KR101752286B1 - Apparatus for skin care and uses thereof - Google Patents

Abstract

The present invention relates to a method and an apparatus for supplying air in the air with an air pump of a skin beautifier, applying a predetermined voltage, and approaching the skin of the object to be treated to discharge plasma to modify the skin surface, . This provides an excellent effect of acting on the skin with low voltage only harmless to the human body by the plasma of the skin beauty machine

Description

[0001] APPARATUS FOR SKIN CARE AND USES THEREOF [0002]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin beauty device for generating plasma.

As a method for improving skin aging, scarring and the like, conventionally, only a treatment by simply applying a drug such as a solution, a cream, a gel, and an ointment for skin regeneration to the skin has been performed. However, the amount of solutions, creams, gels, ointments and the like which are absorbed into the dermal layer of the skin and act effectively on the skin, relative to the amounts of the solutions, creams, gels, ointments and the like applied to the skin, were relatively small. The possibility that the applied liquid passes through the skin layer of the skin is only 0.3% of the total content, and the remaining 99.7% of the applied liquid does not pass through the skin of the outermost skin and remains on the skin or disappears. Therefore, there has been a limit to improving the wrinkles or imparting elasticity to the skin by using the coating liquid. As a result, there has been a problem that the treatment for improving the effective skin tissue is not efficiently performed. Therefore, a method of dramatically increasing the absorption rate of solutions, creams, gels, ointments and the like in the skin layer for effective regeneration of the skin tissue is to apply electric stimulation, cold stimulation or mechanical stimulation (for example, needle therapy) .

Accordingly, a skin beauty machine capable of conveniently performing the above-described method has been developed. Generally, a skin beauty device has been developed and used by administering sound pressure, ultrasonic waves, high frequency heating, etc. to the skin to manage the skin, or to apply stimulation by steam, anion, cold stimulation, or vibration stimulation. Also, as described in Korean Patent Laid-Open Publication No. 2003-0080507, for example, a skin beauty machine capable of performing a combination of two or more of the above-described methods in one device has been developed and used.

On the other hand, it stimulates the skin or forms microchannels in the skin tissue, effectively supplying nutrients such as vitamin C and peptides to the dermis layer containing collagen to improve stretch marks and wrinkles, as well as to restore acne scars and burn scars A suitable skin treatment apparatus (utility model registration No. 395359, microneedle roller) has been started. However, since the above technique relies only on the skin stimulation effect by the microneedles, the effect of softening the skin surface and softening the scar tissue can be expected, but the effect of improving the wrinkle by promoting the regeneration of collagen in the human body is unsatisfactory There was a problem.

In the case of a skin beauty machine capable of cold massage, there is a cold and dry skin beauty machine using a thermoelectric element, which coats the heat sink on the back surface of the thermoelectric element to dissipate heat generated from the thermoelectric element to cool the thermoelectric element. For example, power is supplied to the thermoelectric element to generate cold air on the front surface of the thermoelectric element to perform cold massage. Since the thermoelectric element generates heat, it must be cooled. This is because the temperature of the heat generated from the back surface of the thermoelectric element continuously rises, and the heat affects the front surface of the thermoelectric element. That is, since the heat generated from the rear surface of the thermoelectric element raises the temperature of the cold air generated from the front surface of the thermoelectric element, the cooling massage effect deteriorates. As described above, there is a difficulty in switching between the temperature of the cold air and the temperature of the heat, so that a cooling fan is provided to solve the problem, but the volume of the skin beauty device becomes large.

In addition, a skin cosmetic method using oxygen for skin cell activation is known. Thus, there is disclosed a vacuum swing adsorption type oxygen generator (Utility Model Registration No. 325459), which is a skin beauty machine that performs massaging by intimately closely contacting with the skin while supplying oxygen and nutrients. In the oxygen generator, the oscillating piston type (or oscillating diaphragm type) oxygen vacuum pump for sucking and exhausting oxygen and nitrogen in the adsorption bed and the oscillating piston type (oscillating diaphragm type) nitrogen vacuum pump are driven by a single motor. However, the technique has a problem that noise and vibration are severe.

In addition, a skin beauty machine using ultrasonic waves has developed technology for skin and obesity management by stimulating skin cells by regular vibration of ultrasonic waves to remove waste products and provide skin massage. However, in order to maximize the effect of the ultrasonic wave, the skin beauty machine using such an ultrasonic wave uses ultrasonic waves of 20 KHz to 80 KHz. Therefore, when the user receives the treatment, serious noise (20 Hz to 16,000 Hz Sound may be heard but exceptionally, a sound of 20 KHz or more, that is, the ultrasonic wave may be recognized). In addition, there is a side effect that the massage part which is in direct contact with the skin is formed of a metal material and allergies or troubles are caused on the skin rather than using it for a long time.

An object of the present invention is to provide a skin beauty device for discharging plasma from the skin surface, to provide a method of modifying the skin surface using discharged plasma, a method of promoting percutaneous absorption, a method of improving wrinkles, will be.

