KR101231421B1 - Non-invasive cardiovascular health screening system - Google Patents

Abstract

PURPOSE: A noninvasive health screening system for cardiovascular diseases is provided to screen patients who need anglocardiography with a noninvasive test, thereby preventing a waste of unnecessary tests. CONSTITUTION: A noninvasive health screening system for cardiovascular diseases comprises the following steps: A disposable sensor(150) is adhered noninvasively to a patient body. An impedance cardiograph(100) measures blood pressure, Stroke Volume, and TPRI of a patient. A computer system(200) is connected to the impedance cardiograph. A database saves data obtained from the impedance cardiograph. A blood pressure classification module classifies blood pressure data into hypertension and normal. A TPRI classification module classifies IPRI data into normal and abnormal excess. The first judgement module classifies and classifies a patient into a danger group and a non-danger group.

Description

Non-Invasive Cardiovascular Health Screening System for Non-invasive Cardiovascular Disease

The present invention relates to a health screening system for cardiovascular disease, and more particularly, to a health screening system for diagnosing a cardiovascular disease state of a patient by non-invasive and to determine the extent of future measures.

The cause of a different person can be roughly classified into accidents and diseases. Among them, except for infectious diseases and incurable diseases such as cancer, cardiovascular diseases such as stroke and heart attack are the biggest causes. Such cardiovascular disease is not impossible to predict and prevent by the usual diagnosis, but in patients concerned with myocardial infarction, in the case of cardiovascular angiography, which is widely used as a recommended diagnostic method, the contrast agent is administered by invading blood vessels. On the other hand, life threats caused by physical and mental pain of patients, cost burden of millions of won, and side effects are being raised. However, when there is a risk of developing vascular disease through such angiography, physical assistive devices are inserted into the blood vessels, and thus it may be recommended to patients at high risk. The problem is that it is not easy to determine whether it is a high-risk group, so the judgment that it belongs to a high-risk group is widely applied, even if such a procedure is not essential.

In addition, the recommended medical examination for patients with concern for myocardial infarction is ultrasound, diagnosis of vascular thickness due to Doppler effect (Carotid Doppler US), electrocardiogram (EKG), exercise stress test, vascular pulse rate test. (Vascular Screening Test), 24Hrs EKG (24Hrs EKG (Holter)), 24Hrs Ambulatory BP Monitoring The burden is very large.

In addition, the determination of cardiovascular health may involve the examination of blood vessels such as the integrity of blood vessels, that is, the thickness and elasticity of blood vessels, and clogging of blood vessels by foreign substances such as harmful cholesterol LDL cholesterol. Since the high HDL cholesterol content can be determined by measuring the health of the blood to determine whether it is safe for the development of vascular diseases despite aging of the blood vessels, the above 6 items of health screening and cardiovascular angiography for cardiovascular disease The application of this to all patients with cardiovascular disease concerns would be unfavorable in many ways, with an excessive burden.

On the other hand, the diagnosis of cardiovascular disease can be judged and prescribed with high accuracy by knowing blood pressure, cardiac output and peripheral vascular resistance.However, current cardiac output and peripheral vascular resistance can be measured by inserting a catheter into the artery. Because of the invasive method of inserting the heart to the (insertion) has caused a lot of side effects there is a problem that increases the risk of the patient.

Therefore, an object of the present invention is to provide a new cardiovascular health screening system that greatly reduces the burden on the physical and mental and time and cost aspects, especially cardiovascular system with little risk of side effects using a non-invasive system, unlike conventional cardiovascular angiography. To provide a health screening system.

The present invention is provided with a non-invasive, non-invasive sensor attached to the patient's body impedance cardiograph that can measure the blood pressure (Pulse Pressure), cardiac output volume (Stroke Volume), peripheral vascular resistance index (TPRI) a database connected with an impedance cardiography and storing respective data obtained therefrom;

A blood pressure classification module for setting and storing an upper limit and a lower limit of the normal group so as to classify the blood pressure data drawn from the database into two groups of high blood pressure and normal, and classify the blood pressure data into any one of the two groups;

Peripheral for setting and storing the upper limit of the normal group and judging the peripheral vascular resistance index data to any one of the two groups so that the peripheral vascular resistance index data drawn from the database can be classified into two groups of normal and abnormal excess Vascular resistance index classification module; and

In the cardiovascular disease caused by non-invasive, characterized in that it comprises a; primary judgment module for determining the classification of the risk and non-risk group by combining the determination classification result of the blood pressure classification module and the determination classification result of the peripheral vascular resistance index classification module It can provide a health check device for.

