KR101864373B1 - Device for filtering blood - Google Patents

Abstract

The present invention relates to a blood component separating apparatus. Specifically, according to an embodiment of the present invention, a blood component separation device includes: a first chamber in which supplied blood is filled; A filter for filtering the blood filled in the first chamber; A second chamber through which the blood having passed through the filter flows; And a driving device for vibrating at least one of the first chamber and the filter, and rotating the blood contained in the first chamber.

Description

[0001] DEVICE FOR FILTERING BLOOD [0002]

The present invention relates to a blood component separator.

 Blood is composed of red blood cells, white blood cells, blood platelets, and blood plasma. Plasma is a liquid component of blood, which contains red blood cells. The composition of plasma is about 90% of water and 7 ~ 8% of plasma protein, and lipid, saccharides, inorganic salts and urea, amino acid and uric acid as non-protein nitrogen compounds. Plasma proteins are mainly composed of albumin and globulin, and contain fibrinogen related to blood clotting. Lipids are cholesterol, lecithin, and so on. Inorganic salts such as sodium, chlorine, potassium, calcium, magnesium, etc., the composition is similar to seawater and plays an important role in maintaining normal osmotic pressure in the body. In addition, the total amount and composition of plasma changes significantly depending on the disease, so it is used to diagnose the disease or to know the condition of the disease.

Methods for separating blood cells and plasma from conventional blood include a centrifugation method, a method using capillary phenomenon, and a method of applying electrical pulses in a microfluidic chip at right angles to the direction in which blood flows.

When separating the plasma using a membrane filter, blood cells occupying about 40% of the blood volume can block the holes of the filter in a short time, and once the holes of the filter are plugged, there is a limit that the plasma can no longer pass through the filter , There is a disadvantage in that blood can not be separated continuously.

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned problems, and it is an object of the present invention to provide a blood component separation device capable of filtering blood more effectively by preventing a filter from being clogged.

According to an aspect of the present invention, there is provided a blood supply apparatus comprising: a first chamber in which supplied blood is filled; A filter for filtering the blood filled in the first chamber; A second chamber through which the blood having passed through the filter flows; And a driving device for vibrating at least one of the first chamber and the filter and for rotating the blood contained in the first chamber.

In addition, the first chamber may be provided with a columnar shape having a circular or polygonal cross section.

In addition, the apparatus may further include a support member on which the first chamber is mounted, and the filter may be provided on the support member.

Further, the filter may be provided with a blood component separating device in which a through hole having a size of more than 0 탆 and less than 10 탆 is formed.

In addition, the driving device may further include vibration means for vibrating at least one of the first chamber and the filter; Or rotating means for rotating the first chamber may be provided.

Further, the first chamber may include an upper surface and a peripheral surface, and the rotating means may be configured to rotate at least one of the upper surface and the peripheral surface.

In addition, the filter may be provided on a support, and the first chamber may be provided so as to be rotatable with respect to the support.

Further, the vibrating means may be provided with a blood component separating device including a vibration generating device for applying vibration to at least one of the first chamber and the filter.

In addition, the driving device may be provided with a blood component separator for rotating the blood in the first chamber to 0.1 rpm or more and 200 rpm or less.

In addition, the apparatus may further include a flow controller for controlling the height of the blood contained in the first chamber, wherein the flow controller includes an outlet provided at a predetermined height of the first chamber, and when the predetermined height of the blood is reached And a blood component separation device configured to be discharged to the outside through the discharge port.

In addition, the second chamber may include a blood component separating device including a receiving portion for receiving blood passing through the filter and a protruding portion protruding toward the first chamber.

According to the embodiments of the present invention, there is an effect that the clogging of the through holes of the filter can be prevented.

1 is a conceptual diagram showing a blood component separating apparatus according to an embodiment of the present invention.
2 is a cross-sectional perspective view of the blood component separator of FIG.
3 is an exploded perspective view of the blood component separating apparatus of FIG.
Fig. 4 shows that the first chamber of Fig. 1 is rotated by the driving means.
Figure 5 shows the filter of Figure 1 being rotated by the drive means.
Figure 6 shows that blood is filtered through the filter.

Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

It is also to be understood that when an element is referred to as being connected to another element, it may be directly connected to the other element, but there may be other elements in between.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise.

It should be noted that the expressions of the upper and lower portions in the present specification are described based on the drawings in the drawings and can be expressed differently when the directions of the objects are changed.

Hereinafter, a specific configuration of a blood component separator according to an embodiment of the present invention will be described with reference to FIGS. 1 to 5. FIG. FIG. 1 is a conceptual view showing a blood component separating apparatus according to an embodiment of the present invention, FIG. 2 is a perspective view of the blood component separating apparatus of FIG. 1, FIG. 3 is an exploded perspective view of the blood component separating apparatus of FIG. Fig. 4 shows that the first chamber of Fig. 1 is rotated by the driving means, and Fig. 5 shows that the filter of Fig. 1 is rotated by the driving means.

1 to 5, the blood component separating apparatus 1 may include a first chamber 100, a support 200, a filter 300, a second chamber 400, and a driving device 500 have.

The first chamber 100 may be provided at one side of the supporter 200. For example, the first chamber 100 may be provided on the upper part of the support 200, and the first chamber 100 may be provided to be rotatable with respect to the support 200. The first chamber 100 can receive the blood before it is filtered through a tube or the like from the blood supply part (not shown) and can receive the blood. The first chamber 100 may have a columnar shape including an upper portion 101 and a peripheral portion 102. The cross section of the first chamber 100 may have a circular shape, It is also possible to have various shapes of polygons.

In addition, the first chamber 100 may include a blood inlet 110 through which blood can be injected, and a flow control unit 130 that can control the amount of blood in the first chamber. The blood inlet 110 may be a through-hole provided in the upper portion 101 of the first chamber 100. Blood may be introduced from the blood supply portion through the blood inlet 110. Such blood may be supplied to the extent that the first chamber 100 is not completely filled.

The flow rate regulator 130 can prevent the amount of blood injected into the first chamber 100 from exceeding a certain level. When the blood contained in the first chamber 100 exceeds a predetermined amount, the flow regulator 130 may discharge the blood from the first chamber 100 to the outside. For example, the flow rate regulator 130 may extend from the upper portion 101 of the first chamber 100 to a predetermined depth. The flow control unit 130 discharges the air in the first chamber 100 when the blood is at a height lower than the depth of the flow control unit 130 in the first chamber 100, When the height of the flow control unit 130 is higher than the depth of the flow control unit 130, the blood is blocked by the blood. When the flow rate regulating unit 130 is blocked by the blood filled in the first chamber 100, the air in the first chamber 100 is not discharged to the outside, so that air remains in the upper part of the blood. The residual blood does not fill the first chamber 100 any more. Meanwhile, the flow rate regulator 130 and the flow rate regulator 130 are merely examples, and the present invention is not limited thereto. In another example, the flow rate regulator 130 may be a through-hole provided in the peripheral portion 102 at a position lower than the blood inlet 110. In this case, the blood exceeding the predetermined height may be discharged to the outside of the first chamber 100 through the flow control unit 130, and may be returned to the blood supply unit. The blood and air are filled in the first chamber 100 by the flow rate controller 130 and the vibration and flow of the blood can be more smooth due to the air in the first chamber 100.