In order to accomplish the above object, in a skin beautifier including a plasma generating plate, an AC power supply, a housing, and an air pump in an embodiment of the present invention, the plasma generating plate includes a substrate, a first electrode, a second electrode, The first electrode or the second electrode is a labyrinthine electrode and is disposed on the upper and lower surfaces of the substrate. The dielectric portion surrounds the first electrode or the second electrode. The housing includes a plasma generating plate and an AC power supply unit And the AC power supply unit supplies the skin beauty device with a voltage of 1 to 10 kV.

There is provided a method for modifying a surface of a skin for supplying air in the air with the air pump of the skin beautifier, applying a predetermined voltage, and approaching the skin of the object to be treated to discharge the plasma.

The present invention also provides a method for promoting percutaneous absorption of air by supplying air in the air with the air pump of the skin beautifier, applying a predetermined voltage, and approaching the skin of the object to be treated to discharge the plasma.

The present invention provides a method for improving wrinkles for supplying air in the air with the air pump of the skin beautifier, applying a predetermined voltage, and approaching the skin of the object to be treated to discharge the plasma.

The present invention provides a method of treating a wound to supply air in the atmosphere with the air pump of the skin beautifier, apply a predetermined voltage, and approach the skin of the object to be treated to discharge the plasma.

The skin is damaged, the skin is damaged by supplying air in the air with the air pump of the skin beauty machine containing the stem cell culture as an active ingredient, applying a voltage of 1 to 5 kV to the skin of the object to be treated, A wound for skin, a skin ulcer, a skin scar, or a skin scratch.

According to an embodiment of the present invention, there is provided a method for modifying a surface of a skin by applying an AC voltage of 1 to 5 kV in an atmospheric environment to a plasma display panel to generate a plasma.

According to an embodiment of the present invention, there is provided a method for accelerating transdermal absorption by applying an AC voltage of 1 to 5 kV in an air atmosphere to a plasma display panel to generate a plasma.

According to an embodiment of the present invention, there is provided a method for improving a corrugation by applying an alternating voltage of 1 to 5 kV in an atmospheric environment to a plasma display panel to generate a plasma.

According to an embodiment of the present invention, there is provided a method of generating a plasma by applying an AC voltage of 1 to 5 kV in an air atmosphere to a plasma display panel to thereby heal a wound.

Various embodiments described herein are described with reference to the drawings. In the following description, for purposes of complete understanding of the present invention, various specific details are set forth, such as specific forms, compositions, and processes, and the like. However, certain embodiments may be practiced without one or more of these specific details, or with other known methods and forms. In other instances, well-known processes and techniques of manufacture are not described in any detail, in order not to unnecessarily obscure the present invention. Reference throughout this specification to "one embodiment" or "embodiment" means that a particular feature, form, composition, or characteristic described in connection with the embodiment is included in at least one embodiment of the invention. Accordingly, the appearances of the phrase " in one embodiment "or" the embodiment "in various places throughout this specification are not necessarily indicative of the same embodiment of the present invention. In addition, a particular feature, form, composition, or characteristic may be combined in any suitable manner in one or more embodiments.

Unless defined otherwise in the specification, all scientific and technical terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs

In one embodiment of the present invention, the term " plasma generating plate " refers to a portion of the skin surface or cell surface of a human body to be used as a counter electrode to generate plasma. The plasma generating plate includes a substrate, an electrode, and a dielectric portion.

In one embodiment of the present invention, the term " hydration preventing film " refers to a non-oxide having an oxide film property and has a relatively good secondary electron generating property. The moisture barrier film is made of Al ₂ O ₃ , but is not limited thereto.

In one embodiment of the present invention, the term " substrate " refers to a material capable of forming electrodes by a photolithography technique. Examples of the substrate include a glass substrate, a polyethylene terephthalate (PET), a polyimide (PI), a polyolefin (polyether sulfone), but the type of the substrate is not limited to this, and can be variously changed.

In one embodiment of the present invention, a "dielectric portion" is a component comprising a dielectric material, wherein the dielectric is defined to comprise a substantially non-conducting material. Representative suitable dielectric materials for this purpose include but are not limited to silicon nitride (Si ₃ N ₄ ), silicon dioxide (SiO ₂ ), boron nitride (BN), yttria (Y ₂ O ₃ ), aluminum nitride ), Diamond coated silicon carbide (SiC), and silicon carbon oxide, commercially available as Dylyn (R) from Advance Refractory Technologies Inc., Buffalo, NY .

In one embodiment of the present invention, the term " first electrode and second electrode " refers to an electrode to which an AC power source is applied to supply power necessary for plasma discharge. An inert gas is injected and power is applied to generate a plasma at the surface of the dielectric portion to generate a plasma. A part of the electrode passes between the substrates and connects the electrode on the upper surface of the substrate to the electrode on the lower surface. One of the first electrode or the second electrode is connected to the power supply and the other is grounded. In this manner, it has a structure constituting an electrode in a floating state.

In one embodiment of the present invention, the term " skin beautifier " means treating skin with energy such as plasma to make skin cell walls porous and promoting penetration of cosmetic ingredients (nutrients such as moisture and collagen) But the present invention is not limited thereto.

