KR101855395B1 - Screening method of lung tumor using near-infrared light - Google Patents
Screening method of lung tumor using near-infrared light Download PDFInfo
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- KR101855395B1 KR101855395B1 KR1020160123392A KR20160123392A KR101855395B1 KR 101855395 B1 KR101855395 B1 KR 101855395B1 KR 1020160123392 A KR1020160123392 A KR 1020160123392A KR 20160123392 A KR20160123392 A KR 20160123392A KR 101855395 B1 KR101855395 B1 KR 101855395B1
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- 238000000034 method Methods 0.000 title claims abstract description 50
- 238000012216 screening Methods 0.000 title claims abstract description 31
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- 210000000779 thoracic wall Anatomy 0.000 claims abstract description 20
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- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical group [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 claims description 9
- 229960004657 indocyanine green Drugs 0.000 claims description 9
- 238000003384 imaging method Methods 0.000 claims description 8
- 206010029113 Neovascularisation Diseases 0.000 claims description 4
- 230000005284 excitation Effects 0.000 claims description 3
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- 238000010521 absorption reaction Methods 0.000 claims 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G01N33/57423—Specifically defined cancers of lung
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Abstract
The present invention relates to a method of screening lung tumors using near-infrared rays, comprising the steps of projecting the near-infrared rays irradiated to the location of the chest wall tumor through the chest wall and extrapolating from the body to the outside, and detecting this to image the shade of the chest wall tumor In order to early diagnose malignant hereditary species as a chest wall tumor, it is necessary to periodically screen for a high-risk group having asbestos exposure power. The diagnostic method according to the present invention enables early diagnosis of malignant mesothelioma .
Description
More particularly, the present invention relates to a method for screening lung tumors using near infrared rays. More particularly, the present invention relates to a method for screening lung tumors using near infrared rays. More specifically, near infrared rays or near infrared rays irradiated to chest wall tumors are projected through a chest wall, Or by imaging with a camera in conjunction with a fluorescent dye injected through a blood vessel, or by imaging with a spectroscope through the difference in the absorbance of multiple wavelengths of near-infrared light to determine the presence and extent of chest wall tumors And to a lung tumor screening method using near-infrared rays.
Asbestos classified as a primary carcinogen in the International Agency for Research on Cancer (WHO / IARC) under the World Health Organization is one of the leading causes of malignant mesothelioma, a pulmonary tumor that occurs in the pleura. It has a latency period of 15 to 40 years.
On the other hand, as shown in FIG. 1, the pleura consists of a parietal pleura and a visceral pleura. Pleural plaques occurring in the pleura are also caused by exposure to asbestos. However, because these tuberculosis is also caused by tuberculosis, there is a lack of reason for asbestos-related compensation because of the high prevalence of tuberculosis in Korea and lack of evidence on the clinical symptoms of pleura.
In addition, malignant mesothelioma has poor prognosis (less than 1 year survival rate after diagnosis), and incidence and mortality rate are continuously increasing. This is because early diagnosis is very difficult.
The current X-ray chest examination usually requires the size of the cancer to be 5 to 10 mm or more to identify the abnormal region. It is protected by the ribs, and the lung is overlapped with the position of the heart. There are many limitations that can not be achieved. In addition, even if the abnormality is confirmed by X-ray chest examination, the lung tissue is in direct contact with the air and is closely connected with the blood vessel, so that it is highly likely that the lung is already metastasized. Therefore, X-ray chest examination is very ineffective as an early diagnostic method for lung tumors.
Especially, as shown in Fig. 2, malignant mesothelioma that occurs in the thin pleura or peritoneum is not helpful for early diagnosis because of insufficient resolution of computed tomography or PET-CT.
On the other hand, there have been studies on cancer biomarkers in blood for early diagnosis, but it is difficult to overcome nonspecificity and improvement of diagnosis rate is not done well. As shown in FIG. 2, studies on minimally invasive malignant mesothelioma using these techniques have been conducted on animals. However, since they are invasive methods, they are limited to be used for early diagnosis.
