KR101769456B1 - Cosmetic composition having the function of indication for a lapse of shelf life - Google Patents

Abstract

The present invention provides a cosmetic composition comprising vanillin and a metal ion donor containing a central metal ion as a marker for the expiration of the shelf life.
Since vanillin contained in the cosmetic composition according to the present invention is controlled by the metal ion donor containing a central metal ion, the rate of discoloration of the vanillin can be controlled by the user. Can be confirmed. In particular, the cosmetic composition which does not contain any preservative or contains a very small amount of preservative may be deteriorated when exposed to room temperature or stored for a long period of time in a refrigerated condition. In such a case, It is very useful because it provides visual information on whether or not the user can use the device,

Description

[0001] The present invention relates to a cosmetic composition having a function of indicating the progress of a shelf life,

The present invention relates to a cosmetic composition having a display function with respect to the passage of time, and more particularly, to a cosmetic composition which informs the user of the passage of a shelf life by color change due to a discoloration reaction of vanillin.

Cosmetic products are cosmetic products designed for beauty, skin, whole body and hair for the cleansing and beautifying of the human body, and contain cosmetic materials exhibiting specific effects in the container body. The cosmetic contains a large amount of beneficial ingredients such as amino acids, polysaccharides and vitamins, so that it is easy to propagate the microorganism, and thus the cosmetic can easily be spoiled and the active ingredient may be deteriorated. Preservatives are usually added to prevent deterioration of cosmetics. Such preservatives are added to protect the product from deterioration and to maintain its purity while it is being used or preserved. It protects cosmetics from microorganisms such as bacteria or fungi . Chemical preservatives such as parabens, imidazolidinyl urea, diazolidinyl urea or phenoxyethanol are generally used in cosmetic compositions, but these chemical preservatives are more toxic than other cosmetic ingredients, and have side effects such as skin irritation or allergy .

On the other hand, according to recent well-being trends, there is a demand for a cosmetic composition which does not use any preservative at all, or uses a very small amount of preservative and can circulate refrigerated. In a cosmetic composition which does not use any preservative at all, there is a high risk that the product will deteriorate due to the growth and metabolism of microorganisms. Therefore, it is necessary to confirm whether the predetermined shelf life has elapsed or not.

It is an object of the present invention to provide a cosmetic composition which can easily confirm the passage of a predetermined time-limit by color change.

In order to solve the above object of the present invention, the present invention provides a cosmetic composition comprising vanillin and a metal ion donor containing a central metal ion as a marker for the passage of time. At this time, the content of vanillin is preferably 0.01 to 5% by weight based on the total weight of the cosmetic composition. The content of the metal ion donor is preferably 0.01 to 20% by weight based on the total weight of the cosmetic composition. Wherein the metal ion donor includes at least one metal ion selected from the group consisting of an iron ion, a calcium ion, a magnesium ion, a copper ion, a zinc ion, a manganese ion, a cobalt ion, a potassium ion, For example, casein containing a central metal ion, lactoferrin containing a central metal ion, transferrin containing a central metal ion, transferrin containing a central metal ion, Lactoglobulin, a Milk Fat Globule membrane containing a central metal ion, an oxidase containing a central metal ion, a catalase containing a central metal ion, peroxy containing a central metal ion peroxidase (peroxidase), and from the group consisting of vitamin B ₁₂ comprising a central metal ion It may be composed of at least one element chosen.

Since vanillin contained in the cosmetic composition according to the present invention is controlled by the metal ion donor containing the central metal ion, the rate of discoloration is controlled, so that the user can easily determine whether the predetermined period of time has elapsed or not by changing the color of the cosmetic composition Can be confirmed. In particular, the cosmetic composition which does not contain any preservative or contains a very small amount of preservative may be deteriorated when exposed to room temperature or stored for a long period of time in a refrigerated condition. In such a case, It is very useful because it provides visual information on whether or not the user can use the device,

Hereinafter, the present invention will be described in detail.

The inventors of the present invention have found that when a vanillin (4-hydroxy-3-methoxybenzaldehyde) binds to a metal ion, a galactosylation reaction occurs and the degree of the Galley reaction is controlled to visually check whether the cosmetic composition has passed its shelf life The present invention has been completed. The cosmetic composition according to the present invention contains vanillin and a metal ion donor containing a central metal ion as a marker for the expiration of the shelf life.

vanillin

Vanillin in the present invention includes ethyl vanillin as an equivalent. The content of vanillin in the cosmetic composition according to the present invention can be selected in various ranges according to the expiration date of the predetermined cosmetic composition (for example, 4 weeks at room temperature or 8 weeks in cold condition) By weight, preferably 0.01 to 5% by weight. When the content of vanillin is less than 0.01% by weight based on the total weight of the cosmetic composition, there is a possibility that the color change of the cosmetic composition may be insufficient even if the brownening reaction of vanillin is completed, and the content of vanillin is 5% There is a possibility that the degree of color change due to the excess is not large and the economical efficiency is deteriorated.