In one embodiment of the present invention, in a skin beautifier comprising a plasma generating plate, an AC power supply, a housing and an air pump, the plasma generating plate is composed of a substrate, a first electrode, a second electrode and a dielectric portion, Or the second electrode is a labyrinthine electrode and is located on the upper and lower surfaces of the substrate, the dielectric portion surrounds the first electrode or the second electrode, the housing includes a plasma generating plate and an AC power supply portion, Provides a skin beauty device that supplies voltage from 1 to 10 kV. In the above-described embodiment, the plasma generating plate is a plasma display panel, and the labyrinthine electrode is formed of lines forming a closed loop to form a plurality of vertexes. Wherein the labyrinthine electrode has a plurality of extensions extending from a vertical body portion in a linear shape or a concavo-convex shape.

There is provided a method for modifying a surface of a skin for supplying air in the air with the air pump of the skin beautifier, applying a predetermined voltage, and approaching the skin of the object to be treated to discharge the plasma. In the above-described embodiment, the preset voltage is a method of modifying the surface of the skin, which is an AC voltage of 1 to 5 kV, and the surface of the skin for treating the skin cosmetic device so that the distance therebetween is about 1 to 100 mm The present invention also provides a method for modifying a skin surface for treating the skin beauty device for 1 to 200 seconds.

The present invention also provides a method for promoting percutaneous absorption of air by supplying air in the air with the air pump of the skin beautifier, applying a predetermined voltage, and approaching the skin of the object to be treated to discharge the plasma. In the above-described embodiment, the predetermined voltage is a method of modifying the surface of the skin, which is an alternating voltage of 1 to 5 kV, and the transcutaneous absorption is performed by treating the skin cosmetic device such that the distance therebetween is 1 to 100 mm The present invention also provides a method for promoting transdermal absorption by treating the skin beauty device for 1 to 200 seconds.

The present invention provides a method for improving wrinkles for supplying air in the air with the air pump of the skin beautifier, applying a predetermined voltage, and approaching the skin of the object to be treated to discharge the plasma. In the above-described embodiment, the predetermined voltage may be an AC voltage of 1 to 5 kV, and the method may include modifying the surface of the skin cosmetic device such that the distance between the skin cosmetic device and the subject is 1 to 100 mm. The present invention also provides a method for improving wrinkles in which the skin beautifier is treated for 1 to 200 seconds on an object to be treated.

The present invention provides a method of treating a wound to supply air in the atmosphere with the air pump of the skin beautifier, apply a predetermined voltage, and approach the skin of the object to be treated to discharge the plasma. In the above-described embodiment, the predetermined voltage may be an alternating voltage of 1 to 5 kV, and the skin cosmetic device may be modified so that the distance between the skin cosmetic device and the subject is 1 to 100 mm. The present invention provides a method for treating a wound by treating the skin beauty device for 1 to 200 seconds.

In one embodiment of the present invention, air in the air is supplied to an air pump of a skin-beauty machine according to any one of claims 1 to 4, which comprises a stem cell culture as an active ingredient, and a voltage of 1 to 5 kV is applied A skin wound, a skin ulcer, a skin scar, or a skin scratch by bringing a plasma into contact with a skin of a subject to be treated.

According to an embodiment of the present invention, there is provided a method for modifying a surface of a skin by applying an AC voltage of 1 to 5 kV in an atmospheric environment to a plasma display panel to generate a plasma.

According to one embodiment of the present invention, there is provided a method for accelerating transdermal absorption by applying an AC voltage of 1 to 5 kV in an air atmosphere to a plasma display panel to generate plasma.

According to an embodiment of the present invention, there is provided a method for improving a corrugation by applying an alternating voltage of 1 to 5 kV in an air atmosphere to a plasma display panel to generate a plasma.

In one embodiment of the present invention, there is provided a method of applying a 1 to 5 kV AC voltage to a plasma display panel in an atmospheric environment to generate plasma to heal a wound.

The solid, which has the lowest energy state among the materials, receives energy and is transferred to the liquid or gas. At this time, when energy above the ionization energy is applied to the neutral gas, it is possible to generate a plasma composed of electrons, ions, neutral atoms and molecules by ionization and recombination of electrons and ions. The plasma is said to be electrically ionized conductive gas paper because it maintains electrical neutrality while performing brown movement close to free particles by mixing positive and negative charges. Plasma classifications include plasma density, electron temperature, degree of thermal equilibrium between species (LTE or non-LTE), generation method, and application field. Plasma for research and manufacturing processes is usually either LTE or non-LTE, and is commonly referred to as thermal plasma and the latter as a cold plasma. Atmospheric plasma in low-temperature plasma is mainly used for surface modification, coating and environmental purification of materials. In recent years, research has been expanded to include applications in biomedical applications and biomedical applications. Atmospheric pressure plasma devices are being studied in the biomedical field.

Atmospheric pressure plasma is mainly used for surface modification and coating of materials, environmental purification, and the like. In recent years, research has been expanded to include applications in biomedical applications and biomedical applications. Atmospheric pressure plasma devices are being studied in the biomedical field.

