KR101722508B1 - Catheter assembly - Google Patents

Abstract

The present invention relates to a catheter assembly, and more particularly, a catheter assembly according to the present invention includes an outer tube member inserted into a blood vessel; A first inner tube member inserted into the blood vessel through the outer tube member; A first balloon portion provided on an end side of the first inner tube member; And a second balloon portion formed on one of the outer tubular member and the first inner tubular member, wherein the first balloon portion and the second balloon portion are configured such that, when inflated, the first balloon portion and the second balloon portion, Thereby blocking the blood flow in the blood vessels between the parts.
According to the present invention, it is possible to safely isolate and / or decompose thrombus and atheroma using ultrasound, and to recover the separated and disassembled debris by blocking blood flow before and after the position where the stenosis of the coronary artery occurs.

Description

Catheter assembly.

The present invention relates to a catheter assembly, and more particularly, to a catheter assembly capable of safe destruction and recovery of an embolus such as thrombus or atheroma.

Recently, the incidence of angina, myocardial infarction, and cardiovascular (coronary) disease typified by sudden death has increased rapidly. In the treatment of these cardiovascular diseases, we have made remarkable progress over the past decade. In addition to drug therapy, there are several other treatments such as coronary artery bypass grafting and mesh operation that connect the narrowed blood vessel area by a surgical method, which narrows the coronary artery due to arteriosclerosis and gives hope to the suffering patients. Electricity is coming.

 Specifically, the treatment of coronary artery stenosis is medication in cardiopulmonary medicine, non-surgical expansion plasty, and surgical treatment (coronary artery bypass) in thoracic surgery. Medication can not fundamentally resolve the stenosis. Continuous angina pectoris or coronary artery dilator medication should be used. If medication is used due to the limitation of medication, there may be chest pain caused by persistent angina.

In contrast, coronary angioplasty is a non-invasive method that can be used for the treatment of narrowed blood vessels, is effective in relieving the symptoms of angina, and has the advantage of reducing or eliminating the use of anti-anginal drugs. Coronary angioplasty was developed by Gruentzig et al. In 1979, and in the 1980s, balloon angioplasty was performed. However, 2 to 8% of acute occlusion And 35 ~ 55% restenosis.

Several methods have been studied to overcome these problems, and coronary stents are the most effective. The mesh technique is the most widely used technique for expanding the stenotic area by expanding the narrow metal nail at the stenosis site. The success rate of coronary artery catheterization was more than 95%, and the restenosis rate varies between 15% and 25% depending on the severity of the lesion and the severity of the lesion. The effect of the catheterization procedure is not limited to the primary lesion, Lesions, chronic complete closure lesions, myocardial infarction-related lesions, and coronary lesions after coronary artery bypass grafting.

In addition, in the long term, it is known that the site where the network is inserted does not induce ischemic symptoms in a stable state. In order to reduce the success rate and restenosis of the mesh, an anticoagulant steroid agent is coated , And studies are under way to reduce restenosis by locally irradiating additional radiations after surgery or surgery to slowly release tissue into the tissues or to remove corpus callosum by atherosclerosis by rotating a coronary diamond drill at high speed.

The present invention provides a catheter assembly capable of treating stenosis of a coronary artery using ultrasound.

In addition, the present invention provides a catheter assembly capable of safely recovering thrombus and atheroma by isolating the thrombus or atheroma from a blood vessel where the thrombus or atheroma is originally located so as not to move to another part in the process of decomposing or separating thrombus or atheroma using ultrasonic waves.

Further, the present invention can be applied only to a locally limited part even when a drug for anticoagulation or decomposition of an embolus such as thrombus and / or atheroma is injected, thereby increasing the efficacy of the drug per unit dose, The present invention provides a catheter assembly capable of minimizing the side effects caused by its application.

A catheter assembly according to the present invention comprises: an outer tube member inserted into a blood vessel; A first inner tube member inserted into the blood vessel through the outer tube member; A first balloon portion provided on an end side of the first inner tube member; And a second balloon portion formed on one of the outer tubular member and the first inner tubular member, wherein the first balloon portion and the second balloon portion are configured such that, when inflated, the first balloon portion and the second balloon portion, Thereby blocking the blood flow in the blood vessels between the parts.