Metal ion donor

The cosmetic composition according to the present invention comprises a metal ion donor containing a central metal ion as an adjuster for controlling the degree of browning reaction of vanillin. The metal ion donor containing the central metal ion is generally surrounded by an organic functional group such as an aliphatic group, an aromatic group and an amino group so that the rate of vanillin browning reaction can be controlled by controlling the rate of metal ion release to vanillin have. The metal ion donor of the present invention is not limited in its kind as long as it contains a central metal ion that causes a brownening reaction with vanillin. In this case, the central metal ion of the metal ion donor is an iron ion, a calcium ion, a magnesium ion , Copper ion, zinc ion, manganese ion, cobalt ion, potassium ion, and aluminum ion. In consideration of the compatibility with other cosmetic composition components and the acceptability of cosmetic composition components, the metal ion donor preferably contains casein containing a central metal ion, lactoferrin containing a central metal ion Transferrin containing a central metal ion, β-Lactoglobulin containing a central metal ion, Milk Fat Globule Membrane containing a central metal ion, At least one member selected from the group consisting of Oxidase, Catalase containing a central metal ion, Peroxidase containing a central metal ion, and Vitamin B ₁₂ containing a central metal ion . The casein generally contains calcium ions and the like. Lactoferrin generally contains iron ions, zinc ions, copper ions, etc., and the trans- ferrin generally contains iron ions and the like. The? -Lactoglobulin The oxidizing agent, the catalase, and the peroxidase generally contain iron ions, magnesium ions, etc., and the holding and protecting film generally contains manganese ions, magnesium ions, etc., and vitamin B ₁₂ contains cobalt ions (for example, cyanocobalamin, hydroxocobalamin, methylcobalamin, adenosylcobalamin, etc.) but is not limited thereto.

Other ingredients

The cosmetic composition according to the present invention contains an aqueous medium (generally water) and may contain other ingredients commonly used in cosmetic compositions such as liquids, solid fats, lead, hydrocarbons, higher fatty acids, higher alcohols, esters, Anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, moisturizers, water soluble polymers, thickeners, lower alcohols, polyhydric alcohols, sugars, amino acids, organic amines, polymer emulsions, , An antioxidant auxiliary, a perfume, and the like, if necessary.

The liquid-retaining furnace may include a liquid-retaining furnace, such as avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, Safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea oil, visa oil, rice hull oil, paulownia oil, Japanese paulownia oil, jojoba oil, embryo oil and triglycerin.

Solid retention furnaces include, for example, cacao fat, palm oil, cured palm oil, palm oil, palm kernel oil, kelp seed oil, hardened oil, wax, hardened castor oil and the like.

Examples of the lead include waxes, candelilla waxes, face waxes, carnauba waxes, bayberry waxes, pewter waxes, montan waxes, rice bran waxes, lanolin waxes, lanolin acetic acid, liquid lanolin, sugar cane wax, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, and the like can be given.

The hydrocarbon flow path includes, for example, liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, vaseline, microcrystalline wax and the like.

Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecanoic acid, tall oil fatty acid, isostearic acid, linolic acid, linolenic acid, eicosapentaenoic acid (EPA) And docosahexaenoic acid (DHA).

Examples of the higher alcohol include straight chain alcohols (e.g., lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol and the like); Branched alcohol such as monostearyl glycerin ether (butyl alcohol), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol etc.) .

Examples of esters include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate , Cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, Stearic acid N-alkyl glycol, dicaprylic acid neopentyl glycol, diisostearyl malic acid, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid trimethylol propane, triisostearic acid trimethylolpropane, tetra 2-ethylhexanoic acid pentaerythritol, tri-2-ethylhexanoic acid glycerin, trioctanoic acid glycerin, triisopalmitic acid glycerin, triisose 2-ethylhexyl palmitate, trimyristic glycerin, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic oleyl, acetone 2-octyldodecyl ester, adipic acid di-2-heptyl undecyl, ethyl laurate, diisobutyl adipate, diisobutyl adipate, N-lauroyl- 2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, .

The silicone flow path may be, for example, a chain-type polysiloxane (e.g., dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, etc.); (E.g., octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane), silicone resins forming a three-dimensional mesh structure, silicone rubbers, various modified polysiloxanes (amino modified polysiloxanes, polyether modified Polysiloxane, alkyl-modified polysiloxane, and fluorine-modified polysiloxane).