In one embodiment of the present invention, the plasma generator uses a plasma display panel (PDP), and a gas such as Ne + Ar, Ne + Xe is introduced into a sealed space between both glass Is the next generation display. In particular, in an AC surface discharge plasma display panel, when an address voltage is applied to an address electrode and a scan pulse is applied to a scan electrode, an address discharge is generated between the two electrodes, At this time, a wall charge is formed. When sustain pulses are applied to the sustain electrodes and the scan electrodes in this state, electrons and ions formed in the sustain electrodes and the scan electrodes move between the sustain electrodes and the scan electrodes, and in addition to the wall voltage generated by the wall charges formed during the address discharge, Causing a sustain discharge in the selected discharge cell. The phosphor in the discharge cell is excited to emit light.

In one embodiment, the plasma display panel includes a front glass substrate and a rear glass substrate opposed to each other with a discharge space therebetween, a display electrode formed as a discharge cell in a dielectric layer formed on the inner surface of the front glass substrate, The display electrode may be formed of a conductive metal such as Ag or silver alloy, which is formed to be spaced apart from the barrier rib by a predetermined distance, A bus electrode; And a discharge sustaining electrode made of a transparent transparent electrode (ITO), the discharge sustaining electrode being configured such that one end thereof is in contact with the bus electrode and is extended so as to face each other from the bus electrode to form a discharge gap, The electrodes are arranged in a "C" shape in such a manner that the upper and lower portions are parallel to the bus electrode and the intermediate connection portions are parallel to the barrier ribs and extend so as to face each other to engage to form a discharge gap, The line width of the upper and lower electrodes belonging to the transverse portion of the "C" transparent electrode (ITO), which is the upper and lower portions of the discharge sustaining electrode, is 150 to 250 mu m, The line width of the electrode belonging to the corresponding seed portion is 30 to 60 占 퐉 and the interval of 40 to 70 占 퐉 is spaced apart from the discharge sustaining electrodes Writing to form a discharge gap, the line width of the bus electrode is composed of 80 ~ 120㎛ distance between the two bus electrodes provides a surface discharge type plasma display panel, characterized in that configured so that they are at 1000㎛. In this embodiment, the first and second electrodes on the discharge sustaining electrode are formed on the transparent electrode on the front surface of the discharge cell and are made of transparent transparent electrode (ITO), and the bus electrode is made of Ag The plasma display panel according to claim 1, wherein the barrier ribs are formed on the first substrate and the second substrate, and the bus electrodes are grounded to the first and second electrodes to reduce line resistance. And the address electrodes of the rear glass substrate are formed to have a thickness of 120 to 130 μm for smooth discharge.

On the other hand, the skin is an important organ that is responsible for various physiological functions such as barrier function, body temperature control and excretion, which protects the human body from the external environment and prevents the internal moisture and useful components from flowing out. In general, the main cause of skin aging is the increase in age and external factors.

To improve aging, the synthesis of the major constituents in the skin is balanced and appropriately controlled, so that products or procedures can be used to maintain physiological tissue remodeling and homeostasis. Among them, drugs such as cosmetics or ointments may not be sufficient in terms of stability in skin and external conditions during application of the skin, skin adhesion, feeling on use, and skin persistence. Thus, aggressive surface modification treatments such as high-frequency laser and skin exfoliation can modify the skin to enhance absorption of cosmetics and increase the action effect of medicines. These treatments can cause erythema and scarring, and there is a recovery period. The present invention provides a method for reducing the risk and modifying the skin surface.

There are a method of administering to the skin through the injection or a needle and a method of transdermally applying to the skin. Among them, transdermal application methods are less susceptible to accident and less fear of fear than methods of administration in the body, and many attempts have been made not only for beauty but also for medical use. INDUSTRIAL APPLICABILITY The present invention can obtain an effect of discharging plasma to the skin to enhance the absorbability in transdermal tissue.

As you get older, your skin will lose its hue and soft feel, wrinkles and sagging. Regenerative therapies for aged skin may be to remove damaged tissue and promote collagen, elastin fibers and skin cell growth. In particular, for the purpose of improving wrinkles, it is important to increase the amount of collagen having the mechanical rigidity of the skin, the resistance of the connective tissue and the binding force of the tissue, and the function of supporting adhesion between cells. Accordingly, the present invention promotes the improvement of wrinkles by increasing the synthesis of collagen in skin cells by accelerating the absorption of substances in the dermal by discharging the plasma to the skin.

A wound is a form of injury that can be divided into an open wound, which is torn, punctured or cut, or a closed wound, such as a bruise or bruise caused by blunt force. There are many ways to treat such a wound. Generally, if the wound is mild, it is treated naturally. However, in case of open wound, it is necessary to wash, disinfect, suture, and dressing. Most clean open windows do not require antibiotic treatment, but antibiotic treatment is necessary for bacterial infection or for infected wounds. The present invention can obtain the effect of healing the open window in a shorter time than the natural healing.