SUMMARY OF THE INVENTION The present invention has been made in order to solve all of the above problems, and it is an object of the present invention to provide a method and apparatus for detecting near-infrared rays irradiated up to the position of a chest wall tumor of a pleura through a chest wall, The present invention provides a method for screening lung tumors using near-infrared rays, in which the presence or absence and extent of chest wall tumors are confirmed.
Another objective is to detect the neovascularization of the chest wall tumors when the fluorescent dye emits fluorescence from the chest wall tumor by the fluorescent dye, which is irradiated to the chest wall tumor site when the fluorescent dye is deposited in the chest wall tumor by injecting the fluorescent dye into the blood vessel And a method for screening lung tumors using near-infrared rays to confirm the presence or absence of chest wall tumors.
Another goal was to measure the intensity of light from multiple near-infrared rays of different wavelengths simultaneously or sequentially to the chest wall tumors of the pleura and to measure the intensity of the light by using near- Thereby providing a tumor screening method.
In order to achieve the above object, the present invention provides a method for screening lung tumors using near-infrared rays, comprising: projecting near-infrared rays irradiated to a chest wall tumor through a chest wall through a body; And imaging the shadow of the tumor.
In addition, it is preferable that the near-infrared ray camera irradiates the near-infrared rays through the optical fiber inserted to the position of the chest wall tumor in the projection of the near-infrared rays, and detects the near-infrared rays in the projection.
In addition, it is preferable to insert the optical fiber into the guide sheath, further comprising inserting the guide sheath into the working channel of the bronchoscope to the position of the chest wall tumor before the irradiation of the near infrared rays after the insertion of the optical fiber.
Further, the near-infrared rays are preferably near-infrared rays in the wavelength region of 780 to 2000 nm.
Further, it is preferable that the method further comprises a step of injecting a fluorescent dye into a blood vessel prior to the step of irradiating near-infrared rays, wherein the fluorescent dye leaks from immature blood vessels around the chest wall tumors and is deposited on the wall tumor, , Which is characterized by the imaging of new blood vessels of chest wall tumors that emit fluorescence.
The fluorescent dye is preferably indocyanine green (ICG).
And a radiation filter disposed on the front surface of the near-infrared ray detecting camera.
And an excitation filter disposed on the front surface of the near-infrared light source.
Further, the near-infrared rays are irradiated with near-infrared rays of a plurality of different wavelength ranges, and the intensity of light of each of the near-infrared rays passing through the chest wall is measured or imaged to confirm the presence or absence of a chest wall tumor through the difference in absorbency have.
In addition, it is preferable that the presence of the chest wall tumor is confirmed by the difference in absorbency by the spectroscope or the hyper-spectral camera.
According to the present invention, it is necessary to regularly screen a high-risk group having asbestos exposure power for early diagnosis of malignant hereditary species as a chest wall tumor. In the screening method according to the present invention, malignant mesothelioma It is possible to perform early diagnosis.
Figure 1 shows an anatomical image showing a pleura consisting of a parietal pleura and a visceral pleura.
Figure 2 shows normal findings on PET / CT. However, PET / CT and endoscopic photographs (Roca E, Laroumagne S, Vandemoortele T, Berdah S, Dutau H, Maldonado F , Astoul P., "18F-fluoro-2-deoxy-d-glucose positron emission tomography / computed tomography fused imaging in malignant mesothelioma patients: Lung cancer" 2013 Feb; 79 (2): 187 -90. Doi: 10.1016 / j.lungcan.2012.10.017. Epub 2012 Dec 1.)
FIG. 3 is a conceptual diagram showing a lung tumor screening method using near-infrared rays according to the first embodiment of the present invention
4 is an enlarged view of the main part of Fig. 3
5 is a conceptual diagram showing a lung tumor screening method using near-infrared rays according to a second embodiment of the present invention
6 is a conceptual diagram showing a lung tumor screening method using near-infrared rays according to a third embodiment of the present invention
FIG. 7 shows an example of applying a lung tumor screening method using near-infrared rays to an animal model according to the present invention
8 is an image showing an example of a normal chest wall by applying a lung tumor screening method using near-infrared rays according to the present invention to an animal model
9 is an image showing an example of a chest wall tumor by applying a lung tumor screening method using near-infrared rays according to the present invention to an animal model
Hereinafter, preferred embodiments of a lung tumor screening method using near-infrared rays according to the present invention will be described in detail with reference to the accompanying drawings. It is to be understood that the present invention is not limited to the disclosed embodiments, but may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, It is provided to inform.