Examples of the anionic surfactant include fatty acid soaps (e.g., sodium laurate, sodium palmitate and the like); Higher alkyl sulfate ester salts (e.g., sodium lauryl sulfate, potassium lauryl sulfate and the like); Alkyl ether sulfuric acid ester salts (e.g., POE-laurylsulfuric triethanolamine, POE-laurylsulfate, etc.); N-acyl sarcosinate (e.g., lauroyl sarcosine sodium and the like); Higher fatty acid amide sulfonates (e.g., N-myristoyl-N-methyltaurin sodium, coconut oil fatty acid methyltaurin sodium, laurylmethyltaurin sodium and the like); Phosphoric acid ester salts (sodium POE-oleyl ether phosphate, POE-stearyl ether phosphoric acid, etc.); Sulfosuccinic acid salts (for example, sodium di-2-ethylhexylsulfosuccinate, sodium monooroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.); Alkylbenzenesulfonic acid salts (for example, sodium linear dodecylbenzenesulfonate, linear dodecylbenzenesulfonic acid triethanolamine, linear dodecylbenzenesulfonic acid and the like); Higher fatty acid ester sulfuric acid ester salts (such as hardened coconut oil fatty acid glycerin sodium sulfate); N-acyl glutamic acid salts (such as monosodium N-lauroyl glutamic acid, disodium N-stearoyl glutamic acid, monosodium N-myristoyl-L-glutamic acid, etc.); Sulfated oils (such as lot oils and the like); POE-alkyl ether carboxylic acid; POE-alkyl allyl ether carboxylate; -olefin sulfonic acid salts; Higher fatty acid ester sulfonic acid salts; Secondary alcohol sulfate ester salts; Higher fatty acid alkylolamide sulfates; Sodium lauroyl monoethanolamide succinate; N-palmitoyl aspartic acid ditriethanolamine; Sodium caseinate, and the like.

Examples of the cationic surfactant include alkyltrimethylammonium salts (e.g., stearyltrimethylammonium chloride, lauryltrimethylammonium chloride and the like); Alkylpyridinium salts (e.g., cetylpyridinium chloride); Distearyl dimethylammonium dialkyldimethylammonium chloride; Poly (N, N'-dimethyl-3,5-methylenepiperidinium chloride); Alkyl quaternary ammonium salts; Alkyldimethylbenzylammonium salts; Alkyl isoquinolinium salts; Dialkyl morpholinium salts; POE-alkylamines; Alkylamine salts; Polyamine fatty acid derivatives; Amyl alcohol fatty acid derivatives; Benzalkonium chloride; And benzethonium chloride.

Examples of the amphoteric surfactant include imidazoline type amphoteric surfactants such as 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2- 1-carboxyethyloxy disodium salt and the like); Betaine surfactants such as 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, lauryldimethylaminoacetic acid betaine, alkylbetaine, amide betaine, .

