KR101621009B1 - Composition for skin external application comprising phosphatidylcholine and method for producing thereof - Google Patents

Abstract

The present invention relates to a composition for an external skin use comprising phosphatidylcholine and a producing method thereof. More specifically, the composition comprises phosphatidylcholine and lysophosphatidylcholine known as effective ingredients of adipolysis, has effects on skin elasticity and moisture, and can be useful as cosmetics due to excellent skin absorption.

Description

FIELD OF THE INVENTION [0001] The present invention relates to a composition for external use for skin comprising phosphatidylcholine and a method for producing the same,

The present invention relates to a composition for external use for skin comprising phosphatidylcholine and a method for producing the same, and more particularly, to a composition having phosphatidylcholine and lysophosphatidylcholine, which are effective ingredients for decomposing fat, And a method for manufacturing the same.

The market for cosmetics as an external medicine for skin is a growing industry. Recently, the domestic cosmetics market has seen growth of 7.6% in 2012 and many companies expect it to continue to grow in the future. In particular, the skin care sector, which will lead to the growth of the cosmetics market, is expected to continue its strongest growth until 2017, and hair care products are expected to grow strongly afterwards.

As market conditions improve, environmental awareness raises concerns about carcinogenic ingredients of cosmetic and synthetic chemicals, demand for organic and natural cosmetic products is increasing rapidly. In addition, the demand for high-function cosmetics in past cosmetics has been increasing, and products with added functions such as whitening, skin wrinkle improvement and suppression, ultraviolet ray blocking, skin elasticity enhancement and fat reduction have been continuously developed. Especially, the function of restoration of skin function, prevention of aging, moisturizing, etc. is a target of many consumers who want to maintain youthfulness.

Phosphatidylcholines are phospholipids in the cell membrane, and are composed of fatty acids, which are the minimum units of lipids in chemical structure, and choline, which is one of the phosphorus and vitamin B complexes. Phosphatidylcholine, also known as lecithin, has a unique emulsifying action that mixes water and oil due to its chemical structure as described above. Because of this nature, lecithin constitutes a cell membrane that forms the boundary between cells and cells, It controls the entry and exit of substances entering and exiting the cell. Phosphatidylcholine, which is mainly extracted from soybean, is widely known as a lipolytic enzyme and has an effect of decomposing triglyceride in fat cells. In addition, collagen production induces skin elasticity, and in recent research it has been found to be effective in preventing skin aging. In other words, there is a close relationship between skin aging and cell phospholipid. When the cell ages, the fatty acid composition of phosphatidylcholine molecule changes in glycerol phospholipid, which is a type of phospholipid.

On the other hand, lysophosphatidylcholine is also a type of phospholipid, which is bonded in two positions with an acyl group bonded to an acyl group in a 1-position hydride group having a glycerol skeleton. As one of the products of hydrolysis by phospholipase A of phosphatidylcholine, lysophosphatidylcholine It is known to have a strengthening effect on the dermal-epidermal junction. Such lysophosphatidylcholine is a major component of oxidized LDL, and is known to have a relatively useful effect on sepsis by activating various immune responsive cells including monocytes, phagocytic cells and neutrophilic leukocytes. In addition, peritonitis caused by peritonitis is significantly inhibited by the peritonitis animal model and LPC administration in cecal ligation and puncture (CLP) animal models, and peritonitis, pneumonia, osteomyelitis, It is known to be effective for the treatment of various bacterial infectious diseases including osteomyelitis.

However, a composition that can be applied as an external preparation for skin including both of phosphatidylcholine and lysophosphatidylcholine and capable of being used as an external preparation for skin having functions of restoring skin function, improving wrinkles, strengthening skin elasticity, preventing aging, and moisturizing is not yet known .

KR 1020140120652 A KR 1020120065348 A KR 1020110062160 A KR 101461204 B1

It is an object of the present invention to provide a composition for external use on the skin comprising phosphatidylcholine and lysophosphatidylcholine to activate skin functions such as prevention of skin aging, skin moisturization and elasticity enhancement. It is also intended to provide a composition which can be applied to skin by improving the low solubility of phosphatidylcholine and lysophosphatidylcholine in water.

