KR101635409B1 - Apparatus for tracing vessel and tracing method of the same of - Google Patents
Apparatus for tracing vessel and tracing method of the same of Download PDFInfo
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- KR101635409B1 KR101635409B1 KR1020150091315A KR20150091315A KR101635409B1 KR 101635409 B1 KR101635409 B1 KR 101635409B1 KR 1020150091315 A KR1020150091315 A KR 1020150091315A KR 20150091315 A KR20150091315 A KR 20150091315A KR 101635409 B1 KR101635409 B1 KR 101635409B1
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- blood vessel
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- human body
- body image
- brightness model
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/50—Clinical applications
- A61B6/504—Clinical applications involving diagnosis of blood vessels, e.g. by angiography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/46—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with special arrangements for interfacing with the operator or the patient
- A61B6/461—Displaying means of special interest
- A61B6/466—Displaying means of special interest adapted to display 3D data
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/46—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with special arrangements for interfacing with the operator or the patient
- A61B6/467—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with special arrangements for interfacing with the operator or the patient characterised by special input means
- A61B6/469—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with special arrangements for interfacing with the operator or the patient characterised by special input means for selecting a region of interest [ROI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
- A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
- A61B6/5217—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data extracting a diagnostic or physiological parameter from medical diagnostic data
Abstract
Description
The present invention relates to a computer tomography image, and more particularly, to a blood vessel tracking apparatus and a blood vessel tracking method for tracking a blood vessel in a three-dimensional human body image generated by a computer tomography apparatus.
Generally, a computed tomography (CT) apparatus includes an X-ray generator, a data acquisition device composed of an X-ray detector and a DAS (data acquisition system), and an imaging device.
Such a computerized tomography apparatus is configured to allow a predetermined amount of x-rays to be transmitted through a human body by an x-ray generator, to measure the amount of x-rays transmitted through the human body by a data collecting apparatus and to convert the measured amount into a digital image signal, Thereby creating a tomographic image of the human body or a three-dimensional human body internal image.
A tomographic image or a three-dimensional image of a human body made by a computer tomography apparatus is used for detecting a lesion such as a heart disease or brain disease.
On the other hand, in order to detect a heart disease or cerebral disease, it is required to accurately track the geometric information of the heart or cerebral blood vessel and the position of the blood vessel.
According to such a request, Japanese Patent Application Laid-Open No. 1997-330413 discloses an example of a conventional blood vessel tracking method.
Hereinafter, a conventional blood vessel tracking method disclosed in the above publication will be described with reference to the drawings.
1 is a view for explaining a conventional blood vessel tracking method.
1, a conventional blood vessel tracking method includes selecting a point within a blood vessel V as a starting point S and selecting a straight line L having a predetermined length D1 around a selected starting point S as a radial , Calculates the average concentration of the straight line L, and tracks the blood vessel along the direction D of the straight line having the calculated average concentration value.
However, the conventional blood vessel tracking method has a problem that the blood vessel can not be traced when there is an obstacle such as a plaque in the blood vessel. That is, in the conventional blood vessel tracking method, the average concentration of the straight line is calculated and the blood vessel is traced, so that if there is an obstacle in the blood vessel, it is determined that there is no blood vessel and the blood vessel tracking is stopped.
SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide an apparatus and a method for tracking a blood vessel in a three-dimensional human body image generated by a computed tomography apparatus even when an obstacle such as a plaque is present in a blood vessel And a method for tracking a blood vessel thereof.
According to another aspect of the present invention, there is provided a blood vessel tracking apparatus comprising: an image input unit receiving a three-dimensional human body image generated by a computer tomography apparatus; An input unit for receiving a blood vessel tracking start point by an operation of a user; And a control unit for tracking the blood vessel in the three-dimensional human body image input to the image input unit using the cylindrical blood vessel brightness model and the blood vessel tracking starting point input to the input unit and detecting a branch starting point of the blood vessel branched from the traced blood vessel .
The control unit receives the 3D human body image from the image input unit, receives the vessel tracking start point from the input unit, generates the cylindrical blood vessel brightness model, and sets the center of the cylindrical vessel brightness model to the vessel tracking start point Fitting the cylindrical blood vessel brightness model to a virtual blood vessel on the three-dimensional body image, determining whether the virtual blood vessel on the three-dimensional body image is a real porch, and determining whether the virtual blood vessel on the three- It may be to set a new vein tracing start point on the tracing direction which is the direction in which the axis of the cylindrical blood vessel brightness model is directed.