FIG. 3 is a conceptual view showing a lung tumor screening method using near-infrared rays according to the first embodiment of the present invention, and FIG. 4 is an enlarged view of the main part of FIG.
The near-infrared ray lung tumor screening method according to the first embodiment of the present invention proposes a method of acquiring an image of a chest wall tumor using a projection method using near-infrared rays to simply diagnose screening of chest wall tumors. Near-infrared rays are electromagnetic waves having wavelengths in the range of 780 to 2000 nm, and have high permeability in tissues and are often used for biomedical diagnosis.
As shown in FIG. 3, the NIR source is irradiated to the site of the chest wall tumor. When the irradiated near-infrared ray is projected from the body through the chest wall and projected, , And the near infrared ray that has passed through the chest wall is detected and imaged by a near infrared ray camera located outside the body. At this time, the shade of the chest wall tumor in the near-infrared ray-detected image is acquired by the near-infrared ray detecting camera, so that the presence and spread of the chest wall tumor can be known.
As shown in FIG. 4, the guide sheath is inserted into a working channel of an endoscope, and the projection of the portion having the chest wall tumor is inserted into the working channel of the endoscope, The optical fiber is inserted into the guide sheath, and the near infrared rays are irradiated through the optical fiber to the site of the chest wall tumor and projected through the chest wall to the outside of the body. The near-infrared rays passing through the chest wall are checked for the presence and spread of chest wall tumors through the above-described process.
FIG. 5 is a conceptual diagram showing a lung tumor screening method using near-infrared rays according to a second embodiment of the present invention.
The method for screening lung tumors using near infrared rays according to the second embodiment of the present invention is a method of using fluorescence imaging using fluorescent dye Indocyanine green (ICG) that emits fluorescence by near infrared rays. Indocyanine green (ICG) binds readily to plasma proteins and is commonly used in vascular imaging, and has the property of absorbing maximum 780 nm light and emitting 820 nm fluorescence.
As shown in FIG. 5, when the chest wall tumor progresses, neovascularization occurs around the tumor. In such a case, a fluorescent dye such as ICG is injected into the blood vessel and the fluorescent dye leaking from the immature blood vessel around the chest wall tumor The neovascularization of a chest wall tumor which emits fluorescence by the near-infrared rays passing through the body in the body after being irradiated to the position of the chest wall tumor as described above is imaged by a near-infrared ray detection camera, The presence or absence of the tumor and the extent of spread. At this time, in order to image fluorescence emitted from the chest wall tumor, an 820 nm emission filter is arranged on the front face of the near-infrared ray camera and an excitation filter of 780 nm is arranged on the front face of the near-infrared light source.
In the second embodiment of the present invention, irradiation of the near-infrared rays is performed by the optical fiber as described above, and the optical fiber is inserted into the guide sheath of the working channel to position the chest wall tumor.
FIG. 6 is a conceptual diagram illustrating a lung tumor screening method using near-infrared rays according to a third embodiment of the present invention.
6, a method for screening lung tumors using near-infrared rays according to a third embodiment of the present invention includes the steps of simultaneously or sequentially applying two different wavelengths of a near-infrared ray band or a multi-wavelength NIR source of a plurality of wavelengths, The present invention proposes a near-infrared spectroscopy method for confirming the presence or absence of a tumor by measuring the intensity of near-infrared light passing through the chest wall in vitro, and measuring the intensity of the near-infrared light passing through the body. At this time, the intensity of the near-infrared light is measured or imaged to obtain a difference in absorbance by a near-infrared ray detector such as a spectroscope or a hyperspectral camera located outside the body.
