detect by applying an antigen to the fixed sample fixed unit.

The magnetoresistance sensor that can be used in the present invention includes a normal magnetoresistance (OMR) sensor, anisotropic magnetoresistance (AMR) sensor, a giant magnetoresistance (GMR) sensor, a colossal magnetoresistance (Colossal Magnetoresistance) , CMR) sensor, Tunneling Magnetoresistance (TMR) sensor, MJT (Magnetic Tunneling Junction) sensor is preferably used any one selected from. Particularly preferably, a giant magnetoresistance (GMR) sensor may be used.

Briefly, for each sensor described above, in the case of a non-magnetic conductor and a semiconductor material, the resistance changes because the conduction electrons are subjected to Lorentz force when the magnetic field is applied from the outside. In general, there is a characteristic that the change of resistance is quite small.

In addition, the anisotropic magnetoresistance (AMR) sensor uses an anisotropic magnetoresistance. In other words, in the ferromagnetic conductor material, in addition to the general magnetoresistance, there exist easy and hard axes due to spin-orbit coupling (d-band splitting by Spin-Orbit coupling). This is called AMR (Anisotropic MR) because it is determined by the angle between the external magnetic field direction and the current direction, and is determined by the direction. The sensor is characterized by a 2.5% difference in resistance in each of these directions.

In addition, a giant magnetoresistance (GMR) sensor may be used, and the giant magnetoresistance (GMR) sensor has a feature that has a magnetoresistance several times to several times larger than an anisotropic magnetoresistance material. In particular, the change in resistance is caused by additional scattering of conduction electrons according to the relative spin direction difference of adjacent magnetic layers, and its mechanism is fundamentally different from that of OMR or AMR.

In addition, the Colossal Magnetoresistance (CMR) sensor described above was first discovered by von Helmolt in 1993. The main characteristic is a sensor having a characteristic of changing resistance by 10 times when a magnetic field is applied.

In addition, a tunneling magnetoresistance (TMR) sensor can be utilized as the magnetoresistance sensor of the present invention. Tunneling magnetoresistance, using the above-described GMR theory, allows the middle layer to be replaced with an electrically insulator that is not a non-magnetic material. In theory, therefore, current cannot pass through the insulator. When the thickness is reduced to nano units, it refers to a technology and a system in which electrons are allowed to pass through by a tunneling effect, which is one of quantum mechanical effects, and refers to a sensor using the same.

MJT (Magnetic Tunneling Junction) sensor uses the same concept as TMR, and it can be applied to this. SDT (Spin Dependent Tunneling) also uses external spin up / down like GMR and TMR. It refers to using a method of measuring the resistance change value, all of which can be applied to the magnetoresistive sensor of the present invention. In addition, the magnetoresistive sensor may be formed in the form of a bar chip or a package.

The sample fixing unit 120 according to the present invention may be formed as a measuring cartridge or a membrane, and detects a magnetic signal of the sample in a non-contact manner using a measuring cartridge or a membrane, or mounts a sample on the magnetoresistive sensor. The magnetic signal may be detected by direct contact between the sample and the sample.

An embodiment of the specimen fixing unit 120 according to the present invention will be described with reference to FIG. 4. 4 is a schematic diagram of a large magnetoresistive (GMR) GMR measurement kit and amplification circuit of the magnetoresistive sensor.

As shown, the measurement kit as a sample fixing unit according to an embodiment of the present invention forms an electrode pattern by providing one or a plurality of biosensor GMRs therein. At this time, the GMR element used has a volume of 0.3mm, 0.5mm, 1.0mm or 0.25mm, 1.0mm, 1.5mm, the saturation field is 3 ~ 150Gauss and the sensitivity is minimum 0.9 ~ maximum. An element of 18 (mV / V-Oe) was used.

The GMR device's own interface was a Wheatstone bridge, and a power supply of 5 V was applied. At this time, a sensing element was measured to have a measurement of about 5 KΩ.

The size of the measurement kit using the GMR for biosensors was not limited to the minimum and maximum specifications, and the measurement kit specification could be changed with respect to the number of GMR elements and electrode patterns to be installed.

The measurement kit embedded with the GMR sensor is connected to the amplification circuit that amplifies the detected signal. A frequency filtering stage is added to remove the noise from the power stage and the output stage, and a bridge-amp LMC7101 amplifier is used. In particular, three or more differential amplifiers were installed to increase the sensitivity of the signal, and variable resistors were installed at the output stage to amplify the sensitivity of the sensor itself at the output stage. The amplifier used in the amplification circuit is not limited to the LMC7101 and various amplifiers can be used.