The skin beautifier according to the present invention provides an excellent effect of acting on the skin only at a low voltage by harmless to the human body due to the plasma because the human body itself subjected to the plasma treatment becomes one discharge electrode. In other words, the skin beautifier according to the present invention provides a better wettability by modifying the surface of the skin by discharging the plasma to the skin, so that when the cosmetic ingredient is administered to the skin together with the discharge treatment, The application effect can be further enhanced.

In addition, the skin beauty device according to the present invention can discharge the plasma to the skin to absorb the substance at a higher efficiency in transdermal use. Even if the same amount of the effective ingredient is used, a higher effect can be obtained by using the skin beauty device according to the present invention , Improve wrinkles, and heal wounds.

1 is a perspective view of a skin beauty machine according to the present invention.
2 is a view showing a plasma generator included in a skin beautifier according to the present invention. FIG. 2 (a) is a cross-sectional view of a plasma generator included in the skin beautifier of the present invention, and FIG. 2 (b) is a plan view of an electrode applied to a plasma generator included in the skin beautifier of the present invention.
FIG. 3 is a graph showing the wettability according to the degree of water contact angle when the skin beauty device according to the present invention is applied to the skin surface.
FIG. 4 is a photograph showing the water contact angle obtained when the skin surface is visually observed when the skin beautifier according to the present invention is applied to the skin surface.
Fig. 5 is a photograph showing the result of observation of a skin beauty device according to the present invention on a skin surface followed by a fluorescence microscope. Fig.
FIG. 6 is a photograph showing the result of observation of a skin beautifier according to the present invention on a skin surface followed by a polarizing microscope. FIG.
Fig. 7 is a photograph showing the result of visual observation after application of the skin beautifier according to the present invention to the skin surface.
Fig. 8 is a photograph showing the result of applying the skin beauty device according to the present invention to the surface of the skin and then observing the skin. Fig.
Fig. 9 is a photograph showing the result of visual observation after application of the skin beautifier according to the present invention to the wound area on the skin surface.
FIG. 10 is a graph showing the size of wounds with respect to the elapsed days after applying the skin beauty device according to the present invention to wound areas on the skin surface.
FIG. 11 is a graph showing the recovery rate with respect to the elapsed days after applying the skin-beauty machine according to the present invention to the wound area on the skin surface.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. Hereinafter, an embodiment of the present invention will be described. The present invention is not limited to these.

[Example 1]

In one embodiment of the present invention, the skin beautifier 10 is as follows.

1 and 2 show a skin beauty machine 10 according to the present invention. 1 is a perspective view of a skin beautifier 10 according to the present invention. 2 (a) and 2 (b) show the configuration of the plasma generator 20 included in the skin beautifier 10 according to the present invention. 2 (a) is a cross-sectional view of a plasma generator 20 included in the skin beautifier 10 of the present invention, and FIG. 2 (b) is a cross-sectional view of a plasma generator 20 included in the skin beautifier 10 of the present invention Fig.

Referring to FIG. 1, a skin beautifier 10 according to the present invention includes a plasma generator 20, a power supply and regulator 30, and an air pump 40.

The plasma generator 20 according to the present invention includes a substrate 100, an electrode 200, a dielectric portion 300, a protective layer 400, an anti-hydration layer 500, and a housing 600.

The substrate 100 is installed inside the plasma generator 20 according to the present invention and is spaced apart from the lower end of the plasma generator 20 by a predetermined distance. In addition, although the substrate 100 is generally made of glass, it is not limited thereto.

As shown in Fig. 2 (a), two electrodes 200 are placed on the front surface and the back surface of the substrate 100, respectively. In particular, the cross-sectional shape of the electrode 200 positioned on the back surface of the substrate 100 may be formed by a lithography technique such as a polygon, a closed loop, a maze or the like having a large number of vertexes. In addition, the electrode 200 located on the back surface of the substrate 100 is buried by the dielectric portion 300.

The electrode 200 is surrounded by the dielectric part 300 and the dielectric part 300 is surrounded by the protective layer 400 and the protective layer 400 is surrounded by the moisture barrier 500 to improve the durability of the plasma generator 20 . The dielectric layer 300, the protective layer 400, and the moisture barrier 500 may be formed to a thickness of 20 to 50 탆, respectively. The plasma generating plate A is composed of the substrate 100, the electrode 200, and the dielectric portion 300. The plasma generating plate A generates plasma by using the skin surface of the human body to be used as an opposing electrode.

FIG. 2 (a) is a cross-sectional view showing a configuration in which the skin beauty machine 10 of the present invention is assembled to the housing 600.

A hole is formed in the substrate 100 such that a part of the electrode 200 passes through the skin beautifier 10 to the substrate 100 and is exposed to the front surface (which may be viewed as an upper surface). The electrode 200 has a short-circuited structure, and the short-circuited linear portion is drawn to the front surface through the hole of the substrate 100, so that the power source is connected thereto.

Further, additional gas holes may be further processed in the substrate 100 to further inject a plasma discharge gas outside the atmosphere.