In order to solve the above problems, the present invention provides a composition for external use for skin, which comprises a phosphatidylcholine and a lysophosphatidylcholine mixture, a preservative, purified water, and benzyl alcohol.

As a more specific example of the present invention, the amount of the phosphatidylcholine and lysophosphatidylcholine mixture is preferably 1 to 3% by weight, more preferably 1 to 2% by weight in the total composition. The ratio of phosphatidylcholine to lysophosphatidylcholine is preferably 90 to 95: 1 to 3, more preferably 92 to 95: 1 to 2.

In another embodiment of the present invention, the preservative is preferably a mixture of one or more of the groups selected from the group consisting of phenoxyethanol, methylparaben, ethylparaben, butylparaben and propylparaben, Is provided in a preferred embodiment. The content of the preservative is preferably 0.3 to 0.4% by weight.

According to one embodiment of the present invention, there is provided a composition, wherein the composition comprises 0.8 to 1% by weight of benzyl alcohol.

In another specific example, the present invention provides a composition wherein the composition further comprises carnitine.

The composition is provided as an external preparation for skin, preferably as a cosmetic, and is provided for skin elasticity, skin moisturizing or wrinkle improvement.

In order to achieve still another object of the present invention,

(1) preparing a mixture of phosphatidylcholine and lysophosphatidylcholine,

(2) placing the mixture in purified water and stirring,

(3) a step of adding a preservative and stirring,

(4) adding benzyl alcohol and stirring,

(5) A method for preparing a composition for external use on the skin, comprising the steps of (1) to (4), filling the mixture in a filling container while stirring the mixture.

The amount of the phosphatidylcholine and lysophosphatidylcholine mixture in the above production method is preferably 1 to 3% by weight in the total composition. Also, the preservative preferably contains 0.3 to 0.4% by weight, and the benzyl alcohol preferably contains 0.8 to 1% by weight.

As another example of the present invention, there is provided a method further comprising the step of adding carnitine in the middle of steps (3) and (4).

The present invention relates to a composition for external use for skin and a cosmetic composition, which comprises a phosphatidylcholine and a lysophosphatidylcholine mixture, a preservative, purified water and benzyl alcohol, and a method for producing the same, wherein the composition and the composition provided by the above- It is effective to prevent aging of skin, improve elasticity, and moisturize and strengthen skin moisturizing function, thereby providing a skin-safe product while maintaining healthy and elastic skin.

Hereinafter, preferred embodiments of the present invention will be described in detail. It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are intended to provide further explanation of the invention as claimed. It will be obvious to those who have knowledge of. In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

The phosphatidylcholine contained in the composition of the present invention is a lipolytic enzyme that shows an effect of decomposing triglycerides in adipocytes and induces collagen production to give skin elasticity. It also acts as an effective ingredient in preventing skin aging.

In addition, lysophosphatidylcholine, which is produced by hydrolysis of phosphatidylcholine, was included as a main component due to the effect of strengthening the dermal-epidermal junction.

In the present invention, a mixture of phosphatidylcholine and lysophosphatidylcholine is used as an active ingredient and contains 1 to 3% by weight in total weight. In preparing a mixture of phosphatidylcholine and lysophosphatidylcholine, : 1 to 4 is preferable. This is the optimal composition ratio at which the effect of each component can be elevated and is the most preferable composition ratio in order that the two components have the optimum solubility in which they can be dissolved in a solution state.