Examples of the hydrophilic nonionic surfactant include hexaglyceryl monolaurate (HLB14.5), hexaglyceryl monostearate (HLB11), hexaglyceryl monostearate (HLB9.0), hexaglyceryl monooleate HLB9.0), monocarboxylic acid decaglyceride (HLB15.5), monomyristic decaglyceryl (HLB14.0), monostearic decaglyceryl (HLB12.0), monoisostearic decaglyceryl Polyglycerin fatty acid esters such as decyl glyceryl monostearate (HLB12.0), decaglyceryl monooleate (HLB12.0), decaglyceryl decyl glyceryl (HLB9.5), and diisostearate decaglyceryl (HLB10.0). (5) glyceryl (HLB9.5), monostearic acid POE (15) glyceryl (HLB13.5), monooleic acid POE (5) glyceryl (HLB9 (20) sorbitan (HLB 16.9), monopalmitic acid POE (20), polyoxyethylene glycerin fatty acid esters such as polyoxyethylene glycerin fatty acid esters such as monooleate POE Sorbitan (HLB 15.6), monostearic acid POE (20) sorbitan (HLB 14.9), monostearic acid POE (6) sorbitan (HLB 9.5), and tristearic acid POE (20) sorbitan (HLB 10. 5), monoisostearic acid POE (20) sorbitan (HLB15.0), monooleic acid POE (20) sorbitan (HLB15.0), monooleic acid POE (6) sorbitan (HLB10.0) (20) sorbitan (HLB11.0), monolauric acid POE (6) sorbit (HLB15.5), tetrastearic acid POE (60) sorbitol (HLB13.0 ), Tetraoleic acid POE (30) sorbit (HLB 11.5), tetraoleic acid PO Polyoxyethylene sorbit fatty acid esters such as E (40) sorbit (HLB12.5), tetraoleic acid POE (60) sorbit (HLB14.0), POE (10) lanolin (HLB12.0), POE ) Lanolin (HLB13.0), POE (30) Lanolin (HLB15.0), POE (5) Lanolin Alcohol (HLB12.5), POE (10) Lanolin Alcohol (HLB15.5) HLB 16.0), POE (40), Lanolin alcohol (HLB17.0), POE (20) sorbitol beeswax (HLB9.5) HLB10.5), POE (40) castor oil (HLB12.5), POE (50) castor oil (HLB14.0), POE (60) castor oil (HLB14.0) POE (30) hardened castor oil (HLB11.0), POE (40) hardened castor oil (HLB13.5), POE (60) hardened castor oil (HLB14.0), POE (80) (HLB 16.5), POE (40) hardened castor oil (100) hardened castor oil (HLB 16.5), POE (5) phytosterol (HLB9.5), POE ) Phytosterol (HLB12.5), POE (20) Phytoste Polyoxyethylene sterols such as POE (30) phytosterol (HLB18.0), POE (25) phytosterol (HLB14.5) and POE (30) cholestanol (HLB17.0) POE (2) lauryl ether (HLB9.5), POE (4.2) lauryl ether (HLB11.5), POE (9) lauryl ether (HLB14.5) and POE (5.5) cetyl ether (HLB10. POE (10) cetyl ether (HLB13.5), POE (15) cetyl ether (HLB15.5), POE (20) cetyl ether (HLB17.0) , POE (23) cetyl ether (HLB18.0), POE (4) stearyl ether (HLB9.0), POE (20) stearyl ether (HLB18.0), POE ), POE (10) oleyl ether (HLB14.5), POE (15) oleyl ether (HLB16.0), POE (20) oleyl ether (HLB17.0) POE (10) behenyl ether (HLB10.0), POE (20) behenyl ether (HLB16.5), POE (30) behenyl ether (HLB18.0), POE (2) 15) alkyl ether (HLB9.0), POE (4) (C12-15) alkyl ether (HLB10.5), POE (10) (C12-15) alkyl ether (HLB15.5), POE Alkyl ethers (HLB10.5), Polyoxyethylene alkyl ethers such as POE (7) secondary alkyl ether (HLB12.0), POE (9) alkyl ether (HLB13.5) and POE (12) alkyl ether (HLB14.5), polyoxyethylene (4) cetyl ether (HLB9.5), POE (10) POP (4) cetyl ether (HLB10.5), POE (hereinafter referred to as POE) POP (6) decyltetradecyl ether (HLB11.0), POE (30) POP (6) decyltetradecyl ether (HLB12.0) and the like 10 (HLB12.5), monostearic acid PEG (10) (HLB11.0), monostearic acid (hereinafter abbreviated as " PEG "), polyoxyethylene polyoxypropylene alkyl ethers PEG 25 (HLB 15.0), monostearic acid PEG 40 (HLB 17.5), monostearic acid PEG 45 (HLB 18.0), monostearic acid PEG 55 (HLB 18.0) Polyethylene glycol fatty acid esters such as oleic acid PEG (10) (HLB11.0), distearic acid PEG (HLB16.5), and diisostearic acid PEG (HLB9.5) (HLB10.0), isostearic acid PEG (10) glyceryl (HLB10.0), isostearic acid PEG (15) glyceryl (HLB12.0), isostearic acid PEG (20) (HLB13.0), isostearic acid PEG (25) glyceryl (HLB14.0), isostearic acid PEG glyceryl (30) (HLB15.0), isostearic acid PEG (40) glyceryl , Isostearic acid polyoxyethylene glycerides such as PEG (50) glyceryl isostearate (HLB16.0) and PEG (60) glyceryl isostearate (HLB16.0).

Examples of the lipophilic surfactant include POE (2) stearyl ether (HLB4.0), self-emulsifying propylene glycol monostearate (HLB4.0), myristyl glyceryl (HLB3.5), monostearic acid glyceryl (HLB 4.0), self emulsifying monostearic acid glyceryl (HLB 4.0), monoisostearic acid glyceryl (HLB 4.0), monooleic acid glyceryl (HLB 2.5), tristearate hexaglyceryl (HLB 3.5), pentaerythritol tetraglyceride (HLB 3.5), pentaerythritol decaglyceryl (HLB 3.5), monostearin sorbitan (HLB 4.7), and pentaerythritol tetraglyceride (HLB2.1), monoisostearic acid sorbitan (HLB5.0), sesquiisostearic acid sorbitan (HLB4.5), monooleic acid sorbitan (HLB4.3), hexa stearic acid POE (HLB 3.0), POE (3) castor oil (HLB 3.0), monostearic acid PEG (2) (HLB 4.0), ethylene glycol monostearate (HLB 3.5), stearic acid PEG (2) (HLB 4.5) .