The skin beautifier 10 of the present invention applies AC power to the electrode 200, uses a target object subjected to the plasma treatment as an opposite electrode, and discharges the plasma using the atmosphere as a discharge gas. For example, when an AC power source is applied to the electrode 200 of the plasma generator 20 and approaches the surface of the human skin, a plasma discharge occurs at a point where the gap between the electrode 200 and the surface of the skin acting as a conductor is appropriate. Thus, energy is applied to the surface of the skin by the plasma generator 20 as described above to show the direct effect of the procedure. In addition, since the skin cell wall can be made porous by the plasma energy discharged to the surface of the skin, the plasma discharge can be effected by applying the chemical solution to be applied to the skin or applying the chemical solution immediately after the plasma discharge procedure .

The electrode 200 shown in FIG. 2 (b) is a closed loop type using a lithography technique and having a plurality of horizontal protruding lines like a fork shape.

2 (b) shows an electrode structure in which the electrode shape is further modified so that a plurality of the transverse protruding lines themselves are provided with a plurality of protrusions and depressions to narrow the gap between the protrusions and the opposed protrusions facing each other, .

The electrode 200 of the present invention is not connected to both ends of the power source itself but has a shape such that it is short-circuited and has only one electrical contact point. One end of the power source is connected to the one electrical contact point and the other end is grounded. Therefore, the electrode 200 is in a floating state as a whole.

In the present invention, the structure of the electrode 200 has many vertexes at right angles, and the plasma discharge can be enhanced at such vertexes. That is, due to the electrode structure having such a shape, a plasma discharge having a desired level can be obtained even if a relatively low voltage is applied. Generally, when the electrode has a planar structure for the plasma discharge necessary for making the skin wall of the human skin porous, a high voltage of 3 to 5 kV is required. However, in the case of forming a shape having many vertices as in the present invention, 1 to 3 kV is sufficient. Therefore, more secure and stable operation becomes possible.

The power supply and regulating unit 30 is formed to include a power supply path 32 and an air supply path 31. One side of the power supply path 32 is coupled to the plasma generator 20 and the other side of the power supply path 32 is formed to be coupled to the power supply and control unit 30. The power supply path 32 electrically connects the plasma generator 20 and the power supply and regulating unit 30. The air supply passage 31 is formed to transfer air in the air to the plasma generator 20.

The air pump 40 is configured to pump the air in the atmosphere and to introduce the air into the plasma generator 20 through the air transportation path 41.

[Example 2] Method for modifying skin surface

In the skin beautifier 10 according to the first embodiment, a plasma was generated from atmospheric air using an air pump. The amount of gas injected by the air pump was maintained at 1 to 2 L per minute. At the time of plasma generation, the distance between the electrode and the object to be processed was maintained at about 5 to 10 mm with the plasma discharge plate (substrate 100) including the electrodes. In addition, an AC voltage of 2.5 to 3.5 kV was applied to discharge the plasma. The treatment time of the plasma in the object to be treated was maintained at 30 to 60 seconds. In order to reduce the pain on the human body subjected to the plasma treatment, the plasma treatment time was reduced to a range of several tens of seconds, so that the plasma treatment effect was exhibited.

The degree of modification of the skin surface due to the plasma treatment can be judged by measuring the water contact angle with the skin using a water drop test. As shown in Fig. 3, a water contact angle of about 95 ° means that the wettability of the skin surface with water is lowered, a water contact angle of about 15 ° means good wettability, and a water contact angle close to 0 ° has better wettability it means.

The surface of the skin of the human body was subjected to a water droplet test after the surface of the skin was treated with plasma as described above. As a result, as shown in Fig. 4, when the skin surface was observed with the naked eye, the portion of the surface of the skin treated with plasma showed a water contact angle lower than that of the control group. From these results, it was found that the skin surface treated with plasma exhibited the effect of modifying the skin with better wettability.

[Example 3] Method for promoting transdermal absorption of a substance

A method of confirming the promotion of percutaneous absorption of a substance using the skin beautifier 10 according to the first embodiment is as follows.

Biotin was bound to human serum albumin protein (HSA, 70 kDa) (biotin-conjugated human serum albumin protein; HSA-biotin) and suspended at a concentration of 25 μg / 100 μl (hereinafter referred to as HSA-biotin suspension).

HSA-biotin suspensions were applied to the dorsal area of 7-week-old SKH-1 hairless mice. Thereafter, it was allowed to stand for 1 hour to be absorbed into the transdermal tissue of SKH-1 hairless mouse. The control group was treated with only HSA-biotin suspension without plasma treatment.

After application of the HSA-biotin suspension, the plasma was treated in the same manner as in Example 2 under an applied voltage of about 3.5 kV and then allowed to stand for 1 hour. This was designated PL-A.

The plasma was treated in the same manner as in Example 2 under the application voltage condition of about 2.5 kV and the applied voltage of about 3.5 kV, and then HSA-biotin was applied to the other part of the back side of the mouse, During which time. These were PL-L and PL-H, respectively.

The above-mentioned four sites were biopsied to obtain eight tissue sections.

For immunohistochemical observation, streptavidin, which has a high affinity with biotin, was treated with the tissue sections obtained from the above four sites to immunoprecipitate them. The fluorescent material, tetramethylrhodamine isothiocyanate (TRITC), was treated and observed with a fluorescence microscope in the wavelength range of 550 to 570 nm. From this, the degree of absorption of the HSA-biotin suspension by the plasma treatment was observed. The results are shown in Fig.