At this time, the control unit sequentially sets the center of the cylindrical blood vessel brightness model on a plane perpendicular to the tracking direction to a plurality of points of a circle having a predetermined radius centering on the vessel tracking start point, Dimensional human body image, determines whether there is a real blood vessel in the virtual blood vessels on the 3D human body image, and if it is judged that the real blood vessel exists in the virtual blood vessels on the three-dimensional human body image, Lt; / RTI >
On the other hand, the cylindrical blood vessel brightness model is composed of a plurality of points having different brightnesses, and the brightness of the points forming a straight line passing through the axis of the cylindrical blood vessel brightness model on a section perpendicular to the axis of the cylindrical blood vessel brightness model, The distance from the axis of the brightness model to the points may be obtained by substituting into the expression (1).
[Equation 1]
Here, x is a distance from the axis S1 of the cylindrical blood vessel brightness model M to the points, f (x) is the brightness of the point located at x distance from the axis S1 of the cylindrical blood vessel brightness model M Where μ is the position of the axis S1 of the cylindrical blood vessel brightness model M on the straight line L passing the axis S1 of the cylindrical blood vessel brightness model M and σ is the standard deviation.
According to another aspect of the present invention, there is provided a blood vessel tracking method of a blood vessel tracking apparatus, comprising: receiving a three-dimensional human body image generated by a computer tomography apparatus in an image input unit; The control unit receiving an input of a vessel tracking start point from an input unit; The control unit generating a cylindrical blood vessel brightness model; Matching the center of the cylindrical blood vessel brightness model to the vessel tracing start point; Fitting the cylindrical blood vessel brightness model to a virtual blood vessel on the three-dimensional human body image by the controller; Determining whether the virtual blood vessel on the 3D human body image is a real porch; And setting a new blood vessel tracking start point on the tracking direction of the cylindrical blood vessel brightness model when the controller determines that the virtual blood vessel on the three-dimensional human body image is the actual porch.
Here, the step of fitting the cylindrical blood vessel brightness model to the virtual blood vessel on the 3D human body image may include fitting each of the points constituting the cylindrical blood vessel brightness model and brightness differences of the points of the 3D human body image corresponding thereto Axis rotation angle and the Y-axis rotation angle of the cylindrical blood vessel brightness model so that the sum is minimized, and the cylindrical blood vessel brightness model is rotated by the obtained Z-axis rotation angle and the Y-axis rotation angle.
The step of determining whether the virtual blood vessel on the 3D human body image is the actual porch may be further characterized in that the control unit determines whether the cylindrical blood vessel brightness model is fitted to the virtual blood vessel on the 3D human body image, And determining whether the sum of the brightness differences of the three-dimensional human body image and the brightness differences of the three-dimensional human body image is less than a predetermined value.
In addition, the control unit sequentially sets the center of the cylindrical blood vessel brightness model on a plane perpendicular to the tracking direction to a plurality of points on a circle having a predetermined radius around the center of the blood vessel tracking start point, Fitting a virtual blood vessel on a three-dimensional human body image; Determining whether there are blood vessels diverged from real blood vessels in the virtual blood vessels on the three-dimensional human body image; And if the controller determines that there are blood vessels branched from the real blood vessels in the virtual blood vessels on the 3D human body image, detecting the branching starting point of the blood vessel branched from the real blood vessels.
According to the blood vessel tracking device and the blood vessel tracking method of the present invention, when there is an obstacle such as a plaque in the blood vessel, the blood vessel can be traced in the three-dimensional human body image generated by the computer tomography apparatus .
1 is a view for explaining a conventional blood vessel tracking method.
2 is a block diagram illustrating a blood vessel tracking apparatus according to an embodiment of the present invention.
3 is a view illustrating a cylindrical blood vessel brightness model according to an embodiment of the present invention.
4 is a view for explaining a cylindrical blood vessel brightness model according to an embodiment of the present invention.
5 is a flowchart illustrating a blood vessel tracking method of a blood vessel tracking device according to an embodiment of the present invention.
6 to 8 are views for explaining a blood vessel tracking method of a blood vessel tracking device according to an embodiment of the present invention.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings, which are intended to illustrate the present invention in a manner that will be readily apparent to those skilled in the art, And this does not mean that the technical idea and scope of the present invention are limited.
Hereinafter, a blood vessel tracking device according to an embodiment of the present invention will be described with reference to the drawings.
2 is a block diagram illustrating a blood vessel tracking apparatus according to an embodiment of the present invention.
Referring to FIG. 2, the blood
The computer tomography apparatus can be implemented as a computer tomography apparatus that outputs a three-dimensional human body internal image.
The
The
The
The
Then, the
The more detailed function of the
Hereinafter, a cylindrical blood vessel brightness model according to an embodiment of the present invention will be described in detail with reference to the drawings.
