KR102018814B1 - Apparatus for generating tomography image having modulation and correction apparatusand method of operating the same - Google Patents

Abstract

A tomographic image generating device having a modulation and correction device and a method of operation thereof are disclosed. A tomographic image generating apparatus according to an embodiment of the present invention includes a light source unit for emitting light used to irradiate a subject, an optical control unit for controlling a light traveling direction, an optical coupler for dividing / combining incident light, and an optical coupler. And a plurality of optically coupled optical systems, and a device for modulating and correcting light used for irradiating the subject. The modulation and correction device may be provided between the light control unit and the coupler. In addition, the modulation and correction apparatus may be included in an optical system for irradiating light to the subject of the plurality of optical systems. The light modulator may modulate only incident light reflected by the subject.

Description

Tomographic image generating device having modulation and correction device and its operation method

An embodiment of the present invention relates to a tomographic image generating apparatus, and more particularly, tomographic image generating apparatus having a modulation and correction apparatus capable of generating a more accurate tomographic image by improving the transmission depth and the signal size of the subject and It relates to the operation method.

Tomography is a technique of acquiring a tomography image of a subject using a penetrating wave. Such tomography is used in various fields. Accordingly, the demand for more accurate tomographic images is also increasing. In particular, in the medical field directly related to human life, technology for generating more accurate tomographic images has become an important issue.

One embodiment of the present invention provides a tomography image generating apparatus having a modulation and correction apparatus capable of generating a more accurate tomography image by improving the transmission depth and the signal size of a subject.

An embodiment of the present invention provides a method of operating such a tomographic image generating apparatus.

A tomographic image generating device having a modulation and correction device according to an embodiment of the present invention includes a light source unit for emitting light used to irradiate a subject, a light control unit for controlling a traveling direction of light, an optical coupler for dividing / combining incident light; And a plurality of optical systems optically connected to the optical coupler, and a device for modulating and correcting light used to irradiate the subject.

In the tomography image generating device, the modulation and correction device may be provided between the light controller and the coupler.

The plurality of optical systems may include a first optical system for providing reference light and a second optical system for irradiating light to the subject. In this case, the optical system may further include a third optical system for receiving an interference pattern of light generated from the first optical system and light generated from the second optical system.

The modulation and correction device may be included in the second optical system.

The modulation and correction device may be provided between the coupler and the light control unit.

The modulation and correction device,

It may include a light modulator for modulating only the light incident from the coupler and a grating to cancel the unnecessary diffraction light generated by the light modulator.

The groove density (slit density) of the grating may be the same as the light modulator.

The groove density (slit density) of the grating is lower than that of the light modulator, and first and second lenses may be provided to compensate for the difference in groove density between the light modulator and the grating.

In the light modulator, a reflection area of light incident from the coupler and light incident from the subject may be different.

The groove density (slit density) of the grating is different from the light modulator, and first and second lenses may be provided to compensate for the groove density difference between the light modulator and the grating. In this case, lenses corresponding to the first and second lenses may be provided in the first optical system.

The optical modulator may be a digital micro-mirror device (DMD) or a spatial light modulator (SLM).

The second optical system reflects a spatial light modulator (SLM) for modulating the light incident from the coupler, reflects light incident from the spatial light modulator to the subject, and reflects light incident from the subject to the spatial light modulator. The galvanometer and the objective lens for focusing the light incident from the galvanometer to the subject.

The modulation and correction device may be provided between the coupler and the subject.

A beam splitter may be provided in place of the coupler.

The correction device may be provided between the coupler and the first optical system.

The modulation and correction device may be provided between the second optical system and the coupler.

The tomographic image generating apparatus may be an optical coherence tomography apparatus or an optical coherence tomography.

According to an exemplary embodiment of the present invention, an operation method of a tomography image generating apparatus having an optical modulation and correction apparatus includes: a light source unit for emitting light used to irradiate a subject, a light control unit for controlling a traveling direction of light, and split / combine incident light A method of operating a tomographic image generating device comprising an optical coupler and a plurality of optical systems optically coupled to the optical coupler,

And a device for modulating and correcting light used to irradiate the subject, wherein the light modulator performs modulation only on light reflected by the subject.

In this operation method, light incident from the coupler to the modulator of light is incident on a first region of the modulator of light, and light incident on the modulator of light from the subject is directed to a second region of the modulator of light. The first and second regions are spaced apart from each other, and the light modulation operation may be performed only in the first region of the first and second regions.

