KR101968803B1 - Sensor platform using photoluminescence and detecting device having the same - Google Patents

Abstract

The present invention relates to a wearable sensor platform using photoluminescence and a detection device including the same. The wearable sensor platform according to an embodiment of the present invention includes a flexible polymer matrix which is closely adhered to a living body surface to be measured, at least one kind of first fluorescent material dispersed in the polymer matrix and reacting with the analyte of the living body surface, And a fluorescent sensor film including at least one kind of second fluorescent material that does not react with the analyte on the living body surface, and a second fluorescent material disposed on an upper side of the fluorescent sensing film, A light source layer including at least one light source; And at least one first fluorescent material or a second fluorescent material emitted from the second fluorescent material by the first light incident from the light source layer (20), the first light being disposed on the upper surface of the light source layer (20) Wherein each unit pixel of the plurality of color pixels comprises a plurality of color pixels arranged in a matrix form for receiving light that is mapped to each measurement point of the fluorescent sensing film And a sensor layer (30).

Description

[0001] The present invention relates to a wearable sensor platform using photoluminescence and a sensing device including the sensor platform.

BACKGROUND OF THE INVENTION 1. Field of the Invention [0002] The present invention relates to a wearable sensor platform, and more particularly, to a wearable sensor platform using photoluminescence and a detection device including the same.

Generally, a photoluminescence-based (PL-based) sensor refers to an analyte adsorbed on a fluorescent sensing film, for example, a specific compound such as oxygen, moisture, serum, And the photoluminescence characteristics of the fluorescence sensing film are different. A sensor platform means an independent device composed of a photoluminescence sensor film, an excitation source, and a photodiode. And the photoluminescence based sensor is used in various fields such as environment, medical, food, security, and chemical engineering industries because of its simple principle, high reliability of operation and wide range of applicable compounds.

Meanwhile, the wearable sensor is broadly classified into a flexible sensor, and refers to a device that directly senses a specific chemical element or mechanical movement by attaching directly to the skin or organ of the body. In recent years, As medical technology has developed, interest in wearable sensors in these fields is increasing.

In order to realize this, a photoluminescence-based sensor which is easy to carry and which can be attached and detached to the surface of body skin or organ is needed. In addition, it is desirable to be able to simultaneously detect various analytes in order to perform comprehensive measurement analysis through the wearable sensor. However, researches on photoluminescence based sensor and wearable sensor have been actively carried out, but there is a lack of research to integrate and utilize them.

As an example of a conventional technique for measuring an analyte, there is an oxygen measuring method using a needle electrode type clark electrode or a thin fiber type microelectrode. Since the oxygen measurement method measures oxygen based on point detection, it is difficult to quantitatively analyze the distribution of the analyte in the measurement area, and it is difficult to measure in a wide range. The measurement technique of the analyte using the new photoluminescence based sensor is required to quantitatively measure the distribution of the analyte in a wide measurement range.

SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide a light-emitting device capable of being easily carried and detachable and attachable to a living body surface and being capable of being implemented as a wearable sensor, capable of large area measurement for quantitatively analyzing the distribution of an analyte A wearable sensor platform incorporating a sensor and a wearable sensor is provided.

Another object of the present invention is to provide a detection device having a wearable sensor platform having the above-described advantages.

According to an aspect of the present invention, a wearable sensor platform includes a flexible polymer matrix which is closely adhered along a living body surface to be measured, at least one kind of first fluorescent material dispersed in the polymer matrix, And a fluorescent sensor film including at least one kind of second fluorescent material that does not react with the analyte on the living body surface, and a second fluorescent material disposed on an upper side of the fluorescent sensing film, A light source layer including at least one light source and a light source layer disposed on an upper side of the light source layer and being emitted from the at least one kind of the first fluorescent material or the second fluorescent material by the first light incident from the light source layer A plurality of light sources for separating the second light into at least two colors and for detecting the color- Contains an array of color pixels, each unit pixel of the plurality of color pixels comprises a light receiving sensor layer is mapped with each measurement point the fluorescence sensing film.

In an embodiment of the present invention, the wearable platform includes a first arithmetic section for calculating a relative color intensity ratio of each unit pixel of the plurality of color pixels, using the second light having been color-separated, And a second arithmetic unit for calculating a numerical value for quantifying a characteristic of the analyte using the relative color intensity ratio of the analyte.

In an embodiment of the present invention, the characteristic of the analyte may be at least one of the concentration and the kind of the analyte.

In an embodiment of the present invention, the arithmetic circuit layer includes a first color filter layer and a second color filter layer, wherein when the color-separated second light includes third light emitted from the first fluorescent substance and fourth light emitted from the second fluorescent substance, Calculating a characteristic distribution of the analyte using the ratio of the intensity of the decomposed third light to the intensity of the fourth light that has been color-separated; and calculating, based on the characteristic distribution of the analyte, And a correction unit for correcting the quantified value of the reference value.

In an embodiment of the present invention, each of the plurality of color pixels includes at least two color filters for decomposing the second light into at least two colors, and at least two color filters for transmitting the at least two color filters, And at least two photodiodes for detecting two lights.

In another embodiment of the present invention, each of the plurality of color pixels includes one color filter for decomposing the second light into a specific color, and one for detecting the color-separated second light transmitted through the color filter Of photodiodes.

In another embodiment of the present invention, each of the plurality of color pixels includes at least two photodiodes each responsive to at least two colors included in the second light.

In an embodiment of the present invention, each of the plurality of color pixels includes a photodiode responsive to one specific color contained in the second light, and the specific color may be one of red, green, and blue have.

A first filter layer disposed between the fluorescence sensor film and the light source layer 20 for filtering the first light emitted from the light source layer 20 and a second filter layer disposed between the light source layer and the light source layer 20, And a second filter layer disposed between the sensor layer (30) and for filtering the second light emitted from the fluorescent sensor film (10).

In the embodiment of the present invention, the light emitting device further includes a functional film that seals at least one of the light source layer, the light receiving sensor layer, and the arithmetic circuit layer so that the analytes are not introduced from the outside.

The light source layer further includes a thin film transistor (TFT) for switching the at least one light source.

In an embodiment of the present invention, the flexible polymer matrix is selected from the group consisting of poly (acrylonitrile) (PAN), styrene-co-acrylonitrile (PSAN), poly (vinyl alcohol) (PVC), poly (methyl methacrylate) (PMMA), poly (dimethyl siloxane) (PDMS), poly (hexafluoroisopropyl methacrylate-co-heptafluoro-n-butyl methacrylate) poly (trimethylsilyl propyne) (PolyTMSP), ethyl cellulose (EC), silicone rubbers, polystyrene (PS), poly (styrene- Cellulose derivatives, and poly (hydroxyethyl methacrylate) (pHEMA).