The configuration of the external magnetic field applying device according to the present invention will be described with reference to FIGS. 5 and 6. Electromagnet, magnet yoke and solenoid coil can be used to apply external magnetic field.

As shown in FIG. 5, the external magnetic field applying device according to the present invention is formed by using a solenoid coil, and specifically, it can be designed to be adjustable to 0 to 100 Gauss using a solenoid coil, and an applied magnetic field. The uniformity of can be made to have an error range within 1%. In addition, the size of the solenoid coil, the diameter of the cylinder, the thickness of the coil, the number of turns of the coil is designed to meet the above conditions, of course, can be changed.

6 is a device manufactured using an electromagnet or a permanent magnet as another example of a device for applying a magnetic field from the outside. In the case of the electromagnet yoke, the magnetic field applied from the outside can be adjusted from 0 to 200 Gauss, and the change rate of the magnetic field in the yoke is about 1% in a large range, and it is desirable to design and manufacture the change rate of 10 ^{-5 at} the center. Do. The size of the electromagnet yoke was produced through a simulation, the size and shape can be changed. In addition, an external magnetic field applying device may be manufactured by using a permanent magnet in addition to an electromagnet. In this case, it is preferable to select and manufacture a magnetic field range required from 0 to 200 gauss.

In this experiment, a permanent magnet type yoke was applied to apply 100Gauss, and the change rate of the magnetic field was designed to have an error range of about 1%.

When applying the GMR sensor as an embodiment of the present invention among the magnetoresistive sensors, it is preferable to be placed in the external magnetic field applying apparatus of FIG. 5 or 6 described above so that a magnetic field value of a certain condition is always applied during measurement.

The external magnetic field applying device applied in the present invention stabilizes the sensor by constantly maintaining external conditions at the time of measurement, and at the same time magnetizes the magnetic particles contained in the cartridge or membrane used for the measurement, so that the GMR sensor is magnetic particles. A unique advantage is realized to make it sense.

The external magnetic field applied value applied in the present invention is 0 to 150 Gauss. In general, when the external magnetic field value increases, the magnetization value of the magnetic particles increases, and the signal value of the GMR sensor that detects the magnetization value also appears strong. However, increasing the external magnetic field to increase the magnetization of the magnetic particles will affect the GMR sensor used for the measurement. For this reason, the magnetic particles used in the measurement have the maximum magnetization value, and the GMR sensor needs an external magnetic field applied value to minimize the influence. Therefore, as a preferred embodiment of the present invention, magnetic particles having a magnetization value of 10 to 100 emu / g can be used. In addition, the GMR sensor is preferably formed to have the maximum sensitivity at 0 ~ 150 Gauss.

7 is a graph showing data actually measured by the measurement system according to the present invention. In particular, here is the actual data measured by loading the magnetic material of 60emu / g as an example in the range of the magnetization value of 10 ~ 100emu / g in the sample fixing unit (measurement kit or membrane). In the above experiment, the external magnetic field was applied with 40 Gauss, the distance between the sensor and the measured material was maintained at about 250㎛, and the scan speed was measured at 2.4mm / sec. This condition is not fixed and can be changed.

The upper figure of Fig. 7 shows the signal in the initial state before the measurement. And the picture below shows the result of scanning the cartridge or membrane loaded with magnetic particles in the scanner's measuring loader as shown in ① ~ ⑤. As a criterion for determining the signal strength during measurement, the reference value before measurement or the value when the reference measurement material is scanned is set to noise, and the detected signal is determined as a signal as shown in Fig. 7 below. To judge.

8 is a result of measuring the intensity change of the signal by changing the concentration of the antibody conjugated with the magnetic particles. In the figure, the results of the measurement from 1ng / ml to 12ng / ml are displayed. In the actual measuring device, values of less than 1ng / ml and more than 12ng / ml can be measured. As shown in FIG. 7 and FIG. 8, the measurement system using the GMR sensor specified in the present invention can detect the magnetic particles, and also detect the antibody conjugated with the magnetic particles. In addition, the concentration change of the antibody can be analyzed quantitatively, and it can be confirmed that all substances that can be connected to the magnetic particles other than the antibody can be detected.

FIG. 9 is a variation of concentrations of the antibodies measured in FIG. 8, and the CV (displacement coefficient) value of a general biojidographic device is about 10%. This measuring device is analyzed as 3.34% referring to {Table 1}, the result of measuring the CV value when measuring the antibody as shown in FIG.

