KR101376977B1 - Automated management system for pollution-infection prevention of laboratory animals - Google Patents

Abstract

The present invention relates to an automatic management system for preventing contamination and infection of experimental animals. The automatic management system of the present invention comprises a placing frame, an aseptic growing room, a taking-in and the taking-out unit, and an aseptic working plate. Th placing frame has a structure for allowing water supply. Growing cages for growing animals therein are placed in a row type on the placing frame. The placing frame is installed along the length of any one wall surface or both wall surfaces selected from left and right wall surfaces in an inner space of the aseptic growing room. The aseptic growing room has a doorway. The aseptic growing room has a structure for allowing an aseptic environment, thereby preventing contamination and infection of animals grown in the growing cages. The taking-in and the taking-out unit is installed at one side of the placing frame or between the placing frames in the aseptic growing room. The taking-in and the taking-out unit is movable in X, Y, and Z axis directions with respect to the placing frame to thereby perform the taking-in or taking-out the growing cases placed on the placing frame. The aseptic working plate has an aseptic environment and has a structure for allowing opening and closing in both directions. The aseptic working plate is detachably installed at the gateway while being connected with the taking-in and the taking-out unit, thereby preventing contamination and infection by a manager of the animals in the growing cages entering or exiting from the aseptic growing room. According to the present invention, the experimental animals can be aseptically grown by previously preventing contamination and infection of the experimental animals due to entrance or exit of the manager, thereby removing odors and thus maintaining a clean growing environment, and obtaining reliability and safety of experimental data.

Description

AUTOMATTED MANAGEMENT SYSTEM FOR POLLUTION-INFECTION PREVENTION OF LABORATORY ANIMALS}

The present invention relates to an automatic management system for preventing contamination and infection of laboratory animals, and more particularly, contamination and contamination of laboratory animals due to the prevention of contamination and infection of laboratory animals due to the administrator's entry into and out of the animal. The present invention relates to an automatic management system for preventing contamination and infection of experimental animals, which can maintain a clean breeding environment by removing substances and odors, thereby obtaining reliability and safety of experimental data.

Recently, the development of biotechnology has raised experimental animals, and clinical trials, toxicity trials, safety trials, breeding and breeding have been actively conducted.

In particular, the breeding of experimental animals in clinical and safety experiments has many differences in reliability and safety of experimental data depending on the breeding environment, and requires a pleasant sterile environment without contamination and infection.

To this end, disinfection facilities such as air showers, water showers, and pass rooms, and aseptic equipment such as gloves, torches, hoods, coverings, and protective glasses are installed at the entrances of the kennels to prevent contamination and infection in the kennels. Pollution and infection accidents caused by entry and exit are a common occurrence.

For example, Korean Patent Publication No. 10-1161298 discloses a barrier for invading or discharging bacteria for each breeding cage, thereby confirming forced ventilation into the breeding cage, and carrying the cage out of the breeding rack. A laboratory animal breeding device is disclosed which enables to maintain forced ventilation in a breeding cage, and in which a plurality of breeding cages can be placed in the breeding rack.

However, the above-described technology can cause contamination of experimental animals and infections due to the access of the manager, and thus, not only can the reliability and safety of the experimental data be obtained, but also the access of the manager is required when entering and exiting the cage. There is a problem of low batch density.

Korean Patent Publication No. 10-1161298, "Experimental Animal Breeding Device"

The present invention is to solve such a problem, the contamination of the experimental animals due to the administrator's entry, infection is pre-blocked to enable the sterile breeding of the experimental animals to remove contaminants and odors in the breeding space to maintain a clean breeding environment In addition, the present invention provides an automatic management system for preventing contamination and infection of laboratory animals, thereby obtaining reliability and safety of experimental data.

In addition, it is an automatic management system for preventing contamination and infection of experimental animals that have a large batch density even in a narrow breeding area, as it does not require a manager's entrance and exit as a means of entering and exiting cages and their cages. To provide.