In an embodiment of the present invention, the at least one kind of the first fluorescent material is pyrene, decac2clene, ruthenium (II) -tris (4,7, diphenyl-1,10, phenanthroline) (dpp) 32+), Platinum (II) -2,3,7,8,12,13,17,18-octaethylporphyrin (PtOEP), Platinum (II) -5,10,15,20, tetrakis Palladium (II) -2, 3, 7, 8, 12, 13, 17,18-octaethylporphyrin (PdOEP), Palladium (II) 15,20-tetrakis (2,3,4,5,6-pentafluorophenyl) porphyrin (PdTFPP), Platinum (II) -5,10,15,20-tetrakis (2,3,4,5,6- tris (1,1-phenanthroline) (Ru (phen) 32+), Ruthenium-tris (2,2'- bipyridine) (Ru (bpy) 32+), Ruthenium- bis (2,2 ': 6', 2''terpyridine) (Ru (trpy) 22+), Europium (III) -tris (thenoyltrifluoroacetylacetonato) , 5-dimethylpyrazol-1-yl) -1,3,5-triazine) [Eu (tta) 3 (dpbt)] and 8-Hydroxypyrene-1,3,6-Trisulfonic Acid .

According to an aspect of the present invention, there is provided a detection device comprising: a flexible polymer matrix which is closely adhered along a living body surface to be measured; at least one kind of first fluorescent substance dispersed in the polymer matrix and reacting with the analyte of the living body surface; A sensor including at least one kind of second fluorescent material that does not react with the analyte of the living body surface and at least one light source for irradiating the first light with the sensor, And a measurement module including an array of a plurality of color pixels for decomposing the at least two types of first light emitted from the first fluorescent material or the second fluorescent material into at least two colors and for detecting the second color separated light do.

In an embodiment of the present invention, the measurement module may include a first calculation unit that calculates a relative color intensity ratio of each unit pixel of the plurality of color pixels using the second light that has been color-separated, And a second arithmetic section for calculating a numerical value for quantifying a characteristic of the analyte using the relative color intensity ratio of the unit pixel.

The measurement module may be an electronic device including a light receiving sensor for receiving light reflected from the sensor, and the light source may be a light emitting diode (LED), an organic light-emitting diode (OLED), a quantum dot light Emitting Diode), or LEC (light-emitting electrochemical cell).

According to the embodiment of the present invention, by including the fluorescent sensor film, the light source layer, and the light-receiving sensor layer capable of color degradation, which are closely contacted with the living body surface to be measured, And it is possible to provide a wearable sensor platform that incorporates a wearable sensor and a light emitting based sensor capable of measuring a large area by making it possible to measure the boiling difference by color decomposition.

Further, according to another embodiment of the present invention, a detection apparatus having the above-described advantage can be provided.

BRIEF DESCRIPTION OF THE DRAWINGS Figs. 1A to 1B are cross-sectional views showing one side section of a wearable sensor platform according to an embodiment of the present invention.
2 shows a structure of a fluorescent sensor film according to an embodiment of the present invention.
3 is a detailed cross-sectional view of a light source layer 20 according to an embodiment of the present invention.
4 is a plan view of a light receiving sensor layer divided into a plurality of color pixels according to an embodiment of the present invention.
5 is a diagram showing a mapping relationship between a plurality of color pixel areas of the light receiving sensor layers and a plurality of measurement areas of the fluorescent sensor film according to an embodiment of the present invention.
6A to 6D are diagrams showing the configuration of a unit color pixel according to an embodiment of the present invention.
7 is a configuration diagram of an arithmetic circuit layer according to an embodiment of the present invention.
8 is a system configuration diagram of a wearable sensor platform according to a second embodiment of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

The embodiments of the present invention are described in order to more fully explain the present invention to those skilled in the art, and the following embodiments may be modified into various other forms, It is not limited to the embodiment. Rather, these embodiments are provided so that this disclosure will be more faithful and complete, and will fully convey the scope of the invention to those skilled in the art.

Like numbers refer to like elements in the drawings. Also, as used herein, the term " and / or " includes any and all combinations of any of the listed items.

The terms used herein are used to illustrate the embodiments and are not intended to limit the scope of the invention. Also, although described in the singular, unless the context clearly indicates a singular form, the singular forms may include plural forms. Also, the terms "comprise" and / or "comprising" used herein should be interpreted as referring to the presence of stated shapes, numbers, steps, operations, elements, elements and / And does not exclude the presence or addition of other features, numbers, operations, elements, elements, and / or groups.

Reference herein to a layer formed " on " a substrate or other layer refers to a layer formed directly on top of the substrate or other layer, or may be formed on intermediate or intermediate layers formed on the substrate or other layer Layer. ≪ / RTI > It will also be appreciated by those skilled in the art that structures or shapes that are " adjacent " to other features may have portions that overlap or are disposed below the adjacent features.

As used herein, the terms "below," "above," "upper," "lower," "horizontal," or " May be used to describe the relationship of one constituent member, layer or regions with other constituent members, layers or regions, as shown in the Figures. It is to be understood that these terms encompass not only the directions indicated in the Figures but also the other directions of the devices.

As used herein, a " probe " refers to a substance in which at least one dye and at least one polymer are combined to detect a single analyte. Also, in this specification, the term " transparent " is not to be construed as having transparency in the band of both visible light, infrared, or ultraviolet region, and should be interpreted as having transmittance in some wavelength bands of these regions.

In the following, embodiments of the present invention will be described with reference to cross-sectional views schematically illustrating ideal embodiments (and intermediate structures) of the present invention. In these figures, for example, the size and shape of the members may be exaggerated for convenience and clarity of explanation, and in actual implementation, variations of the illustrated shape may be expected. Accordingly, embodiments of the present invention should not be construed as limited to any particular shape of the regions shown herein. In addition, reference numerals of members in the drawings refer to the same members throughout the drawings.

1A and 1B are cross-sectional views of a wearable sensor platform 100 according to an embodiment of the present invention.

1A, a wearable sensor platform 100 may include a fluorescent sensor film 10, a light source layer 20, and a light receiving sensor layer 30. The wearable sensor platform 100 includes an operational circuit layer 40 for analyzing characteristics of an analyte of a living body surface 10S to be measured based on an electrical signal detected from the light receiving sensor layer 30 ). ≪ / RTI >

The fluorescent sensor film 10 comprises a flexible polymer matrix which is closely adhered along a living body surface 10S to be measured, at least one kind of first fluorescent material dispersed in the polymer matrix and reacting with the analyte of the living body surface, And at least one second fluorescent substance that does not react with the analyte of the living body surface.

The subject to be measured may be a person, an animal or a plant, and the analyte is transferred through the skin or epithelial tissue and is present in the living body surface 10S or contained in the living body, oxygen or activated oxygen, moisture, nitrogen monoxide NO), hydrogen ion concentration (pH), temperature, serum, lactate, alchol and / or glucose. The present invention is not limited to the kind of the analyte.

The flexible polymer matrix is formed by polymers of at least one middle stream. The polymer may be selected from the group consisting of poly (acrylonitrile) (PAN), styrene-co-acrylonitrile (PSAN), polyvinyl alcohol (PVA), polyvinyl methyl ketone (PVMK) (PVC), poly (methyl methacrylate) (PMMA), poly (dimethyl siloxane) (PDMS), poly (hexafluoroisopropyl methacrylate-co-heptafluoro-n-butyl methacrylate) (FIB), poly (isobutyl methacrylate- Poly (trimethylsilyl propyne) (PolyTMSP), ethyl cellulose (EC), silicone rubbers, polystyrene (PS), cellulose derivatives, Poly (hydroxyethyl methacrylate) (pHEMA), or a combination thereof. However, the present invention is not limited thereto, and any transparent material having high light transmittance and being flexible can be used.