The first chamber 100 may be mounted on the support 200. The support 200 may be provided between the first chamber 100 and a second chamber 400 described later. The support 200 may include a first support plate 201 provided below the first chamber 100 and rotatably supporting the first chamber 100 and a first support plate 201 for supporting the filter 300 to be described later And a second support plate 202 having a filter mount 210, The filter mounting portion 210 may have a shape corresponding to the filter 300. The filter mounting portion 210 may be configured to allow the filtered blood to move to the second chamber portion 400. For example, the filter mounting portion 210 may include a discharge hole 211, a protrusion 212, A depression 213 can be formed. In other words, the projecting portion 212 supports the filter 300, and the blood filtered in the filter moves along the depression 213 to the discharge hole 211, passes through the discharge hole 211, Lt; RTI ID = 0.0 > 400 < / RTI >

The filter 300 may filter the blood passing from the first chamber 100 to the second chamber 400. For example, the filter 300 may be provided at a lower portion of the first chamber 100. The filter 300 may have a through-hole 301 having a predetermined size. The through-hole 301 may be formed in a circular shape having a diameter of, for example, less than 10 占 퐉. A component having a size larger than the through hole 301 in the blood can not pass through the filter 300 (uninterrupted component 11), and a component having a smaller size than the through hole 301 passes through the filter 300, 2 chamber 400 (pass component 12). This allows the filter to classify blood cells and plasma in the blood.

The non-penetrating component 11 may be blood cells of the blood, and the passing component 12 may be blood plasma, but this is merely an example, and the spirit of the present invention is not necessarily limited thereto. For example, the infusion and component 11 may be cancer cells of blood, and the passing component 12 may be bacteria of blood. In this case, the filter 300 can classify bacteria and cancer cells by filtering the cancer cells of blood and passing the bacteria of blood. As such, the blood that has passed through the filter 300 flows into the second chamber 400.

The second chamber 400 may be provided on the other side of the supporter 200. For example, the second chamber 400 may be provided on the opposite side of the first chamber 100 from the lower portion of the support 200. In the second chamber 400, the blood filtered by the filter 300 may be collected, and the blood may include, for example, blood plasma, bacteria, and the like. In addition, the second chamber 400 may have a predetermined volume for collecting the filtered blood.

In order to prevent the through hole 301 of the filter 300 from being clogged and to easily introduce the blood into the second chamber 400, a driving device 500 to be described later may be provided.

The driving device 500 may be configured to cause at least one of the first chamber 100 and the filter 300 to vibrate and rotate the blood contained in the first chamber 100. The blood can be rotated in the first chamber 100 at a relatively slow rate of 0.1 rpm or more and 200 rpm or less. If the blood's rotational speed exceeds 200 rpm, the cells will only be damaged without a positive effect on blood filtration. That is, blood may not be affected by the centrifugal force when the rotational speed of the blood is 200 rpm or less. On the other hand, the driving device 500 may include the vibration means 510, for example.

The vibrating means 510 may be installed on the support 200 and may be configured to vibrate when blood is supplied to the first chamber 100. The vibration generated by the vibration means 510 can vibrate and rotate the blood filled in the first chamber 100. The voids and components 11 that sink to the bottom of the first chamber 100 and block the through holes 301 of the filter 300 can float by this vibration and rotation. The effect that the passage component 12 can pass through the through hole 301 of the filter 300 more easily can be obtained by floating the component 11 and the hollow component. The vibration means 510 may be a vibration generating device such as a coin type vibration motor, but is not limited thereto.

Meanwhile, the driving device 500 may further include a rotation means 520 for more effectively rotating the blood contained in the first chamber 100. The rotating means 520 may be configured to rotate at least one of the first chamber 100 and the filter 300. For example, the rotation means 520 may be connected to the first chamber 100 to rotate the first chamber 100 as shown in FIG. 4. By rotation of the first chamber 100, Can rotate. In this case, a sealing member 103 may be provided at a portion where the first chamber 100 and the support 200 are connected to each other to secure airtightness between the first chamber 100 and the support 200. As another example, the rotating means 520 may be connected to a filter provided in the lower portion of the first chamber 100, as shown in FIG. 5, so that the blood in the internal space can be rotated by rotating the filter. In this case, a sealing member 103 may be provided at a portion where the second chamber 400 and the rotating means 520 are connected to each other to secure airtightness between the second chamber 400 and the rotating means 520.

On the other hand, the rotating means 520 can rotate the blood contained in the first chamber 100 to 0.1 rpm or more and 200 rpm or less. By rotating the blood at a relatively slow speed, the rotating means 520 can float the blood trough and the component 11 more effectively. The rotating means 520 may include, but is not limited to, an electric motor, a gear, and a rotary shaft.