The first inner tube member includes an inflow tube communicating with the inside of the first inner tube member to allow fluid to flow into the isolated blood vessel; And an outflow pipe communicating with the isolated blood vessel so that fluid can flow out from the isolated blood vessel.

In addition, at least one of physiological saline solution, blood, anticoagulation or dissolution medicine for embolus may be introduced into the inflow tube.

Also, the embolization may be at least one of thrombosis and atherom.

Also, the drug introduced into the inflow pipe may be at least one of Streptokinase, Urokinase, Tissue-type plasminogen activator, Warfarin, Hirudin, Paclitaxel, Sirolimus, Everolimus and Zotarolimus.

In addition, the outflow pipe may have a relatively larger cross-sectional area than the inflow pipe.

In addition, the first balloon and the second balloon may be formed of a material having a relatively weaker strength than the other portions so that the first balloon and the second balloon can swell relative to other portions of the same member.

Further, the first balloon and the second balloon may be inflated by the injection of physiological saline.

The first inner tube member may include a transducer for irradiating ultrasonic waves of a therapeutic frequency band.

The first inner tube member may further include at least one of a transducer for irradiating ultrasonic waves in a diagnostic frequency band and an imaging device for image acquisition.

The transducer may irradiate ultrasonic waves in the insertion direction of the first inner tube member.

The transducer may irradiate ultrasonic waves in a radial direction.

In addition, at least one of a groove and a projection may be formed on the outer circumferential surface of the first inner tube member where the transducer is located.

Further, a ring member formed in a ring shape may be provided on the outer circumferential surface of the first inner tube member where the transducer is located.

The ring member may be formed of a sponge made of PVA (polyvinyl alcohol) and converted into a hydrogel in the blood vessel.

On the other hand, the catheter assembly according to the present invention comprises an outer tube member inserted into a blood vessel; A first inner tube member inserted into the blood vessel through the inside of the outer tube member; A second inner tube member inserted into the blood vessel through the outer tube member and guiding insertion of the first inner tube member; A first balloon portion provided on an end side of any one of the first inner tube member and the second inner tube member; And a second balloon portion formed on any one of the outer tube member, the first inner tube member, and the second inner tube member, wherein the first balloon portion and the second balloon portion are configured such that, when inflated, The blood flow in the blood vessel between the balloon portion and the second balloon portion can be blocked from the outside.

The first inner tube member may be provided with an inflow pipe communicating with the isolated blood vessel so as to allow fluid to flow therethrough.

The first inner tube member may further include an outflow pipe communicated with the first inner tube member to allow fluid to flow out from the isolated blood vessel.

In addition, the outflow pipe may have a relatively larger cross-sectional area than the inflow pipe.

According to the present invention, it is possible to safely isolate and / or decompose thrombus and atheroma using ultrasound, and to recover the separated and disassembled debris by blocking blood flow before and after the position where the stenosis of the coronary artery occurs.

In addition, according to the present invention, by injecting a drug for anticoagulation or degradation of thrombus and / or atheroma in a blood vessel that is blocked from the outside, the drug is applied to a locally limited portion, and the efficacy of the drug per unit dose is increased , It is possible to minimize the side effects such as unintended bleeding by preventing the drug from leaking to other organs and the like.

1 is a perspective view showing an outer tube member according to an embodiment.
2 is a perspective view showing a second inner tube member according to one embodiment.
3 is a top view of a catheter having a first inner tube member according to one embodiment.
4 is a schematic view showing a relationship between an outer tube member, a first inner tube member, and a second inner tube member according to an embodiment.
5 is a schematic view showing a state of a first inner tube member according to an embodiment.
6 is a schematic view showing an inner appearance of a first inner tube member according to an embodiment.
Figs. 7 and 8 are schematic views showing operation modes according to types of transducers. Fig.
9 to 12 are schematic views sequentially illustrating a method of using a catheter assembly according to an embodiment.
13 and 14 are schematic views showing the appearance of the balloon portion according to another embodiment, respectively.
15 is a schematic view showing a state of a second inner tube member according to another embodiment.
16 is a schematic view showing a state of an outer tube member according to another embodiment.
17 and 18 are schematic views showing an internal view of a first inner tube member according to another embodiment.
19 and 20 are schematic views showing a state of a third tube member according to an embodiment.
21 is a schematic view for explaining the function and operation of the third tubular member according to one embodiment.
22 is a schematic view showing a state of a third tube member according to another embodiment.
23 and 24 are schematic views for explaining embodiments having a structure for external exposure of a transducer.
25 is a schematic view showing a state of a third tube member according to still another embodiment.