At least one kind of fluorescent substance may be dispersed in the flexible polymer matrix. The fluorescent material may be physically, electrically, or chemically adsorbed to the surface or internal pores of the polymer matrix, or may be embedded in the polymer matrix.

In one embodiment, the fluorescent material may include at least one kind of fluorescent material that reacts with a predetermined analyte and at least one kind of second fluorescent material that does not react with the analyte. The at least one kind of the first fluorescent material may include an indicator dye. The indicator dye is selected from the group consisting of pyrene, decac2clene, ruthenium (II) -tris (4,7, diphenyl-1,10, phenanthroline) (PdOEP), Platinum (II), Palladium (II) -2,3,7,8,12,13,17,18-octaethylporphyrin -5,10,15,20 tetrakis (2,3,4,5,6-pentafluorophenyl) porphyrin (PtTFPP), Palladium (II) -5,10,15,20-tetrakis (2,3,4,5 , 6-pentafluorophenyl) porphyrin (PdTFPP), Platinum (II) -5,10,15,20-tetrakis (2,3,4,5,6-pentafluorophenyl) porpholactone (PtTFPL), Ruthenium-tris Bis (2,2'-bipyridine) (Ru (bpy) 32+), Ruthenium-bis terpyridine (Ru (trpy) 22+), Europium (III) -tris (2- (4-diethylaminophenyl) -4,6-bis (3,5-dimethylpyrazol- , 5-triazine) [Eu (tta) 3 (dpbt)], 8-Hydroxypyrene-1,3,6-Trisulfonic Acid (HPTS) or a combination thereof. However, the present invention is not limited thereto.

In some embodiments, a core shell may be fabricated using different dyes and different polymer classes to detect the characteristics (e.g., type, concentration, distribution) of a plurality of analytes of interest. A plurality of probes of the structure may be included in the fluorescent sensor film 10. [ 2 shows a structure 200 of a fluorescent sensor membrane 10 according to an embodiment of the present invention. Referring to Fig. 2, the flexible fluorescence sensor film 10 is brought into close contact with the living body surface 10S to react with oxygen, temperature, and / or pH. The probe 10 for detecting oxygen includes a PtTFPL (indicator dye) / PSAN (polymer) particles 10C and a probe for temperature sensing includes Eu (tta) 3 (dpbt) / PVC particles 10B, and the probe for pH sensing may comprise HPTS / pHEMA particles 10A. In addition, each of the Eu (tta) 3 (dpbt) / PVC particles 10B is coated with a polymer having an oxygen impermeable property so that the temperature-sensitive probe does not react with oxygen And may be combined with a polymer having oxygen impermeable properties. On the other hand, each of the PtTFPL (indicator dye) / PSAN (polymer) particles (10C) may be coated with a non-temperature sensitive polymer or combined with a non-temperature sensitive polymer to prevent oxygen sensitive probes from reacting with temperature have. This can prevent the analyte (eg, oxygen) from reacting in addition to the analyte (eg, temperature) to be measured in one probe.

In order for the analytes to be quantitatively measured uniformly, HPTS / pHEMA particles 10A, Eu (tta) 3 (dpbt) / PVC particles 10B and PtTFPL / PSAN particles 10C are uniformly distributed .

In another embodiment, a probe for detecting lactate, alchol, or glucose may be composed of a polymer with a dye in combination with two or more indicator dyes. have.

The at least one kind of second fluorescent material includes a reference dye which does not react with the analyte. For example, in the case of measuring the oxygen concentration in the analyte, PtTFPP is used as the indicator dye and fluorophore N- (5-carboxypentyl) -4-piperidino-1,8-naphthalimide can be used as the reference dye. The PtTFPP material reacts with oxygen to produce light of a red wavelength and the fluorophore N- (5-carboxypentyl) -4-piperidino-1,8-naphthalimide material does not react with oxygen and can generate green wavelength light have. The reference dye may be used as long as it is a dye which does not react with the analyte but generates a wavelength different from the wavelength band generated in response to the analyte.

In another embodiment, the reference dye may be an indicator dye comprising a layer coded with a polymer that does not react with the analyte. For example, the reference dye may be an indicator dye in which at least one polymer that does not react with the reference dye is coded to prevent it from reacting with oxygen, temperature, and pH.

1A, when the fluorescent sensor film 10 is closely adhered along the living body surface 10S to be measured, at least one or more analytes are adsorbed and / or absorbed in the fluorescent sensor film 10 And the first light (or light) 20S can be irradiated from the light source layer 20 to the fluorescent sensor film 10. [ At this time, the fluorescence sensor film 10 reacts with the light 20S (hereinafter referred to as first light) emitted from the light source layer 20 and the analyte materials of the living body surface 10S to generate photoluminescence The light 30S (hereinafter referred to as the second light) emitted by the light receiving sensor layer 30 can be transmitted to the light receiving sensor layer 30. At this time, since the various kinds of fluorescent materials included in the first fluorescent material have different luminescence intensity patterns according to respective wavelengths, the type of the analyte can be determined through the photoluminescence characteristic. For example, emission from a photoluminescence pattern 10C 'emitted from PtTFPL / PSAN polymer particles responsive to oxygen and Eu (tta) 3 (dpbt) / PVC particles responsive to temperature And the photoluminescence pattern 10A 'emitted from the HPTS / pHEMA particles responsive to the pH may have unique characteristics. The light emission pattern may have a continuous or discontinuous light emission intensity profile within a predetermined wavelength range. The light emission intensity profile may include wavelength information for classifying the type of the analyte and light emission intensity information for quantifying the concentration of the analyte.

In various embodiments, the type and concentration of the analyte can be determined through the wavelength of the light emitted from the various kinds of fluorescent materials included in the first fluorescent material and the luminescence intensity of the wavelength. For example, when a first wavelength is emitted by a PtTFPL (indicator dye) / PSAN (polymer) that reacts with oxygen, the analyte is determined to be oxygen by the first wavelength, The concentration can be determined. When the second wavelength is emitted by Eu (tta) 3 (dpbt) / PVC which reacts with temperature, the analyte is determined to be the temperature by the second wavelength, and the temperature value is determined by the emission intensity of the second wavelength And when the third wavelength is released by HPTS / pHEMA in response to pH, the analyte is determined to be pH by the third wavelength, and the pH concentration can be determined by the emission intensity of the third wavelength have.