It is well known that carnitine, which is included in the composition provided as another example of the present invention, plays an important role in the lipid metabolism of human body. Carnitine binds enzymatically to fatty acids liberated from fat and has the action of a carrier that transports fatty acids into the mitochondria of intracellular organs, the site of burning lipids. The presence of excess lipid is caused not only by obesity by subcutaneous fat accumulation but also by cellulite formation, shine or stickiness of skin surface due to sebum excess, hair loss accompanying seborrheic dermatitis, acne, body odor, And the quality of life (QOL), in particular, the aging of the skin accompanied by the aging of the skin. In order for lipid metabolism to take place, fatty acids need to be introduced into the mitochondria, and carnitine is essential for its introduction. Therefore, the rate of lipid metabolism depends on the amount of carnitine present in the cells. Increasing the concentration of carnitine in tissues to promote lipid metabolism leads to the promotion of lipid metabolism, thereby preventing the lipid excess, and thereby eliminating the trouble due to lipid excess . Thus, the present invention provides a composition to which carnitine can be selectively added to a composition according to need, as an external preparation for skin, and to which the composition is added.

As used herein, the term " improvement of skin condition "or" skin care "means improvement of various skin conditions and maintenance of skin in excellent condition. Such skin condition improvement and skin care are, for example, It is possible to suppress or improve the skin allergy and skin inflammatory reaction such as antioxidation, anti-inflammation, suppression of skin damage by ultraviolet rays, inhibition of cell regeneration and sebum secretion as well as improvement and maintenance of direct skin conditions such as wrinkle improvement and skin moisturization, And secondary skin condition improvement to prevent skin aging such as inhibition and promotion of collagen synthesis. Also, as the scalp is covered with the skin, moisturizing, antioxidant, anti-inflammation, cell regeneration and sebum secretion suppressing effect of the scalp are also included in the improvement of the skin condition. Therefore, the cosmetic composition for skin condition improvement or skin care of the present invention is a composition for skin wrinkle improvement, antioxidation, skin cell regeneration, anti-inflammation, skin damage prevention by ultraviolet rays, skin aging prevention, sebum secretion Inhibiting and skin moisturizing, and cosmetics.

The composition provided in the present invention may contain an emulsifying agent depending on the formulation and may be selected from the group consisting of glycol stearate, cetearyl alcohol, stearic acid, hydrogenated lecithin, cetearyl olivate, sorbitan olivate, One or a mixture of two or more selected from the group consisting of polyvinylpyrrolidone, polyvinylpyrrolidone, polyvinylpyrrolidone, polyvinylpyrrolidone, polyvinylpyrrolidone, polyvinylpyrrolidone, polyvinylpyrrolidone, polyvinylpyrrolidone,

In addition, it may further include a moisturizing agent in water, and it may contain an appropriate amount of butyleneglycol glycerin sodium hyaluronate, panthenol, betaglucan and the like.

Skin protectants may also be included and it is preferred to use dipotassium glycyrrhizate adenosine allantoin niacinamide aloe vera leaf juice, octagonal fennel extract, or a mixture thereof.

If necessary, it may contain an acidity controlling agent, which is suitable as a triethanolamine chelating agent, disodium and dithia.

The composition of the present invention may contain a viscosity modifier depending on the formulation, which is preferably xanthan gum. It may also contain components such as skin conditioners, moisture barrier agents, skin softening agents and the like, such as butyleneglycol dicaprylate / dicaprate, cetylhexanohexanoate, trimethylolpropane tricaprylate / Tricaprylate, hydrogenated coconut oil, trimethylpentanediol / adipic acid copolymer, dimethicone, tocopheryl acetate, and the like.

The cosmetic composition of the present invention is not particularly limited in its formulation and may be, for example, a cosmetic composition having a formulation of softening water, a nutritional lotion, a massage cream, a nutritional cream, a pack, a gel or a skin adhesive type cosmetic.

The external preparation for skin or the cosmetic of the present invention may be in any form or form as long as it is used in contact with the skin at the time of use, and the subcutaneous fat may be used in contact with the skin near the desired site.

