KR101580826B1

KR101580826B1 - Scaffold made of electroactive polymer for bone healing and method for manufacturing thereof

Info

Publication number: KR101580826B1
Application number: KR1020150060184A
Authority: KR
Inventors: 장승환; 정경채
Original assignee: 중앙대학교 산학협력단
Priority date: 2015-04-29
Filing date: 2015-04-29
Publication date: 2015-12-30

Abstract

In a scaffold, a technique for promoting cell growth in a living body region to which a scaffold is adhered can be promoted through various stimuli, thereby providing a technique for inducing substantial cell growth and improving treatment efficiency. A scaffold for fracture treatment using an electroactive polymer according to an embodiment of the present invention includes an electroactive polymer material having biocompatibility that prevents resistance by foreign substances when attached to a body, As a scaffold, it is configured such that electrical stimulation can be applied to cells attached to a scaffold using electrical energy generated by an electroactive polymer material when mechanical stimulation from the outside is applied, or a current induced by an external electric field Wherein the scaffold is mechanically deformed to give a stimulus to cells attached to the scaffold.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a scaffold for treating fractures using an electroactive polymer and a method for manufacturing the scaffold,

The present invention relates to a scaffold that is artificially manufactured for tissue formation and treatment through control of cell function. More specifically, the present invention relates to a scaffold used for treatment of fracture and the like, On the other hand, the present invention relates to a technique for enhancing the efficiency of stimulation applied to cells, thereby promoting differentiation and proliferation of cells.

Various medical devices have been studied to improve the efficiency of treatment by promoting bone growth in medical fields such as fracture treatment. Among them, a scaffold is a device attached to a human organ, particularly a bone, and capable of promoting the growth of human cells such as bone tissue, and has recently been used in various treatment fields such as fracture treatment.

Scaffolds are devices that attach to organs and tissues of the human body and must be biocompatible and have conditions that allow cells to attach and propagate on the scaffold to form equivalents of tissue or organ.

For this purpose, Korean Patent No. 0791512 and the like disclose a therapeutic scaffold, a nanostructure complex, and the like, and provide technical features for treatment of the scaffold. In particular, a composite membrane of nanostructures and a porous scaffold are provided to show a technique showing excellent bone cell response.

The above-described conventional scaffold-related technology is a technique for chemically accelerating osteoclast activation by a component coated on the outer surface of a scaffold, and there is a limitation in practically promoting the differentiation and proliferation of bone cells .

That is, since the rate of growth of the cells in the living body to which the scaffold is attached is limited and the adaptability to various sites and cells is insufficient, the efficiency of treatment is inadequate, and accordingly, the cost and time consumed for treatment are increased Problems have been pointed out.

Accordingly, the present invention provides a technique for enhancing the efficiency of treatment by inducing substantial cell growth by providing a technique for promoting the promotion of cells in a living body region to which a scaffold is adhered by various stimuli in a scaffold It has its purpose.

In order to accomplish the above object, according to one embodiment of the present invention, there is provided a scaffold for fracture treatment using an electroactive polymer, comprising: a biocompatible electroactive polymer material for preventing resistance by foreign substances when attached to a body; Wherein the scaffold is attached to a body, and when an external stimulus is applied, electrical stimulation is applied to the cells attached to the scaffold using electrical energy generated by the electroactive polymer material do.

Meanwhile, a method for manufacturing a scaffold for fracture treatment using an electroactive polymer according to an embodiment of the present invention includes: preparing a biocompatible electroactive polymer material that prevents resistance by foreign substances when attached to a body; ; And a step of preparing a scaffold using the material prepared by the mixing step.

According to the present invention, not only a direct mechanical stimulation but also a mechanical stimulation of an electroactive polymer contained in a scaffold is converted into electrical energy, thereby giving electrical stimulation to a body part such as a fractured part with a scaffold attached thereto , The function of the damaged cells is revitalized, the wound healing and the nerve regeneration are positively influenced, and the treatment efficiency is enhanced.