{Table 1}

The results of the experiments of FIGS. 7 to 9 confirmed the possibility of using a magnetic signal detector using GMR, and in particular, confirm the feasibility as a bio diagnostic device. This is especially the result confirming that it can be used as a quantitative analyzer using GMR.

Hereinafter, an application example as one embodiment including a signal detection system of a specimen using a magnetoresistive sensor according to the present invention will be described with reference to FIGS. 10 to 12.

Referring to FIG. 10, in the configuration of the detection system according to the present invention, a component for enhancing efficiency is formed in a basic configuration including a magnetoresistive sensor, a sample fixing unit, and an external magnetic field applying device. That is, in the present embodiment, the signal detection system further includes a scan unit for scanning the magnetic signal detected by the magnetic sensor, the scan unit for holding the sample support unit and the sample fixing unit for supporting the sample scan unit (loader) It may be formed to include more.

In addition, the signal detection system includes a measurement unit for driving the sample support unit or the magnetic sensor to reciprocate by a predetermined frequency and the magnetic signal sensed by the magnetic sensor as an electrical component, the measurement to output the results It is also possible to further form a value processing section.

Referring to the driving example with reference to the drawings, a sample fixing unit (cartridge or membrane) is attached to the measurement loader of the scanner, and the measurement is performed by scanning left and right from above or below the magnetoresistance sensor.

In this case, it is preferable to configure the measuring loader to be able to adjust the height up and down, and to minimize the distance between the magnetoresistive sensor and the measuring material (cartridge or membrane) before scanning to the left and right to maximize the sensitivity. It is desirable. (The height set during the actual measurement was measured by placing the measuring material (cartridge or membrane) 50 ~ 300㎛ away from the upper surface of the sensor.)

Due to the characteristics of the GMR sensor, the sensitivity varies depending on the distance between the measurement material and the sensor, and the change is inversely proportional to the third square of the distance. Therefore, minimizing the distance during measurement is the most important part. The above-described measurement according to the present invention are all measured by a non-contact method, and of course, the contact method may be measured to reduce the distance to a minimum. To make contact measurements, you need to build a system that detects signals in-situ rather than scan.

In the above-described system according to the present invention, if the distance between the magnetoresistive sensor and the measurement material (cartridge or membrane) is minimized as described above, the scan speed becomes an important factor when scanning left and right, and the signal strength of the GMR sensor depends on the scan speed. Changes. Therefore, the scanning speed should be changed according to the concentration and number of substances to be measured. The speed varies depending on whether one or more (two or more) substances are detected in one scan and the exact signal shape of the measured substance.

Referring to Figure 11 will be described a specific experimental example of one embodiment of the application of the measurement system of FIG. 11 shows a scanning jig system that is actually manufactured.

That is, FIG. 11 is a design drawing of a scanner device for installing a sample fixing unit (measurement cartridge or membrane) on which a biomaterial (antibody or sample) is fixed to a measurement loader and outputting an electric signal in a manner of reciprocating by a predetermined frequency. And an image of the actual product.

11, various types of scanners can be manufactured, and the size of the scanner can be changed according to the size of the external magnetic field applying device mounted on the scanner. The operating range of the scanner was driven to ± 100mm based on the center, and the scan time can be scanned at 0.0005 ~ 5.0mm / sec per second to detect the detection material of the entire cartridge range. , output in real-time.

The sensitivity of GMR (Giant Magneto Resistance) for biosensors is inversely proportional to the distance cube, so the micrometer (μ-meter) is installed up and down and back and forth to secure the minimum distance after the measurement loader is installed. The change in sensitivity is maximized.

In addition, the measurement cartridge or membrane in which the biomaterial (antibody or sample) for detection is fixed outputs the output signal by reciprocating scan, and the post time between round trips is set to 0 to 10Sec, so that the sensing response Signal cancellation due to sensing response relaxation is minimized.

This measurement method is advantageous for GMR devices for biosensors that generate higher output at dynamic moments than static conditions, and biomaterials (antibodies or Specimen) It is advantageous to know the distribution profile.

The cartridge or membrane mounted on the scanner's measuring loader is designed to apply the POCT products that are currently used in the market. The size and shape of the scanner can be changed in the future.

12 shows a combination example of a magnetoresistive sensor and a measured value processing unit according to the present invention, and shows that the magnetoresistive sensor is applied with GMR. The component is composed of the magnetoresistive sensor 20 and the measured value processing unit 30, the measured value processing unit amplifies the signal output from the magnetoresistive sensor by the bridge amplifier and the variable resistor, the thrust from the magnetoresistive sensor by the filter The noise is removed from the signal, and the measurement value processing unit distinguishes the particle free state, the particle ratio increase state, and the particle detection state check so that the measured value can be output quantitatively.