Specific examples of the emulsified skin external agent and cosmetic include skin milk, skin cream, foundation cream, massage cream, cleansing cream, shaving cream, cleansing foam, lotion, lotion, pack, lipstick, ball touch, eye shadow, Manicure, soap, body shampoo, hand soap, shampoo, rinse, hair tonic, treatment, hair cream, hair spray, hair restorer, hair restorer, hair dye, correcting agent, depilator, dandruff agent, toothpaste, denture adhesive, toothbrush, The present invention includes a wide variety of forms such as an antioxidant, an antioxidant, a curling agent, a styling agent, an ointment agent, a puff agent, a tape agent, a bath agent, a perspiration inhibitor, and an ultraviolet screening agent. Also, regardless of the sex of the user or the old or young. Furthermore, it includes contact with the skin of animals other than humans.

In addition to the above-mentioned components, conventional cosmetic raw materials may be further used in the cosmetic of the present invention.

Example  One. Phosphatidylcholine  And Lysophosphatidylcholine  Compositions containing

Each sample was prepared so as to have a composition ratio (w / w%) as shown in the following table. First, 94% by weight of phosphatidylcholine, 3% by weight of lysophosphatidylcholine and 3% by weight of purified water were weighed and mixed by stirring.

The mixture is added to purified water and the mixture is stirred for 1 hour while heating to 65 캜. After the mixture was completely dissolved by stirring, a preservative consisting of benzyl alcohol and phenoxyethanol, methylparaben, ethylparaben, butylparaben and propylparaben was added while maintaining the temperature of the mixer at 40 占 폚, And stirred for 2 hours. The mixture is filtered and then introduced into a second agitator, which is then poured into a packaging container (ampoule) at the same time as stirring.

Samples of Production Examples 1 to 6 were prepared according to the above-mentioned method.

Phosphatidylcholine and / or
Lysophosphatidyl collidine benzyl
Alcohol
antiseptic
Carnitine
Purified water weight %
Production Example 1 Phosphatidylcholine +
Lysophosphatidyl collidine
One
0.8 Phenoxyethanol, methylparaben, ethylparaben, butylparaben, propylparaben
Mixture 0.3
-
97.9
Production Example 2 Phosphatidylcholine +
Lysophosphatidyl collidine
One
0.9 Phenoxyethanol, methylparaben, ethylparaben, butylparaben, propylparaben
Mixture 0.4
0.0005
97.7
Production Example 3 Phosphatidylcholine
One
0.8 Methylparaben, ethylparaben, butylparaben, propylparaben
Mixture 0.3
0.0005
97.9
Production Example 4 Phosphatidylcholine +
Lysophosphatidyl collidine
2
.9 Phenoxyethanol, methylparaben, ethylparaben, butylparaben, propylparaben
Mixture 0.3
-
96.8
Production Example 5 Phosphatidylcholine +
Lysophosphatidyl collidine
3
0.8 Butyl paraben, propyl paraben
Mixture 0.3
0.0005
95.9 Production Example 6 Phosphatidylcholine
One
0.8 Phenoxyethanol, methylparaben, ethylparaben, butylparaben, propylparaben
Mixture 0.3
-
97.9

Example  2. Skin elasticity improvement effect

The clinical effect of the skin elasticity improving effect on the composition of the present invention was measured. Clinical trials were evaluated through actual use tests of each manufacturing example.

Namely, the ampules containing the compositions of Examples 1 to 5 were divided into five groups (A, B, C, D, and E) Example 2 was applied to Group B, Example 3 was applied to Group C, Example 4 was applied to Group D, Example 4 was applied to Group E, and eye wrinkles were observed. / Day, 0.2 g / times), skin elasticity before and after use of the product was measured using a skin elasticity meter (Kyutomater SEM 575), and the results are shown in the following table as ΔR8 values.

The value of? R8 indicates viscoelasticity of the skin.

Skin elasticity improvement effect (ΔR8) Production Example 1 0.884 Production Example 2 0.851 Production Example 3 0.594 Production Example 4 0.788 Production Example 5 0.795 Production Example 6 0.502 Comparative Example (purified water) 0.268

As can be seen from the results of the above Table 2, about 3 times as compared with the composition containing phosphatidylcholine and lysophosphatidylcholine as the active ingredient and the comparative example (purified water) containing no phosphatidylcholine and lysophosphatidylcholine as compared with the sample containing only phosphatidylcholine 1.5 times or more. Thus, it can be seen that the external skin or cosmetic composition containing the composition of the present invention has an excellent skin elasticity improving effect.