On the other hand, for histological observation, other tissue sections obtained from the above-mentioned four sites were subjected to hematoxylin-eosin stain (H & E) and observed with a polarizing microscope. From this, it was observed whether or not the skin tissue was damaged by the plasma treatment. The results are shown in Fig.

The degree of absorption of the substance in the transdermal patch was determined according to the presence or absence of the plasma treatment. As shown in FIG. 5 (a), FIG. 5 (b), and FIG. 5 (d), the experimental group subjected to the plasma treatment further accelerated the percutaneous absorption of the HSA-biotin suspension as compared with the control group. Because HSA-biotin suspensions are relatively large proteins of 70 kDa, they are naturally unable to enter the skin. However, when the plasma is treated, such large-sized proteins also promote absorption into the skin. The skin beautifier 10 according to the present invention is capable of promoting the absorption of a much higher molecular weight protein into the skin than the conventional beauty machine.

In addition, the degree of absorption of the substance in the transdermal tissue was determined depending on whether the step of applying the substance precedes or follows the plasma treatment step. As shown in Fig. 5 (b) and Fig. 5 (d), the transdermal absorption of the HSA-biotin suspension was further promoted as compared with the case where the plasma treatment step was preceded by the following step.

In addition, the degree of absorption of the substance in the transdermal tissue can be determined according to the intensity of the applied voltage to the plasma. As shown in Fig. 5 (c) and Fig. 5 (d), fluorescence intensity indicates that the transdermal absorption of the HSA-biotin suspension is further promoted as the applied voltage for plasma is larger.

On the other hand, as shown in Fig. 6, it shows whether or not the skin tissue is damaged by the plasma treatment. 6 (a), 6 (b), 6 (c), and 6 (d), it was possible to compare the degree of damage of the skin tissue not subjected to the plasma treatment and the skin tissue treated with the plasma. 6 (b), Fig. 6 (c) and Fig. 6 (d) show that there is no abnormality such as defect or deformation of the skin area as compared with Fig. 6 (a) But it was not.

[Example 4] Wrinkle improvement method

A method for confirming the improvement of the wrinkles using the skin beautifier 10 according to the first embodiment is as follows.

Prior to confirming whether or not the wrinkles were improved by plasma treatment, the adipose tissues separated from the human body were homogenized with PBS (phosphate buffered saline) and centrifuged to separate the cell debris including the red blood cells and the mononuclear cells, Cells were isolated. Then, it was incubated and concentrated to prepare a concentrate. The concentrate thus obtained is referred to as "stem cell culture product ".

For the purpose of confirming the improvement of the wrinkles due to the plasma treatment, 14-week-old SKH-1 hairless mice with naturally wrinkles were prepared by applying the stem cell culture.

On the back of the mouse, the plasma was not treated on the left side with respect to the vertebra, and the plasma was treated on the right side in the same manner as in Example 2. [ Subsequently, 200 占 퐇 of each of 10 占 퐂 / ml of the stem cell culture known to be effective for improving wrinkles was applied to the left and right sides of the mice. The above-described procedure was carried out on the right and left sides of the mouse three times for two weeks once every four days, and visual observation was performed. The results are shown in Fig.

After performing the above-described procedure for 2 weeks, the right and left side portions were individually biopsied to obtain four tissue sections. In order to measure the thickness of the skin dermal layer, H & E staining was performed on the tissue sections of the right and left abdomen. Further, in order to measure the amount of collagen synthesis in the skin tissue, Masson's trichrome stain was performed on the other tissue sections of the left and right dorsal regions. The results are shown in Fig.

The difference in the action effect of the substance can be seen depending on whether the plasma is treated or not. As shown in Figs. 7 (a) and 7 (b), the wrinkle-improving effect of the stem cell culture is more improved than the left side in which the right side treated with plasma and treated with the stem cell culture alone treated the stem cell culture Show good things. In addition, as shown in Figs. 8 (a) and 8 (b), the thickness of the skin dermis layer also showed a difference. The thickness of the skin dermal layer when the stem cell culture was solely applied was 164.92 탆, and the thickness of the skin dermal layer when the plasma was further treated was 200.83 탆. Applying the material after treating the plasma further promoted the wrinkle-reducing effect. In addition, as shown in Figs. 8 (c) and 8 (d), there was also a difference in the amount of collagen synthesis in the skin tissue. When the plasma was further treated (Fig. 8 (d)), collagen synthesis in the skin tissue was promoted as compared with the case where the stem cell culture was applied alone.

[Example 5] Wound healing method

A method for confirming whether or not a wound is healed using the skin beautifier 10 according to the first embodiment is as follows.