In addition, when the first light 20S having a short energy with high energy is irradiated from the light source layer 20 to the first fluorescent material of the fluorescent sensor film 10, the first fluorescent material is in an excited state (ground state) exciting state. In the excited state, the energy level of the luminescent material is unstable and returns to the ground state while releasing energy again. The emitted second light (fluorescence and / or phosphorescence) 30S may have a weaker energy than the first light 20S. The intensity of light output from the first fluorescent material may decrease or increase depending on the characteristics of the analyte, since the first fluorescent material has a characteristic of transmitting a part of emission energy to the analyte . For example, when the analyte is oxygen, when the first fluorescent material is combined with oxygen molecules, a partial emission energy of the first fluorescent material is transferred to oxygen molecules, and the intensity of light of the first fluorescent material is increased (Oxygen photon extinction: O2 quenching).

However, the second fluorescent material emits emission energy according to the light 20S emitted from the light source layer 20 without reacting with the analyte. In other words, the second fluorescent material can emit emission energy uniformly according to the light 20S emitted from the light source layer 20 without transmitting some emission energy to the analyte.

Here, the first fluorescent material and the second fluorescent material may emit light 20S having the same wavelength from the light source layer 20, but may emit second light 30S having different wavelengths. For example, in the first fluorescent material that reacts with oxygen, the intensity of the second light varies at the first wavelength depending on the oxygen concentration, but the second fluorescent material that does not react with oxygen changes the intensity of the second wavelength And emits a second light having a constant intensity. In this case, for the same one analyte, the fluorescent sensor film 10 can emit the second light of different wavelengths. Therefore, according to the embodiment of the present invention, the intensity of the light emitted from the first fluorescent material with respect to the intensity of the light emitted from the second fluorescent material is transmitted through the ratio to the brightness of the object to be measured, 20) of the analyte can be prevented from being detected incorrectly.

The light source layer 20 is disposed on the upper surface of the fluorescent sensing film 10 and includes at least one light source for irradiating the fluorescent light sensing film 10 with the first light 20S. The light source layer 20 may be an organic light emitting diode (OLED) or an organic light emitting diode (OLED) or a combination thereof, and the present invention is not limited thereto.

In one embodiment, one OLED pixel or pixel in the OLED can correspond to one light source. The OLED emits light of a specific wavelength (hereinafter referred to as electroluminescence) by combining electrons and electrons supplied from a first electrode (for example, an anode) and a second electrode (for example, a cathode) . The light source layer 20 will be described in detail with reference to FIG.

The light receiving sensor layer 30 may be disposed on the upper surface of the light source layer 20. The light receiving sensor layer 30 is formed by the first light 20S emitted from the light source layer 20 and the second light 30S emitted from the at least one kind of the first fluorescent material and / Into at least two colors, and detects the color-separated second light 30S. The second light is a light emitted from the photoluminescence (light from the first fluorescent material), which is emitted in response to each of the at least one analyte, and the photoluminescence emitted from the second fluorescent material without reaction with the at least one analyte Of light). That is, the photoluminescence emitted from each of the at least one kind of the first fluorescent materials is decomposed into at least two colors. In the embodiment, each of the photoluminescence emitted from each of the at least one or more second fluorescent materials may be decomposed into at least two colors. At least two colors separated in this way may be colors selected from a predetermined color system to improve the degree of contrast of the decomposed color.

For example, the second light emitted from the first or the second fluorescent material may be decomposed into red, green, and blue, respectively, or may be red, green, (Red) and blue (Blue).

In another embodiment, the second light emitted from the first or the second fluorescent material may be decomposed into at least two of cyan, magenta, and yellow, respectively. When cyan and magenta are mixed, they become blue. When magenta and yellow are mixed, they become red. When cyan and yellow are mixed, do.

In another embodiment, the second light emitted from the first or the second fluorescent material may be decomposed into at least two of YUV, respectively. The relational expression of RGB-YUV is expressed by Equation (1) below.

4, the unit pixel of each of the plurality of color pixels has a ratio of 1: 1 or 1: 1 to each measurement region of the fluorescent sensing film, n (where n is an integer). In addition, in each unit pixel of the plurality of color pixels, the light emitting (third light) emitted from the at least one kind of first fluorescent material contained in each measuring region of the fluorescent sensing film, (Fourth light) emitted from the at least one kind of second fluorescent material contained in the second fluorescent material is color-decomposed and detected. The mapping relationship between each unit pixel region of the light receiving sensor layer 30 and each measurement region of the fluorescent sensing film will be described in FIG.

The present invention can measure a large area through the arrangement of a plurality of color pixels of the light receiving sensor layer 30 and quantitatively analyze the characteristic distribution (e.g., concentration distribution) of the analyte on the living body surface. Therefore, according to the embodiment of the present invention, not only the concentration of the analyte on the living body surface, but also the concentration distribution of the analyte on the living body surface can be determined by determining the concentration in each region in the living body surface.

The operational circuit layer 40 may be coupled to the light receiving sensor layer 30. 7 is a configuration diagram of an arithmetic circuit layer according to an embodiment of the present invention. Referring to Fig. 7 together with Fig. 1A, the arithmetic circuit layer 40 uses the second light that has been color-separated by the light-receiving sensor layer 30 so that the relative color intensity ratio (40B) for calculating a numerical value for quantifying a characteristic of the analyte using the relative color intensity ratio of each unit pixel, and a second calculation unit have. The operational circuitry layer 40 may be a chip or a circuit composed of a combination of passive and / or active components.

The first calculation unit 40A calculates the relative ratios of the two colors from the respective color intensities for at least two of the first color, the second color and the third color of the color-separated second light 30S. For example, when the wavelength of a fluorescent material responsive to oxygen is red, the wavelength of a fluorescent material responsive to pH is green, and a reference dye that does not react with oxygen and pH (2), the relative ratio of the color related to the pH concentration can be determined by the following equation (3). &Quot; (2) "

The second calculation unit 40B can calculate the concentration and concentration distribution of the analyte of each unit pixel by using the relative intensity ratio of each unit pixel calculated by the first calculation unit 40A .

For example, in order to calculate the oxygen concentration of each unit pixel, the relationship between the relative ratio of red and green (R0) when the relative ratio of red to green (R) and anoxic (C = 0) The oxygen concentration can be calculated using Equation (4) below. Equation (4) can also be applied to other analytes (pH, temperature, etc.) other than oxygen concentration.

Here,? Is the non-optical extinction portion and KSV is the Sterm-Volmer quenching constant.

When the second light (30S) that has been color-separated includes the third light emitted from the first fluorescent material and the fourth light emitted from the second fluorescent material, the arithmetic circuit layer (40) A correcting unit 40C for correcting the quantified value of the analyte based on the characteristic distribution of the analyte using the ratio of the intensity of the third light to the intensity of the fourth light that has been color- .

The third light emitted from the first fluorescent material is photoluminescence responsive to the analyte and the fourth light emitted from the second fluorescent material is photoluminescence free from reaction with the analyte. Preferably, the wavelength of the third light and the wavelength of the fourth light have different values. For example, in the first fluorescent material that reacts with oxygen, the intensity of light changes at the first wavelength depending on the oxygen concentration, but the second fluorescent material that does not react with oxygen emits a constant light intensity at the second wavelength do.