The tomographic image generating apparatus according to an embodiment of the present invention includes a diffraction correction apparatus based on DMD. Accordingly, by transmitting a desired light pattern deeper in the subject, a tomography image corresponding to a deeper depth that cannot be observed in the general OCT of the subject can be accurately obtained.

1 is a block diagram illustrating an apparatus for generating tomographic images, according to an exemplary embodiment.
FIG. 2A is a cross-sectional view illustrating a first embodiment of the configuration of the second optical system of FIG. 1.
FIG. 2B is a perspective view illustrating a case where a region where light incident from a coupler is reflected and a region where light incident from a subject is reflected are different from each other in the light modulator of FIG.
3 is a cross-sectional view illustrating a second embodiment of the configuration of the second optical system of FIG. 1.
4 is a cross-sectional view illustrating a third embodiment of the configuration of the second optical system of FIG. 1.
5 is a cross-sectional view illustrating a configuration of the third optical system of FIG. 1.
6 is a cross-sectional view illustrating a first embodiment of the configuration of the first optical system of FIG. 1.
7 is a cross-sectional view illustrating a second embodiment of the configuration of the first optical system of FIG. 1.
8 and 9 are cross-sectional views illustrating main parts of a tomographic image generating apparatus according to another exemplary embodiment of the present invention.
FIG. 10 is a cross-sectional view showing a modification of some components of FIG. 9. FIG.
11 is a cross-sectional view of a beam splitter replacing a coupler in a tomographic image generating apparatus according to embodiments of the present invention.

Hereinafter, a tomographic image generating apparatus and an operation method thereof according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings. The operation method is described together in the description of the tomographic image generating apparatus. In this process, the thicknesses of layers or regions illustrated in the drawings are exaggerated for clarity.

1 shows a configuration of a tomography image generating apparatus (hereinafter, referred to as a first apparatus of the present invention) according to an embodiment of the present invention.

Referring to FIG. 1, the first apparatus of the present invention includes a light source unit 20, a light control unit 22, and a coupler 24. The first device of the present invention may also include first to third optical systems 30, 40, 50 connected to the coupler 24. The light source unit 20 emits light irradiated onto the subject. The light source unit 20 may emit light having coherence. The light source unit 20 may include a light source that emits light having coherence. Alternatively, the light source unit 20 may include a light source that emits light having no coherence, and a means for converting into coherence of light emitted from the light source. The light source for emitting light having coherence included in the light source unit 20 may be, for example, a laser diode. The light source for emitting the light having no coherence included in the light source unit 20 may be, for example, a light emitting diode (LED). The means for converting into coherence may be located between the light source unit 20 and the light control unit 22. The light emitted from the light source unit 20 may be light having a center wavelength of, for example, 1025 nm and having a predetermined bandwidth around the center wavelength. The light control unit 22 may be a device that prevents the light emitted from the light source unit 20 from being reflected from other components of the first device of the present invention and entering the light source unit 20 again. The coupler 24 divides the light emitted from the light source unit 20 into the first and second optical systems 30 and 40 or combines the light incident from the first and second optical systems 30 and 40 so that the third optical system ( 50). The split ratio of the light split into the first and second optical systems 30 and 40 by the coupler 24 may be different. For example, the light split into the second optical system 40 in the coupler 24 may be larger than the light split into the first optical system 30. The first optical system 30 may be an optical device connected to the coupler 24 to receive light from the coupler 24, and then reflect the light to the coupler 24. The first optical system 30 may provide a reference light for light processed by the second optical system 40. Therefore, the first optical system 30 may be a reference optical system for the second optical system 40. The second optical system 40 is connected to the coupler 24 to receive light from the coupler 24. The second optical system 40 irradiates the subject with amplitude or frequency modulation on the light received from the coupler 24. The second optical system 40 transmits the light reflected from the subject to the coupler 40. In this case, the subject may be a tissue including a plurality of cells. The subject may be, for example, a living tissue, and may be a skin of a living body or a surface (epidermis) of a living organ. The third optical system 50 is connected to the coupler 24 to generate tomographic information in the tissue of the subject obtained from the combination of the light given from the first and second optical system 30, 40 transmitted through the coupler 24 Can be. In addition, the third optical system 50 may record tomographic information in the tissue of the subject. The configuration of the first to third optical systems 30, 40, and 50 will be described later.

