KR102169712B1 - Evacuated blood collection tube manufacturing equipment capable of uniform reagent dispensing - Google Patents

Abstract

The present invention relates to a vacuum blood collection tube manufacturing facility and manufacturing method capable of uniform reagent dispensing, and includes a transfer unit for transferring cartridges forming insertion holes arranged in one or more rows and columns from one side to the other, and an insertion hole of the transferred cartridge. A tube insertion part for mounting a tube on the cartridge, a reagent injection part for filling or spraying a liquid filler of a gel or reagent into the tube mounted on the cartridge in microliter units, and drying for drying the liquid filler filled or sprayed into the tube In the vacuum blood collection tube manufacturing facility comprising a unit and a cap coupling unit for coupling a cap to the tube, the reagent injection unit includes a reagent injection device configured to suck the liquid filler and then to flow and discharge the liquid filling material for a predetermined distance, and the reagent The input device is formed so that the upper and lower sides of the reagent pipe through which the liquid filler flows are pressurized by a shaft assembly to temporarily stop the flow of the liquid filler, and the shaft assembly that pressurizes the upper side is a shaft assembly that presses the lower side after pressing. Homogeneous reagent dispensing, characterized in that the liquid filling is dispensed as much as the intervals between the axes by moving along the reagent pipe to the position, and the shaft assembly that pressurizes the lower side is formed to alternately move to the position of the shaft assembly that presses the upper side. It relates to a possible vacuum blood collection tube manufacturing equipment and manufacturing method.

Description

Evacuated blood collection tube manufacturing equipment capable of uniform reagent dispensing}

The present invention relates to a vacuum blood collection tube manufacturing facility and manufacturing method capable of uniform reagent dispensing, and more particularly, to a uniform reagent dispensing capable of uniformly dispensing reagents through multi-axial rolling bearings symmetrical so that the axial spacing is constant. It relates to a co-collection facility and manufacturing method.

With increasing interest in health and rapid progress in health screening technology, extensive blood tests including serum biochemical tests, serum immunity tests, and blood count tests are contributing greatly to disease prevention and early stage diagnosis. These blood tests collect a certain amount of blood irrespective of the object and type of the test, and store it in a certain container during the process of storing, transporting, and processing it. The most common container used at this time is a blood collection tube, and a part of this blood collection tube is provided as a vacuum blood collection tube through which blood can be easily drawn into the container during the blood collection process by forming a vacuum inside.

These blood collection tubes are of various types depending on the use and size, but are generally composed of a tube with an open top and a cap inserted or covered in the opening of the tube to seal the inside of the tube. It is filled or coated with a liquid filling of a gel or reagent that promotes separation into plasma or the like.

At this time, when the liquid filling material is uniformly filled or applied, it is easy to separate the blood components, and accurate blood diagnosis results can be derived. In this regard, Korean Patent Registration No. 10-1318995'Method of manufacturing a blood collection tube' discloses a method of manufacturing a vacuum blood collection tube, while dispensing a reagent in a uniform amount using a uniform pressure of a pump, Disclosed is a technique for filling or coating by spraying.

However, although such a method of simply controlling the pumping pressure makes the pressure uniform, it is difficult to always uniformly form the pumping pressure for each pump, and it is even more difficult to precisely control the pressure. In addition, when spraying into the tube of the vacuum blood collection tube, it is sprayed in units of microliters, and it is very difficult to control the pressure of the pump to make the injection amount constant.

In particular, it is common to have a plurality of reagent injection devices to apply liquid fillers to a plurality of tubes per process. At this time, in order to form a uniform pressure for each reagent injection device, a pump is installed individually for each reagent injection device. Although desirable, this increases the cost and has the advantage of being inefficient.

Accordingly, a small number of pumps should be provided to uniformly dispense with a plurality of reagent spraying devices, but there is a problem that it is impossible to uniformly dispense a liquid filler to a plurality of reagent spraying devices with a substantially uniformly small number of pumps.

In order to solve the above problems, the present invention provides a multi-axial rolling bearing formed in a constant axial spacing to rotate while pressing a reagent pipe formed in a reagent spraying device that sucks and discharges a gel or reagent that promotes separation of blood components. An object of the present invention is to provide a vacuum blood collection tube manufacturing facility and a manufacturing method capable of uniform reagent dispensing, in which a gel or reagent is uniformly dispensed by the amount of rotation.