Examples of the moisturizing agent may include at least one selected from the group consisting of polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucotin sulfate, (EO) PO adducts, Rosa roxburghii extract, wormwood extract, Meryl road extract, and the like can be used as the active ingredient. .

Examples of natural water-soluble polymers include vegetable polymers such as gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, queen seed (marmalade) Seaweed), starch (rice, corn, potato, wheat), glycylic acid); Microbial polymers (e.g., xanthan gum, dextran, succinoglucan, pullulan, etc.); And animal-based polymers (for example, collagen, casein, albumin, gelatin, etc.).

Examples of the semi-synthetic water-soluble polymer include starch-based polymers (e.g., carboxymethyl starch, methylhydroxypropyl starch, etc.); Cellulose polymers such as methyl cellulose, ethyl cellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, carboxymethylcellulose, carboxymethylcellulose sodium, crystalline cellulose, cellulose powder and the like); And alginic acid-based polymers (for example, sodium alginate, propylene glycol alginate and the like).

Examples of the water-soluble polymer synthesized include vinyl polymers (for example, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer, etc.); Polyoxyethylene-based polymers (e.g., polyoxyethylene polyoxypropylene copolymers of polyethylene glycol 20,000, 40,000, and 60,000); Acrylic polymers (for example, sodium polyacrylate, polyethylacrylate, polyacrylamide and the like); Polyethylene imine; Cationic polymers, and the like.

Examples of the thickening agent include gum arabic, carrageenan, karaya gum, tragacanth gum, carob gum, queen seed (marmalade), dextrin, gelatin, sodium pectate, sodium araginate, methylcellulose, ethylcellulose, CMC, Hydroxypropylcellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium sulfate, cellulose sulfate, xanthan gum, Magnesium aluminum silicate, bentonite, hectorite, silicic acid AlMg (non-sieved), laponite, silicic anhydride and the like.

Examples of the lower alcohol include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.

Examples of the polyhydric alcohol include dihydric alcohols such as ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, Methylene glycol, 2-butylene-1,4-diol, hexylene glycol, octylene glycol, etc.); Trivalent alcohols (e.g., glycerin, trimethylolpropane, etc.); Tetravalent alcohols (e.g., pentaerythritol such as 1,2,6-hexanetriol); Pentahydric alcohols (such as xylitol); Hexahydric alcohols (e.g., sorbitol, mannitol, etc.); Polyhydric alcohol polymers (e.g., diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerol, tetraglycerine, polyglycerin and the like); Divalent alcohol alkyl ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, Petroleum ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether and the like); (E.g., diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol diethyl ether, Diethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, diethylene glycol monomethyl ether, diethylene glycol monomethyl ether, Propylene glycol ethyl ether, dipropylene glycol butyl ether, etc.); (Such as ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadipate, ethylene glycol diglycinate, diethylene glycol Monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, etc.); Glycerin monoalkyl ethers (such as xylic alcohol, ceracill alcohol, batyl alcohol and the like); Sugar alcohols (e.g., sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, starch hydrolyzate, maltose, xylitose, starch hydrolyzate-reduced alcohol, etc.); Glysalide; Tetrahydroperfuryl alcohol; POE-tetrahydroperfuryl alcohol; POP-butyl ether; POP-POE-butyl ether; Tripolyoxypropylene glycerin ether; POP-glycerin ether; POP-glycerin ether phosphoric acid; POP · POE-pentane erythritol ether, polyglycerin and the like.

Monosaccharides include, for example, tertiary sugars (e.g., D-glyceryl aldehyde, dihydroxyacetone and the like); Quaternary (e.g., D-erythrose, D-erythrose, D-threose, erythritol, etc.); (For example, L-arabinose, D-xylose, L-lysine, D-arabinose, D-ribose, D-ribose, D-xylose and L-xylose); (For example, D-glucose, D-talose, D-busucose, D-galactose, D-fructose, L-galactose, L-mannose and D-tagatose); 7-valent sugar (e.g., aldoheptose, heptose, etc.); Octadecane (such as octylose and the like); Deoxy sugars such as 2-deoxy-D-ribose, 6-deoxy-galactose, 6-deoxy-L-mannose, and the like; Amino sugars (e.g., D-glucosamine, D-galactoxamine, sialic acid, aminuronic acid, myristic acid, etc.); Uronic acid (e.g., D-glucuronic acid, D-mannuronic acid, L-glucuronic acid, D-galacturonic acid, L-iduronic acid and the like).

Examples of the oligosaccharide include sugars such as sucrose, umbelliferone, lactose, plantaose, isoricinose, α, α-trehalose, raffinose, ricinose, umbiricin, stachy- And the like.