As described above, the arithmetic circuit layer 40 is formed on the basis of the ratio of the intensity of the color-separated third light emitted from the first fluorescent material to the intensity of the fourth color-separated light emitted from the second fluorescent material You can detect the concentration or type of material.

In various embodiments, the wearable sensor platform 100 of the present invention includes a flexible and stretchable material and biocompatible functional membrane (not shown) that can be deformed to conform to the bend and area of the surface to which it is attached, It is removable on the surface (eg skin, organ, eyeball). The functional film may be disposed on the lower side of the fluorescent sensor film 10. [ In addition, the apparatus further includes a shielding cover for shielding the analytes (oxygen, temperature, pH) from being introduced into the wearable sensor platform 100 from the outside.

In one embodiment, the light source layer 20 may be supplied with voltage from a power source (not shown) such as a battery. Here, the light source layer 20 may further include a switch (not shown) using an element such as a thin film transistor (TFT) in order to minimize power consumption. It is preferable that the switch periodically turn on / off the power supplied from the light source layer 20 to minimize power consumption. The on / off time interval is preferably a time interval during which the light emitted from the light source layer 20 is received by the light receiving sensor layer 30, but is not limited thereto.

In various embodiments, a power supply for supplying power to drive the wearable sensor platform 100 of FIG. 1A may be further added. Preferably, the power source unit may be an external device that supplies DC or AC power.

1B is a cross-sectional view of a wearable sensor platform 100 according to another embodiment of the present invention.

1B, the fluorescent sensor film 10, the light source layer 20, the light receiving sensor layer 30, and the arithmetic circuit layer 40 are the same as those of the fluorescent sensor film 10, The light source layer 20, the light receiving sensor layer 30, and the arithmetic circuit layer 40 may be referred to. The wearable sensor platform 100 of FIG. 1B may further include a first filter layer 50 and a second filter layer 60 in the wearable sensor platform 100 of FIG. 1A. The first filter layer 50 including a plurality of first filters 50A is disposed between the fluorescent sensor film 10 and the light source layer 20 and filters the light 20S emitted from the light source layer 20 And can be discharged to the fluorescent sensor film 10. [ The plurality of first filters may be spaced apart. The light emitted from the light source layer 20 through the first filters is transferred to the fluorescent sensor film 10 but not to the gap 50B between the first filters 50A.

The second filter layer 60 including the plurality of second filters 60A is disposed between the light source layer 20 and the light receiving sensor layer 30 and is configured to emit the light 30S emitted from the fluorescent sensor film 10 And can be filtered and emitted to the light receiving sensor layer 30. The plurality of second filters may be spaced apart. The light emitted from the fluorescent sensor film 10 is transmitted to the light receiving sensor layer 30 through the second filters but is not transmitted to the gap 60B between the second filters 60A.

The light 20S emitted from the light source layer 20 and the light 30S emitted from the fluorescent sensor film 10 may have different characteristics from each other. For example, light 20S may be short wavelength and light 30S may be long wavelength. Or the light 20S and the light 30S are both long wavelengths but have different long wavelengths or the light 20S and the light 30S are both short wavelengths but may be different short wavelengths. In another embodiment, light 20S and light 30S may have different wavelength intensities at the same or different wavelengths. The first filter layer 50 is separated into a wavelength band that can be excited in the fluorescent sensor layer 10 and the second filter layer 60 is separated into a wavelength band that can be detected in the light receiving sensor layer 30, , The detection accuracy of the characteristics of the analyte can be enhanced. In another embodiment, either the first filter layer 50 or the second filter layer 60 may be disposed in the wearable sensor platform 100.

The present invention is not limited to a structure in which the first filter layer 50, the light source layer 20, and the second filter layer 60 are formed in a multi-layer structure. In the single layer, the first filters and the second filters are arranged in a checkered pattern, One filter layer in which the first filters and the second filters are arranged may be disposed between the fluorescent sensor film 10 and the light source layer 20.

In various embodiments, the fluorescent sensor membrane 10 in the wearable sensor platform 100 of FIG. 1A or 1B is removable from the wearable sensor platform 100. In this case, the fluorescent sensor film 10 can be independently removed from the wearable sensor platform 100 according to repeated use, so that the remaining wearable sensor platform 100 can be reused together with a new fluorescent sensor film. In another embodiment, the fluorescent sensor film 10 is detached from the wearable sensor platform 100 when necessary, so that only the fluorescent sensor film 10 can be attached to the living body surface 10S to be measured. At this time, the functions of the light source layer 20, the light receiving sensor layer 30, and the arithmetic circuit layer 40 of the wearable sensor platform may be replaced with separate measurement devices or measurement modules such as a smart phone or a camera. In the present invention, a device including a fluorescence sensor film and a measurement module is defined as a detection device.

The fluorescent sensor film 10 and the light source layer 20 may be laminated on the wearable sensor platform 100 and attached to the living body surface 10S to be measured. At this time, the functions of the light receiving sensor layer 30 and the arithmetic circuit layer 40 of the wearable sensor platform 100 may be replaced with separate devices such as a smart phone or a camera including an image sensor.

In another embodiment, the fluorescent sensor film 10, the light source layer 20, and the light receiving sensor layer 30 may be laminated on the wearable sensor platform 100 and attached to the living body surface 10S to be measured. At this time, the functions of the computing circuit layer 40 of the wearable sensor platform 100 may be replaced with separate devices such as a smart phone or a server.

3 is a detailed cross-sectional view of a light source layer 20 according to an embodiment of the present invention.

Referring to FIG. 3, the light source layer 20 may include a first electrode 20A, a second electrode 20C, and an organic material layer 20B. When the anode is a top emission type ITO (indium tin oxide) transparent electrode, the first electrode 20A may be an anode and the second electrode 20C may be a cathode. On the other hand, in the case of a back light emitting structure in which the cathode is an ITO transparent electrode, the first electrode 20A may be a cathode and the second electrode 20C may be an anode.

The first electrode 20A may serve to supply electrons to the organic layer 20B when power is applied. In addition, in the back light emitting structure, the second electrode 20C has a predetermined reflectivity to reflect light in the direction of the first electrode 20A, and has a low work function to supply electrons to the organic layer 20B Metal (Ca, AI: Li, Ma: Ag, etc.).

The first electrode 20A serves to supply holes to the organic layer 20B when the power is applied. A transparent electrode (ITO) having a high transmittance may be used for the first electrode 20A to use a material having a high work function and to transmit light.

The organic layer 20B may emit the electroluminescent light 300 by recombining the electrons of the second electrode 20C and the holes of the first electrode 20A. The organic layer 20B includes an electron injection layer (EIL) for injecting electrons generated in the second electrode 20C, an electron transport layer (ETL) for transporting electrons in the EIL to the emission layer (EML) A light emitting layer for recombining the holes of the first electrode 20A with the electrons of the second electrode 20C to emit light, and a hole injection layer (HIL) A hole transport layer (HTL) for transporting the light emitting layer, and a hole injection layer (HIL) for allowing the holes to enter the light emitting layer without loss.