A vacuum blood collection tube manufacturing facility capable of uniform reagent dispensing according to an embodiment of the present invention for solving the above problem includes a transfer unit for transferring cartridges forming insertion holes arranged in one or more rows and columns from one side to the other, and the transfer A tube insertion part for mounting a tube in the insertion hole of the cartridge, a reagent injection part for filling or injecting a liquid filling of a gel or reagent into the tube installed in the cartridge in microliter units, and a liquid filled or sprayed into the tube In the vacuum blood collection tube manufacturing facility comprising a drying unit for drying the filling and a cap coupling unit for coupling a cap to the tube, the reagent injection unit comprises a reagent injection device formed to suck the liquid filling and then discharge it by flowing a predetermined distance. And the reagent injection device is formed so that the upper and lower sides of the reagent pipe through which the liquid filler flows are respectively pressurized by a shaft coupling body to temporarily stop the flow of the liquid filler, and the shaft coupling body that pressurizes the upper side moves the lower side after pressurization. The shaft assembly that moves along the reagent pipe to the position of the pressurizing shaft assembly, and the shaft assembly that pressurizes the lower side is formed to alternately repeat moving to the position of the shaft assembly that pressurizes the upper side, so that the liquid filler can be dispensed.

Here, the reagent injection device comprises: a reagent suction unit for sucking the liquid filling material; A reagent discharge unit for discharging the liquid filling material; The reagent suction part and the reagent discharge part are connected so that the sucked liquid filling is discharged to the reagent discharge part, and is driven by a connection hose forming the reagent pipe and a servo motor installed at one side to pressurize the middle part of the connection hose, At least two or more axes are formed radially so as to form a symmetrical structure, and include a multiaxial rolling bearing having the same distance between the axes, and uniform dispensing of the liquid filling is possible as much as the rotation amount of the multiaxial rolling bearing, and the dispensed liquid filling is kept as it is. It can be discharged and filled into the tube.

In addition, the reagent injection device further includes an air injection device installed to be connected to one side of the reagent discharge unit to inject compressed air, and the compressed air is first injected to discharge the liquid filling material into the tube. It can be made to be sprayed with uniform droplets of.

In addition, the connection hose may be a silicone hose.

In addition, the multi-axial rolling bearing has the position of the upper pressurization point, which is the pressurization start point of the connection hose, and the lower pressurization point, which is the pressurization end point, and the connection hose distance from the pressurization start point to the reagent suction unit and the reagent discharge unit from the pressurization end point. The connected hose distance may be a location forming the same distance.

In addition, when a plurality of reagent injection devices are provided, the multi-axial rolling bearings of the plurality of reagent injection devices are connected to each other, so that it can be uniformly controlled by the servomotor.

Next, a method for manufacturing a vacuum blood collection tube capable of uniform reagent dispensing according to an embodiment of the present invention for solving the above problem includes a cartridge supply step of supplying cartridges forming insertion holes arranged in one or more rows and columns, and transfer A tube insertion step of inserting a tube into the cartridge supplied to the device, a reagent input step of introducing a liquid filler of a gel or reagent that promotes blood separation into the tube inserted into the cartridge, and a liquid filler input in the reagent injection step In the method for producing a vacuum blood collection tube capable of uniform reagent dispensing, including a drying step of drying the liquid and a cap coupling step of completing the production of the vacuum blood collection tube by combining the cap with the tube on which the liquid filler is dried, the reagent input The step includes filling the liquid filler, and the filling of the liquid filler comprises: sucking a liquid filler of a gel or a reagent; Uniformly dispensing liquid fillings by rotating multi-axial rolling bearings having the same axial spacing by the servomotor; It may include the step of discharging the dispensed liquid filler into the tube as it is.

In addition, the step of introducing the reagent further includes spraying a liquid filler, and the spraying of the liquid filler comprises: sucking a liquid filler of a gel or a reagent; Spraying compressed air; Uniformly dispensing liquid fillings by rotating multi-axial rolling bearings having the same axial spacing by the servomotor; It may include the step of discharging the dispensed liquid filler into uniform droplets in units of microliters by pushing out the jetted compressed air.

In the vacuum blood collection tube manufacturing facility and manufacturing method capable of uniform reagent dispensing according to an embodiment of the present invention, a liquid filling material is uniformly filled into the vacuum blood collection tube tube using a device equipped with a uniform reagent dispensing system, or microliters It is possible to uniformly apply droplets, and since reagent dispensing can be uniformly controlled, all vacuum blood vessels produced can exhibit the same performance, and thus, there is an advantage that can greatly contribute to the improvement of precision in the field of blood diagnosis.