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings. In the absence of special definitions or references, the terms used in this description are based on the conditions indicated in the drawings. The same reference numerals denote the same members throughout the embodiments. For the sake of convenience, the thicknesses and dimensions of the structures shown in the drawings may be exaggerated, and they do not mean that the dimensions and the proportions of the structures should be actually set.

The outer tube member according to an embodiment of the present invention will be described with reference to FIG. 1 is a perspective view showing an outer tube member according to an embodiment.

The outer tube member according to one embodiment may be a catheter or a cannula having a large diameter used for a general catheter or a stent. Each tubular member in the present embodiment is not limited to a medical instrument for a specific purpose. That is, various medical instruments may be applicable regardless of the name, which has a similar configuration to the outer tube member in this embodiment or performs a similar function.

The outer tube member 10 is formed into a tube shape having a predetermined length. The outer tube member 10 is inserted into the blood vessel of the patient so that the blood vessel is not injured and various medical instruments including the first inner tube member and the second inner tube member described later can pass through the blood vessel.

It is also possible to inject dyes and other drugs necessary for angiography or the like through the outer tube member 10 as necessary.

The second inner tube member will be described with reference to Fig. 2 is a perspective view showing a second inner tube member according to one embodiment.

The second inner tube member 20 is formed into a tube shape having a smaller diameter in cross section than the outer tube member 10 described above. The second inner tube member 20 may be used for guiding a first inner tube member, which will be described later, when it is inserted into a blood vessel, and may be used for the purpose of blocking a blood flow by forming a balloon inside the blood vessel, . A detailed configuration thereof will be described later.

Although the second inner tube member 20 is described as being formed in the shape of a tube in the present embodiment, the second inner tube member 20 may be formed of a simple wire It is also possible to replace it with a type. That is, the case where the second inner tube member 20 is a guide wire which is generally used for guiding the insertion of a simple wire type, for example, the first inner tube member, is a general technique, and a detailed description thereof will be omitted.

The first inner tube member will be described with reference to Figs. 3 to 6. Fig. FIG. 3 is a plan view showing a catheter having a first inner tube member according to an embodiment, and FIG. 4 is a cross-sectional view illustrating a relationship between an outer tube member, a first inner tube member, Fig. FIG. 5 is a schematic view showing a state of a first inner tube member according to an embodiment, and FIG. 6 is a schematic diagram showing an inner appearance of a first inner tube member according to an embodiment.

First, referring to Fig. 3, the first inner tube member 31 in the present embodiment can be provided in a type of a generally used catheter 30. The first inner tube member 31 is provided with one or more independent tubes according to the purpose and a drug or physiological saline solution injected through the first and second regulating portions 32 and 33 flows into the blood vessel And may provide a passage through which foreign substances such as blood clots and atheroma mixed in blood and blood may be discharged to the outside as needed.

Also, as shown in FIG. 4, a guide hole 313 may be formed through the end side of the first inner tube member 31 from the end thereof. When the first inner tubular member 31 is inserted into the blood vessel directly through the outer tubular member 10, the first inner tubular member 31 is curled in the outer tubular member 10 It may be difficult to insert easily.

For this reason, the second inner tube member 20 is first inserted into the blood vessel, and then the outer tube member 10 is inserted along the second inner tube member 20. The second inner tube member 20 is inserted into the guide hole 313 on the end side of the first inner tube member 31 in a state in which the second inner tube member 20 is inserted into the first inner tube member 31, (31). In this case, the first inner tube member 31 can be easily inserted into the outer tube member 10 without bending or curling along the second inner tube member 20.

Alternatively, the guide wire 20 and the first inner tube member 31 may be first inserted in the above-described order, and then the outer tube member 10 may be inserted with the first inner tube member 31 serving as a core It is also possible.