The light 300 generated in the organic layer 20B is emitted to the fluorescent sensor film 10 through the transparent first electrode 20A and the light 310 emitted from the fluorescent sensor film 10, May be transmitted to the light receiving sensor layer 30 through the gap between the second electrodes 20C. The gap between the second electrodes 20C can define a gap between one OLED pixel and the OLED pixel.

When the first electrode 20A becomes a cathode and the second electrode 20C becomes an anode, the anode is made of a material having a high reflectance so as to reflect light in the direction of the cathode, A transparent electrode having a high transmittance can be used.

The light 300 generated in the organic material layer 20B is emitted to the fluorescent sensor film 10 through the transparent cathode and the light 310 emitted from the fluorescent sensor film 10 passes through the gap between the anode and the light receiving sensor layer 30). The gap between the anodes can define the gap between one OLED pixel and the OLED pixel.

4 is a plan view of the light receiving sensor layer 30 divided into a plurality of color pixels according to an embodiment of the present invention.

4, the light receiving sensor layer 30 illustratively includes four color pixel areas: a first color pixel area 30A, a second color pixel area 30B, a third color pixel area A third color pixel region 30C and a fourth color pixel region 30D of the light receiving sensor layer 30. However, this is exemplary and the light receiving sensor layer 30 may have two, three, or more than five color pixel regions .

The light receiving sensor layer 30 detects the second light 30S emitted from the fluorescent sensor film 10 through the four color pixel regions 30A, 30B, 30C and 30D and outputs the detected light to the respective electric signals 30A ', 30B', 30C ', 30D'). The second light 30S emits light (third light) and / or light (fourth light), respectively, emitted from the at least one kind of second fluorescent material, respectively, emitted from the at least one kind of first fluorescent material, . ≪ / RTI >

Each unit pixel region of the four color pixel regions can detect light emitted from different measurement regions of the fluorescent sensor film 10 as shown in FIG. 5 and generate an electric signal according to the intensity of the detected light. 5 is a diagram showing a mapping relationship between a plurality of color pixel areas of the light receiving sensor layer 30 and a plurality of measurement areas of the fluorescent sensor film 10 according to an embodiment of the present invention.

5, the fluorescence sensor film 10 is in close contact with a living body surface 10S to be measured and reacts with the analyte of the living body surface and the first light 20S of the light source layer 20, And emits (photoluminesces) the second light 30S. At this time, the intensity of light emitted from the partial regions of the fluorescent sensor film 10 may be different depending on the distribution of the analyte of the living body surface 10S. The measurement area of the fluorescent sensor film 10 is in close contact with at least a part of the area of the living body surface 10S and is in a region where light emission occurs depending on the presence and concentration of the analyte contained in the at least a part of the area to be. The color pixel region of the light receiving sensor layer 30 is a region for detecting light emission from the measurement region of the corresponding fluorescent sensor film 10 and generating an electrical signal according to the intensity of the detected light.

For example, if the amount of the analyte is small in the first measurement region of the fluorescent sensor film 10 adhered to the living body surface and the amount of the analyte substance is large in the second region of the fluorescent sensor film 10, The intensity of the light emitted from the first measuring region of the fluorescent sensor film 10 adhered to the surface may be greater than the intensity of the light emitted from the second region of the fluorescent sensor film 10 adhered to the living body surface. On the contrary, if the amount of the analyte in the first region of the fluorescent sensor film 10 adhered to the living body surface is large and the amount of the analyte in the second measuring region of the fluorescent sensor film 10 is small, The intensity of light emitted from the first measuring region of the fluorescent sensor film 10 adhered to the living body surface may be smaller than the intensity of the light emitted from the second measuring region of the fluorescent sensor film 10 adhered to the living body surface .

In one embodiment, when light emission occurs in each unit measurement area of the plurality of measurement areas of the fluorescent sensor film 10, each unit color pixel area of the plurality of color pixel areas of the light receiving sensor layer 30 corresponds And the intensity of the detected light can be converted into an electrical signal.

For example, the light emission generated from the first measurement region of the fluorescent sensor film 10 may be detected 500 in the first color pixel region of the light receiving sensor layer 30. Photoluminescence generated from the second measurement region of the fluorescent sensor film 10 may be detected 510 in the second color pixel region of the light receiving sensor layer 30. Photoluminescence generated from the third measuring region of the fluorescent sensor film 10 may be detected 520 in the third color pixel region of the light receiving sensor layer 30. Photoluminescence generated from the fourth measuring region of the fluorescent sensor film 10 may be detected 530 in the fourth color pixel region of the light receiving sensor layer 30. Therefore, according to the embodiment of the present invention, the light receiving sensor layer 30 can detect a change in light for analyzing characteristics of the analyte of the living body surface 10S over a large area.

Although the measurement area or color pixel area in FIG. 5 is shown to have the same size and / or shape, it is not limited to the same size and shape in the present invention, and the measurement area or color pixel area may have different sizes and / Lt; / RTI >

6A to 6D are diagrams showing the configuration of a unit color pixel according to an embodiment of the present invention.

6A to 6D, each unit color pixel is composed of two sub-color pixels (Fig. 6A) or each unit color pixel is composed of three sub-color pixels (Fig. 6B) (Fig. 6C), or each unit color pixel may be composed of six sub-color pixels (Fig. 6D).

Referring to FIG. 6A, the unit pixel regions 30A, 30B, 30C and 30D decompose the light 30S emitted from the corresponding measurement region into two colors and form two sub-color pixels 600 and 610 Lt; / RTI > For example, light emitted from a corresponding measurement area may be decomposed into red and green, or red and blue, and in the first sub-color pixel area, the intensity of light having a wavelength of reddish red is detected, In the sub-color pixel region, the intensity of the light having the wavelength of the decomposed green can be detected.

Here, in order to decompose light into a corresponding color, the first sub-color pixel 600 includes a first color filter 601 for decomposing light into a first color and a first photodiode (for example, Color pixel 610 comprises a second color filter 610 for decomposing light into a second color and a second photodiode 612 for detecting light decomposed into a second color .

In another embodiment, the photodiode may be a photodiode responsive only to the corresponding color. For example, without a color filter, the photodiode itself can only generate an electrical signal in response to the corresponding color contained in the light.

6B, the unit pixel regions 30A, 30B, 30C, and 30D decompose the light 30S emitted from the corresponding measurement region into three colors, and three subcolor pixels 620, 630, 640). For example, light emitted from a corresponding measurement region may be decomposed into red, green, and blue. In the first sub-color pixel region 620, the intensity of light having the wavelength of the decomposed red color is detected, In the pixel region 630, the intensity of the light having the decomposed green wavelength is detected, and in the third sub-color pixel region 640, the intensity of the light having the wavelength of the blue color decomposed can be detected.

In order to decompose light into a corresponding color, a first sub-color pixel 620 includes a first color filter 621 for decomposing light into a first color and a first photodiode (for example, 622, and the second sub-color pixel 630 comprises a second color filter 631 for decomposing light into a second color and a second photodiode 632 for detecting light decomposed into a second color And the third sub-color pixel 640 may be composed of a third color filter 640 for decomposing the light into a third color and a third photodiode 642 for detecting the light decomposed into the second color .