2A shows an example of the configuration of the second optical system 40 of FIG. 1. FIG. 2B illustrates a case where an area where light incident from the coupler 24 is reflected and an area where light incident from the subject 60 is reflected are different from each other in the optical modulator 40a of (a).

Referring to FIG. 2, the second optical system 40 includes an optical modulator 40a, a first grating 40b, first and second mirrors 40c and 40d, and a first objective lens. 40e). The first and second mirrors 40c and 40d may be arranged at a predetermined angle with each other and may be rotated within a predetermined rotation range about a given central axis. The first and second mirrors 40c and 40d may constitute a galvanometer. In this case, means for driving the first and second mirrors 40c and 40d may be further included, for example, a rotating motor (not shown). The light modulator 40a may be a device for modulating the amplitude or frequency of incident light (solid line) incident from the coupler 24. The optical modulator 40a may include a plurality of pixels. The plurality of pixels may form an array, and the pixel interval may be, for example, about 10 μm. The light modulator 40a may correspond to a grating having a plurality of grooves. When the distance between the pixels is about 10 μm, the light modulator 40a may have a groove density of 100. have. Groove density means slit density (number of slits / mm). Each of the plurality of pixels functions as a wave source. By controlling the plurality of pixels of the optical modulator 40a, a wavefront of light (plane wave) incident on the optical modulator 40a can be newly configured. Accordingly, the light reflected by the light modulator 40a (solid line) may have a wavefront different from that of the light incident on the light modulator 40a. In other words, the light reflected by the light modulator 40a may have a different pattern from the light incident on the light modulator 40a. For such light modulation, the pixels located in the area where the light of the light modulator 40a is incident can be controlled, and through this control, the pattern of the incident light can be modulated into a desired pattern.

On the other hand, the light modulator 40a does not perform a modulation operation on the light (dotted line) reflected from the subject 60. The light modulator 40a performs light modulation only on light (solid line) incident from the coupler 24.

Specifically, as shown in FIG. 2B, light L11 incident from the coupler 24 to the light modulator 40a is incident to the first region A1 of the light modulator 40a. The first area A1 is an area where the light modulation operation occurs. Therefore, the light L11 incident from the coupler 24 to the light modulator 40a is modulated and reflected by the first grating 40b.

On the other hand, the light L22 incident on the light modulator 40a from the subject 60 is incident on the second area A2 of the light modulator 40a. The second area A2 is an area spaced apart from the first area A1. The second area A2 is an area where the light modulation operation does not occur. Therefore, the light L22 incident on the light modulator 40a from the subject 60 is reflected to the coupler 24 without modulation.

The optical modulator 40a may be, for example, a digital micro-mirror device (DMD) or a spatial light modulator (SLM). The DMD has a plurality of micro mirrors, and each micro mirror may serve as a pixel. The light modulator 40a may serve as a grating, and thus a lot of diffracted light may be generated from the light modulator 40a. Of these diffracted light, only specific diffracted light, for example, 4th diffraction light, is used to obtain a tomographic image of the subject 60. Therefore, the remaining diffracted light may cause noise. Therefore, the diffracted light which is not used to obtain the tomographic image of the subject 60 may be unnecessary light, and the first grating 40b is provided to remove the diffracted light. The first grating 40b may have the same groove density (slit density) as the light modulator 40a. As a result, only specific diffracted light generated by the optical modulator 40a may be incident on the subject 60, and unnecessary diffracted light may be canceled. Therefore, light may be transmitted to a deeper region of the subject 60, and the corresponding region may be transmitted. The tomographic image of can be obtained clearly. The first mirror 40c reflects the light incident from the first grating 40b to the second mirror 40d. By adjusting the rotation angle of the first mirror 40c, the incident angle of the light incident on the second mirror 40d can be adjusted. The second mirror 40d reflects the light incident from the first mirror 40c to the subject 60. By adjusting the rotation angle of the second mirror 40d, the reflection angle of the light reflected by the second mirror 40d may be adjusted, and as a result, the incident angle of the light (solid line) incident on the subject 60 may be adjusted. The incident angle of the light incident on the subject 60 can be controlled by adjusting the rotation angles of the first and second mirrors 40c and 40d. This can be performed while adjusting the rotation angles of the two mirrors 40c and 40d. The light (solid line) reflected by the second mirror 40d is focused on the subject 60 through the first objective lens 40e. The light (dotted line) reflected from the subject 60 includes tomographic image information of the transmitted region of the subject 60, and includes a first objective lens 40e, a second mirror 40d, a first mirror 40c, Incident on the coupler 24 via the first grating 40b and the light modulator 40a in sequence. Light incident on the coupler 24 from the light modulator 40a interferes with the reference light incident from the first optical system 30, and the result of the interference (interference pattern) is transmitted to the third optical system 50.