Hereinafter, the operation and effect of the configuration of the blood component separating apparatus having the above-described configuration with reference to Fig. 6 will be described. Figure 6 shows that blood is filtered through the filter.

Blood is supplied from the blood supply part to the blood component separation device 1 in order to separate components of the blood. The blood flows into the first chamber 100 through the inlet 110. At this time, the first chamber 100 is not completely filled with blood, and air may remain in the upper portion of the first chamber 100. The flow control unit 130 of the first chamber 100 prevents the blood from being filled when the blood is filled in a certain amount, thereby effectively allowing the air to remain.

When blood flows into the first chamber 100, the driving device 500 operates to vibrate the first chamber 100 and the filter 300, and rotate the blood. In addition, the rotating means 520 of the driving device 500 can rotate the blood more effectively. In other words, either the first chamber 100 or the filter 300 is rotated by the rotating means 520 of the driving device 500, or the first chamber 100 and the filter 300 are rotated together, Can be rotated. Referring to FIG. 6, the rotation of the blood enables the blood vessel component 11 to float on the blood. This prevents the passage hole 301 of the filter 300 from being clogged by the hollow portion 11 due to the floating of the hollow portion 11 and thus prevents the passage component 12 in the blood flowing into the first chamber 100, Can be smoothly moved through the through hole (301) of the filter (300).

Although the blood component separating apparatus according to the embodiment of the present invention has been described above as a specific embodiment, the present invention is not limited thereto, and the present invention is not limited thereto, and may be interpreted as having the widest range according to the basic idea disclosed in this specification . Skilled artisans may implement a pattern of features that are not described in a combinatorial and / or permutational manner with the disclosed embodiments, but this is not to depart from the scope of the present invention. It will be apparent to those skilled in the art that various changes and modifications may be readily made without departing from the spirit and scope of the invention as defined by the appended claims.

1: blood component separation apparatus 100: first chamber
101: upper part 102:
103: sealing member 110: inlet
130: Flow control unit 200:
201: first support plate 202: second support plate
210: filter holder 211: exhaust hole
212: protrusion 213: depression
300: filter 301: through hole
400: second chamber 500: driving device
510: Vibrating means 520: Rotating means

Claims (11)

support fixture;
A first chamber provided on the upper side of the support, the supplied blood being filled in the first chamber, the first chamber including an upper surface and a peripheral surface;
A filter provided in the support to filter blood filled in the first chamber;
A second chamber provided below the support and through which the blood having passed through the filter flows;
A sealing member provided between the first chamber and the support; And
And a driving device for vibrating at least one of the first chamber and the filter and for rotating the blood contained in the first chamber,
Wherein the first chamber is configured to be rotatable with respect to the support,
Wherein the driving device includes rotation means for rotating the first chamber so that the blood in the first chamber rotates at 0.1 rpm or more and 200 rpm or less,
Wherein the rotating means is configured to rotate at least one of the upper surface and the peripheral surface. The method according to claim 1,
Wherein the first chamber is of a columnar shape having a circular or polygonal cross section. delete The method according to claim 1,
Wherein a through hole having a size of more than 0 [mu] m and less than 10 [mu] m is formed in the filter. The method according to claim 1,
The driving device includes:
Further comprising vibrating means for vibrating at least one of said first chamber and said filter. delete delete 6. The method of claim 5,
Wherein the vibrating means includes a vibration generating device for applying vibration to at least one of the first chamber and the filter. delete The method according to claim 1,
And a flow controller for controlling the height of the blood contained in the first chamber,
The flow rate regulator
And a discharge port provided at a predetermined height of the first chamber, and when the blood reaches a predetermined height, the blood is discharged to the outside through the discharge port. The method according to claim 1,
Wherein the second chamber includes a receiving portion for receiving blood passing through the filter,
And a protrusion protruding toward the first chamber.

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