A marker 311 is provided on the end side of the first inner tube member 31. The marker 311 is formed of a metal material or the like that can be detected through diagnostic equipment such as an X-ray. The marker 311 can be used to determine to which position the end of the first inner tube member 31 is inserted through the X-ray imaging apparatus or the like when the first inner tube member 31 is inserted into the blood vessel have.

In addition, a transducer 319 for irradiating ultrasonic waves is provided at one point of the first inner tube member 31 according to the present embodiment. The transducer 319 is used to irradiate ultrasound to separate blood clots and / or atheroma from the blood vessels or decompose them into smaller clumps. Such a transducer 319 irradiates ultrasound with an intensity that is stronger than a transducer for image acquisition for diagnostic purposes.

It is also possible to further include a second transducer (not shown) separately from the transducer 319 according to the present embodiment or integrally to acquire the diagnostic image described above. Such a second transducer can be replaced by a micro camera or the like for acquiring a direct image.

The first inner tube member 31 may further include various tubes. For example, as shown in FIG. 5, an inlet pipe 317 and an outlet pipe 315 may be provided. The inflow pipe 317 serves as a passage for allowing the physiological saline solution supplied from the outside, the blood or medicines required for the treatment to flow into the blood vessel through the inlet 3171.

These drugs include Paclitaxel, Sirolimus, Everolimus, Zotarolimus, non-steroidal anti-inflammatory drugs and steroids that decompose and / or alleviate atheroma, such as Streptokinase, Urokinase, Tissue-type plasminogen activator, Warfarin and Hirudin. .

The outflow tube 315 is provided as a passage through which an embolus mixed with blood and blood in the blood vessel through the outlet 3151, that is, foreign matter such as thrombus or atheroma can be discharged to the outside.

Unlike the inflow pipe 317, the outflow pipe 315 functions as a passage through which solid matter such as thrombus or atheroma passes. Therefore, the outflow pipe 315 can be made to have a larger diameter than the diameter L1 of the inflow pipe 317, (L2) is larger than the diameter (L2). On the other hand, the inflow pipe 317 is provided as a passage through which the physiological saline solution, blood or drugs are introduced into the liquid phase, and the flow rate introduced per unit time can be adjusted as a pressure, so that the diameter L1 of the cross section need not be formed large.

There is no restriction on the positional relationship between the position of the inlet pipe 317, the inlet port 3171, the outlet pipe 315 and the outlet 3151 and the relative positional relationship with the transducer 319. Various arrangements and arrangements It is possible.

Various tubes and wires may be provided inside the first inner tube member 31 according to an embodiment and the second balloon portion 312b, the first balloon portion 312a, and the second balloon portion 312b may be provided. And the first balloon portion 312a may have different internal structures.

6, pressure control tubes 316a and 316, an inflow tube 317, an outflow tube 315 and a lead wire 318 are provided on the inner side of the first inner tube member 31 .

Specifically, inside the second balloon portion 312b, a balloon 316 is formed outside the tube TB. The balloon 316 is formed of a thin elastic membrane material and is formed to be easily inflated when a fluid flows into the balloon 316. The space between the balloon 316 and the tube 316 communicates with the pressure control pipe 316a so that the fluid such as physiological saline can be delivered through the pressure control pipe 316a. Similarly, in the case of the first balloon portion 312a, a balloon 316 is formed outside the tube TB and can communicate with the pressure control tube 316a to receive a fluid such as physiological saline. At this time, the balloon 316 of the first balloon portion 312a and the second balloon portion 312b can receive the saline solution by the independent pressure control pipe 316a, It is also possible to receive the saline solution by using the saline solution 316a.

In the initial state before using the catheter assembly according to the present embodiment, as shown in FIG. 6A, the balloons BL, 316 of the first balloon portion 312a and the second balloon portion 312b are contracted Lt; / RTI > Thereafter, when physiological saline solution flows in through the inlet of the pressure control pipe 316, the saline solution flows into the balloon 316 as shown in FIG. 6 (b), and the balloon 316 expands. It is observed that the outer diameters of the first balloon portion 312a and the second balloon portion 312b are enlarged on the outer side of the first inner tube member 31 in this case.

On the other hand, in the portion where the expansion is not required, that is, for example, between the first balloon portion 312a and the second balloon portion 312b, the strength of the tube forming the pressure control tube 316a is lower than the strength of the first balloon portion 312a And the balloon BL of the second balloon portion 312b. Therefore, even when the pressure rises due to the injection of the physiological saline solution, the shape of the balloon BL does not expand relatively.