In addition, it has a simple structure, so that the maintenance cost is simple, and the cost is relatively low at the time of manufacturing or maintenance of equipment.

1 is a structure of a vacuum blood collection tube manufactured according to an embodiment of the present invention.
2 is a block diagram of a vacuum blood collection tube manufacturing facility capable of uniform reagent dispensing according to an embodiment of the present invention.
3 is an exemplary view of mounting a tube of a tube insertion unit, which is a configuration of the vacuum blood collection tube manufacturing facility of FIG. 2.
4 is a schematic diagram of a reagent injection unit, which is a configuration of the vacuum blood collection tube manufacturing facility of FIG. 2.
Figure 5 (a) is a front view between the reagent inlet and the reagent discharge portion of the reagent inlet device among the reagent inlet of Figure 4, (b) is a side view of (a), and (c) is a schematic diagram of the reagent inlet device to be.
6 is a block diagram of a vacuum blood collection tube manufacturing facility capable of uniform reagent dispensing according to an embodiment of the present invention in which an observation unit is added.
7 is a block diagram showing a detailed configuration of the observation unit of FIG. 6.
8 is a flow chart of a method for manufacturing a vacuum blood vessel capable of uniform reagent dispensing according to an embodiment of the present invention.
9 is a diagram showing detailed steps of a reagent injection step among the steps of the manufacturing method of FIG. 8.
10 is a flowchart of a step of filling a liquid filler during the reagent injection step of FIG. 9.
11 is a flowchart of a step of spraying a liquid filler during the reagent injection step of FIG. 9.

Hereinafter, the description of the present invention with reference to the drawings is not limited to a specific embodiment, and various transformations may be applied and various embodiments may be provided. In addition, the content described below should be understood to include all conversions, equivalents, and substitutes included in the spirit and scope of the present invention.

In the following description, terms such as first and second are terms used to describe various elements, and their meanings are not limited thereto, and are used only for the purpose of distinguishing one element from other elements.

The same reference numbers used throughout this specification denote the same elements.

Singular expressions used in the present invention include plural expressions unless the context clearly indicates otherwise. In addition, terms such as "include", "include" or "have" described below are intended to designate the presence of features, numbers, steps, actions, components, parts, or combinations thereof described in the specification. It is to be construed and not to preclude the possibility of addition or presence of one or more other features, numbers, steps, actions, components, parts, or combinations thereof.

Hereinafter, a vacuum blood collection tube manufacturing facility and manufacturing method capable of uniform reagent dispensing according to an embodiment of the present invention will be described in detail with reference to FIGS. 1 to 11.

1 is a structure of a vacuum blood collection tube manufactured according to an embodiment of the present invention.

First, a brief description of the vacuum blood collection tube 1 manufactured according to the present invention with reference to FIG. 1 is a tube for storing blood collected during a blood test, and a body with an open top to accommodate blood B It is composed of a cylindrical tube (T) and a cap (C) that seals the cylindrical tube (T) by being inserted or covered in the opening of the cylindrical tube (T), and a gel that promotes the separation of blood components inside the cylindrical tube (T). Alternatively, a reagent (LC) (hereinafter referred to as a “liquid filler”) may be filled, or applied in micro units.

At this time, when the liquid filling material LC is uniformly filled or applied for each tube, it is easy to separate the blood (B) component, and an accurate blood diagnosis result can be derived. However, in the related art, since the liquid filling material is dispensed by simply controlling the pump amount, the dispensing amount is not accurate, and it is not easy to uniformly spray the filling or the liquid filling material in microliter units.

In addition, it is common to have a plurality of reagent spraying devices to fill or apply liquid fillers to multiple tubes per process.At this time, it is difficult to have a pump provided for each reagent spraying device, and even if equipped, it is difficult to uniformly control it. There was a problem in that the amount of reagent dispensed per tube was not constant.

The present invention is a device equipped with a uniform reagent dispensing system to solve the above problems and to uniformly fill or apply a liquid filler. It has a simple structure and can be uniformly applied with a fine liquid filler in microliter units. Since dispensing can be uniformly controlled, there is an advantage that can greatly contribute to the improvement of precision in the field of blood diagnosis.