In addition, the present invention, by combining the result of the classification classification of the blood pressure classification module and the determination result of the peripheral vascular resistance index classification module for the group determined to be non-risk group, normal, lifestyle improvement prescription subjects, lifestyle improvement and It may provide a medical examination device for non-invasive cardiovascular disease further comprises a; second judgment module for determining the classification as a drug prescription target.

In addition, the present invention, the impedance cardiography (impedance cardiography) measures the change in the amount of fluid in the cardiovascular, the database further includes the cardiovascular fluid volume data,

The upper limit of the normal group is set and stored so that the cardiovascular fluid volume data drawn from the database can be classified into two groups of normal and abnormal excess, and the cardiovascular fluid volume data is classified into one of the two groups. Cardiovascular fluid volume classification module; further comprising in the second judgment module,

 In the first judgment module, in the case of a group with abnormality in cardiovascular fluid volume for the lifestyle improvement prescription group and the lifestyle improvement and drug prescription group among the groups judged as non-risk groups, the classification is made as a diuretic prescription target group. It is possible to provide a medical examination device for non-invasive cardiovascular disease characterized in that.

In addition, the present invention, the impedance cardiography (Impedance cardiography) measures the stroke volume data (Stroke Volume) data, the database further comprises a single cardiac volume data,

The upper limit and the lower limit of the normal group are set and stored so that one-time cardiac output data drawn from the database can be classified into two groups, the abnormal vascular stiffness according to the value divided by the difference between the highest blood pressure and the lowest blood pressure, and the vascular stiffness data is stored. And further including the blood vessel stiffness classification determination module to classify and determine any one of the groups in the secondary determination module.

 Among the groups classified as the non-risk group in the primary judgment module, when blood pressure belongs to the normal group and the peripheral vascular resistance index belongs to the abnormally excessive group, when the vascular stiffness is an abnormal group, drug prescription and atherosclerosis examination are included. In the normal group, vascular stiffness can provide a medical examination apparatus for non-invasive cardiovascular disease, characterized in that it is determined to classify as a re-examination subject.

In addition, the present invention, the impedance cardiography (impedance cardiography) measures the inflammation index data, the database further comprises the inflammation index data,

Inflammation classification determination module for setting and storing the upper and lower limits of the normal group so that the inflammation index data drawn from the database can be classified into abnormal and normal 2 groups, and classifying the inflammation index data into any one of the 2 groups. And further included in the secondary determination module,

 Among the groups determined as non-risk in the primary judgment module, if blood pressure belongs to the normal group and peripheral vascular resistance index belongs to the abnormally excessive group, if the inflammatory index is the abnormal group, drug prescription and atherosclerosis screening are included. In the case where the inflammatory index is a normal group, a medical examination apparatus for non-invasive cardiovascular disease, which may be classified as a re-examination subject after a period of time, may be provided.

In addition, the present invention, the database further includes a database for storing the HDL (High Density Lipoprotein) level of the patient,

HDL numerical classification determination to set and store the upper and lower limits of the normal group so that HDL numerical data drawn from the database can be classified into abnormal and normal two groups, and to classify the HDL numerical data into any one of the two groups. A module; further included in the secondary determination module,

 Among the groups classified as the non-risk group in the primary judgment module, if the blood pressure belongs to the normal group and the peripheral vascular resistance index belongs to the abnormally excessive group, and the HDL level is the abnormal group, drug prescription and atherosclerosis screening are included. For example, when the HDL level is a normal group, a medical examination device for non-invasive cardiovascular disease, which may be classified as a re-examination subject after a period of time, may be provided.

In addition, the present invention, non-invasive, characterized in that the database for storing the High Density Lipoprotein (HDL) value is connected to the impedance cardiography, and integrally configured with the database for storing each data obtained therefrom By providing a medical examination device for cardiovascular diseases.

According to the present invention, a patient who needs a procedure such as cardiovascular angiography must be performed by a noninvasive simple test without prescribing a checkup such as cardiovascular angiography such as high risk to the patients concerned with cardiovascular disease. Since it can be screened, unnecessary waste of examination can be prevented. In particular, in view of the high cost and high risk of cardiovascular examination, the examination device of the present invention can receive cardiovascular examination without any risk at low cost.

In addition, according to the present invention, it is possible to grasp the data on the patient in real time and thus can be checked in real time, there is an effect of providing quick results compared to the conventional check-up for a long time the results of the examination.