The inner structure of the first inner tube member 31 is limited to the arrangement of the components and components of FIG. 6, and may be changed as the position of the transducer 319 and related structures is changed. . Also, the pressure control pipes 316 and 316a may be formed integrally with the first inner tube member 31 as described above. Alternatively, the first inner tube member 311 may be formed by using a separate tube member such as the inflow pipe 317, (Not shown). In addition, the first inner tube member 31 can include or omit various types of tubes depending on the purpose of the treatment, or the configuration in which the balloon is formed. Additional embodiments related thereto will be described later.

The first inner tube member 31 and the second inner tube member 20 described above can be implemented with various medical instruments regardless of the name, which performs the same or similar function and function as the outer tube member. .

7 and 8, a transducer according to embodiments of the present invention and additional configurations are described. Figs. 7 and 8 are schematic views showing operation modes according to types of transducers. Fig.

7, the transducer 319 according to one embodiment is inserted into the blood vessel B together with the first inner tube member 31 until just before the thrombus and / or the atheroma E, A therapeutic ultrasonic wave can be irradiated to the target.

Also, as shown in FIG. 8, the transducer 319 may be inserted to the thrombus and / or the position of the atheroma E to irradiate ultrasound in a radial direction. In this case, in order to increase the effect of the transducer 319, a plurality of grooves 3102, protrusions 3101 and the like may be formed on the outer circumferential surface of the first inner tube member 31 corresponding to the position of the transducer 319, A ring member 3103 formed of a biocompatible material such as PVA may be attached to the outer circumferential surface.

The grooves 3102 on the outer circumferential surface, the protrusions 3101 and the ring member 3103 vibrate together with the transducer 319 so that the embers can easily To be removed. For example, the catheter assembly according to the present invention can achieve the effect of eliminating the embolization without using the stent. However, even in the case of an eluting stent for slowly releasing a drug dissolving atheroma or the like, Structure, it is possible to easily remove residual debris from the atheroma exposed to the drug, thereby maximizing the efficiency of the vasodilation stent.

A plurality of through-holes 3104 may be formed in the first inner tube member 31 corresponding to the transducer 319 as shown in FIG. 8D. The transducer 319 provided in the first inner tube member 31 through the through-hole allows direct contact with blood or liquid (fluid) such as physiological saline to be injected. That is, in the case of ultrasonic waves, reflections may occur at the boundary line between media. However, by forming the through-holes 3104, the transducer 319 can irradiate ultrasonic waves to a liquid (fluid) such as physiological saline The efficiency of the transducer 319 can be increased.

The inlet 3171 and the outlet 3151 are preferably formed on the upstream side and the downstream side of the blood, respectively. This is the same even when the transducers 319a and 319 are included. Specifically, when the transducer 319 irradiates the ultrasonic waves forward as shown in Fig. 7, the transducer 319 is preferably positioned on the upstream side of the blood based on the thrombus and / or atheroma E In this case, the inlet 3171 may be located on the right side of the transducer 319 located on the upstream side of the blood, and may also be located on the left side of the drain 319 as shown in the reference diagram of FIG. 7A. Can be located. On the other hand, the outlet 3151 is located on the downstream side of the blood based on thrombus and / or atheroma (E). That is, the outlet 3151 is preferably located on the opposite side of the transducer 319 in order to discharge the separated thrombus as shown in FIG.

When the transducer 319a is of a type radially irradiating as shown in Fig. 14, the transducer 319a is inserted to a position adjacent to the thrombus or the like as described above. At this time, it is preferable that the inlet 3171 is located on the upstream side of the blood and the outlet 3151 is located on the downstream side of the blood on the other side.

A method of using the catheter assembly according to one embodiment will be sequentially described with reference to Figs. 9 to 12. Fig. 9 to 12 are schematic views sequentially illustrating a method of using a catheter assembly according to an embodiment.

For example, the catheter assembly according to the present embodiment can be used in the following order.