Example 3 Evaluation of wrinkle improvement effect

The skin wrinkle-improving effect of the composition for external use on the skin of the present invention was evaluated through practical use tests. The composition of Example 1 and the composition containing adenosine, which is known to have a skin wrinkle-reducing effect, were prepared from Comparative Example 1 and purified water (Comparative Example 2). Ten women aged 30 to 40 years were randomly divided into two groups, and each of Example 1 and Comparative Examples 1 and 2 was applied twice a day, morning and evening, followed by an appropriate amount of eyes for one month, and then each subject's wrinkle- And evaluated by visual observation. The results are shown in Table 3 below.

Wrinkle improvement effect Great usually none Production Example 1 7 One 2 Comparative Example 1 (purified water) One 2 7 Comparative Example 1 (adenosine) 7 2 One

Example  4. Skin Moisture power  Improvement effect

The skin moisturizing power improving effect of the composition for external use on the skin of the present invention was evaluated through practical use tests. The composition of Example 1 was administered to five 30- to 40-year-

After one wash, the appropriate amount of composition was applied to the first half of the face for one month, and the skin moisturizing condition of each subject was measured using a TEWA meter.

TEWL (g / h / m 2) Initial value 2 weeks 4 weeks Production Example 1 18 16.5 16.4

As can be seen from Tables 3 and 4, Production Example 1, which is a composition containing phosphatidylcholine and lysophosphatidylcholine as an active ingredient, has excellent skin moisturizing effect and wrinkle-reducing effect.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art without departing from the spirit and scope of the invention. There will be. The invention is not limited by these variations and modifications, but is limited only by the claims appended hereto.

Claims (15)

A cosmetic composition for skin elasticity enhancement comprising a phosphatidylcholine and a lysophosphatidylcholine mixture, a preservative, purified water and benzyl alcohol,
The amount of the phosphatidylcholine and lysophosphatidylcholine mixture is 1 to 3% by weight in the total composition,
Wherein the mixture of phosphatidylcholine and lysophosphatidylcholine is 90 to 95: 1 to 4 by weight.
delete delete The cosmetic composition for skin elasticity enhancement according to claim 1, wherein the preservative is at least one compound selected from the group consisting of phenoxyethanol, methylparaben, ethylparaben, butylparaben, and propylparaben
The cosmetic composition for skin elasticity enhancement according to claim 1, wherein the preservative is a mixture of phenoxyethanol, methylparaben, ethylparaben, butylparaben, and propylparaben
The cosmetic composition for enhancing skin elasticity according to claim 1, wherein the preservative comprises 0.3 to 0.4% by weight
The cosmetic composition for enhancing skin elasticity according to claim 1, wherein the benzyl alcohol comprises 0.8 to 1% by weight
The cosmetic composition for skin elasticity enhancement according to claim 1, wherein the composition comprises carnitine
delete delete (1) preparing a mixture of phosphatidylcholine and lysophosphatidylcholine
(2) placing the mixture in purified water and stirring,
(3) a step of adding a preservative and stirring,
(4) adding benzyl alcohol and stirring,
(5) filling the mixture through the steps (1) to (4) into a filling container while stirring the mixture;
A method for producing a cosmetic composition for skin elasticity enhancement comprising 12. The cosmetic composition for enhancing skin elasticity according to claim 11, wherein the amount of the phosphatidylcholine and lysophosphatidylcholine mixture is 1 to 3% by weight of the total composition
12. The cosmetic composition for enhancing skin elasticity according to claim 11, wherein the preservative comprises 0.3 to 0.4% by weight
12. The cosmetic composition for skin elasticity enhancement according to claim 11, wherein the benzyl alcohol comprises 0.8 to 1% by weight
12. The method of manufacturing a cosmetic composition for skin elasticity enhancement according to claim 11, further comprising the step of adding carnitine in the middle of steps (3) and (4)