KR102076394B1 - Device of injecting bio-absorbing and biodegradable polymers and materials - Google Patents

Abstract

The present invention discloses an injector of a bioabsorbable material.
The injector of the bioabsorbable material according to the present invention is characterized in that it comprises a body portion to which the microneedle is fixed and a bioabsorbable material layer decomposed in the skin covered on the surface of the microneedle. In addition, it can be applied to the scalp areas such as skin beauty (improving face and neck wrinkles, maintaining skin elasticity, skin whitening, etc.), hair loss prevention, and the applicable fields are wide, and the method of use is not particularly limited, It can be used easily.

Description

Device of injecting bio-absorbing and biodegradable polymers and materials

The present invention relates to an injector of a bio-absorbing and biodegradable material, and in particular, in the medical field as well as skin care (improving face and neck wrinkles, maintaining skin elasticity, skin whitening, etc.), hair loss Applicable to the field of scalp, such as prevention, the field of application is wide, and the use of the method is not particularly limited, and relates to the injector of bioabsorbable material and biodegradable material can be easily used by the general public.

The meditation procedure, also called meditation therapy, is used to stretch the skin or muscles without cutting the skin of the body to improve wrinkles or to maintain the elasticity of the skin tissue as well as to maintain a stable state by stretching the ligaments. It is used a lot in the procedure.

Such a resuscitation procedure uses a surgical suture made of an absorbable or degradable polymer material as a medical seal, for example, polylactic acid, polydiaxonone, or lactic acid. Acid) and glycolic acid (copolymer of Glycolic acid), such as using a material that can be absorbed in vivo, there is an advantage that does not have to remove it after the procedure.

In the 3rd to 6 months or several years after the procedure, the medical thread is absorbed into the body. The medical thread becomes a factor that continuously causes wound irritation in the skin and secretes immune substances that heals the wound. (Wound Healing effect) will be induced continuously, so that after the healing of the body tissues passed through the medical thread, the state of being pulled (lifted) by the medical thread can be maintained continuously so that the stretched skin is kept taut or wrinkled. You can get the effect of improving the spread.

The above-described open-ended procedure is intended to operate the injector after inserting a medical thread having a diameter smaller than the hole of the injector into a hole of the injector formed in the injector such as a needle having a small diameter of 0.45 mm or less. After infiltrating into the skin tissue, the injector is removed from the skin tissue and is completed.

As shown in FIG. 16, a general sales thread 1 to which the prior art is applied is obtained by spinning a twist thread having a predetermined diameter as manufactured by drawing a conventional thread with a material that is absorbed in the body. Using a shipping line is twisted one or more strands with each other to form a rope for the sale (1).

Of course, the rope 1 is made of a cross-sectional diameter of a substantially circular shape, if necessary to form a knot or false knot (2) in the middle.

However, the needles or the medical seals used for the above-described treatment procedures are limited to the medical field and are used as medical materials. Therefore, the field has limited fundamental limitations, and the medical thread itself is injected into an injector such as a needle and used for the skin. There was a problem that the entry into the inside could not be performed by the general public, but only by a professional.

Therefore, the technical problem to be solved by the present invention can be applied not only in the medical field but also in the skin care field (improving face and neck wrinkles, maintaining skin elasticity, skin whitening, etc.), and scalp areas such as hair loss prevention. And, since the use method is not particularly limited, it is to provide an injector of bioabsorbable material and biodegradable material that can be easily used by the general public.

In order to solve the above technical problem, the present invention provides an injector of a bioabsorbable material, characterized in that it comprises a body portion fixed to the microneedle and a bioabsorbable material layer decomposed in the skin covered on the surface of the microneedle. do.

According to one embodiment of the present invention, a lubricating layer may be stacked inside the bioabsorbable material layer.

According to another embodiment of the present invention, the bioabsorbable material layer may have a coating angle larger than the center angle of the microneedle to have a coating height reaching the coating end.

According to another embodiment of the present invention, the bioabsorbable material layer may be formed of an advanced inlet and a backward inlet, and the inlet may be thinner than the backward inlet.