FIG. 2 is a configuration diagram of a vacuum blood collection tube manufacturing facility capable of uniform reagent dispensing according to an embodiment of the present invention, and FIG. 3 is an exemplary view of mounting a tube of a tube insertion unit, which is a configuration of the vacuum blood collection tube manufacturing facility of FIG. 4 is a schematic diagram of a reagent injection unit, which is a component of the vacuum blood collection tube manufacturing facility of FIG. 2.

In addition, (a) of FIG. 5 is a front view between the reagent intake part and the reagent discharge part of the reagent injection device among the reagent injection parts of FIG. 4, (b) is a side view of (a), and (c) is a reagent injection device. 6 is a schematic diagram of a vacuum blood collection tube manufacturing facility capable of uniform reagent dispensing according to an embodiment of the present invention in which an observation unit is added, and FIG. 7 is a block diagram showing a detailed configuration of the observation unit of FIG. 6.

2 to 7, the vacuum blood collection tube manufacturing facility capable of uniform reagent dispensing according to an embodiment of the present invention includes a tube insertion unit 20, a transfer unit 10, a reagent injection unit 30, and a drying unit ( 40) and the cap coupling portion 50 may be included.

Specifically, the tube insertion unit 20 may be mounted on a cartridge CT forming an insertion hole arranged in one or more rows and columns of the cylindrical tube. To this end, the tube insertion unit 20 may include a tube support (TS) provided with a number equal to or less than the number of columns and rows of the cartridge (CT), and each tube support (TS) is a tube (T) It is supplied and temporarily supported, and when the cartridge CT is transferred or mounted under the tube support TS, as shown in FIG. 3, the lower end of the cylindrical tube may correspond to the insertion hole, and then inserted.

At this time, it is preferable to insert the tube insertion unit 20 in an upright alignment so that the tube T is accurately mounted on the cartridge CT, and for this purpose, the tube insertion unit 20 uses a tube alignment device (not shown). It may contain more. That is, the tube (T) is first aligned to be upright through the tube alignment device, and then the tube (T) aligned with the tube support (TS) is supplied to allow the tube support (TS) to insert the tube (T) into the insertion hole. I can.

The transfer unit 10 may transfer the cartridge CT. That is, the transfer unit 10 may be formed to pass through the tube insertion unit 20, the reagent injection unit 30, the drying unit 40, and the cap coupling unit 50, and may be connected to the cartridge supply unit 5 . At this time, the transfer unit 10 may be formed in a conveyor type, but is not limited and may be used by applying various means such as an LM guide.

As shown in FIG. 4, the reagent injection unit 30 may include a reagent storage unit 32 and a reagent injection device 36. Here, the reagent storage unit 32 is a space for storing a liquid filling material, and may be connected to the reagent injection device 36.

At this time, the connection between the reagent storage unit 32 and the reagent injection device 36 may be connected by a connection pipe 34 such as a hose or pipe, and at this time, the liquid filling flows along the connection pipe 34 by osmotic pressure. It can be sucked into the reagent injection device 36.

The reagent injection device 36 may be formed so that the upper and lower sides of the reagent pipe through which the liquid filler flows are pressurized by a shaft assembly, so that the flow of the liquid filler is temporarily stopped.

At this time, the shaft assembly that presses the upper side moves along the reagent pipe to the position of the shaft assembly that presses the lower side after pressing, and the shaft assembly that presses the lower side is formed to alternately move to the position of the shaft assembly that presses the upper side. The liquid filling may be dispensed by the interval between the axes.

To this end, the reagent injection device 36 may include a reagent suction unit 361, a reagent discharge unit 362, a connection hose 363 and a multiaxial rolling bearing 364, as shown in FIG. It may further include an injection device 366.

Specifically, the reagent suction unit 361 is formed on the reagent injection device 36 to suck the liquid filling material from the reagent storage unit 32 through the connection pipe 34.

In addition, the reagent discharge unit 362 is a place for discharging the liquid filler sucked into the reagent suction unit 361, and is located under the reagent injection device 36, and a spray nozzle that forms a discharge path for the liquid filler therein. Is provided, and an air injection device 366 may be connected to one side.

That is, an air reagent pipe (not shown) through which compressed air of the air injection device 366 flows may be formed to be connected to one side of the discharge path in the injection nozzle.

The connection hose 363 is a device that forms a reagent pipe of the reagent injection device 36 described above, and may connect the reagent suction part 361 and the reagent discharge part 362. That is, one end of the connection hose 363 is coupled to the reagent suction unit 361, and the other end is coupled to the reagent discharge unit 362 to allow the liquid filling to flow between the reagent suction unit 361 and the reagent discharge unit 362. I can.