Examples of polysaccharides include polysaccharides such as cellulose, queen seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycollagen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, Tin sulfate, guar gum, dextran, kerato sulfuric acid, locust bean gum, succinoglucan, and karonic acid.

Examples of amino acids include neutral amino acids (e.g., threonine, cysteine, etc.); Basic amino acids (e.g., hydroxylysine), and the like. Examples of the amino acid derivatives include acylsacosin sodium (lauroylsarcosine sodium), acylglutamate, acyl β-alanine sodium, glutathione, and pyrrolidonecarboxylic acid.

Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino- .

Examples of the polymer emulsion include an acrylic resin emulsion, a poly ethyl acrylate emulsion, an acrylic resin solution, a polyacryl alkyl ester emulsion, a polyvinyl acetate resin emulsion, and a natural rubber latex.

Examples of the pH adjusting agent include buffers such as sodium lactate-lactate, sodium citrate-sodium citrate, and sodium succinate-sodium succinate.

Examples of vitamins include vitamin A, B1, B2, B6, C, E and its derivatives, pantothenic acid and its derivatives, and biotin.

Examples of the antioxidant include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, and glyceryl esters.

Examples of the antioxidant auxiliary include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, caparin, hexametaphosphate, phytic acid, ethylenediaminetetraacetic acid and the like.

Other compoundable components include antiinflammatory agents (e.g., glycyrrhizinic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.); A whitening agent (e.g., suckling extract, arbutin, etc.); Various extracts (for example, yellow rye, yellow rye, rhododendron, peony, mulberry, mulberry, sage, lemonade, ginseng, aloe, sugarcane, iris, grape, citron, water lily, lily, saffron, , Red pepper, dermis, angelica, seaweed, etc.), active agents (e.g., royal jelly, photosensitizer, cholesterol derivatives and the like); A blood circulation accelerator such as nicotinic acid benzyl ester, nicotinic acid? -Butoxyethyl ester, capsaicin, gingeron, kantaris tincture, ichthymol, tannic acid,? -Borneol, nicotinic acid tocopherol, inositol hexanicotinate, cyclandelate , Cinnarginine, triazoline, acetylcholine, verapamil, cephalin, gamma-orzanol, etc.); Antifungal agents (e.g., sulfur, thianthol, etc.); Anti-inflammatory agents (e.g., tranexamic acid, thiotaurin, hippotaurin, etc.) and the like.

In addition, the cosmetic composition according to the present invention is preferably characterized in that it can be contained at a low level that does not contain preservatives or does not irritate the skin, and preferably does not contain a preservative. The preservative in the present invention is not limited to synthetic preservatives such as parabens ((methylparaben, ethylparaben, propylparaben, butylparaben), imidazolidinyl urea, diazolidinyl urea, phenoxyethanol and benzoic acid, Salts, antibacterial and repellent polyols, natural plant extracts, natural animal extracts, bacteriocins produced by microorganisms such as lactic acid bacteria, etc. When the cosmetic composition according to the present invention does not contain preservatives or contains trace amounts It is preferable that the cosmetic composition according to the present invention is stored in a refrigerator at 0 to 10 ° C. When the cosmetic composition according to the present invention is a composition with no release agent, When it is distributed under the condition, it is effective such as antioxidant, whitening agent, wrinkle improving agent, skin regenerating agent, sunscreen agent This modification has the advantage that rarely occurs in minutes.

Formulation

In addition, the cosmetic composition according to the present invention is not limited to a formulation and may have formulations such as lotion, essence, lotion, cream, spray, gel, balm and the like. Especially, it is preferable that the vanillin and the metal ion donor flow freely so that the discoloration reaction can be smoothly performed.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the following examples are illustrative only and do not limit the scope of protection of the present invention.

One. Cosmetics  Preparation of composition

(1) Production of flexible lotion

The raw materials were mixed as shown in the following Tables 1 to 3 to prepare a soft lotion.

Examples 1 to 8 Raw material name Raw material content (% by weight) Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 ethanol 10 10 10 10 10 10 10 10 Polyoxyethylene sorbitan polylauric acid 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Methyl paraoxybenzoate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 glycerin 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 1,3-butylene glycol 6.0 6.0 6.0 6.0 6.0 6.0 6.0 6.0 vanillin 0.01 0.01 0.01 0.01 0.1 0.1 0.1 0.1 Lactoferrin 0.1 0.5 5.0 10.0 0.1 0.5 5.0 10.0 Purified water Balance Balance Balance Balance Balance Balance Balance Balance