The automatic management system for preventing contamination and infection of the experimental animals of the present invention for achieving the above object has a structure capable of supplying water and the settle frame so that the breeding cages are raised in the breeding animals breeding animals; The settle frame is installed along the length of any one or all of the left and right walls of the interior space along the length, has a doorway and has a structure capable of aseptic environment, contamination, infection of the breeding animals in the breeding cages Aseptic kennels to be prevented; An entrance and exit means installed in one side of the settle frame or the settle frame of the aseptic rearing room, and installed to be movable in the X, Y, and Z axis directions with respect to the settle frame so as to enter and rear the cages settled in the settle frame; And a sterile environment, which has a structure capable of opening and closing on both sides, and is detachably installed at the entrance to be connected to the entry and exit means, so that the breeding animals of the breeding cages entering and leaving the sterile cage are prevented from being contaminated and infected by the manager. Worktable; is configured to include.

The access means is the X frame is installed on the floor of the aseptic cage in the longitudinal direction of the settle frame, the Y frame is installed on the bottom of the X frame, fitted to the Y frame is installed in the Y frame to move up and down or Rotating Z frame, one end of the Z frame is installed so as to be movable before and after, the width is adjustable to be installed, it is preferable to pick up the cage cage fed in and out of the aseptic cage.

In addition, the access means is a base having a structure that can be moved indoors of a sterile room, a clamp portion that is installed to be adjustable width at a predetermined distance from the base, one end of the clamp portion and the other end is rotatably installed with the upper portion of the base It is preferable that a plurality of articulated limbs be picked up so as to pick up the cages fed from and out of the aseptic cage.

In addition, it is preferable that the imaging unit is further installed in the tongs to monitor the breeding animals.

In addition, the inside of the sterile breeding room, through the air supply and exhaust air conditioning means, sterilization means to remove contaminants and odors generated during the breeding of the test animal, it is preferable to supply sterile air which is always maintained at a constant temperature.

In addition, the breeding cages, it is preferable to install and manage each of the identification means containing the information of the breeding animals.

According to the present invention by the above solution, contamination and infection of the experimental animal due to the administrator's entry and exit is pre-blocked, so that the sterile breeding of the experimental animal can be removed to maintain a clean breeding environment by removing contaminants and odors in the breeding space. Therefore, the reliability and safety of the experimental data can be obtained.

In addition, as the entry and exit means for entering and rearing the cages and the cages that are placed in a row type, there is no effect of the administrator, there is also the effect of having a large batch density even in a narrow breeding room area.

1 is a plan sectional view of an automatic management system for preventing contamination and infection of experimental animals of the present invention.
Figure 2 is a left side cross-sectional view of the automatic management system for preventing contamination of the experimental animals of the present invention.
Figure 3 is a front sectional view of the automatic management system for preventing contamination of the experimental animals of the present invention.
Figure 4 is a detailed view of the entry and exit means of the automatic management system for preventing contamination of the experimental animals of the present invention.
5 is a view showing another example of the front cross-sectional view of the automatic management system for preventing contamination of the experimental animals of the present invention.
Figure 6 is a view showing a detailed example of another example of the entry and exit means of the automatic management system for preventing contamination of the experimental animals of the present invention.

The automatic management system for preventing the contamination and infection of the experimental animals of the present invention is configured to allow the entry and exit of experimental animals without the administrator's access, in order to prevent the contamination and infection of the experimental animals in advance,

Breeding cages were placed in an alliance type so as to have a large batch density even in a small breeding room area, but were configured to be accessible to the outside through an access means.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

1 is a plan sectional view of an automatic management system for preventing contamination and infection of a test animal of the present invention, Figure 2 is a left sectional view of an automatic management system for preventing contamination and infection of a test animal of the present invention, Figure 3 is 4 is a front sectional view of an automatic management system for preventing contamination and infection of an experimental animal, and FIG. 4 is a detailed view of an entry and exit means of an automatic management system for preventing contamination and infection of an experimental animal of the present invention, and FIG. 6 is a view showing another example of the front sectional view of the automatic management system for pollution and infection prevention, Figure 6 is a view showing a detailed view of another example of the entry and exit means of the automatic management system for pollution and infection prevention of experimental animals of the present invention.

As shown in Figures 1 to 6, the automatic management system for preventing contamination of the experimental animals of the present invention is settle frame 10, sterile breeding room 20, access means 30, aseptic working table 40 Is done.

As the settle frame 10 is shown in Figures 1 to 3, has a structure capable of supplying water and is made in a grid shape so that the breeding cages (11) in which the breeding animals are raised in the inner space are placed in an alliance type. It is preferable that the size is determined according to the area of the aseptic breeding room 20 so as to have a wide batch density even in a narrow area.