In addition, the connection hose 363 may be provided with a silicone hose that is flexible and has a predetermined rigidity. However, this is not limited as an example, and a hose made of a material having a flexible, compressive, and resilient material such as a silicone hose is sufficient.

At this time, the multi-axial rolling bearing 364 may be formed to pressurize the intermediate portion of the connection hose 363, through which uniform dispensing of the liquid filling material, which is a feature of the present invention, may be possible.

More specifically, the multi-axial rolling bearing 364 may be installed to be driven by a servo motor 365 provided at one side. In addition, the multi-axial rolling bearing 364 is formed radially so that a plurality of axes form a symmetrical structure, and the intervals between the axes may be the same. That is, the multi-axial rolling bearing 364 may be formed by connecting all of the aforementioned axial coupling bodies, and may be formed in a regular polygonal arrangement when viewed from the side.

The multi-axial rolling bearing 364 of such a structure can move the liquid filling by the interval between the axes, so that the liquid filling can be uniformly dispensed.

At this time, the multi-axial rolling bearing 364 is not limited, but a position at which the position of the pressure start point and the pressure end point with respect to the connection hose is symmetric, that is, one end of the connection hose 363 connected to the reagent suction part 361 from the pressure start point. It is preferable that it is installed so as to pressurize a position in which the distance from the pressure end point to the other end of the connection hose 363 connected to the reagent discharge unit 362 forms the same distance.

That is, it is formed to pressurize the position where the reagent injection device 36 is equally divided into upper and lower portions. Through this, since the pressure between the upper and lower portions can be made uniform, the dispensing of the liquid filling can be more accurate.

On the other hand, as illustrated in FIGS. 4 to 5, when a three-axis rolling bearing is described as an example, the connection hose 363 may connect the reagent suction part 361 and the reagent discharge part 362 in a straight line, but FIG. 5 As described above, the length may be provided in the front direction or not shown in the drawings, but a length may be formed to pass through a predetermined space provided in the rear direction to form a section forming a circular pipe.

In this case, in the three-axis rolling bearing, the part where the circular pipe starts and ends may be matched on a virtual vertical line with respect to the ground. That is, the multi-axial rolling bearing 364 is formed to rotate while pressing along the inner circumferential surface of the circular pipe aligned on the vertical line. Through this structure, it is possible to prevent the multi-axial rolling bearing 364 from unintentionally rotating due to the self-weight of the liquid filling material.

Through the above-described multi-axial rolling bearing 364, the present invention has the advantage of being able to always fill a certain amount of liquid filler when filling a liquid filler into a tube.

Meanwhile, the reagent injection device 36 according to an embodiment of the present invention may further include an air injection device 366 as described above.

Specifically, the air injection device 366 is installed to be connected to one side of the reagent discharge unit 362 to supply compressed air to the reagent discharge unit 362, and for this purpose, the air injection device 366 is a compressor (not shown). Etc. may be provided.

Here, the compressed air is continuously supplied for a set period of time before the liquid filler that has been uniformly pushed out by the distance between the axes of the multiaxial rolling bearing 364 is dispensed, and the liquid filler is dispensed with the supplied compressed air and pushed out. It can be sprayed into microliters of droplets and applied into the tube.

Here, when the compressed air is supplied after dispensing of the liquid filler, even if the dispensing amount of the liquid filler is constant, it is sprayed as non-uniform microliter droplets, so it is preferable to supply compressed air first.

In the reagent injection device 36 having such a structure, as long as the multi-axial rolling bearing 364 has the same distance between the shafts and the rotational speed is different or the suction amount is different, the dispensed amount of the liquid filling can always be constant as the distance between the shafts. In addition, by pressing the position of the connection hose that divides the upper and lower portions of the reagent injection device 36 evenly, the pressure of the upper and lower portions of the reagent injection device 36 is uniform, so that the discharge amount is more accurate. It has the advantage of maximizing dispensing precision by forming a circular pipe that easily prevents rotation due to the weight of the filling material.

Meanwhile, although the description has been made on the basis of one reagent injection device 36, it is preferable that a plurality of reagent injection devices 36 are formed so as to efficiently manufacture a vacuum blood collection tube. At this time, the reagent injection device 36 does not have a servo motor 365, but has one servo motor 365, and all of the multi-axial rolling bearings 364 provided for each reagent injection device 36 are provided. It is connected to the servo motor 365 and can be uniformly controlled by the operation of the servo motor 365.