Examples 9 to 16 Raw material name Raw material content (% by weight) Example 9 Example 10 Example 11 Example 12 Example 13 Example 14 Example 15 Example 16 ethanol 10 10 10 10 10 10 10 10 Polyoxyethylene sorbitan polylauric acid 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Methyl paraoxybenzoate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 glycerin 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 1,3-butylene glycol 6.0 6.0 6.0 6.0 6.0 6.0 6.0 6.0 vanillin 0.25 0.25 0.25 0.25 0.5 0.5 0.5 0.5 Lactoferrin 0.1 0.5 5.0 10.0 0.1 0.5 5.0 10.0 Purified water Balance Balance Balance Balance Balance Balance Balance Balance

Comparative Examples 1 to 4 Raw material name Raw material content (% by weight) Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 ethanol 10 10 10 10 Polyoxyethylene sorbitan polylauric acid 1.0 1.0 1.0 1.0 Methyl paraoxybenzoate 0.2 0.2 0.2 0.2 glycerin 5.0 5.0 5.0 5.0 1,3-butylene glycol 6.0 6.0 6.0 6.0 vanillin 0.01 0.1 0.25 0.5 Lactoferrin - - - - Purified water Balance Balance Balance Balance

(2) Production of unsubstituted essence

The ingredients were mixed as shown in the following Tables 4 to 6 to prepare unscented-enzyme essences.

Examples 17 to 24 Raw material name Raw material content (% by weight) Example 17 Example 18 Example 19 Example 20 Example 21 Example 22 Example 23 Example 24 Propylene glycol 10 10 10 10 10 10 10 10 glycerin 10 10 10 10 10 10 10 10 Hyaluronic acid aqueous solution (1%) 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 ethanol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Polyoxyethylene hardened pharmacy 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 vanillin 0.01 0.01 0.01 0.01 0.1 0.1 0.1 0.1 Casein 0.1 0.5 5.0 10.0 0.1 0.5 5.0 10.0 Purified water Balance Balance Balance Balance Balance Balance Balance Balance

Examples 25 to 32 Raw material name Raw material content (% by weight) Example 25 Example 26 Example 27 Example 28 Example 29 Example 30 Example 31 Example 32 Propylene glycol 10 10 10 10 10 10 10 10 glycerin 10 10 10 10 10 10 10 10 Hyaluronic acid aqueous solution (1%) 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 ethanol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Polyoxyethylene hardened pharmacy 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 vanillin 0.25 0.25 0.25 0.25 0.5 0.5 0.5 0.5 Casein 0.1 0.5 5.0 10.0 0.1 0.5 5.0 10.0 Purified water Balance Balance Balance Balance Balance Balance Balance Balance

Comparative Examples 5 to 8 Raw material name Raw material content (% by weight) Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 Propylene glycol 10 10 10 10 glycerin 10 10 10 10 Hyaluronic acid aqueous solution (1%) 5.0 5.0 5.0 5.0 ethanol 5.0 5.0 5.0 5.0 Polyoxyethylene hardened pharmacy 1.0 1.0 1.0 1.0 vanillin 0.01 0.1 0.25 0.5 Casein - - - - Purified water Balance Balance Balance Balance

2. Cosmetics  Discoloration experiments according to the storage conditions of the composition

(1) The discoloration characteristics of the emollient lotion when stored at room temperature

The softened lotion prepared in Examples 1 to 16 and Comparative Examples 1 to 4 was stored at a room temperature of about 20 캜 for 4 weeks. The color change characteristics of the emollient lotion after storage for 4 weeks were measured using a L * a * b * colorimeter (Model: CR-10; manufactured by KONICA MINOLTA SENSING, INC. The value of ΔE * was calculated by the following equation.

_{ΔL * = L * t - L} *, Δa * = a * t - a *, Δb * = b * t - b *

? E * = [(? L *) ² + (? A *) ² + (? B *) ² ] ^1/2

L * _t , a * _t , b * _t : L * a * b * value

L *, a *, b *: L * a * b * values of the flexible lotion stored at room temperature for 4 weeks

When the ΔE * value is 0 to 0.5, there is almost no color difference, 0.5 to 1.5 is a slight difference, 1.5 to 3.0 is a detectable difference, and 3.0 to 6.0 is a difference in sensory color difference according to ΔE * Significant difference, 6.0 ~ 12.0 is a very noticeable difference, 12 or more is a different system color.

Table 7 shows the results of the discoloration test of the flexible lotion when stored at room temperature.