According to another embodiment of the present invention, the second coating angle of the second bioabsorbable material layer formed at the coating end of the back entry portion may be greater than the coating angle.

According to another embodiment of the present invention, the peak may be provided with a seating groove.

According to another embodiment of the present invention, the side of the microneedle may be provided with a separation groove.

According to another embodiment of the present invention, the intaglio surface of the leaving groove portion is provided with a lower angle and the upper angle toward the body portion is formed with a peak angle of the surface of the microneedle, the lower angle may be larger than the upper angle have.

According to another embodiment of the present invention, the body portion may be arranged so that the tip of the plurality of microneedle protrudes into a flat plate.

According to another embodiment of the present invention, the body portion may be arranged such that the tip of the plurality of microneedle protrudes into a cylindrical roller.

According to the injector of the bio-absorbing and biodegradable material according to the present invention, not only in the medical field but also in the skin care field (face and neck wrinkle improvement, skin elasticity maintenance, skin whitening, etc.), hair loss prevention Because it can be applied to the scalp field, the applicable field is wide, and the use method is not particularly limited, so that the general public can easily use it.

1 is a view showing a cross section of the microneedle and the bioabsorbable material layer according to an embodiment of the present invention,
2 is a view showing a cross-section of the microneedle and the bioabsorbable material layer according to another embodiment of the present invention,
3 is a cross-sectional view of the microneedle and the bioabsorbable material layer according to another embodiment of the present invention,
4 is a view showing a cross section of the seating groove and the release groove on the surface of the microneedle according to another embodiment of the present invention,
5 is a view showing a cross-section of the beginning of the bioabsorbing material layer of the leaving groove provided on the surface of the microneedle according to another embodiment of the present invention,
FIG. 6 is a perspective view illustrating a shape in which a body part according to another exemplary embodiment of the present invention is provided with a plate-shaped plate and fixed and disposed therein.
Figure 7 is a perspective view showing the shape of the body portion fixed to the rotatable cylindrical roller surface according to another embodiment of the present invention,
8 is a cross-sectional view showing a shape in which a microneedle is fixed to a cylindrical roller surface of a body part and a bioabsorbable material layer is formed on the surface thereof;
9 is a cross-sectional view showing the shape of the bioabsorbable material layer according to the present invention seated in the skin,
10 is a cross-sectional view of the body portion of the present invention is provided in the shape of a roller, moving the skin and the shape of the microneedle enters the skin,
11 is a perspective view showing a state in which a roller shape is implemented as a body part and a leaving groove is formed on the surface of the microneedle fixed to the surface thereof;
FIG. 12 is a cross-sectional view illustrating a shape that enters the skin while the bioabsorbing material layer is covered in the leaving groove of FIG. 11.
FIG. 13 is a cross-sectional view illustrating a shape of entering the skin with the bioabsorbable material layer covered with the leaving groove part shown in FIG. 11. FIG.
14 is a view showing a roller-shaped cross-section formed so that the bioabsorbable material layer has a coating end on the microneedle according to the present invention,
15 is a view showing a shape in which the body part is implemented with a roller according to the present invention, and the bioabsorbable material layer remaining on the surface of the body part remains in the skin after the microneedle enters and retracts.
FIG. 16 is a perspective view showing a needle penetrated through a center of a conventional rope for sale.

Hereinafter, the present invention will be described in detail.

However, it should be noted that the technical terms used in the present invention are merely used to describe specific embodiments, and are not intended to limit the present invention.

In addition, the technical terms used in the present invention should be interpreted as meanings generally understood by those skilled in the art unless the present invention is defined in any other meaning in the present invention, and is excessively comprehensive. It should not be interpreted in the sense of being, or in an excessively reduced sense, and when a technical term used in the present invention is an incorrect technical term that does not accurately express the spirit of the present invention, it should be interpreted as a technical term correctly understood by those skilled in the art. It is to be understood that the generic terms used in the present invention should be interpreted as defined in the dictionary or according to the context before and after, and should not be interpreted in an excessively reduced sense, and the singular used in the present invention The expression of is used in the plural form unless the context clearly indicates otherwise. In the present invention, terms such as “consisting of” or “comprising” are not to be construed as necessarily including all of the various components or steps described in the invention, and some or some of them Steps may not be included, or should be construed that they may further include additional components or steps, when it is determined that the detailed description of the known art related to the present invention may obscure the subject matter of the present invention. The detailed description is omitted.