In this case, the breeding cage 11 has an inner space in which an experimental animal is bred and is partially opened, and is made of a cover (not shown) for opening and closing the opening, and the breeding cages 11 each contain information about the breeding animal. It is preferable to install and manage the containment identification means 80.

Here, the identification means 80 is preferably any one selected from a barcode, QR code, RFID tag.

In addition, a water supply device (not shown) is installed in the interior space of the settle frame 10 so as to be connected to the breeding cages 11, and the water supply device (not shown) is a Korean registered patent registered by the present applicant in advance. Publication No. 10-0932112, 'water supply valve device of the cage for animal breeding' is preferably used.

The water supply device (not shown) is a water supply valve means (not shown) for supplying the drinking water of the water supply line when the animal of the breeding cage licking one end with a tongue, and a water supply valve to surround one end of the water supply valve means (not shown) Cap member (not shown) and cap member (not shown) installed to be detachably fitted to the means (not shown) to block the leaked water from entering the cage when the water leakage occurs in the water supply valve means (not shown) and the cap member ( Not shown) is configured to include a discharge hole for discharging the leaked water to the outside of the breeding cage will be omitted in the present invention.

As shown in Figures 1 to 3, the sterile breeding room 20 has a structure in which the six sides are closed with the entrance 21, the settle frame 10 is selected from any one of the left and right walls of the interior space or It is installed along the length of the whole wall.

At this time, it is preferable that the air curtain 23 is further installed at the upper end of the doorway 21.

The sterile breeding room 20 has a structure of a sterile environment to prevent contamination and infection of the breeding animals bred in the breeding cages 11.

In order to have a sterile environment, the sterile breeding room 20 is provided with an air supply / exhaust air conditioning unit 60 and a disinfection means 70 to remove contaminants and odors generated when breeding experimental animals, as well as to maintain a constant temperature at all times. It is desirable to supply sterile air which is

The air supply and exhaust air conditioning means 60 is composed of one or more air supply 61, the exhaust port 63, the air supply 61 is installed to be embedded in the ceiling of the aseptic breeding room 20, the air supply blower (not shown) It is a structure for supplying air at a constant temperature at all times through the air supply pipe (not shown) by the exhaust pipe, the exhaust port 63 is buried in one or more selected walls of the wall of the aseptic chamber 20 It is installed to discharge the contaminated air of the aseptic breeding chamber 20 through the exhaust pipe (not shown) by the exhaust blower (not shown).

At this time, one end of the air supply pipe (not shown) and the exhaust pipe (not shown) are provided with a hepa filter (not shown), respectively, to filter the pollutants of the air supplied through the air supply port 61 to supply clean air, and the exhaust port It is preferable to filter the contaminants of the air discharged through the 63 to remove the contaminants and to discharge them to the outside.

The disinfection means 70 is installed to be buried in the ceiling of the aseptic breeding room 20 to enable the spraying or mixing of the disinfectant using a conventional UV lamp, or is connected to the air supply and exhaust air conditioning means 60 It is preferable to remove contaminants and odors in the sterile breeding room 20.

As shown in FIGS. 3 to 6, the access means 30 is installed with one side or the settle frame 10 between the settled frame 10 of the sterile breeding room 20, and placed in the settled frame 10. On the other hand, it is provided so as to be movable in the X, Y, Z-axis direction, and the breeding cages 11 placed in the settle frame 10, without entering and exiting the manager.

Here, the entry and exit means 30 is preferably installed in a control room (not shown) provided in the outside of the sterile breeding room 20 under the control of an administrator.

Through this, it is possible to prevent the contamination and infection of the laboratory animals due to the access of the administrator in advance, and it is possible to enter and exit the laboratory animals without the administrator's access.

At this time, the access means 30 is shown in Fig. 3, 4, receives the power from the outside, X frame 31 is installed on the bottom of the aseptic nursery room 20 in the longitudinal direction of the settle frame 10 The Y frame 32 installed on the X frame 31 to be installed from the bottom, the Z frame 33 installed on the Y frame 32 to move up or down or rotate along the Y frame 32. It is made of a tongs portion 35 which is installed to be movable front and rear at one end of the Z frame 33, the width adjustable, or

5 and 6, the base 36 having the indoor movable structure of the sterile breeding room 20, the clamp portion 35 is installed to be adjustable width at a predetermined distance from the base 36. , One end of the tongs 35 and the other end is composed of a plurality of joints (37) rotatably installed with the upper portion of the base 36, the breeding cage (11) entering and exiting the aseptic breeding room (20) It is preferably made to pick up.

