KR102091737B1 - Method for Producing Red ginseng Pill - Google Patents

Abstract

The present invention relates to a method for producing a red ginseng pill. The red ginseng pill produced by the method of the present invention has a high red ginseng content, so it is possible to reduce the intake of other components added to produce a pill formulation, such as excipients, and to sufficiently provide functional components exhibiting physiological effects. Since the red ginseng pill can be consumed without water, and can be manufactured in a uniform spherical shape, the method of the present invention can be favorably used in manufacturing a pill using red ginseng as a raw material.

Description

Method of Producing Red Ginseng Pill}

The present invention relates to a method for manufacturing a ring using red ginseng as a raw material.

Ginseng is a plant that has been used as a valuable hematopoietic tonic in Korea and China from the past to the present, and is known to have tonic, gangjeong, hematopoietic, warmth, fatigue recovery, mental stability, and sedative effects. It is known to be mainly due to ginseng saponin, that is, ginsenoside.

Ginseng is divided into ginseng, red ginseng, and white ginseng according to the processing method. Ginseng is a raw ginseng harvested from the field and contains 70-80% of moisture, which has the disadvantage of long-term storage. White ginseng is prepared by peeling the skin of ginseng or drying the ginseng as it is by sun drying or hot air drying and has a milky white or light yellow color. Red ginseng is manufactured through the process of steaming, drying, etc. after washing the raw ginseng without peeling the skin, and it has a pale brown or dark red color.

In general, red ginseng is selected from only six-year-old fresh ginseng, which is steamed and dried before drying. It is known that hydrolysis by heat occurs in the steaming process to generate ginseng, white ginseng and other components. It has been found that such red ginseng specific ginsenosides have excellent effects on cancer prevention, cancer cell growth suppression, blood pressure lowering, cranial nerve cell protection, antithrombotic, and antioxidant activity.

Ginseng products are round ginseng products such as ginseng, white ginseng, and red ginseng, or ginseng concentrates extracted by extracting ginseng and spray-dried concentrate powders, mixed ginseng concentrates with excipients such as lactose and glucose, and dried. Various types of products are available on the market, such as processed ginseng products such as ginseng tea, ginseng powder capsules, and sugar ginseng. Among these ginseng products, it is inconvenient to eat the original product as it is, and recently, the preference for processed ginseng products has been increasing.

In particular, it is common for red ginseng to be extracted and consumed at home or consumed in the form of a concentrate, capsule, pill, or tablet. Patent Document 1 discloses a method of preparing a ring by adding an excipient to herbal materials including red ginseng. When manufactured in a pill form as described above, since other ingredients such as excipients are added to realize a spherical shape, there is a problem that the intake of red ginseng exhibiting physiological activity is lowered. In addition, in the case of existing red ginseng raw materials, there are many rings that are hard to chew, so many products are swallowed with water.

Therefore, there is a need to develop a method for preparing a ring that can be consumed without water because it is possible to chew while increasing the intake of functional ingredients by increasing the content of the red ginseng component as much as possible. When food is ingested, the appearance, ease of intake, etc., including the shape of the product, greatly affects product preference, and thus, it is necessary to develop a method of manufacturing a pill in a spherical shape while containing a high content of red ginseng.

Korean Registered Patent Publication No. 1,002,774

An object of the present invention is to provide a method of manufacturing a red ginseng ring capable of producing a spherical shape while increasing the content of a functional ingredient by increasing the red ginseng content as much as possible.

In order to solve the above problems, the present invention comprises the steps of freezing the red ginseng extract with liquid nitrogen to prepare a frozen body; And lyophilizing the frozen body.

In addition, the present invention provides a red ginseng ring produced by the method of manufacturing the red ginseng ring.

The red ginseng ring produced by the method of manufacturing the red ginseng ring of the present invention has the advantage of being able to be consumed without water because it contains a high content of red ginseng components without other ingredients such as excipients, and is capable of chewing. In addition, pores are present in the tissue through a freeze-drying process, so that the solubility in water is improved.

Figure 1 shows a red ginseng frozen body obtained by freezing each red ginseng concentrate diluted with 10 to 40 Brix with liquid nitrogen.
Figure 2 shows the freeze-dried red ginseng obtained by applying a freeze-drying process to the freeze-dried body of FIG.
Figure 3 shows a freeze-dried red ginseng prepared using red ginseng concentrate diluted with 20 to 30 Brix as a raw material.

Hereinafter, the present invention will be described in detail.