That is, when described as an example that 10 rows of reagent injection devices 36 are provided, each multiaxial rolling bearing 364 of the 10 rows of reagent injection devices 36 is connected by one shaft, and at this time, the multiaxial rolling bearing 364 ) Connected to the axis can be rotated by the servomotor (365). Accordingly, 10 multi-axis rolling bearings 364 may rotate uniformly according to the set pulse amount of the servomotor 365.

The tube filled or coated with a uniform amount of liquid filler on the inner wall by the reagent injection unit 30 is transferred to the drying unit 40 and dried to complete the coating, and thereafter, the cap coupling unit 50 having a vacuum chamber. ), and the cap can be combined to seal the tube under a vacuum atmosphere.

Since the drying part 40 and the cap coupling part 50 follow a known technique, a detailed description will be omitted below.

In addition, the configuration described above, that is, the cartridge supply unit 5, the tube insertion unit 20, the transfer unit 10, the reagent injection unit 30, the drying unit 40, and the cap coupling unit 50 are all the control unit 60 ) Can be controlled automatically or manually, and for this purpose, the control unit 60 includes a display (not shown) and an operation button (not shown), and may be wirelessly connected to an external controller (not shown).

In addition, as shown in Fig. 6, the vacuum blood collection tube manufacturing facility capable of uniform reagent dispensing of the present invention may further include an observation unit 70 for recognizing a failure or a risk of the device. Here, the observation unit 70 may be provided with an image camera 71, a thermal image camera 72, a temperature sensor 73, a water spray device 74, a humidity sensor 75, and the like, referring to FIG. , It can be linked with the control unit 60.

Here, the image camera 71 is provided in one or more so that the state of the device operation can be visually checked from the outside, and the thermal image camera 72 and the temperature sensor 73 detect a rapid thermal change in the device. It can detect whether or not there is a fire.

In addition, the humidity sensor 75 may detect the humidity around the device so that the controller 60 controls the spray of the water spray device 74. Accordingly, it is possible to prevent peeling of the liquid filler applied to the tube T by appropriately adjusting the humidity inside the space in which the process is performed.

Such a vacuum blood collection tube manufacturing facility capable of uniform reagent dispensing has a simple structure and can be uniformly applied with a microliter unit of a fine liquid filling, and the reagent dispensing can be uniformly controlled, improving precision in the field of blood diagnosis. There is an advantage that can greatly contribute to

Hereinafter, a method of manufacturing a vacuum blood collection tube using a vacuum blood collection tube manufacturing facility capable of uniform reagent dispensing will be described with reference to FIGS. 8 to 11.

FIG. 8 is a flowchart of a method of manufacturing a vacuum blood collection tube capable of uniform reagent dispensing according to an embodiment of the present invention, and FIG. 9 is a view showing detailed steps of a reagent injection step among the steps of the manufacturing method of FIG. 8, and FIG. 9 is a flowchart of a step of filling a liquid filler during the reagent injection step of FIG. 9, and FIG. 11 is a flowchart illustrating a step of spraying a liquid filler during the reagent injection step of FIG. 9.

8 and 11, the method of manufacturing a vacuum blood collection tube includes a cartridge supply step (S10), a tube insertion step (S20), a reagent input step (S30), a drying step (S40), and a cap in a vacuum atmosphere. It may include a step (S50).

Specifically, the cartridge supply step (S10) is a step of supplying a cartridge forming an insertion hole arranged in one or more rows and columns, and a step of supplying a cartridge using a conveying unit having a conveyer type or LM guide type conveying device to be.

The tube insertion step (S20) is a step of inserting the tube into the cartridge supplied to the transfer device. Here, first, the tube is vertically aligned so that the opening formed at the top faces upward, and the sealed sealing portion faces downward, and is mounted on the tube support (TS), and then the tube support (TS) descends to allow the tubes to enter the cartridge insertion hole. Can be inserted.

The reagent injection step (S30) is a step of filling or spraying a liquid filling material of a gel or reagent that promotes blood separation into the tube inserted into the cartridge. That is, the reagent input step (S30) may include a step of filling a liquid filler (S31) or a step of spraying the liquid filler (S32).

Here, the step of filling the liquid filler (S31) may include a step of sucking the liquid filler (S311), dispensing the liquid filler (S312), and discharging the dispensed liquid filler (S313).