In addition, unless otherwise specified, the reference numbers indicated in the drawings are denoted by the same reference numerals, and the description thereof may be omitted in the overlapping parts.

1 is a view showing a cross-section of the microneedle and the bioabsorbable material layer according to an embodiment of the present invention, Figure 2 is a view showing a cross-section of the microneedle and the bioabsorbable material layer according to another embodiment of the present invention, 3 is a cross-sectional view showing a microneedle and a bioabsorbable material layer according to another embodiment of the present invention, and FIG. 4 is a cross-sectional view showing a seating groove and a release groove on a surface of the microneedle according to another embodiment of the present invention. 5 is a view showing a cross-sectional view of the starting portion of the bioabsorbing material layer of the leaving groove portion provided on the surface of the microneedle according to another embodiment of the present invention, Figure 6 is a body portion according to another embodiment of the present invention Is provided with a plate-like plate, the microneedle is fixed and disposed therein showing a perspective view, Figure 7 is a body portion according to another embodiment of the present invention Is a perspective view showing a shape fixed to the surface of the cylindrical roller is transferable, Figure 8 is a cross-sectional view showing the shape in which the microneedle is fixed to the cylindrical roller surface of the body portion, the bioabsorbable material layer is formed on the surface, 9 is a cross-sectional view showing the shape of the bioabsorbable material layer according to the present invention seated in the skin, Figure 10 is a body portion of the present invention is provided with a roller shape, the shape of the microneedle to move the skin and enter the skin Figure 11 is a cross-sectional view, Figure 11 is a perspective view showing the appearance of the separation groove formed on the surface of the microneedle fixed to the surface, the roller shape is implemented in the body portion, Figure 12 is a biological FIG. 13 is a cross-sectional view illustrating a shape that enters the skin while covering the absorbent material layer, and FIG. Figure showing the cross-sectional view of the shape of the body absorbing material is entered into the skin, the biocompatible material is provided in a multi-layer, Figure 14 is a micro-needle according to the present invention the bioabsorbing material layer coated end portion Figure 15 is a view showing a cross-section of the roller shape formed to include, Figure 15 is a roller in accordance with the present invention is implemented by the body portion of the microneedle after entering and retreating the shape of the bioabsorbable material layer covered on the surface of the body remains in the skin It is shown, referring to this.

The injector of the bioabsorbable material according to the present invention is characterized in that it comprises a body portion 1100 to which the micro needle (1000, micro needle) is fixed, and the bioabsorbable material layer (1300) covered on the surface of the microneedle.

The microneedle 1000 is a needle-shaped material that can enter the skin (S) of the epidermis and the dermis layer by entering a peak into the skin of the face, forehead, arms and legs of the human body. It is sufficient if it is a raw material, Preferably a metal material can be used.

The bioabsorbable material layer covered by the microneedles may be covered by the entire microneedles, but has a coating height (H) of about tens to hundreds of micrometers from the peak, so that the microneedles remain in the skin when retreating after entering the skin. It is desirable to continuously stimulate the surrounding skin cells for months to years to induce skin activation steadily.

The bioabsorbable material layer 1300 may include polylactic acid (PLA, PDLA, PLLA), polydioxonone, polycaprolactone (PCL), and polyglycolide (Polyglycolide). Poly (glycolic acid), PGA), polyglycolide-co-lactide (PGLA), polyglycolide-co-ε-caprolactone (Poly (L-lactide-co-) ε-caprolactone (LCL)), poly-p-dioxanone (PDO), polydeoxyribonucleotide (PDRN), hyaluronic acid (HA), lactic acid / It includes both bioabsorbable materials and biodegradable materials, such as glycolic acid (PLGA) copolymers, and materials that can be slowly decomposed and absorbed and released into the body after several months to several years when injected into a living body. It may be made of a layer.