6C, the unit pixel regions 30A, 30B, 30C and 30D decompose the light 30S emitted from the corresponding measurement region into three colors and form four sub-color pixels 650, 660 and 670 , 680). For example, the light emitted from the corresponding measurement region may be red, green, and blue, and in the first sub-color pixel region 650, the intensity of light having a wavelength of the reddish red is detected, In the region 660 and the third sub-color pixel region 670, the intensity of the light having the decomposed green wavelength is detected, and in the fourth sub-color pixel region 680, the intensity of the light having the blue wavelength decomposed is detected .

In order to decompose light into a corresponding color, a first sub-color pixel 650 includes a first color filter 651 for decomposing light into a first color and a first photodiode (for example, 652, and the second sub-color pixel 660 comprises a second color filter 661 for decomposing light into a second color and a second photodiode 662 for detecting light decomposed into a second color Color pixel 660 comprises a third color filter 671 for decomposing light into a second color and a second photodiode 672 for detecting light decomposed into a second color, Four sub-color pixels 640 may be comprised of a third color filter 681 for decomposing light into a third color and a third photodiode 682 for detecting light decomposed into a second color.

6D, the unit pixel regions 30A, 30B, 30C and 30D decompose the light 30S emitted from the corresponding measurement region into three colors and form six sub-color pixels 690, 691 and 692 , 693, 694, 695). For example, the light emitted from the corresponding measurement area may be red, green, and blue, and the first sub-color pixel area 690 and the sixth sub-color pixel area 695 may have a red Intensity is detected, and in the second sub-color pixel area 691 and the fourth sub-color pixel area 693, the intensity of the light having the decomposed green wavelength is detected, and the intensity of the third sub-color pixel area 692 and the fifth In the sub-color pixel region 694, the intensity of the light having the wavelength of the decomposed blue color can be detected.

Here, in order to decompose the light into a corresponding color, the first sub-color pixel region 690 and the sixth sub-color pixel region 695 include first color filters 690 'and 695' for decomposing light into a first color And a first sub-color pixel area 691 and a fourth sub-color pixel area 693 are constituted by first photodiodes 690 " and 695 " for detecting light decomposed into a first color, 693 " for detecting light decomposed into a first color and a second photodiode 691 ", 693 " for detecting light decomposed into a second color, and the third sub-color pixel 660 is composed of light And a second photodiode 672 for detecting light decomposed into a second color, and the third sub-color pixel region 692 and the fifth sub-pixel 672 are constituted by a third sub- The color pixel region 694 includes a third color filter 692 ', 694' for decomposing light into a third color and a third color filter 692 ' And a third photodiode 692 ", 694 ".

6A to 6D may further include a thin film transistor for turning on / off an electrical signal detected through each photodiode. Although the above-described embodiments disclose a photodiode as a light receiving sensor, the present invention is not limited thereto. For example, the photodiode may be a phototransistor, a port transistor, a photothyristor, a photomultiplier tube, a photodiode using photoconductivity of cadmium sulfide (CdS), a charge coupled device (CCD) oxide semiconductor image sensor, or may be combined with any one of them to form a light receiving sensor. The array of the light receiving sensors may be any one of or a combination of CCD type, MOS type, CID (charge injection device) type, PDC (plasma coupled device) type, CPD (charge priming device) type and BBD have.

8 is a system configuration diagram 800 of a wearable sensor platform according to a second embodiment of the present invention.

8, a system 800 of a wearable sensor platform includes an electronic device 820 (e.g., a smart phone, a camera) including a fluorescent sensor film 10 and an image sensor module 822 in FIG. 1A or 1B. . ≪ / RTI >

The fluorescence sensor film 10 is attached to a part of the body 810 of the body to be measured, for example. The electronic device 820 including the image sensor module 822 enlarges or reduces a part of the arm 810 to which the fluorescent sensor film 10 is attached through the image sensor module 822 by user operation (840).

The light source layer 20 of the wearable sensor platform may be replaced by the light emitted from the natural light 830 or the flash 821 of the electronic device 820 and the fluorescent sensor film 10 may be replaced with the natural light 830, Can react with the analyte materials in some areas of the arm 810 in close contact with the light emitted from the flashes 821 of the device 820 to emit photoluminescence.

In various embodiments, the light source layer may be one of an LED (Light Emitting Diode), an OLED (organic light-emitting diode), a QD-LED (Quantum Dot Light Emitting Diode), or a LEC (light-emitting electrochemical cell). However, the present invention is not limited thereto.

The electronic device 820 then processes the image image corresponding to a portion of the arm where the photographed fluorescent sensor film 10 is attached so that the characteristics of the analyte materials in some areas of the arm 810 ) To the display device (not shown) of the electronic device 820. The characteristics of the analytes can be displayed graphically, textually or in various ways. For example, the electronic device 820 can be used to determine the color difference metric using, for example, the RGB (red, green, and blue) color ratio metric using the various color systems disclosed with reference to FIG. , The color change ratios of the image pixels can be respectively calculated and the concentration distribution can be displayed in a graph on a large area.

The photographed image or image can be divided into colors of red, green, and blue through the software (e.g., smartphone application, app) of the electronic device 820 to calculate the intensity. The ratio of the red and green of each pixel (or the ratio of red and blue) of each pixel to the image or image is reconstructed at the ratio, as shown in Equation (1) or Equation (2) do. The concentration of the analyte is then calculated and displayed from the reconstructed images and photographs.

The second embodiment of the present invention can display the functions of the light receiving sensor layer 30 and the arithmetic circuit layer 40 of the wearable sensor platform by quantifying the concentration of the analyte in a smartphone or a camera, . However, software or / and hardware may be required to extract and compute the boiling difference for each pixel of the image or image containing the subject to be measured.

As described above, in the wearable sensor platform of the present invention, the fluorescent sensing film 10, the light source layer 20, and the light receiving sensor layer 30 are integrally integrated into one wearable sensor Can operate.

Each of the fluorescence sensing film 10, the light source layer 20 and the light receiving sensor layer 30 is a flexible element and conformal to flexion even when attached to a human body part (e.g., skin, organ, , The distance between the sensing film, the light source, and the photodiode is kept constant and the accuracy is very high. Also, the components of the fluorescence sensing film, which is a portion contacting with the sensor such as human skin or organ, are non-toxic -toxicity), and it is made of a material having bio-compatibility, which is harmless to the human body and is flexible sensor, which has a variety of applications. For example, the wearable sensor platform of the present invention can be used to diagnose diseases such as diabetes and cancer by measuring the oxygen concentration contained in the organs attached to organs of the human body, And can be used to diagnose diseases such as glaucoma and cataracts. In addition, the wearable sensor platform is attached to the inside of the human body, and the measured analyte is measured based on the photoluminescence reacted with the analyte to be measured contained in the human body. It is possible to measure the oxygen concentration of the human body more accurately than the technique of predicting the oxygen concentration contained therein and it is possible to diagnose the disease accurately based on the measured oxygen concentration of the human body.