Specifically, the step of sucking the liquid filler (S311) is a step of sucking the liquid filler through the reagent suction unit 361 formed on the upper portion of the reagent injection device 36, and rotating the multi-axis rolling bearing 364, the reagent suction The liquid filler may be sucked from the reagent storage unit 32 connected to the unit 361 by osmotic pressure. That is, in the initial suction without liquid filler, the internal air of the connecting hose 363 may be pushed out when rotating the multi-axial rolling bearing 364 to form osmotic pressure, and when there is a liquid filler, osmotic pressure may be generated by the flow of the liquid filler. I can.

The step of dispensing the liquid filler (S312) may be a step in which the servomotor 365 rotates the multi-axis rolling bearing 364 to flow the sucked liquid filler by a uniform amount. Here, the multi-axis rolling bearing 364 rotates to pressurize the connection hose 363, which is the reagent pipe of the liquid-filled material, as described above in the facility, and the plurality of shafts are the same, so that the liquid-filled material is uniformly rotated by the amount of rotation during rotation. It can be busy. At this time, when a plurality of reagent injection devices 36 are provided, a multiaxial rolling bearing 364 provided for each reagent injection device 36 is connected to one servomotor 365 and rotates uniformly, There is an advantage that the same amount of reagent can be filled.

The step of discharging the liquid filler (S313) is a step of filling the liquid filler dispensed into the tube, wherein the liquid filler pushed and flowed when the multi-axis rolling bearing 364 rotates is a reagent as much as the rotation amount of the multi-axis rolling bearing 364 This is a step of being discharged to the discharge unit 362. At this time, the discharge amount of the liquid filling is the same as the axial spacing of the multi-axial rolling bearing 364, so that the environment such as changing the rotation amount, rotation speed, etc. of the multi-axial rolling bearing 364, or changing the diameter of the connecting hose 363 Unless changed, there is an advantage that a certain amount of liquid filler can be filled into the tube at any time.

The step of spraying the liquid filler (S32) may be performed when the air spraying device 366 is provided, the step of inhaling the liquid filler (S321), the step of spraying the compressed air (S322), and the step of dispensing the liquid filler ( S323), it may include a step (S324) of pushing the dispensed liquid filler with compressed air to be ejected into a uniform droplet.

Specifically, the step (S321) of sucking the liquid filler may be substantially the same as the step (S311) of sucking the liquid filler of the step (31) of filling the liquid filler described above. Therefore, a detailed description will be omitted.

Injecting compressed air (S322) is a step of supplying compressed air to the reagent discharge unit 362 through the air injection device 366. Here, the injection of compressed air before dispensing the liquid filler is to ensure that the droplets formed when spraying the liquid filler are sprayed into droplets in uniform microliter units, so that the compressed air is supplied from the side. If compressed air is sprayed after dispensing, the size of the droplets is formed separately, and uniform application may not be achieved. Accordingly, the step of spraying compressed air (S322) may be formed to start spraying compressed air before the liquid filler of a uniform amount reaches the reagent discharge unit 362 and continue to spray compressed air until the injection of the liquid filler is completed. .

The step (S323) of dispensing the liquid filler may be substantially the same as the step (S312) of dispensing the liquid filler when filling the liquid filler described above. That is, by rotating the multi-axis rolling bearing 364, a uniform amount of liquid filling can be dispensed by the amount of rotation.

The step of pushing the dispensed liquid filler into a uniform droplet by pushing it out with sprayed compressed air (S324) is a step in which a uniform amount of liquid filler pushed by the liquid filler dispensing is sprayed into the tube by compressed air. In this case, since the compressed air is injected in advance as described above, the liquid filler may be applied into the tube as microscopic droplets of a unit of microliter formed to have a uniform size when discharged as droplets.

Thereafter, the drying step (S40) is a step of drying the droplet-formed liquid filling applied in the reagent input step (S30), and a drying device typically used in a vacuum blood collection tube manufacturing facility can be used, through which Coating of a gel or reagent to facilitate separation of the blood against the blood can be completed.

The step of combining the caps in a vacuum atmosphere (S50) is a step of combining the caps with the tubes to complete the manufacture of a vacuum blood collection tube.After the tube coated with the liquid filler is inserted into the vacuum chamber, the caps are combined under a vacuum atmosphere. The co-collection can be completed.

In the method of manufacturing such a vacuum blood collection tube, the same amount of gel or liquid filling of reagents is filled or coated for each tube by the reagent input step (S30) capable of uniform dispensing, so that all vacuum blood collection tubes have the same performance. There is an advantage that blood separation may be easier because the liquid filler can be evenly filled or applied.