First, as shown in Fig. 9, the outer tube member 10 is inserted into the blood vessel B using a second inner tube member, that is, a guide wire, and brought close to a foreign substance such as thrombus or atheroma (E). 10, when the second inner tube member 20 is accommodated in the outer tube member 10, the second inner tube member 20 is fixed to the end portion of the first inner tube member 31 The first inner tube member 31 is inserted. At this time, the transducer 319 can be inserted close to the thrombus (E) or inserted to a position corresponding to the thrombus (E) according to the purpose.

When the first balloon portion 312a is inserted up to the position of the thrombus etc., the first balloon portion 312a may be expanded as shown in FIG. 11 to form the thrombus etc. E ) Can be radially compressed and expanded. In this case, the thrombus and the like can be separated or decomposed more efficiently from the inner wall of the blood vessel by the drug such as the thrombolytic agent or the ultrasonic wave because the tightly formed bonding structure is torn or separated as the outer diameter expands. In this way, myocardial infarction is temporarily relieved by thoroughly perfusing the bloodstream with the clogged distal part.

12, the first balloon portion 312a and the second balloon portion 312b may be connected to each other with the thrombus (E) positioned between the first balloon portion 312a and the second balloon portion 312b, Lt; / RTI > In this case, blood or blood flow in the certain space BL1 is isolated from the outside by the first balloon portion 312a and the second balloon portion 312b.

Various measures can be taken in this isolated state. For example, it is possible to separate and / or decompose the thrombus (E) by using the transducer 319, or to inject a thrombolytic agent or a therapeutic agent through the inlet 3171, and the outlet 3151 It is also possible to discharge the blood in the isolation space BL1 to the outside in a state where the thrombus or the like E is decomposed or separated. In this case, it is also possible to further supply physiological saline through the inflow pipe 3171. By closing the inflow pipe 3171, negative pressure is applied to the intravascular occlusion space BL1 to remove debris separated from the thrombus etc. It is also possible to easily discharge it.

At this time, the periphery of the thrombus (E) is isolated from the outside by the first balloon portion (312a) and the second balloon portion (312b), so that particles and lumps of the separated debris It is possible to minimize the possibility of leakage to the outside and causing another embolization. In addition, since the thrombolytic agent and the like are applied only locally, the amount of drug required for dissolution of the thrombus (E) is drastically reduced, and it can be applied to a portion of the human body where application is unnecessary, thereby reducing unexpected side effects such as bleeding.

Other types of embodiments in which the balloon is formed will be described with reference to Figs. 15 is a schematic view showing a state of a second inner tube member according to another embodiment, and FIG. 16 is a schematic view showing an outer tube according to another embodiment, and FIG. Fig.

On the other hand, the first balloon portion and the second balloon portion may be formed in the second inner tube member 20 and the outer tube member 10, respectively. 13, the rear-side balloon portion 112b can be generally formed on the outer tube member 10a. As shown in Fig. 14, the second inner tube member 20 is provided with the front- The portion 212a may be formed generally.

Specifically, as shown in FIG. 15, the first inner balloon portion 212a may be formed at the one end of the second inner tube member 20 by replacing the first balloon portion described above. The second inner tube member 20 can be formed in a manner similar to the inner structure of the outer tube member. That is, as shown in FIG. 15A, the balloon BL2 communicating with the pressure control pipe 216a can be formed on the outer side of the front side balloon portion 212a. The balloon Bl2 expands when the physiological saline solution flows through the pressure control pipe 216a as shown in FIG. 15 (b). The inner space 214 of the second inner tube member 20 may be formed as necessary or may be formed in a state in which the portion other than the pressure control tube 216 of the second inner tube member 20 is closed It is possible.

16, the rear balloon portion 112b is formed by replacing the second balloon portion (refer to 312b in Fig. 6) of the first inner tube member described above at one end with the outer tube member 10 . When the physiological saline solution is supplied through the pressure control pipe 116a, the saline solution is introduced into the balloon BL3 of the rear side balloon portion 112b, thereby expanding the balloon BL3.

As described above, the first balloon unit and the second balloon unit according to the present invention can be implemented in various positions and shapes.

As described above, the first inner tube member and the second inner tube member can be inserted into the inner passage 114 of the outer tube member 10, and foreign matter contained in the blood or blood in the blood vessel can be discharged to the outside It can also be used as a passageway.

The first inner tube member according to another embodiment will be described with reference to Fig. 17 is a schematic view showing an inner appearance of a first inner tube member according to another embodiment.