3 shows another example of the configuration of the second optical system 40 of FIG. 1. Only parts different from FIG. 2 will be described. Like numbers refer to like elements.

Referring to FIG. 3, another example includes a second grating 40h at the position of the first grating 40b of FIG. 2. The groove density (slit density) of the second grating 40h may be different from the light modulator 40a. The groove density of the second grating 40h may be smaller than the light modulator 40a, for example the groove density of the light modulator 40a may be 400 corresponding to the fourth order diffracted light, and the second grating 40h The diffraction density of may be about 300 smaller than this. In order to compensate for the difference in groove density (diffraction density) between the light modulator 40a and the second grating 40h, the first and second lenses 40f and 40g are disposed between the light modulator 40a and the second grating 40h. It is provided side by side. The first and second lenses 40f and 40g may be convex lenses and may have the same or different focal lengths. For example, the focal length of the first lens 40f may be 30 nm, and the focal length of the second lens 40g may be 40 nm. The optical modulator 40a, the first lens 40f, the second lens 40g, and the second grating 40h may be aligned on the same optical axis. The first and second lenses 40f and 40g are two-sided convex lenses, but are not limited to these lenses.

4 illustrates another example of the configuration of the second optical system 40 of FIG. 1.

Referring to FIG. 4, the second optical system 40 includes a spatial light modulator 40i, first and second mirrors 40c and 40d, and a first objective lens 40e. The spatial light modulator 40i reflects the light (solid line) incident from the coupler 24 to the first mirror 40c. The light propagation after the first mirror 40c is as described above. In addition, after light is irradiated to the subject 60, the light (dotted line) reflected from the subject 60 may include the first objective lens 40e, the second mirror 40d, the first mirror 40c, and the spatial light modulator ( Incident on the coupler 24 via 40i).

FIG. 5 shows an example of the configuration of the third optical system 50 of FIG. 1.

Referring to FIG. 5, the third optical system 50 may include a third grating 50a, a third lens 50b, and an optical image sensing device 50c. The light L2 incident from the coupler 24 includes information on a tomographic image of a given depth of the subject 60, and sequentially passes through the third grating 50a and the third lens 50b to detect the optical image sensing device ( Light received at 50c). The slit density of the third grating 50a may be, for example, 1200 lines / mm. The optical image sensing device 50c is a device for recognizing a tomography image included in the light L2 and may be, for example, a charge coupled device (CCD).

6 illustrates an example of a configuration of the first optical system 30 of FIG. 1.

Referring to FIG. 6, the first optical system 30 includes a second objective lens 30a and a third mirror 30b having the same optical axis. The second objective lens 30a may be equivalent to the first objective lens 40e of FIG. 2. The light (solid line) incident from the coupler 24 passes through the second objective lens 30a and enters the third mirror 30b, is reflected from the surface of the third mirror 30b, and then again the second objective lens. It enters into the coupler 24 through 30a. The optical path from the coupler 24 to the third mirror 30b may be the same as the optical path from the coupler 24 to the subject 60. Therefore, a tomographic image corresponding to the predetermined depth of the subject 60 is generated through an interference pattern of light split into the first optical system (reference light) and the second optical system 40 and transmitted to a predetermined depth of the subject 60. You can get it.

FIG. 7 shows another embodiment of the configuration of the first optical system 30 of FIG. 1. The configuration of FIG. 7 corresponds to the configuration of the second optical system of FIG. 3.

Referring to FIG. 7, the first optical system 30 includes fourth and fifth lenses 30c and 30d, a second objective lens 30a, and a third mirror 30b having the same optical axis. The fourth and fifth lenses 30c and 30d are aligned between the coupler 24 and the second objective lens 30a. Light (solid line) incident from the coupler 24 is incident on the third mirror 30b via the fourth lens 30c, the fifth lens 30d, and the second objective lens 30a, and the third mirror 30b. The light (dotted line) reflected by the light beam passes through the second objective lens 30a, the fifth lens 30d, and the fourth lens 30c, and is incident on the coupler 24.