Flexible lotion classification ? E * Flexible lotion classification ? E * Example 1 5.33 Example 11 21.31 Example 2 8.98 Example 12 29.69 Example 3 12.13 Example 13 15.17 Example 4 15.29 Example 14 20.64 Example 5 6.92 Example 15 28.00 Example 6 10.03 Example 16 36.66 Example 7 13.98 Comparative Example 1 0.88 Example 8 19.30 Comparative Example 2 0.97 Example 9 11.21 Comparative Example 3 1.39 Example 10 16.25 Comparative Example 4 1.55

As shown in Table 7, when vanillin and lactoferrin containing iron ion as the central metal ion are included as components of the cosmetic composition, it is possible to visually inform the user whether the shelf life of the cosmetic composition has elapsed. At this time, the content of vanillin and the content of lactoferrin can be variously adjusted according to the expiration date of the predetermined cosmetic composition.

(2) Discoloration characteristics of unscreened essence in refrigerated storage

The unscented unsubsidized essences prepared in Examples 17 to 32 and Comparative Examples 5 to 6 were stored at a temperature of about 5 캜 for 6 weeks. After storage for 6 weeks, the discoloration characteristics of the unseeded essence were measured using a L * a * b * colorimeter (model: CR-10; manufactured by KONICA MINOLTA SENSING, INC. , And the value of ΔE * was calculated by the following equation.

_{ΔL * = L * t - L} *, Δa * = a * t - a *, Δb * = b * t - b *

? E * = [(? L *) ² + (? A *) ² + (? B *) ² ] ^1/2

L * _t , a * _t , b * _t : The L * a * b * value of the unsubstituted essence immediately after preparation

L *, a *, b *: The L * a * b * value of unsweetened essence stored for 6 weeks in a refrigerated condition

When the ΔE * value is 0 to 0.5, there is almost no color difference, 0.5 to 1.5 is a slight difference, 1.5 to 3.0 is a detectable difference, and 3.0 to 6.0 is a difference in sensory color difference according to ΔE * Significant difference, 6.0 ~ 12.0 is a very noticeable difference, 12 or more is a different system color.

Table 8 shows the results of the discoloration test of the unscreened essence in the refrigerated storage.

Unsurpassed essence classification ? E * Unsurpassed essence classification ? E * Example 17 2.50 Example 27 11.03 Example 18 3.99 Example 28 16.29 Example 19 4.97 Example 29 8.11 Example 20 6.31 Example 30 12.17 Example 21 3.28 Example 31 15.34 Example 22 5.55 Example 32 19.40 Example 23 7.30 Comparative Example 5 0.83 Example 24 9.78 Comparative Example 6 0.94 Example 25 6.15 Comparative Example 7 1.26 Example 26 9.08 Comparative Example 8 1.51

As shown in Table 8, when casein containing vanillin and calcium ion as the central metal ion is included as a component of the cosmetic composition, it is possible to visually inform the user whether the cosmetic composition has passed its expiration date. At this time, the content of vanillin and the content of casein can be variously adjusted according to the expiration date of the predetermined cosmetic composition.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. In addition, many modifications may be made to adapt a particular situation and material to the teachings of the invention without departing from the essential scope thereof. Accordingly, the protection scope of the present invention should not be construed as being limited to the particular embodiments disclosed as the best mode contemplated for carrying out the invention but to cover all embodiments falling within the scope of the appended claims.

Claims (8)

A cosmetic composition comprising a metal ion donor containing vanillin and a central metal ion as markers for the passage of time,
Wherein the metal ion donor containing the central metal ion is selected from the group consisting of casein containing calcium ion, lactoferrin containing iron ion, zinc ion or copper ion, transferrin containing iron ion, Lactoglobulin, a manganese ion, or a Milk Fat Globule Membrane containing magnesium ions, an iron ion, or an oxidase containing a magnesium ion, an iron ion, Or at least one selected from the group consisting of Catalase containing magnesium ions, Peroxidase containing iron ions or magnesium ions, and Vitamin B ₁₂ containing cobalt ions. / RTI >
The cosmetic composition according to claim 1, wherein the content of vanillin is 0.01 to 5% by weight based on the total weight of the cosmetic composition.
The cosmetic composition according to claim 1, wherein the content of the metal ion donor is 0.01 to 20% by weight based on the total weight of the cosmetic composition.
The method of claim 1, wherein the metal ion donor containing the central metal ion is selected from the group consisting of casein containing iron ions, calcium ions, and lactoferrin containing iron ions, zinc ions, or copper ions. Wherein the cosmetic composition is at least one selected from the group consisting of a cosmetic composition and a cosmetic composition.
delete The cosmetic composition according to any one of claims 1 to 4, wherein the cosmetic composition contains no preservative.
The cosmetic composition according to any one of claims 1 to 4, wherein the cosmetic composition is for cold storage which is stored at 0 to 10 ° C.
The cosmetic composition according to any one of claims 1 to 4, wherein the cosmetic composition has any one of formulations selected from the group consisting of lotion, essence, lotion, cream, spray, and gel.