The bioabsorbable material may be covered by a method such as dipping, brushing, or spraying the surface of the microneedle after synthesis, and depending on the degree of drying or curing, the bioabsorbable material layer 1300 You can adjust the degree of softness or hardness.

In addition, such a bioabsorbable material may be prepared with powders having an average particle diameter of several to several tens of micrometers, and dispersed in a coating solution and covered by a method such as dipping, brushing, and spraying, and the coating solution is dried to the living body. Preferred are materials that can be decomposed after being seated.

In addition, the lubrication layer is laminated to the inside of the bioabsorbable material layer, the bioabsorbable material layer 1300 applied to the surface of the microneedle is separated into the microneedle after entering the skin with the microneedle 1000 and separated from the skin. Since it is necessary to reduce the microneedle surface and the adhesion force in order to be seated inside, the lubrication layer 1400 may be further implemented between the surface and the bioabsorbable material layer.

The lubrication layer 1400 is a separate coating layer, but does not need to be specifically limited as long as the adhesion force with the microneedle is larger than the adhesion force with the bioabsorbable material layer, but is preferably provided as an oxide layer, a polymer material, or a biocompatible material. Can be.

For example, when the lubrication layer is formed of the oxide layer, when the microneedle is provided with a metal material, it is preferable to form an oxide layer on the surface of the metal material by physical or chemical vapor deposition, electroplating, or micro arc method. Examples thereof include aluminum oxide, zirconium oxide, titanium dioxide and the like.

In addition, the polymer material does not need to be specifically limited as long as it is a coating material used in the medical field. However, since the lubricating layer may be damaged and remain in the skin, a material having biocompatibility is preferable, and as the biomaterial, Calcium phosphate, Calcium metaphosphate, and the like.

Meanwhile, the bioabsorbable material layer 1300 of the microneedle 1000 may have a coating angle b larger than the center angle 2a of the microneedle so as to have a coating height H. b) when the microneedle 1000 enters the skin and retreats by the advanced entry portion 1210 close to the peak 1200 and the backward entry portion 1230 extending therefrom to the coating end portion 1220. The bioabsorbable material layer 1300 may be seated in the skin, and the center angle may be represented as twice the center line CL, which is an imaginary line extending along the center portion from the peak of the microneedle, and the angle a to the surface thereof. The coating angle may be understood as an angle formed from the surface of the microneedle to the surface of the bioabsorbable material layer.

That is, the advanced entry portion 1210 has a thin coating thickness, so when the microneedle 1000 enters the skin, the advanced entry portion 1210 has a role to enter together, and the backward entry portion 1230 has a thick thickness but the advanced entry portion. Although it extends to 1210 and enters the skin as it is, when the microneedles retreat, they are separated from the microneedles by the frictional force of the coating end 1220 and remain in the skin.

The coating thickness h1 of the advanced entry portion 1210 and the coating thickness h2 of the post entry portion 1230 may be expressed by Equation 1 below.

<Equation 1>

Coating thickness (h1) of advanced inlet area = H1 × {tan (a + b) -tan (a)}

Coating thickness (h2) at the back entry part (h2) = H2 × {tan (a + b) -tan (a)}

Here, H1 is the coating height from the peak 1200 to the advanced entry portion, H2 is the coating height from the peak to the backward entry portion.

In addition, the coating end portion 1220 may further include a second bioabsorbable material layer 1300 'as the body portion 1100 to which the microneedle is fixed, thus failing to settle in the skin during repeated entry and retreat. The probability of remaining in the skin of the bioabsorbable material layer can be increased.

For example, even if the bioabsorbable material layer 1300 remains in the skin when the microneedle is retracted after the first entry, the second bioabsorbable material layer 1300 'may remain in the skin after the entry of the microneedle. Also, even when the microneedle is retracted after entering once, the bioabsorbable material layer 1300 does not remain in the skin and retreats with the microneedle, even when the second needle is retracted after entering the second bioabsorbable material layer 1300 '. It will be possible to remain in the skin after this entry.

The second bioabsorbable material layer 1300 ′ may also use the same material as the bioabsorbable material layer 1300 or a bioabsorbable material having a longer decomposition time in the living body, thereby regulating in vivo cell activation. .