FIG. 7 is an image showing an example in which near infrared rays are projected through a chest wall and extruded in vitro from the body by an endoscopic method, using a near-infrared ray lung-based screening method according to the present invention.
As shown in FIG. 7, the result is an image showing the chest wall near-infrared projection method using the near-infrared ray lung screening method of the first embodiment using the normal New Zealand white rabbit as the experimental animal as the animal model. In this image, it can be seen that a considerable amount of near-infrared rays are projected through the chest wall and projected to the outside in the red visible portion.
FIG. 8 is an image showing near infrared rays projected through the normal chest wall of New Zealand white rabbit; and FIG. 9 is an image showing near infrared rays projected through the tumor chest wall.
As can be seen from FIGS. 8 and 9, the normal chest wall projection image shows shadows parallel to the sternum but the tumor chest wall projection image is darker as the tumor shade is added.
As described above, the method for screening pulmonary tumor using near-infrared rays according to the present invention has been described with reference to the drawings. However, the present invention is not limited to the embodiments and drawings disclosed in the present specification, It is needless to say that various modifications can be made by those skilled in the art within the scope of the present invention.
Claims (9)
Wherein the near infrared rays are irradiated through an optical fiber inserted to the position of the chest wall tumor in the projecting step of the near infrared rays and the near infrared rays are detected by the near infrared ray camera in the step of detecting the near infrared rays projected into the projection, Way.
Further comprising the step of inserting the guide sheath into the working channel of the bronchoscope to the position of the chest wall tumor before the irradiation of the near infrared rays after the insertion of the optical fiber, wherein the optical fiber is inserted into the guide sheath Lung tumor screening method.
Wherein the near-infrared rays are near-infrared rays in a wavelength range of 780 to 2000 nm.
The method of claim 1, further comprising injecting a fluorescent dye into a blood vessel prior to the step of irradiating near infrared rays, wherein the fluorescent dye leaks from immature blood vessels around the chest wall tumor and is deposited on the chest wall tumor, A method for screening pulmonary tumors using near-infrared light, characterized by imaging neovascularization of a chest wall tumor releasing.
Wherein the fluorescent dye is indocyanine green (ICG).
Further comprising a radiation filter disposed on a front surface of the near-infrared ray detecting camera and an excitation filter disposed on a front surface of the near-infrared ray light source.
Wherein the near-infrared rays are irradiated with near-infrared rays of a plurality of different wavelength ranges, and the intensity of light of each of the near-infrared rays passing through the chest wall is measured or imaged to confirm presence or absence of chest wall tumors through a difference in absorption degree. Lung tumor screening method.
Wherein the presence or absence of the chest wall tumor is confirmed by the difference in absorbency by the spectroscope.
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| KR1020160123392A KR101855395B1 (en) | 2016-09-26 | 2016-09-26 | Screening method of lung tumor using near-infrared light |
| PCT/KR2017/008771 WO2018056574A1 (en) | 2016-09-26 | 2017-08-11 | Pulmonary tumor screening method using near infrared rays |
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| KR1020160123392A KR101855395B1 (en) | 2016-09-26 | 2016-09-26 | Screening method of lung tumor using near-infrared light |
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| KR101460908B1 (en) | 2013-08-09 | 2014-11-17 | 서울여자대학교 산학협력단 | Lung tumor tracking system and the method in 4D CT images |
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| US20080218732A1 (en) * | 2005-07-27 | 2008-09-11 | University Of Massachusetts Lowell | Infrared Scanner for Biological Applications |
| JP6275382B2 (en) * | 2009-12-15 | 2018-02-07 | エモリー ユニバーシティ | System and method for providing real-time anatomical guidance in diagnostic or therapeutic procedures |
| US20130211246A1 (en) * | 2011-12-27 | 2013-08-15 | Vinod PARASHER | METHODS AND DEVICES FOR GASTROINTESTINAL SURGICAL PROCEDURES USING NEAR INFRARED (nIR) IMAGING TECHNIQUES |
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