In the present invention, "extract" means a material extracted by an arbitrary method from a raw material, and is used in a sense including, without limitation, extracts, concentrates obtainable therefrom, dry matter and powders of the concentrates.

In the present invention, the term "ring" means not only a spherical shape, but also includes all of various forms of a round shape such as an oval shape. For example, it includes a light oval shape. In the present invention, "light oval" means an ellipse with a small difference between a long diameter and a short diameter and close to a circle.

The present invention comprises the steps of freezing the red ginseng extract with liquid nitrogen to prepare a frozen body; And lyophilizing the frozen body.

The red ginseng extract can be obtained by extracting from red ginseng or dried products thereof, and the red ginseng can be used without limitation, such as those grown or commercially available.

When the extract is obtained by extracting from red ginseng, any conventional extraction methods known in the art, such as a solvent extraction method, an ultrasonic extraction method, a filtration method, and a reflux extraction method, may be used as the extraction method, and preferably prepared by using a solvent extraction method or a reflux extraction method. can do. The extraction process may be repeated several times, after which it may be further subjected to steps such as concentration or lyophilization. Specifically, the obtained extract is concentrated under reduced pressure to obtain a concentrated solution, and the concentrated solution is lyophilized and then a high-concentration extract powder can be prepared using a grinder.

The red ginseng extract may be extracted using water, an organic solvent or a mixture thereof as an extraction solvent. The organic solvent may be an alcohol, preferably C ₁ -C ₄ alcohol, hexane (n-hexane), ethyl acetate, acetone, isopropyl alcohol, methyl alcohol, and the like, and a mixed solvent thereof. The red ginseng extract may be extracted with water, ethanol and mixtures thereof, and preferably may be extracted with water, but is not limited thereto.

The red ginseng extract may be a concentrate of red ginseng extract (hereinafter referred to as 'red ginseng concentrate'). The solid content of the red ginseng concentrate may be 60 parts by weight to 90 parts by weight, 60 parts by weight to 85 parts by weight, and 60 parts by weight to 80 parts by weight based on 100 parts by weight of the red ginseng concentrate before drying, but is not limited thereto. When the solid content of the red ginseng concentrate is less than the lower limit, the content of the functional component may be low, and when the solid content of the red ginseng concentrate exceeds the upper limit, the flowability of the concentrate is poor, so it is difficult to drop in a round shape during the preparation of the frozen body. Even if a frozen body is made from a raw material diluted with purified water, the shape of the frozen body is amorphous and the size is not uniform.

The red ginseng concentrate may be used in a concentrated state, but may be preferably used after being diluted to a specific Brix. The red ginseng concentrate may be 17 Brix to 37 Brix, preferably 20 Brix to 35 Brix, and more preferably 20 Brix to 30 Brix. When diluted with Brix below the lower limit, the frozen body obtained by rapid cooling with liquid nitrogen often has a non-spherical shape, has many amorphous freeze bodies, and is easily broken and difficult to commercialize. When diluted with Brix exceeding the upper limit, spherical freeze bodies are produced upon rapid cooling with liquid nitrogen, but the freeze bodies adhere to each other, and even if the freeze bodies are freeze-dried, water evaporation is insufficient. When the red ginseng concentrate diluted with Brix outside the above range is used as a raw material, it is difficult to manufacture spherically, so it takes additional time and money to select only spherical rings suitable for commercialization, and the amount of rings suitable for commercialization compared to the raw materials used. There are few disadvantages of low yield.

The frozen body manufacturing step is a process of obtaining a frozen body by inserting a red ginseng extract having a pre-treatment process through a nozzle into a frozen body manufacturing apparatus in which a refrigerant is sprayed. The red ginseng extract is discharged through a nozzle having a spherical cross section, and the discharged red ginseng extract becomes spherical by surface tension.

In the frozen body manufacturing step according to the present invention, the refrigerant flows at a constant speed in the frozen body manufacturing apparatus, or is pumped by the spray nozzle of the frozen body manufacturing apparatus, or the sprayed refrigerant is sprayed from the Dewar vessel and sprayed. (spraying umbrella) can cover the red ginseng extract. The amount of refrigerant sprayed is controlled by a valve and pressure gauge mounted before the nozzle. The operation technique of the general frozen body manufacturing apparatus is the same as the normal method. The frozen body manufacturing apparatus includes a cryogenic freezer (liquid nitrogen freezer).

According to the method of the present invention, in addition to liquid nitrogen, liquid carbon dioxide, liquid dichlorodifluoromethane, liquid nitros oxide, or the like may be used as a refrigerant sprayed to produce a frozen body of a frozen material.