FIG. 1 is a view for explaining an example in which a scaffold for fracture treatment using an electroactive polymer according to an embodiment of the present invention is attached to a fracture portion. FIG.
2 is a detailed configuration example of a scaffold for fracture treatment using an electroactive polymer according to an embodiment of the present invention.
3 is a cross-sectional view of a portion of a scaffold for fracture treatment using an electroactive polymer according to an embodiment of the present invention.
4 is a view for explaining an example in which a power supply means is attached to a body to perform another function of a scaffold for fracture treatment using an electroactive polymer according to an embodiment of the present invention;

Hereinafter, a scaffold for fracture treatment using an electroactive polymer according to an embodiment of the present invention will be described with reference to the accompanying drawings.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in detail with reference to the accompanying drawings. The following examples are intended to illustrate the present invention and should not be construed as limiting the scope of the present invention. Accordingly, equivalent inventions performing the same functions as the present invention are also within the scope of the present invention.

In the following description, the same reference numerals denote the same components, and unnecessary redundant explanations and descriptions of known technologies will be omitted.

1 is a view for explaining an example in which a scaffold for fracture treatment using an electroactive polymer according to an embodiment of the present invention is attached to a fracture portion.

Referring to FIG. 1, a scaffold 10 for treating fractures using an electroactive polymer according to an embodiment of the present invention may be located between bones as, for example, a site A where a fracture occurs. FIG. 1 illustrates that the scaffold 10 is located at the fracture site A between the bones 20 for the purpose of regenerating the osteocyte due to the fracture.

However, it will be understood that the scaffold 10 according to the present invention can be installed in all therapeutic and regenerating parts of the body that require cell regeneration and nerve regeneration in addition to the above examples.

The scaffold 10 for fracture treatment using an electroactive polymer according to an embodiment of the present invention is made of a material attachable to the body.

Meanwhile, the scaffold 10 is characterized in that a biocompatible electroactive polymer material is included for performing the function of the present invention. An electroactive polymer material refers to a material that generates mechanical motion when an electrical stimulus is applied and generates electrical energy when a mechanical stimulus is applied.

On the other hand, the electroactive polymer material should include biocompatibility for the function and safety of the installation position and purpose of the scaffold 10. For this purpose, the electroactive polymer material included in the scaffold 10 may include at least one of materials such as polyaniline and polypyrrole.

Such a material functions as a biocompatible material that prevents resistance from being recognized as foreign matter when attached to the body.

Since the scaffold 10 includes the biocompatible electroactive polymer material as mentioned above, when the scaffold 10 is applied with external stimuli, for example, a walking load or the like, Electrical energy is generated by the active polymer material. The scaffold 10 is configured so that electrical stimulation can be applied to the body to which the scaffold 10 is attached as it is converted to an electrical stimulus by an additional configuration.

In order to apply the electric energy generated by the electroactive polymer material to the body, the scaffold 10 according to an embodiment of the present invention may further include a scaffold 10 (Not shown) that converts electric charges generated from the electroactive polymer material included in the scaffold 10 into electrical energy and applies electrical stimulation to the cells provided with the scaffold 10. [

Electrodes must also be biocompatible because they must prevent resistance from being recognized as foreign matter from the body. For example, a pure gold or biocompatible conductive polymer may be included in the scaffold 10 as an electrode.

Such a scaffold 10 may be prepared by first preparing a biocompatible electroactive polymer material as described above, and then manufacturing the scaffold 10 by mixing the prepared material in various manners. In addition, the above-mentioned scaffold 10 can be manufactured by a process of applying a biocompatible electrode to the outer surface of the manufactured scaffold 10. [

On the other hand, as an additional configuration, the present plate 30 or the like may be included to support the fracture portion A.

According to the present invention, the scaffold 10 includes an electroactive polymer material and an electrode. When a mechanical stimulus such as a walking load is generated on a body part where the scaffold 10 is installed, an electric energy is generated by the electroactive polymer material and the electrode can transmit the body part including the cell.

Accordingly, in addition to mechanical stimulation, electrical stimulation is applied to the treatment target region. Electrical stimulation can have a significant impact on cell adhesion, proliferation, and differentiation, while at the same time reversing the function of damaged cells, and positively affect wound healing and nerve regeneration.

According to the present invention, electric energy is generated in the scaffold 10 itself attached to an internal treatment target site, and is transmitted to the treatment target site through the electrode, without a separate device installed inside from the outside of the body, It is advantageous to stimulate differentiation and proliferation of cells by stimulating surrounding cells only by a simple constitution, thereby greatly increasing treatment efficiency.