As described above, the present invention provides a signal detection system of a sample using a magnetoresistive sensor, but after mounting the sample on the sample fixing unit and applying an external magnetic field through an external magnetic field applying device, the magnetic field of the sample combined with the magnetic component in the magnetic sensor. It detects signals and allows them to be separated and analyzed into electrical components.

In particular, while applying the value of the external magnetic field using the solenoid, to maximize the magnetization value of the magnetic particles, it is possible to maximize the efficiency of the detection by minimizing the influence on the magnetic sensor.

In the foregoing detailed description of the present invention, specific examples have been described. However, various modifications are possible within the scope of the present invention. The technical idea of the present invention should not be limited to the embodiments of the present invention but should be determined by the equivalents of the claims and the claims.

1 is a conceptual diagram of a conventional giant magnetoresistive sensor cartridge and a sensing cell array using the same.

2 is a conceptual diagram illustrating a sensing principle of a magnetoresistive sensor used in the present invention.

3 is a block diagram of a basic detection system according to the present invention.

4 is a schematic diagram of a large magnetoresistive (GMR) GMR measurement kit and amplification circuit of the magnetoresistive sensor.

5 and 6 are views showing the configuration of the external magnetic field applying apparatus according to the present invention.

7 is a graph showing data actually measured by the measurement system according to the present invention.

8 is a result of measuring the intensity change of the signal by changing the concentration of the antibody conjugated with the magnetic particles.

FIG. 9 is a variation of concentration values measured for the antibody measured in FIG. 8.

10 is a temporary example of a detection system according to the present invention.

FIG. 11 illustrates a specific experimental example of an application example of the measurement system of FIG. 10.

12 illustrates a combination example of a magnetoresistive sensor and a measured value processor according to the present invention.

Claims (15)

A sample fixing unit to which a sample to which magnetic particles are bound is fixed; An external magnetic field applying device for applying an external magnetic field to the specimen; A magnetoresistance (MR) sensor for detecting a magnetic component of the specimen according to the external magnetic field; Signal detection system of the specimen using a magnetoresistive sensor comprising a. The method according to claim 1, The external magnetic field applying device is a signal detection system for a specimen using a magnetoresistive sensor, characterized in that any one selected from solenoid, electromagnet, yoke. The method according to claim 2, The magnetoresistive sensor is a signal detection system for a specimen using a magnetoresistive sensor, characterized in that composed of at least one giant magnetoresistive (GMR) device. The method according to claim 2, The magnetoresistive sensor is a signal detection system of the specimen using a magnetoresistive sensor, characterized in that the bar chip form or package form. The method according to claim 1, The specimen holding unit is a signal detection system of the specimen using a magnetoresistive sensor, characterized in that the measuring cartridge or membrane. The method according to claim 2, The detection of the magnetic component is a signal detection system using a magnetic sensor, characterized in that for detecting the magnetic signal of the sample in a non-contact manner using a measuring cartridge or membrane. The method according to claim 2, The detection of the magnetic component is a signal detection system using a magnetic sensor, characterized in that for mounting a sample on the magnetoresistive sensor to detect a magnetic signal in a direct contact between the sensor and the sample. The method according to claim 1, The signal detection system further comprises a scan unit for scanning the magnetic signal detected by the magnetic sensor signal detection system of the specimen using a magnetoresistive sensor. The method according to claim 8, wherein the scan unit, Specimen signal detection system using a magnetoresistance sensor, characterized in that it further comprises a specimen support for supporting the specimen and a measurement loader for fixing the specimen fixing unit. The method according to claim 9, A signal detection system for a specimen using a magnetoresistive sensor, characterized in that the specimen fixing unit is fixed to the measurement loader and the signal is detected by applying a constant frequency. The method according to claim 9, And a measurement value processing unit for separating the magnetic signal detected by the magnetic sensor into an electrical component, analyzing the magnetic signal, and outputting a result. The method of claim 11, The signal detection system further comprises a drive unit driven to reciprocate the specimen support unit or the magnetic sensor by a predetermined frequency. The method according to claim 1, The sample is a signal detection system of the sample using a magnetoresistance sensor, characterized in that the biomaterial containing an antigen. The method according to any one of claims 1 to 13, The magnetic particle is a signal detection system of the specimen using a magnetoresistive sensor, characterized in that having a magnetization value of 10 ~ 100emu / g. The method according to claim 14, The magnetoresistive sensor is a signal detection system of the specimen using a magnetoresistive sensor, characterized in that it has a maximum sensitivity at 0 ~ 150Gauss.

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