Embodiments of the present invention have been described above with reference to the accompanying drawings, but those of ordinary skill in the art to which the present invention pertains can be implemented in other specific forms without changing the technical spirit or essential features of the present invention. You can understand. Therefore, the embodiments described above are illustrative and non-limiting in all respects.

1: vacuum blood collection tube
5: cartridge supply unit
10: transfer unit
20: tube insertion part
30: reagent injection part
32: reagent storage unit
34: connector
36: reagent injection device
361: reagent suction part
362: reagent outlet
363: connecting hose
364: Multi-axis rolling bearing
365: servo motor
366: air injection device
40: drying part
50: cap coupling portion
60: control unit
70: observation unit
71: image camera
72: thermal imaging camera
73: temperature sensor
74: water spray device
75: humidity sensor
LC: Liquid filling
CT: cartridge
TS: Tube support
T: tube
C: cap
B: blood

Claims (8)

A transfer unit for transferring cartridges forming insertion holes arranged in one or more rows and columns from one side to the other, a tube insertion unit for mounting a tube in the insertion hole of the cartridge to be transferred, and a gel or reagent into the tube mounted on the cartridge In a vacuum blood collection tube manufacturing facility including a reagent injection part for filling or spraying the liquid filler of the tube in units of microliters, a drying part for drying the liquid filler filled or sprayed into the tube, and a cap coupling part for coupling a cap to the tube In,
The reagent injection unit,
It comprises a reagent injection device formed to discharge the liquid filling after suction by flowing a predetermined distance,
The reagent injection device,
The upper and lower sides of the reagent pipe through which the liquid filler flows are respectively pressurized by a shaft assembly to temporarily stop the flow of the liquid filler, but the shaft coupling body that pressurizes the upper side is the position of the shaft coupling body that presses the lower side after pressing the reagent. The shaft assembly that moves along the pipeline and pressurizes the lower side is formed to alternately repeat moving to the position of the shaft assembly that presses the upper side, and the liquid filling is dispensed by the interval between the axes,
A reagent suction unit for sucking the liquid filling material;
A reagent discharge unit for discharging the liquid filling material;
A connection hose for forming the reagent pipe by connecting a reagent suction part and a reagent discharge part so that the sucked liquid filling is discharged to the reagent discharge part, and
It is driven by a servo motor installed on one side and rotates to pressurize the middle portion of the connection hose, and includes a multiaxial rolling bearing having at least two or more axes formed radially so as to form a symmetrical structure, and having the same distance between the axes,
Uniform dispensing of the liquid filler is possible as much as the rotation amount of the multi-axial rolling bearing, and the dispensed liquid filler can be discharged as it is and filled into the tube,
The multi-axial rolling bearing,
The position of the upper pressurization point, which is the pressurization start point for the connection hose, and the lower pressurization point, which is the pressurization end point, are the same distance between the connecting hose distance from the pressurization start point to the reagent suction unit and the reagent discharge unit from the pressurization end point. Is a position to form,
The connecting hose,
The shape from the point connected to the reagent suction unit to the upper pressing point of the multi-axial rolling bearing is formed in a'b' shape, and the shape from the upper pressing point to the lower pressing point is formed in a'C' shape, , The form from the lower pressurization point to the point connected to the reagent discharge part is formed in a'b' shape,
The position of the upper pressing point is formed at a position lower than the height of the uppermost end of the'C'-shaped part of the connecting hose, and the position of the lower pressing point is higher than the lowermost height of the'C'-shaped part of the connecting hose. A vacuum blood collection tube manufacturing facility capable of uniform reagent dispensing, characterized in that it is formed.
delete The method of claim 1,
The reagent injection device,
Further comprising an air injection device installed to be connected to one side of the reagent discharge unit to inject compressed air,
A vacuum blood collection tube manufacturing facility capable of uniform reagent dispensing, characterized in that by spraying the compressed air first and discharging the liquid filling material to be sprayed into the tube as uniform droplets in units of microliters.
The method of claim 1,
The connection hose is a vacuum blood collection tube manufacturing facility capable of uniform reagent dispensing, characterized in that the silicone hose.
delete The method of claim 1,
When a plurality of reagent injection devices are provided, each multiaxial rolling bearing of the plurality of reagent injection devices is connected to each other and is uniformly controlled by the servo motor. A vacuum blood collection tube manufacturing facility capable of uniform reagent dispensing.
delete delete

Images