Here, it is preferable that the tong unit 35 is further provided with an imaging means 50 to monitor the breeding animals in the management room (not shown).

1 to 3, the sterile work bench 40 is a double-sided opening and closing structure, as shown in Figure 1 to 3 is installed detachably to the entrance 21 to be connected to the entry and exit means 30 aseptic nursery room 20 Breeding animals of the breeding cages 11 are extracted from the pollution and infection caused by the manager is made to wait.

Here, the sterile work table 40 has an internal space to allow the entry and exit of the breeding cages 11 through the entry and exit means 30 under the control of the manager, and has a work outlet entrance 41 on the front and rear surfaces.

At this time, it is obvious that the aseptic working table 40 is provided with an air supply blower (not shown) and a hepa filter (not shown) to supply sterile air to the internal space in which the breeding cages 11 wait.

As described above, the present invention removes contaminants and odors in the breeding space by pre-blocking the contamination and infection of the experimental animals due to the administrator's entry and exit, thereby maintaining a clean breeding environment, and thus experimenting. It is possible to obtain the reliability and safety of the data, and the feeding cages that are placed in a row and the feeding cages are not required for the administrator, and have a large batch density even in a narrow breeding area.

According to the present invention, the contamination and infection of the experimental animals due to the access of the administrator is pre-blocked, so that the sterile breeding of the experimental animals is possible, thereby removing contaminants and odors in the breeding space to maintain a clean breeding environment, and thus, experimental data. It provides automatic management system to prevent contamination and infection of laboratory animals that can obtain reliability and safety.

In addition, it is an automatic management system for preventing contamination and infection of experimental animals that have a large batch density even in a narrow breeding area, as it does not require a manager's entrance and exit as a means of entering and exiting cages and their cages. to provide.

10: Settle frame
11: Breeding cage
20: Aseptic breeding room
21: entrance
23: air curtain
30: access means
31: X frame
32: Y frame
33: Z frame
35: clip part
36: bass
37: joint
40: Aseptic workbench
41: workbench entrance
50: Video means
60: air supply and exhaust air conditioning means
61: air supply
63: exhaust vent
70: disinfection means
80: identification means

Claims (6)

A settling frame 10 having a structure capable of supplying water and allowing the breeding cages 11 in which the breeding animals are raised to be placed in an alliance type;
The settle frame 10 is installed along the length of any one or all of the left or right wall surface of the inner space along the length, has a doorway 21 and has a structure capable of aseptic environment, to the breeding cages 11 Aseptic breeding room 20 to prevent contamination, infection of the breeding animals to be bred;
It is installed with one side or the settle frame 10 between the settle frame 10 of the aseptic nursery chamber 20, with respect to the settle frame 10, is installed to be movable in the X, Y, Z axis direction settle frame Entry and exit means 30 for entering and exiting the breeding cages 11 enclosed in 10; And
It has a sterile environment, the structure is possible to open and close both sides, connected to the entry and exit means 30 is installed detachably at the entrance 21, the breeding animals of the breeding cages 11, which is entered and exited from the aseptic breeding room 20 manager It is configured to include;
The access means 30 is a base 36 having a structure capable of moving indoors of the aseptic breeding room 20, a tong part 35 installed at a predetermined distance from the base 36 at a predetermined distance, and one end of the tongs Part 35 and the other end is composed of a plurality of joints (37) rotatably installed with the upper portion of the base 36, to pick up the breeding cage 11 entering and exiting the sterile breeding room (20) Features,
The clip unit 35 is an image management means 50 is further installed, the automatic management system for preventing contamination and infection of experimental animals, characterized in that the monitoring of the breeding animals. delete delete delete According to claim 1, The interior of the sterile breeding room 20, through the air supply and exhaust air conditioning means 60, disinfection means 70 to remove contaminants and odors generated during the breeding of the experimental animals, as well as always at a constant temperature Automatic management system for preventing contamination and infection of laboratory animals, characterized by supplying sterile air to be maintained. The automatic management system of claim 1, wherein the breeding cages (11) further install and manage identification means (80) each containing information about a breeding animal.

Images