In the frozen body manufacturing step, the pressure in the frozen body manufacturing apparatus may be adjusted to a range of 0.01 mbar to 1 mbar, preferably 0.1 mbar to 0.7 mbar, and more preferably 0.1 mbar to 0.5 mbar, It is not limited. The temperature in the apparatus for manufacturing a frozen body may be maintained between -40 ° C and -85 ° C, preferably between -45 ° C and -80 ° C, and more preferably between -53 ° C and -74 ° C However, it is not limited thereto. The nozzle size may be 0.5 mm to 6 mm, preferably 1 mm to 5 mm, and more preferably 1 mm to 3 mm, but is not limited thereto. If the conditions at the time of manufacturing the frozen body do not satisfy the above range, the frozen body cannot be implemented in a spherical shape.

The size of the freeze body may be 3 mm to 15 mm, preferably 3 mm to 10 mm, more preferably 3 mm to 8 mm, even more preferably 3 mm to 6 mm It may be, but is not limited to this. If the size of the frozen body is less than the lower limit, the size may be small and the amount of rings lost when taken out of the container may be large. When the size of the frozen body exceeds the upper limit, there may be foreign body sensation in chewing, and moisture removal may be insufficient during lyophilization. The size of the frozen body is controlled by adjusting the size of a spherical nozzle discharging the diluent built in the frozen body manufacturing apparatus.

For the prepared frozen body, the step of storing the frozen body at -50 ° C to -35 ° C may be further included. Preferably, the frozen body may be stored at -45 ° C to -35 ° C, more preferably -40 ° C to -35 ° C, but is not limited thereto. For example, the freezing temperature storage conditions and the Brix of red ginseng concentrate may affect the formulation of a frozen body or a lyophilized ring. The red ginseng concentrate can be used diluted with 17 Brix to 37 Brix, but when it is prepared with Brix exceeding the upper limit, the freezing point of the frozen body is lowered, so it exceeds -35 ° C, that is, the frozen body at a temperature of -35 ° C to 0 ° C. Alternatively, there may be restrictions on the formulation of the lyophilized ring.

The frozen body may be stored at -50 ° C to -35 ° C for 6 hours to 36 hours, preferably 10 hours to 30 hours, and more preferably 12 hours to 24 hours. The temperature of the frozen bodies can be made uniform by storing the frozen bodies for the time.

The frozen body is taken out using a tool or transferred to a conveyor belt and put into a freeze dryer. The inside of the drying chamber of the freeze dryer should be pre-cooled below the freezing point of the freeze body before the freeze body is added. After adjusting the temperature of the hot plate, turn on the vacuum and monitor the product temperature, the temperature inside the drying room and the temperature of the condenser. When the product temperature is above room temperature, lyophilization is completed and the product is taken out.

The lyophilization may be performed at -80 ° C to -20 ° C for 10 to 72 hours, preferably at -60 ° C to -25 ° C for 15 to 60 hours, and more preferably -50 ° C It may be performed at ∼-30 ° C for 20 to 55 hours, preferably at -40 ° C to -35 ° C for 24 to 48 hours, but is not limited thereto.

In general, dripping an aqueous solution in liquid nitrogen rapidly freezes from the surface that is in contact with nitrogen, and the internal pressure increases as the water freezes, which causes the rapidly solidified spherical solid to crack or become weaker. It is difficult for the emulsion to elute and form a clean sphere. Since red ginseng extract contains moisture, it was difficult to obtain a clean spherical shape due to the above problems. The present invention is a process for producing a frozen body using a red ginseng extract controlled by Brix as a raw material and liquid nitrogen; And by applying a process of lyophilizing the freeze-dried body, it is possible to manufacture a red ginseng freeze-dried ring that is stable in shape and spherical at room temperature.

In one embodiment of the present invention, the red ginseng concentrate is diluted with 20 Brix to 30 Brix as a raw material, respectively, and rapidly cooled with liquid nitrogen to prepare a frozen red ginseng, and the freeze-dried freeze-dried as described above is freeze-dried to red ginseng. As a result of preparing the lyophilized ring, it was confirmed that the shape of the ring was spherical, the size was uniform, and there was no phenomenon of sticking between the rings (see FIGS. 1 to 3). In addition, as a result of sensory tests on texture and preference, such as hardness and feeding, texture and preference were superior to the red ginseng freeze-dried ring produced by the method of the present invention compared to the conventional method.