8 shows a main part of a tomographic image generating apparatus (hereinafter, referred to as a second apparatus of the present invention) according to another embodiment of the present invention. Only parts different from FIG. 1 will be described. Like numbers refer to like elements.

Referring to FIG. 8, the second device of the present invention comprises the light compensator of FIG. 2, the light modulator 40a and the first grating 40b, between the light controller 22 and the coupler 24. In the second device of the present invention, the light L3 emitted from the light controller 22 is reflected by the fourth mirror 70 and is incident to the light modulator 40a. Light L4 modulated by light modulator 40a is incident on first grating 40b. The modulated light L4 is reflected by the first grating 40b and is incident to the fifth mirror 72. Light incident on the fifth mirror 72 is reflected on the surface of the fifth mirror 72 and is incident on the coupler 24. The configuration of the second optical system 40 of the second apparatus of the present invention may be the same as that of the rest of the optical modulator 40a and the first grating 40b in FIG. 2.

 Meanwhile, in FIG. 8, at least one mirror other than the fourth mirror 70 may be further involved in changing the optical path between the optical controller 22 and the optical modulator 40a. In other words, one or more mirrors may be further provided between the optical controller 22 and the optical modulator 40a in addition to the fourth mirror 70.

In addition, at least one mirror may be further provided between the first grating 40b and the coupler 24 in addition to the fifth mirror 72.

9 shows a main part of a tomographic image generating apparatus (hereinafter, the third apparatus of the present invention) according to another embodiment of the present invention. Only parts different from those in Fig. 1 will be described, and like reference numerals denote like elements.

Referring to FIG. 9, the third apparatus of the present invention includes fourth and fifth mirrors 70, 72 between the light controller 22 and the coupler 24, and the fourth and fifth mirrors 70, 72. ), The optical modulator 40a, the first and second lenses 40f and 40g, and the second grating 40h. Light emitted from the light controller 22 is reflected by the fourth mirror 70 and is incident on the light modulator 40a. The light L4 modulated by the optical modulator 40a sequentially passes through the first lens 40f and the second lens 40g and is incident on the second grating 40h. Light incident on the second grating 40h is reflected by the fifth mirror 72 and is incident on the coupler 24. In the third apparatus of the present invention, the configuration of the second optical system 40 is the remaining configuration in which the optical modulator 40a, the first lens 40f, the second lens 40g, and the second grating 40h are removed from FIG. May be the same.

In FIG. 9, at least one mirror other than the fourth mirror 70 may be further involved in changing the optical path between the optical controller 22 and the optical modulator 40a. In other words, one or more mirrors may be further provided between the optical controller 22 and the optical modulator 40a in addition to the fourth mirror 70.

In addition, at least one mirror may be further provided between the second grating 40h and the coupler 24 in addition to the fifth mirror 72.

Meanwhile, as shown in FIG. 10, a light source 25 connected to the light controller 22 may be used instead of the fourth mirror 70 of FIG. 9. Light of plane wave from the light source 25 may be incident on the light modulator 40a. The light controller 22 and the light source 25 may be connected by a light transmission medium, for example an optical fiber.

In addition, a sixth mirror (not shown) may be provided between the fifth mirror 72 and the coupler 24. In this case, the sixth mirror may serve to reflect the light reflected from the fifth mirror 72 and incident to the coupler 24. In addition to the fifth mirror 72 and the sixth mirror, one or more mirrors may be further provided between the second grating 40h and the coupler 24.

11 shows a beam splitter 45 in place of the coupler 24. Light incident on the beam splitter 45 by the light control unit 22 is divided into first and second optical systems 30 and 40. Light incident from the first and second optical systems 30 and 40 to the beam splitter 45 is combined and transmitted to the third optical system 50. Light transmitted from the beam splitter 45 to the third optical system 50 may be transmitted using an optical transmission medium such as an optical fiber.

In FIG. 11, the modulation and correction apparatus described with reference to FIGS. 8 to 10 may be provided between the light control unit 22 and the beam splitter 45.

On the other hand, in the above-described first to third devices of the present invention, each component may be spaced apart on the same optical axis, each component may be connected to the light transmission means, but may be configured without the light transmission means. The light transmitting means may be, for example, an optical fiber or may be a waveguide.

When each of the components is configured without the light transmitting means, the components are in a spaced apart state with the optical axis aligned. Thus, light emitted from one component, such as beam splitter 45, may be incident directly on another component, such as second optical system 40.