For the purpose of confirming the effect of wound healing by plasma treatment using a stem cell culture, wound was made to the dermal layer using a biopsy punch having a diameter of 8 mm on the left and right sides of a 7-week-old SKH-1 hairless mouse. Plasma was not treated on the left side with respect to the vertebrae and the plasma was treated on the right side in the same manner as in Example 2, while the blood at the wound site was not cleaned and disinfected separately. Next, 200 占 퐇 of 10 占 퐂 / ml of the stem cell culture known to be effective for wound healing was applied to the left and right wound areas of the mice. The procedure described above was performed on the right and left wounds of the mouse three times for 2 weeks, once every four days. The length of the long axis and the short axis of the wound area were measured using a digital vernier caliper for 2 weeks, Respectively. Further, the recovery rate according to the following general formula (1) was measured.

In general formula (1)

Recovery rate = (Initial wound area - Wound area at present) / Initial wound area × 100

Details of wound size and recovery rate with respect to elapsed days are shown in Table 1, and graphs are shown in FIGS. 10 and 11, respectively, in order to compare the wound size and recovery rate of the control and plasma treatment groups.

The difference in the action effect of the substance can be seen depending on whether the plasma is treated or not. In Fig. 9, as shown in Fig. 9 (a), which is a wounded blade (Day 0) and Fig. 9 (b) The wound healing effect of the stem cell culture was better than that of the left side treated with the stem cell culture alone on the right side. Also, as shown in Fig. 10, it was shown that the wound size of the experimental group treated with plasma decreased more rapidly. As shown in Fig. 11, the recovery rate of the experimental group treated with plasma was better. That is, applying the substance after the plasma treatment further promoted the wound healing effect.

The skin beautifier 10 according to the present invention is excellent in absorption of a substance as the applied voltage is higher, but the inventors of the present invention have found a safe range of the applied voltage to the human body.

It is to be understood that the invention is not limited to the disclosed embodiments and that various changes and modifications may be made without departing from the spirit and scope of the invention as defined by the appended claims. It is obvious that the present invention can be implemented in a modified manner.

10: Skin beauty machine 20: Plasma generator
30: Power supply and control unit 31: Air supply path
32: Power supply line 40: Air pump
41: Air transport path A: Plasma generating plate
100: substrate 200: first electrode and second electrode
300: dielectric portion 400: protective layer
500: moisture barrier 600: housing

Claims (26)

delete delete delete delete 1. A method for modifying a skin surface that causes a skin beautifier, including a plasma generating plate, an AC power supply, a housing, and an air pump, to approach a skin of a subject to discharge a plasma,
Wherein the plasma generating plate comprises a substrate, a first electrode, a second electrode, and a dielectric portion,
Wherein the plasma generating plate is a plasma display panel,
The first electrode or the second electrode is a labyrinthine electrode and is located on the upper and lower surfaces of the substrate,
The dielectric portion surrounds the first electrode or the second electrode,
The housing includes a plasma generating plate and an AC power supply unit,
The air pump supplies 1 to 2 liters of air per minute,
And the AC power supply supplies a voltage of 2.5 to 3.5 kV. delete 6. The method of claim 5,
Wherein the skin beautifier is treated so as to be spaced from the object to be treated by about 1 to 100 mm. 6. The method of claim 5,
A method for modifying a surface of a skin for treating the skin beauty cosmetic for 1 to 200 seconds. A method for promoting percutaneous absorption by bringing a skin beautifier including a plasma generating plate, an AC power supply, a housing, and an air pump into close proximity to a skin of an object to discharge plasma,
Wherein the plasma generating plate comprises a substrate, a first electrode, a second electrode, and a dielectric portion,
Wherein the plasma generating plate is a plasma display panel,
The first electrode or the second electrode is a labyrinthine electrode and is located on the upper and lower surfaces of the substrate,
The dielectric portion surrounds the first electrode or the second electrode,
The housing includes a plasma generating plate and an AC power supply unit,
The air pump supplies 1 to 2 liters of air per minute,
And the AC power supply supplies a voltage of 2.5 to 3.5 kV. delete 10. The method of claim 9,
Wherein the skin beautifier is treated so as to be spaced from the object to be treated by about 1 to 100 mm. 10. The method of claim 9,
A method for promoting transdermal absorption by treating the skin beauty device for 1 to 200 seconds. CLAIMS 1. A method for improving a wrinkle which causes a skin beautifier including a plasma generating plate, an AC power supply, a housing, and an air pump to approach a skin of a subject to discharge a plasma,
Wherein the plasma generating plate comprises a substrate, a first electrode, a second electrode, and a dielectric portion,
Wherein the plasma generating plate is a plasma display panel,
The first electrode or the second electrode is a labyrinthine electrode and is located on the upper and lower surfaces of the substrate,
The dielectric portion surrounds the first electrode or the second electrode,
The housing includes a plasma generating plate and an AC power supply unit,
The air pump supplies 1 to 2 liters of air per minute,
And the AC power supply supplies a voltage of 2.5 to 3.5 kV. delete 14. The method of claim 13,
Wherein the skin beautifier is treated so as to be spaced from the object to be treated by a distance of about 1 to 100 mm. 14. The method of claim 13,
A method for improving wrinkles for treating a skin beauty cosmetic product for 1 to 200 seconds. delete delete delete delete delete delete delete delete delete delete

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