In the method of the present invention, a red ginseng ring prepared according to preference may be coated with a shielding material (xylitol and / or cacao powder, etc.) to cover the bitter taste of red ginseng and improve the taste and aroma, and contact with the hand when taking red ginseng ring It can provide an effect of preventing contamination from bacteria on the site. In addition, the shielding layer may further include functional substances such as minerals such as calcium and iron, antler powder, vitamins such as chlorella, vitamin C, and vitamin B, colostrum protein powder, and various red ginseng components. By adding a functional component, the functionality of the lyophilized red ginseng can be improved.

The shielding layer may include substances having tastes and aromas preferred by children when the target of intake of red ginseng is a child. This shields the smell and bitterness of red ginseng's unique Chinese medicine, and enhances the taste of children with good aroma and taste. The material forming the shielding layer is xylitol; Cacao powder; Food raw materials such as flavor powders such as strawberry flavor powder, banana flavor powder, and chocolate flavor powder, or pharmaceutically acceptable substances to mask bad taste or flavor may be used. The shielding layer may be formed of one layer or two or more layers having different compositions. The shielding layer of one or more layers may further include a functional material in addition to the shielding material, and the functional material may be mixed with a material forming the shielding layer and included in the shielding layer.

The present invention provides a red ginseng ring produced by the method of manufacturing the red ginseng ring.

Since the red ginseng ring of the present invention is spherical and sized to be easily eaten by hand, it gives a feeling like a snack rather than a health functional food containing a functional ingredient, and thus, when consumed, has less rejection than other forms such as a block form.

The size of the red ginseng ring may be 3 mm to 15 mm, preferably 3 mm to 10 mm, more preferably 3 mm to 8 mm, and even more preferably 3 mm to 6 mm. However, it is not limited thereto. If the size of the red ginseng ring is less than the lower limit, the size of the ring is too small and may be lost when taken out of the container. When the size of the red ginseng ring exceeds the upper limit, there may be foreign body sensation in chewing, and moisture removal may not be sufficient during lyophilization.

Hereinafter, the present invention will be described in detail by examples.

However, the following manufacturing examples and experimental examples are only for illustrating the present invention, and the contents of the present invention are not limited by the following manufacturing examples and experimental examples.

<Production Example 1> Preparation of freeze-dried red ginseng

Red ginseng content is high, spherical shape, it was confirmed whether it is possible to manufacture the ring in a uniform size. First, the red ginseng concentrate is rapidly cooled with liquid nitrogen to make a frozen body (hereinafter referred to as 'red ginseng frozen body'), and then the freeze-dried freeze-dried red ginseng freeze-dried ring (hereinafter referred to as 'red ginseng freeze-dried ring') As described).

<1-1> Preparation of red ginseng frozen body

Purified water was added to the red ginseng concentrate (Korea Ginseng Corporation, 60% solids) to dilute the red ginseng concentrate to a Brix concentration of 10, 15, 20, 25, 35, 40 Brix. The diluted solution of the red ginseng concentrate diluted by concentration was put into a frozen body manufacturing apparatus. In the frozen body manufacturing apparatus, the diluent is discharged through a spherical nozzle in the form of a bead, and the discharged diluent is dropped into liquid nitrogen and cooled rapidly. As a result, a frozen red ginseng of 3 to 6 mm was prepared. The frozen red ginseng was stored at -40 ° C so as not to stick to each other and to maintain a spherical shape.

<1-2> Lyophilization of frozen bodies

In order to stabilize the shape of the red ginseng frozen body prepared in Preparation Example 1-1, the red ginseng frozen body is placed in a freeze dryer and preliminarily frozen at a temperature of -40 ° C, followed by stepwise low-temperature heat at a vacuum condition of 0.5 torr or less to solid. Sublimated ice was lyophilized at -40 ° C for 36 hours. The freeze-dried red ginseng freeze-dried rings were checked for formulation stability for each Brix of the red ginseng concentrate used in the preparation of the red ginseng frozen body.

<Example 1> Red ginseng frozen body and red ginseng freeze-dried morphology confirmation

<1-1> Red ginseng frozen body confirmation

The shape of the frozen red ginseng prepared in Preparation Example 1-1 was confirmed. After completing the preparation of the frozen body, the prepared frozen body was placed in a container and visually confirmed.