In addition, the shape of the wearable sensor flat can be manufactured in a patch shape on the surface in a desired shape and size, and when the body is attached to a desired site, the concentration of desired body information can be measured in a large area and in real time.

Also, by using the principle of the boiling difference of RGB, the change of the light emitted from the large-area sensing film is quantified and displayed on the plane, and the two-dimensional concentration distribution can be measured by the large area.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the invention as defined in the appended claims. It will be clear to those who have knowledge.

100: wearable sensor platform
10: Fluorescence sensor membrane
20: Light source layer
30: Light receiving sensor layer
40: operational circuit layer
50: first filter layer
60: second filter layer

Claims (17)

At least one kind of first fluorescent substance dispersed in the polymer matrix and reacting with the analyte of the living body surface, and a second fluorescent substance dispersed in the polymer matrix and not reacting with the analyte of the living body surface A fluorescent sensor film containing at least one kind of second fluorescent material,
A light source layer disposed on the upper surface of the fluorescent sensor film and including at least one light source for irradiating the fluorescent sensor film with the first light; And
Wherein the first light emitted from the at least one kind of the first fluorescent material or the second fluorescent material is decomposed into at least two colors by the first light incident from the light source layer A light receiving sensor layer including an array of a plurality of color pixels for detecting the second light color-separated, each unit pixel of the plurality of color pixels being mapped to each measuring point of the fluorescent sensor film; And
A first calculation unit for calculating a relative color intensity ratio of each unit pixel of the plurality of color pixels using the color-separated second light, a first calculation unit for calculating a relative color intensity ratio of each of the plurality of color pixels, A second computation unit for computing a numerical value for quantifying characteristics of the analyte, the second decomposition of the color decomposition includes a third light emitted from the first fluorescent substance and a fourth light emitted from the second fluorescent substance The characteristic distribution of the analyte is calculated using the ratio of the intensity of the color-separated third light to the intensity of the color-separated fourth light, and based on the characteristic distribution of the analyte, And a correction circuit for correcting the quantified value of the analyte.
delete The method according to claim 1,
Wherein the characteristic of the analyte is at least one of a concentration and a kind of the analyte.
delete The method according to claim 1,
Wherein each of the plurality of color pixels comprises:
At least two color filters for decomposing the second light into at least two colors; And
And at least two photodiodes for detecting the color-separated second light transmitted through the at least two color filters.
The method according to claim 1,
Wherein each of the plurality of color pixels comprises:
One color filter for decomposing the second light into a specific color; And
And a photodiode for detecting the color-separated second light transmitted through the color filter.
The method according to claim 1,
Wherein each of the plurality of color pixels comprises:
And at least two photodiodes each responsive to at least two colors included in the second light.
The method according to claim 1,
Wherein each of the plurality of color pixels comprises:
And a photodiode responsive to one specific color contained in the second light,
Wherein the specific color is one of red, green, and blue colors.
The method according to claim 1,
A first filter layer disposed between the fluorescent sensor film and the light source layer and filtering the first light emitted from the light source layer;
And a second filter layer disposed between the light source layer and the light receiving sensor layer (30) for filtering the second light emitted from the fluorescent sensor film (10).
The method according to claim 1,
And a functional film sealing at least one of the light source layer, the light receiving sensor layer, and the arithmetic circuit layer so as to prevent the analytes from flowing from the outside.
The method according to claim 1,
The light-
Further comprising a thin film transistor (TFT) for switching the at least one light source.
The method according to claim 1,
The flexible polymer matrix may be selected from the group consisting of poly (acrylonitrile) (PAN), styrene-co-acrylonitrile (PSAN), polyvinyl alcohol (PVA), polyvinyl methyl ketone (PVMK) (PVC), poly (methyl methacrylate) (PMMA), poly (dimethyl siloxane) (PDMS), poly (hexafluoroisopropyl methacrylate-co-heptafluoro-n-butyl methacrylate) (FIB), poly (isobutyl methacrylate- Poly (trimethylsilyl propyne) (PolyTMSP), ethyl cellulose (EC), silicone rubbers, polystyrene (PS), cellulose derivatives, And poly (hydroxyethyl methacrylate) (pHEMA).
The method according to claim 1,
The at least one first fluorescent material may be at least one selected from the group consisting of pyrene, decac2clene, ruthenium (II) -tris (4,7, diphenyl-1,10, phenanthroline) Platinum (II) -5, 10, 15, 20, tetrakis (2, 3, 4, 5, 6, 7, 8, 12, 13,17,18-octaethylporphyrin pentafluorophenyl) porphyrin (PtTFPP), Palladium (II) -2,3,7,8,12,13,17,18-octaethylporphyrin (PdOEP), Palladium (II) -5,10,15,20- (PdTFPP), Platinum (II) -5,10,15,20-tetrakis (2,3,4,5,6-penta-fluorophenyl) porpholactone (PtTFPL), 3,4,5,6-pentafluorophenyl) ), Ruthenium-tris (1,10-phenanthroline) (Ru (phen) 32+), Ruthenium-tris (2,2'- bipyridine) 6 ', 2''terpyridine (Ru (trpy) 22+), Europium (III) - tris (thenoyltrifluoroacetylacetonato) - (2- (4-diethylaminophenyl) 1, 3, 5-triazine) [Eu (tta) 3 (dpbt)] and 8-Hydroxypyrene-1,3,6-Trisulfonic Acid (HPTS).
At least one kind of first fluorescent substance dispersed in the polymer matrix and reacting with the analyte of the living body surface, and a second fluorescent substance dispersed in the polymer matrix and not reacting with the analyte of the living body surface A sensor including at least one kind of second fluorescent material; And
And at least one light source for irradiating the first light with the sensor, the second light emitted from the at least one kind of the first fluorescent material or the second fluorescent material by at least two colors And a measurement module including an array of a plurality of color pixels for detecting the second light decomposed and color-separated,
The measurement module
A first arithmetic unit for calculating a relative color intensity ratio of each unit pixel of the plurality of color pixels using the color-separated second light;
A second calculating unit for calculating a value for quantifying a characteristic of the analyte using the relative color intensity ratio of each unit pixel; And
When the color-separated second light includes third light emitted from the first fluorescent material and fourth light emitted from the second fluorescent material, the intensity of the color-separated third light and the intensity of the color- And a correction section for calculating the characteristic distribution of the analyte using the ratio of the intensity of light and correcting the quantified value of the analyte based on the characteristic distribution of the analyte. .
15. The method of claim 14,
The measurement module comprising:
A first arithmetic unit for calculating a relative color intensity ratio of each unit pixel of the plurality of color pixels using the color-separated second light; And
And a second arithmetic unit for calculating a numerical value for quantifying a characteristic of the analyte using the relative color intensity ratio of each unit pixel.
15. The method of claim 14,
Wherein the light source is one of an LED (Light Emitting Diode), an OLED (organic light-emitting diode), a QD-LED (Quantum Dot Light Emitting Diode), and a LEC (light-emitting electrochemical cell).
15. The method of claim 14,
Wherein the measurement module is an electronic device including a light receiving sensor for receiving light reflected from the sensor.

Images