FIG. 3 is a view showing a cylindrical blood vessel brightness model according to an embodiment of the present invention, and FIG. 4 is a view for explaining a cylindrical blood vessel brightness model according to an embodiment of the present invention.
3 and 4, the cylindrical blood vessel brightness model M generated by the
[Equation 1]
Here, x is a distance from the axis S1 of the cylindrical blood vessel brightness model M to the points, f (x) is the brightness of the point located at x distance from the axis S1 of the cylindrical blood vessel brightness model M Where μ is the position of the axis S1 of the cylindrical blood vessel brightness model M on the straight line L passing the axis S1 of the cylindrical blood vessel brightness model M and σ is the standard deviation. The brightnesses of the respective points constituting the straight line L passing through the axis S1 of the cylindrical blood vessel brightness model M have a normal distribution form as shown in Fig.
In the present invention, by using the cylindrical blood vessel brightness model (M) as described above, even when there is an obstacle such as a plaque in the blood vessel, the blood vessel can be traced in the three-dimensional human body image generated by the computer tomography apparatus .
Hereinafter, a blood vessel tracking method of a blood vessel tracking device according to an embodiment of the present invention will be described with reference to the drawings.
FIG. 5 is a flowchart illustrating a blood vessel tracking method of a blood vessel tracking apparatus according to an embodiment of the present invention, and FIGS. 6 and 7 illustrate a blood vessel tracking method of a blood vessel tracking apparatus according to an embodiment of the present invention .
5, the
6, the
Next, the
Next, the
Next, the cylindrical blood vessel brightness model M is fitted to the virtual blood vessel VV on the three-dimensional body image I (305).
That is, as shown in FIG. 6, the Z-axis rotation angle of the cylindrical blood vessel brightness model M
) And the Y-axis rotation angle ( (M) of the cylindrical blood vessel brightness model (M) so as to minimize the sum of the differences between the respective points forming the cylindrical blood vessel brightness model (M) and the brightness differences of the three-dimensional human body image Rotation angle ) And the Y-axis rotation angle ( ), And the cylindrical blood vessel brightness model (M) ) And the Y-axis rotation angle ( ).Next, the
That is, in the state where the cylindrical blood vessel brightness model M is fitted to the virtual blood vessel VV on the three-dimensional body image I, the respective points constituting the cylindrical blood vessel brightness model M and the three- I) is less than or equal to a predetermined value. This is because the cylindrical blood vessel brightness model M is fitted to the virtual blood vessel VV on the three-dimensional human body image I and each of the points constituting the cylindrical blood vessel brightness model M and the three-dimensional human body image I The virtual vein VV on the three-dimensional human body image I is not similar to the cylindrical blood vessel brightness model M unless the sum of the differences in the brightness of the points of the three-dimensional human body image I is less than a certain value.
If it is determined that the virtual blood vessel VV on the three-dimensional body image I is not the real blood vessel, the
Next, the
Next, the
If it is determined that there are no blood vessels branched from the real blood vessels among the virtual blood vessels VV on the three-dimensional body image I, the
Then, the
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the scope of the invention as defined by the appended claims. will be. Accordingly, the true scope of the present invention should be determined by the technical idea of the appended claims.
100: blood vessel tracking device 110:
120: input unit 130: display device
140:
Claims (8)
An input unit for receiving a blood vessel tracking start point by an operation of a user; And
A blood vessel tracking apparatus comprising: a blood vessel tracking unit for tracking a blood vessel in a three-dimensional human body image input to the image input unit using a cylindrical blood vessel brightness model and a blood vessel tracking starting point input to the input unit, Tracking device.
Wherein the control unit receives the 3D human body image from the image input unit, receives the blood vessel tracking start point from the input unit, generates the cylindrical blood vessel brightness model, and adjusts the center of the cylindrical blood vessel brightness model to match the blood vessel tracking start point Dimensional human body image, fitting the cylindrical blood vessel brightness model to a virtual blood vessel on the three-dimensional human body image, determining whether the virtual blood vessel on the three-dimensional human body image is a real porch, And sets a new blood vessel tracking start point on a tracking direction that is a direction in which the axis of the cylindrical blood vessel brightness model is oriented.
Wherein the control unit sequentially adjusts the center of the cylindrical blood vessel brightness model to a plurality of points on a circle having a predetermined radius around a center of the blood vessel tracking starting point on a plane perpendicular to the tracking direction, Determining whether there is a real blood vessel in the virtual blood vessels on the 3D human body image and detecting a branching starting point of the real blood vessel when it is determined that virtual blood vessels are present in the virtual blood vessels on the 3D human body image Wherein the blood vessel tracking device is a blood vessel tracking device.