Also, like the bioabsorbable material layer 1300, the second bioabsorbable material layer 1300 ′ also includes a second pre-entry part 1210 ′ and a second post-entry part 1230 ′ starting at the coating end 1220. 2), the second pre-entry part is thin so that the microneedle 1000 enters the skin so that it can enter together, and the second post-entry part 1230 'is thick. (B) it extends from the second entry portion 1210 'and enters the skin together, but when the microneedles retreat, they are separated from the microneedles by the frictional force of the second coating end 1220' and remain in the skin. It becomes possible.

The coating thickness h3 of the second pre-entry part 1210 ′ and the coating thickness h4 of the second post-entry part 1230 ′ may be expressed by Equation 2 below.

<Equation 2>

Coating thickness (h3) of the second pre-entry part = H3 × {tan (a + b ')-tan (a)}

Coating thickness of the second post-entry part (h4) = H4 × {tan (a + b ')-tan (a)}

Here, H3 is the coating height from the coating end 1220 to the second pre-entry part, and H4 is the coating height from the coating end to the second post-entry part.

Here, a is the angle between the centerline CL and the surface of the microneedle, which is an imaginary line extending along the center at the peak 1200 of the microneedle, and b 'is the second coating angle to absorb the second biological body at the surface of the microneedle. It can be understood from the angle to the surface of the material layer.

In addition, the coating angle (b) and the second coating angle (b ') may be set to the same angle, and furthermore, the second coating angle may be set larger than the coating angle, in this case the second coating end ( Since the frictional force of 1220 ') may be greater than that of the coating end 1220, the benefits of remaining in the skin of the bioabsorbable material layer and the second bioabsorbable material layer may be great.

On the other hand, the tip or side of the microneedles may have grooves formed in the intaglio to facilitate the intake of the skin of the bioabsorbable material layer, these grooves in a variety of materials that are different in the time of absorption and decomposition in the skin of the bioabsorbable material May be arranged in several layers BM1 and BM2.

The peak 1200 is provided with a recessed recess 1240, which is engraved, so that the applied bioabsorbable material may be filled in the seating recess 1240, and the microneedle 1000 enters the skin when the bioabsorbable material layer ( 1300 may be prevented from being separated.

The seating groove 1240 may be formed to the inclined surface 1250 to the intaglio inner surface to be inclined toward the center line (CL), it can effectively perform the separation and mounting of the bioabsorbable material layer (1300) when the microneedle retreats in the skin. have.

In addition, the surface corresponding to the side of the microneedle except for the tip portion may be provided with a recessed groove 1010 of the intaglio shape, so that the surface of the bioabsorbable material that is covered along the surface without the departure groove portion and the surface with the departure groove portion Since the bending is formed in the bioabsorbable material layer 1300, since the friction force is generated along the curved surface when the microneedle enters and retracts, it is effective in separating the bioabsorbable material layer.

The leaving groove 1010 may be provided in plurality, such as the second leaving groove 1020 can be formed in a variety of bends of the absorbing material to help the separation of the absorbing material layer of course.

Here, the separation of the bioabsorbable material layer may be controlled in the skin by adjusting the intaglios of the leaving grooves 1010 and 1020, the lower side of which the intaglio surface of the leaving groove is formed with the surface of the microneedle to the peak side. Defining the angle (β) and the upper angle (α) toward the body portion, it is preferable that the lower angle (β) is larger than the upper angle (α), whereby the bioabsorbing material covering the microneedle by the lower angle This is because the bending degree of the bending shape will be greater than the bending degree by the upper angle, so that the microabsorber smoothly separates the bioabsorbable material layer when retracting from the skin.

In addition, the bioabsorbing material layer 1300 covering the separation groove 1010 or the second separation groove 1020 is not formed in the peak 1200, and the body portion 1100 is formed in the separation grooves 1010 and 1020. The coating end portion 1220 may be formed so as to face a side surface of the coating layer 1220. Since the start portion 1302 of the bioabsorbable material layer starting from the leaving groove portion 1010 is present in the intaglio shape R of the leaving groove portion, Since the resistance of the microneedle 1000 may be hardly received, the bioabsorbable material layer may be accurately seated at the entry point into the skin, and the coating height described above may have a tens to several hundred μm from the initiation unit 1302. have.