The first inner tube member 31 according to the present embodiment is formed as a double pipe type of the outer tube OT and the inner tube IT. At this time, the inner tube IT functions as the outflow tube 315 described above. The outflow pipe 315 also functions as a passage for discharging foreign substances in the blood to the outside, and therefore it is preferable that the outflow pipe 315 is formed to have the largest cross-sectional area.

A pressure control pipe 316a is provided between the outer and inner pipes OT and IT and an inlet pipe 317 and a wire 318 may be provided depending on the position. The pressure regulating tube 316a in this embodiment is formed into one tube shape within the first inner tube member 31. [

The balloon OT 'is formed on the outer side of the first balloon portion 312a and the second balloon portion 312b and the space between the balloon OT` and the inner tube IT is connected to the pressure control pipe 316a .

As described above, the balloon (OT ') 316 is made of an elastic material having a smaller strength than other portions, for example, a balloon, so that it can be easily inflated as compared with other portions. 17 (b), when the saline solution is injected into the pressure control tube 316a to increase the pressure, the balloon OT '316 of the first balloon portion 312a swells.

On the other hand, as shown in FIG. 17A, the balloon OT 'of the first balloon portion 312a is emptied before the saline solution is introduced. Alternatively, as shown in FIG. 18A, Likewise, the balloon OT 'of the first balloon portion 312a is kept in a vacuum state before the saline solution is introduced and is adsorbed to the inner tube IT, thereby preventing other gases such as air from being introduced into the human body during use .

The bypass structure and its operation will be described with reference to FIGS. 19 to 24. FIG. 19 and 20 are schematic views showing a third tube member having a bypass tube according to an embodiment of the present invention. 21 is a schematic view for explaining the function and action of the third tube member according to the embodiment, FIG. 22 is a schematic view showing a state of the third tube member according to another embodiment, and FIGS. 23 and 24 are cross- FIG. 3 is a schematic view for explaining embodiments having a structure for external exposure of a ducer. FIG.

19 and 20, a bypass tube 419 connecting the outer sides of the third balloon portion 412a and the fourth balloon portion 412b of the third tube member 40a so as to communicate with each other . Specifically, in the third tubular member 40a according to the present embodiment, a first bypass hole 4192 is formed at the outer end of the third balloon portion 412a, and a second bypass hole 4192 is formed in the left outer surface of the fourth balloon portion 412b. 2 bypass holes 4191 are formed. The first bypass hole 4192 and the second bypass hole 4191 are communicated with each other by the bypass pipe 419. In addition, the third balloon portion 412a and the fourth balloon portion 412b may be formed of the double pipe type balloon structure described above.

At this time, the outflow pipe 4151 and the inflow pipe (not shown) perform the same functions as those in the above-described embodiment, and thus a detailed description thereof will be omitted.

21, when the third balloon portion 412a and the fourth balloon portion 412b extend to block a certain portion of the blood vessel B, conventionally, a certain space in the blood vessel B is isolated , The blood flow is blocked.

However, in the case of this embodiment, even when both sides of the third and fourth balloons 412a and 412b are blocked, a certain amount of blood can continuously flow through the bypass tube 419, It is possible to minimize the time required for measures such as temporary relief of myocardial infarction or cerebral infarction by thoroughly perfusing the blood flow with a clogged distal portion even in the case of urgent surgery such as removal of a cerebral thrombus, It is possible to further extend the time limit of tissue reperfusion surgery.

Further, as shown in FIG. 22, a transducer 418 may be provided between the inner tube IT and the outer tube OT of the third tube member 40b. In this case, as described above, a plurality of through holes 4102 are formed in the outer tube OT corresponding to the position of the transducer 418, or at least a portion of the outer tube OT is exposed so that the transducer 418 is exposed to the outside The transducer 418 directly contacts the blood or fluid and irradiates ultrasonic waves to minimize the reflection occurring at the boundary of the medium. Specifically, as shown in FIG. 23, it is possible to form a cutout 4104 such that most of the outer circumferential surface of the transducer 418 is exposed to the outside. At this time, the strength of the cutout 4104 is weakened, The reinforcing portion 4105 may be further formed in the axial direction as shown in Fig. 24 in order to prevent the tube member 40b from being bent or cut at the portion of the transducer 418 or the like. The reinforcing portion 4105 can be formed using a material having a higher strength than the material forming the outer circumferential surface of the third tube member 41. [

On the other hand, the third tube member can be manufactured as a separate tubular mechanism, but it is also possible to modify or additionally form the constitution of the first inner tube member and the outer tube member described above. That is, in the case of the first and second inner tube members, the outer tube member, and the third tube member described above, the term is merely a convenience name for describing the respective functions, and does not refer to a device of a specific type or type.