The tomography image generating apparatus according to the embodiments of the present invention described above may be an optical coherence tomography or an optical coherence tomography.

While many details are set forth in the foregoing description, they should be construed as illustrative of preferred embodiments, rather than to limit the scope of the invention. Therefore, the scope of the present invention should not be defined by the described embodiments, but should be determined by the technical spirit described in the claims.

20: light source part 22: light controller
23: Optical fiber 24: Coupler
25: light source 30, 40, 50: first to third optical system
40f, 40g: First and second lenses 45: Beam splitter
50b: third lens 30c, 30d: fourth and fifth lenses
40a: light modulator
40c, 40d, 30b, 70, 72: first to fifth mirrors
40b, 40h, 50a: first to third gratings
40e, 30a: first and second objective lenses
50c: Optical image sensing device 60: Subject

Claims (24)

The light source unit emitting light used to irradiate the subject
An optical control unit controlling the traveling direction of the light
Optical coupler to split / combine incident light
A plurality of optical systems optically coupled to the optical coupler;
And a device for modulating and correcting light used to irradiate the subject,
The modulation and correction device includes an optical modulator for modulating only the light incident from the optical coupler,
And a reflection area of light incident from the optical coupler and light incident from the subject in the optical modulator. The method of claim 1,
The modulation and correction apparatus is a tomography image generating device provided between the optical control unit and the optical coupler. The method of claim 1,
The plurality of optical systems
A first optical system providing a reference light and
And a second optical system for irradiating light to the subject. The method of claim 3, wherein
And a third optical system configured to receive an interference pattern of light generated from the first optical system and light generated from the second optical system. The method of claim 3, wherein
The modulation and correction apparatus is included in the second optical system. The method of claim 1,
The modulation and correction device,
And a grating canceling unnecessary diffraction light generated by the light modulator. The method of claim 6,
The groove density (slit density) of the grating is the same as the optical modulator. The method of claim 6,
The groove density (slit density) of the grating is lower than that of the light modulator, and the tomography image generating device includes first and second lenses for compensating for the difference in groove density between the light modulator and the grating. delete The method of claim 5,
And a grating for canceling the unnecessary diffraction light generated by the light modulator. The method of claim 10,
The groove density (slit density) of the grating is different from the light modulator, and a tomographic image generating device is provided with first and second lenses for compensating the groove density difference between the light modulator and the grating. The method of claim 11,
And a lens corresponding to the first and second lenses in the first optical system. The method of claim 6,
The optical modulator is a digital micro-mirror device (DMD) or spatial light modulator (SLM). The method of claim 3, wherein
The second optical system,
SLM for modulating light incident from the optical coupler
A galvanometer for reflecting light incident from the spatial light modulator to the subject and reflecting light incident from the subject to the spatial light modulator;
And an objective lens configured to focus light incident from the galvanometer on the subject. The method of claim 1,
The modulation and correction device is a tomography image generating device provided between the optical coupler and the subject. The method of claim 1,
A tomographic image generating device having a beam splitter instead of the optical coupler. The method of claim 3, wherein
And a modulation and correction device provided between the optical coupler and the first optical system. The method of claim 14,
The modulation and correction apparatus is a tomographic image generating device provided between the second optical system and the optical coupler. The method according to any one of claims 1, 3, 6 and 14,
The tomography image generating apparatus may be an optical coherence tomography apparatus or an optical interference tomography microscope. A light source unit for emitting light used for subject irradiation, a light control unit for controlling the direction of the light, an optical coupler for splitting / coupling incident light, and a plurality of optical systems optically connected to the optical coupler In the operation method,
Further comprising a device for modulating and correcting the light used to irradiate the subject,
The light modulator performs a modulation operation only on the light reflected by the subject,
Light incident from the optical coupler to the modulator of light is incident to a first region of the modulator of light,
The light incident from the subject to the modulator of light is incident to a second region of the modulator of light,
The first and second regions are spaced apart,
And a light modulation operation performed only in the first region among the first and second regions. delete The method of claim 20,
The modulation and correction apparatus is an operation method of the tomographic image generating device provided between the optical control unit and the optical coupler. The method of claim 20,
The modulation and correction apparatus is a method of operating a tomographic image generating device provided between the optical coupler and the subject. The method of claim 20,
And a beam splitter provided in place of the optical coupler.

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