FIG. 2 is a detailed configuration example of a scaffold for fracture treatment using an electroactive polymer according to an embodiment of the present invention. FIG. 3 is a cross-sectional view of a part of a scaffold for fracture treatment using an electroactive polymer according to an embodiment of the present invention. Fig.

Referring to FIG. 2, the scaffold structure 11 is shown as being capable of scraping the tissue of the porous scaffold. The scaffold structure 11 may comprise a biocompatible electroactive polymer material as described above and additionally a biocompatible electrode.

3, one end surface of the scaffold structure 11 is shown. As shown in FIG. 3, one end face of the scaffold structure may comprise a scaffold body 12 and an electrode 13.

The scaffold body 12 has a configuration including a biocompatible electroactive polymer material in the structure of a scaffold. The scaffold body 12 is attached to a tissue to support a target site to be treated, stimulates the stimulation of the cell, .

On the other hand, the electrode 13 is composed of a biocompatible material as mentioned above, and transfers electrical energy generated by mechanical stimulation to the scaffold body 12 to the body part in a state where it is not harmful to the body , And to perform electrical stimulation to the cells of the target site.

4 is a view for explaining an example in which a power supply means is attached to a body to perform another function of a scaffold for fracture treatment using an electroactive polymer according to an embodiment of the present invention.

Referring to FIG. 4, additional functions and effects can be expected when the power supply means 40 is attached to the body. In other words, it is assumed that an external power supply means 40 such as a stator structure is attached so as to supply an induced current to the scaffold 10 attached to the bones 20 of the body.

In this case, when an induced electromotive force is generated from the external power supply means 40, an induced current is supplied to the electroactive polymer material contained in the scaffold 20. In this case, depending on the nature of the electroactive polymer material, Mechanical motion occurs.

When electric energy is supplied to the scaffold 20 wirelessly from the external power supply means 40 as in this example, the electroactive polymer material contained in the scaffold 20 generates electric energy (induced current in the above example) So as to apply mechanical stimulation to the cells attached to the scaffold 20.

In this case, even when the user does not move, a mechanical stimulus can similarly be applied to the cell, such as during walking, and thus the cell stimulation can be more effectively implemented using the scaffold 20 according to the present invention .

While the present invention has been described in connection with what is presently considered to be the most practical and preferred embodiments, it is to be understood that the invention is not limited to the disclosed embodiments. That is, within the scope of the present invention, all of the components may be selectively coupled to at least one.

It is also to be understood that the terms such as " comprises, "" comprising," or "having ", as used herein, mean that a component can be implanted unless specifically stated to the contrary. But should be construed as including other elements. All terms, including technical and scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, unless otherwise defined. Commonly used terms, such as predefined terms, should be interpreted to be consistent with the contextual meanings of the related art, and are not to be construed as ideal or overly formal, unless expressly defined to the contrary.

The foregoing description is merely illustrative of the technical idea of the present invention, and various changes and modifications may be made by those skilled in the art without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are intended to illustrate rather than limit the scope of the present invention, and the scope of the technical idea of the present invention is not limited by these embodiments. The scope of protection of the present invention should be construed according to the following claims, and all technical ideas within the scope of equivalents should be construed as falling within the scope of the present invention.

Claims

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A scaffold attached to a body comprising an electroactive polymer material having biocompatibility that prevents resistance by foreign matter when attached to a body,
Wherein electrical stimulation is applied to cells attached to the scaffold using electrical energy generated by the electroactive polymer material when mechanical stimulation from the outside is applied,
Wherein external electrical power supply means attachable to the body is attached to the body and electrical energy is supplied to the scaffold from the external power supply means such that the electroactive polymer material contained in the scaffold uses the electrical energy Wherein the scaffold is configured to apply mechanical stimulation to cells attached to the scaffold.

3. The method of claim 2,
The electroactive polymer material may be a polymer electrolyte,
Polyaniline, and polypyrrole. &Lt; RTI ID = 0.0 > 11. < / RTI >

3. The method of claim 2,
And a biocompatible electrode applied to the outside of the scaffold to convert electrical charges generated from the electroactive polymer material into electrical energy to apply electrical stimulation to the body. Scaffold.

5. The method of claim 4,
The biocompatible electrode may be formed of a metal,
A biocompatible metal, and a biocompatible conductive polymer. The scaffold for treating fractures using the electroactive polymer according to claim 1,

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