Meanwhile, the microneedle 1000 and the bioabsorbable material layer 1300 described above may be provided in plural numbers, and may be fixed to the body portion 1100. Such a body portion may be provided as a plate-shaped plate to form the microneedle. The peaks can be arranged to protrude.

As long as the plate can be arranged by fixing a plurality of microneedles, it is not necessary to limit the material, but it may be desirable to have a flexible characteristic to some extent.

Through this flexibility, the microneedle 1000 and the bioabsorbable material layer 1300 according to the present invention may enter the skin in response to various external shapes formed on the face, forehead, chin, arm, leg, etc., which are the parts of the living body.

For example, such a body portion 1100 may be disposed on a cylindrical roller-like surface to arrange the peaks of the plurality of microneedles.

Body portion 1100 implemented in the roller (Roller) is a rotating shaft (not shown) embedded in the roller and a rotating support 2000 for guiding and supporting the rotating shaft to rotate, and is fixed to one side of the rotating support It may include a handle portion 3000 that can be gripped.

The technical gist of the microneedle 1100 and the bioabsorbable material layer 1300 fixed to the body part 1100 implemented as a roller is omitted in more detail as described above.

Micro Needle 1000, Breakaway 1010,
Second release groove portion 1020, body portion 1100,
Peak of the microneedle 1200,
Advanced Entry 1210, Second Entry 1210 ',
Coated end 1220, second coated end 1220 ',
Back entry 1230, second back entry 1230 ',
Seating groove 1240, slope 1250,
Bioabsorbable material layer 1300, second bioabsorbable material layer 1300 ',
Initiation part 1302, lubrication layer 1400,
Revolving Support 2000, Handle 3000,
Coating height H, center line CL,
Angle a, coating angle b,
Coating thickness h1 at the advanced entry, Coating thickness h2 at the downstream entry,
Coating height H1 from peak to advanced inlet,
Coating height H2 from peak to back entry
Coating height H3 from the coating end to the second pre-entry;
Coating height H4 from the coating end to the second back entry,
Coating thickness h3 of the second pre-entry part, coating thickness h4 of the second post-entry part,
Coating angle b, second coating angle b ',
Lower angle β, upper angle α,
R in intaglio shape

Claims (10)

A body portion fixing the microneedle; And
And a bioabsorbable material layer decomposed in the skin covered on the surface of the microneedle.
Lubricating layer is laminated to the inside of the bioabsorbable material layer,
The lubricating layer is a bioabsorber material injector, characterized in that the adhesion with the microneedle is greater than the adhesion with the bioabsorbable material layer.
delete The method of claim 1,
The bioabsorbable material injector of the bioabsorbable material, characterized in that it has a coating angle larger than the center angle of the microneedle to have a coating height to the coating end.
The method of claim 3, wherein
The bioabsorbable material layer is composed of a pre-entry and a back-entry, the inlet of the bio-absorbing material, characterized in that the thinner than the back-entry.
The method of claim 4, wherein
And a second coating angle of the second bioabsorbable material layer formed at the coating end of the back entry portion is greater than the coating angle.
The method of claim 1,
Injector of the bioabsorbable material, characterized in that the tip of the microneedle is provided with a seating groove.
The method of claim 1,
Injector of the bioabsorbing material, characterized in that provided with a separation groove in the side of the microneedle.
The method of claim 7, wherein
Injector of the bioabsorbable material, characterized in that the inclined surface of the leaving groove portion is formed with the upper angle toward the body portion and the lower angle formed to the top of the microneedle, the lower angle is larger than the upper angle.
The method of claim 1,
The body portion is a flat plate-shaped plate of bioabsorbable material, characterized in that the tip of the plurality of microneedle is arranged to protrude.
The method of claim 1,
The body portion of the bioabsorbable material injector, characterized in that the cylindrical roller is arranged so that the tip of the plurality of microneedle protrudes.

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