As a result of checking, as shown in FIG. 1, among red ginseng concentrates diluted with 10, 15, 20, 25, 35, and 40 Brix, when red ginseng concentrates of 20 to 35 Brix were used, the frozen bodies were in a shape close to a sphere, and frozen The sieve size was also uniform in the range of 3-6 mm. On the other hand, freeze bodies using red ginseng concentrate having a Brix concentration excluding 20-35 Brix as a raw material were not spherical in shape, but amorphous or in size. For example, when 10 ~ 15Brix diluent was used as a raw material, when cooled with liquid nitrogen, the shape of the frozen body was more amorphous than the spherical shape, and many frozen bodies larger than the size of the frozen body, which was intended to be manufactured, were also found. In addition, when a 40-Brix red ginseng concentrate was used, the shape of the frozen body was spherical, but the frozen bodies were stuck to each other.

<1-2> Red Ginseng Lyophilization Ring

When lyophilization was applied to a red ginseng frozen body, it was confirmed that the resulting red ginseng lyophilized formulation was stable. In the case of red ginseng frozen body, the temperature below the freezing point of the frozen body should be maintained during distribution and storage, and storage was difficult at room temperature. It was confirmed by applying a freeze-drying process to see if the ginseng freeze-dried spheres could be maintained even at room temperature.

As a result, as can be seen in Figure 2, in the case of freeze-dried red ginseng prepared by using 15-30 Brix red ginseng concentrate as a raw material, the freeze-dried process after the preparation of the frozen body maintains the shape of the frozen body even when moisture evaporates. Therefore, it was found that the formulation was stable. However, when the 10 Brix red ginseng concentrate was used as a raw material, the freeze-dried ring was moved to another container or easily broken during transportation. In addition, when the red ginseng concentrate of 35-40 Brix is used as a raw material, even if the freeze-dried body is freeze-dried, moisture evaporation is insufficient, and when left at room temperature after freeze-drying, the ice remaining inside the freeze-dried ring melts to form a freeze-dried ring. Is not formed in a spherical shape, lyophilized rings are entangled with each other or adhere to a storage container.

From the above results, when the freeze-drying process was applied, the shape of the freeze-dried ring was maintained in a spherical shape, the size was uniform, and the condition of no crushing when transporting the freeze-dried ring was red ginseng concentrate diluted with 15 to 30 Brix. Could know.

Summary of Example 1

When using frozen ginseng, 20 ~ 35 Brix red ginseng concentrate was used for commercialization compared to red ginseng concentrates of different concentrations in the shape and size of the frozen body, and 15-30 Brix when freeze-dried rings were used. When red ginseng concentrate was used, formulation stabilization was possible. In the case of using the red ginseng concentrate of 10 to 15 Brix at the time of manufacturing the frozen body, a large number of amorphous freeze bodies were identified, and the size of the frozen body was not uniform. Even if the formulation was stabilized, the shape of the ring was not spherical and the size of the ring was not uniform, making it difficult to commercialize. The lyophilized ring according to the present invention was found to have a spherical shape and a uniform size of the lyophilized ring when using 20-30Brix red ginseng concentrate.

Therefore, it was found that when the red ginseng freeze-dried red ginseng concentrate is used as a raw material, the red ginseng concentrate, which is high in red ginseng content and utilizes liquid nitrogen cooling method and freeze drying technique, is most suitable for stabilizing the formulation (see FIG. 3). ).

Claims (11)

Preparing a frozen body by freezing the red ginseng concentrate of 17 Brix to 37 Brix concentrated red ginseng extract with liquid nitrogen while discharging through a nozzle; And lyophilizing the frozen body. delete The method according to claim 1,
The solids content of the red ginseng concentrate is a method for preparing red ginseng rings, which are 60 to 90 parts by weight based on 100 parts by weight of the red ginseng concentrate before drying. delete The method according to claim 1,
The red ginseng concentrate is 20 Brix to 35 Brix method of producing red ginseng ring. The method according to claim 5,
The red ginseng concentrate is 20 Brix to 30 Brix method of producing red ginseng ring. The method according to claim 1,
The size of the frozen body is 3 mm to 15 mm manufacturing method of red ginseng ring. The method according to claim 1.
A method of manufacturing a red ginseng ring further comprising storing the frozen body at -50 ° C to -35 ° C before performing freeze-drying on the prepared frozen body. Claim 1, claim 3, claim 5 to claim 8, ginseng ring produced by the method of any one of the red ginseng ring. The method according to claim 9,
The shape of the red ginseng ring is spherical red ginseng ring. The method according to claim 10,
The size of the red ginseng ring is 3 mm to 15 mm red ginseng ring.

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