A third tube member according to yet another embodiment will be described with reference to Fig. 25 is a schematic view showing a state of a third tube member according to still another embodiment.

On the other hand, when the third tube member 40d is the outer tube member type described above, the first inner tube member 31 can be inserted inward. At this time, in order to prevent the blood flowing to the distal portion BL2 through the bypass tube 419 from flowing back through the inner tube (IT) 415 of the third tube member 40d, It is preferable to expand the one balloon portion 312a to close the inner tube IT 415.

While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. have.

10: outer tube member
20: second inner tube member
30: catheter
31: first inner tube member
312a and 312b:
319: Transducer
40: third tube member

Claims (20)

An outer tube member inserted into the blood vessel and having a third balloon portion and a fourth balloon portion, the outer tube member having a second bypass tube communicating both outer sides of the third and fourth balloons;
A first inner tube member inserted into the blood vessel through the outer tube member; And
And a first balloon portion provided on an end side of the first inner tube member,
Wherein the third balloon and the fourth balloon block the blood flow in the blood vessel between the third balloon and the fourth balloon when the balloon is inflated and the first balloon portion expands so that the first inner tube member is inflow A catheter assembly capable of closing a passageway. The method according to claim 1,
The first inner tube member has, on the inner side,
An inflow tube communicating with the distal side blood vessel such that fluid can flow into the distal side blood vessel with reference to the first balloon portion; And
And a drain tube communicating with the distal side of the blood vessel so as to allow fluid to flow out from the distal side blood vessel. 3. The method of claim 2,
Wherein at least one of physiological saline, blood, a drug for anticoagulation or dissolution of an embolus is introduced into the inflow tube. The method of claim 3,
Wherein the embolism is at least one of a thrombus and an atheroma. 5. The method of claim 4,
Wherein the drug introduced into the inflow tube is at least one of Streptokinase, Urokinase, Tissue-type plasminogen activator, Warfarin, Hirudin, Paclitaxel, Sirolimus, Everolimus, Zotarolimus, non-steroidal anti-inflammatory agent and steroid. The method of claim 3,
Wherein the outlet tube has a relatively larger cross-sectional area than the inlet tube. The method according to claim 1,
Wherein the outer layer of the first balloon is formed of a relatively weaker material than that of the other portion so that the outer layer of the first balloon can swell relative to the other portion of the same member. 8. The method of claim 7,
Wherein the first balloon portion is inflated by injection of physiological saline. The method according to claim 1,
Wherein the first inner tube member comprises a transducer for irradiating ultrasound in a therapeutic frequency band. 10. The method of claim 9,
Wherein the first inner tube member further comprises at least one of a transducer for irradiating ultrasonic waves in a diagnostic frequency band and an imaging device for image acquisition. 10. The method of claim 9,
Wherein the transducer irradiates ultrasonic waves in an insertion direction of the first inner tube member. 10. The method of claim 9,
Wherein the transducer radially irradiates ultrasound. 13. The method of claim 12,
Wherein at least one of a groove and a projection is formed on an outer circumferential surface of the first inner tube member where the transducer is located. 13. The method of claim 12,
And a ring member formed on an outer circumferential surface of the first inner tube member where the transducer is located. 15. The method of claim 14,
Wherein the ring member is formed of a sponge made of polyvinyl alcohol (PVA) and converted into a hydrogel in the blood vessel. delete The method according to claim 1,
Wherein the outer tube member comprises:
A second inflow pipe communicating with the blocked blood vessel so as to allow fluid to flow therethrough; And
And a second outlet tube communicating with the outlet vessel so that fluid can flow out from the inside of the blocked vessel. The method according to claim 1,
Wherein the first inner tubular member further comprises a second balloon portion distal to the first balloon portion. delete delete

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