Wherein the cylindrical blood vessel brightness model comprises a plurality of points having different brightnesses,
The brightness of the points forming the straight line passing through the axis of the cylindrical blood vessel brightness model on the section perpendicular to the axis of the cylindrical blood vessel brightness model is obtained by substituting the distance from the axis of the cylindrical blood vessel brightness model to the point of the equation Characterized by a blood vessel tracking device.
[Equation 1]
Here, x is a distance from the axis S1 of the cylindrical blood vessel brightness model M to the points, f (x) is the brightness of the point located at x distance from the axis S1 of the cylindrical blood vessel brightness model M Where μ is the position of the axis S1 of the cylindrical blood vessel brightness model M on the straight line L passing the axis S1 of the cylindrical blood vessel brightness model M and σ is the standard deviation.
The control unit receiving an input of a vessel tracking start point from an input unit;
The control unit generating a cylindrical blood vessel brightness model;
Matching the center of the cylindrical blood vessel brightness model to the vessel tracing start point;
Fitting the cylindrical blood vessel brightness model to a virtual blood vessel on the three-dimensional human body image by the controller;
Determining whether the virtual blood vessel on the 3D human body image is a real porch; And
And setting a new blood vessel tracking starting point on a tracking direction that the axis of the cylindrical blood vessel brightness model is set to when the controller determines that the virtual blood vessel on the three-dimensional human body image is a real porch. .
Wherein the step of fitting the cylindrical blood vessel brightness model to the virtual blood vessel on the 3D human body image comprises: calculating a sum of brightness difference values of the points of the cylindrical blood vessel brightness model and the points of the 3D human body image corresponding to the cylindrical blood vessel brightness model, Axis rotation angle and the Y-axis rotation angle of the cylindrical blood vessel brightness model to minimize the Z-axis rotation angle and the Y-axis rotation angle of the cylindrical blood vessel brightness model, Tracking method.
Wherein the controller determines whether the virtual blood vessel on the three-dimensional human body image is a real por- tion, the method comprising the steps of: obtaining the cylindrical blood vessel brightness model with the virtual blood vessel on the three- And determining whether the sum of differences in brightness of the points of the three-dimensional human body image corresponding to each of the three-dimensional human body images is equal to or less than a predetermined value.
Wherein the controller sequentially aligns the center of the cylindrical blood vessel brightness model with a plurality of points on a circle having a predetermined radius centering on the blood vessel tracking start point on a plane perpendicular to the tracking direction, Fitting a virtual blood vessel on a human body image;
Determining whether there are blood vessels diverged from real blood vessels in the virtual blood vessels on the three-dimensional human body image; And
Further comprising the step of detecting a branch starting point of a blood vessel branched from a real blood vessel when it is determined that there are blood vessels diverged from real blood vessels in virtual blood vessels on the 3D human body image, Tracking method.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2020111557A1 (en) * | 2018-11-26 | 2020-06-04 | 사회복지법인 삼성생명공익재단 | Device and method for constructing blood vessel map, and computer program for executing said method |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09330413A (en) | 1996-06-13 | 1997-12-22 | Hitachi Medical Corp | Blood vessel tracking processing method |
KR20090089158A (en) * | 2008-02-18 | 2009-08-21 | 중앙대학교 산학협력단 | Apparatus and method for tracking retinal vessel using canny edge detection method |
KR20090131825A (en) * | 2008-06-19 | 2009-12-30 | 한국과학기술원 | Modeling based pharmacokinetic feature extraction for monitoring peripheral tissue perfusion |
KR20110077740A (en) * | 2009-12-30 | 2011-07-07 | 서울여자대학교 산학협력단 | Apparatus and method for vessel and calcification extraction |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09330413A (en) | 1996-06-13 | 1997-12-22 | Hitachi Medical Corp | Blood vessel tracking processing method |
KR20090089158A (en) * | 2008-02-18 | 2009-08-21 | 중앙대학교 산학협력단 | Apparatus and method for tracking retinal vessel using canny edge detection method |
KR20090131825A (en) * | 2008-06-19 | 2009-12-30 | 한국과학기술원 | Modeling based pharmacokinetic feature extraction for monitoring peripheral tissue perfusion |
KR20110077740A (en) * | 2009-12-30 | 2011-07-07 | 서울여자대학교 산학협력단 | Apparatus and method for vessel and calcification extraction |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020111557A1 (en) * | 2018-11-26 | 2020-06-04 | 사회복지법인 삼성생명공익재단 | Device and method for constructing blood vessel map, and computer program for executing said method |
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