1 is a schematic diagram showing a preferred embodiment of the present invention.
Figure 2 is a flow chart for determining a cardiovascular risk group and non-risk group by TPRI and blood pressure in a preferred embodiment of the present invention.
Figure 3 is a flow chart showing a prescription example for the non-risk group by TPRI and blood pressure in a preferred embodiment of the present invention.
Figure 4 is a flow chart for determining the prescription for the non-risk group by the TPRI, blood pressure, cardiovascular fluid in a preferred embodiment of the present invention.
Figure 5 is a flow chart for determining the prescription for the non-risk group by TPRI, blood pressure, vascular stiffness in a preferred embodiment of the present invention.
Figure 6 is a flow chart for determining the prescription for the non-risk group by TPRI, blood pressure, inflammation index in a preferred embodiment of the present invention.
Figure 7 is a flow chart for determining the prescription for the non-risk group by TPRI, blood pressure, HDL in a preferred embodiment of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

FIG. 1 illustrates a noninvasive cardiac output monitor (NICOM) 100 (manufactured by a cheetah), four disposable sensors 150, and a computer 200 connected thereto used in an embodiment of the present invention. Indicates. The NICOM 100 has a disposable sensor that can be attached to a specific part of the patient's body, for example, a major blood vessel, in a patch type, so that the patient's blood pressure, stroke volume, and peripheral blood vessels It is a new medical measuring instrument that can measure the index of vital activity of the human body related to the heart such as resistance index (TPRI) and oxygen saturation. Originally, the NICOM (100) was developed to compensate for the difficulty of medical personnel visualizing whether or not the vital activity of a critically ill patient is serious, and does not apply any invasion to the patient, and only attaches a patch type disposable sensor. It is a medical device that can check various data on the screen about 5 minutes after attaching the sensor, and is currently certified as a new medical technology in Korea. The application of the NICOM, which is used to identify the vital activity of the critically ill, is not a life-threatening general medical disease, especially a cardiovascular disease, but it is easy to collect useful data. As described above, the present invention has been completed in view of the fact that accurate diagnosis is possible through a convenient examination system without having to undergo a cardiovascular examination that has a large time, cost, and risk.

That is, when the patient maintains the state in which the disposable sensor 150 of the NICOM 100 is attached to a specific body part for 5 minutes or more, the data is transmitted from the NICOM 100 to the computer 200 to which various data are connected. And stored in the database.

The computer 200 sets the upper and lower limits of the normal group so that blood pressure data drawn from the database can be classified into three groups of high blood pressure, normal blood pressure, and low blood pressure, and stores the blood pressure data transmitted from the NICOM 100. And a blood pressure classification module for extracting data from the database and judging and classifying the data into any one of the three groups.

The blood pressure data indicate the lowest blood pressure compared to the highest blood pressure. The upper and lower limits of the normal group can be set using knowledge known in the medical field in consideration of the age group of patients undergoing NICOM screening.

In addition, even if blood pressure data is normal, the blood pressure data alone predicts the health of the blood pressure itself, and the possibility of developing a vascular disease depends on the health of blood vessels. Therefore, a peripheral vascular resistance index (TPRI) that can determine blood vessel health may be considered. There is a need. Therefore, to retrieve the peripheral vascular resistance index data transmitted and stored from the NICOM 100 to be classified into two groups of normal and abnormal excess, the computer 200 sets and stores the upper limit of the normal group and peripheral vascular resistance index data Peripheral vascular resistance index classification module to determine the classification of any one of the two groups.

If the peripheral vascular resistance index is normal, even if the blood pressure indicates high blood pressure, it is not necessary to undergo cardiovascular examination due to the health of the blood, but it is prescribed by exercise therapy, diet therapy, drug therapy, etc. to lower the blood pressure. Even if this is normal, if the peripheral vascular index is abnormally high risk, and even if the cardiovascular overhaul can be considered a special prescription, that is, exercise therapy, diet.

If the blood pressure appears to be hypertension and abnormal peripheral vascular resistance index, the risk of developing cardiovascular disease is high, so it is desirable to have a cardiovascular examination only for these patients.

Accordingly, the computer 200 includes a first judgment module that determines the classification into a risk group and a non-risk group by combining the judgment classification result of the blood pressure classification module and the judgment classification result of the peripheral blood vessel resistance index classification module, and classify it as a risk group. If so, screening may be performed for cardiovascular examination. This is because the conventional peripheral vascular resistance index is not easily invasive. Therefore, only the patients who are at high risk of the disease are screened to receive a detailed examination as compared to the case where a high blood pressure patients receive a large cardiovascular examination. It works.

The operation of the medical examination system of the present invention as described above is shown in a flow chart in FIG.

In addition, the secondary determination module for providing a prescription by further subdividing the group classified as a non-risk group in the primary determination module, the classification result of the blood pressure classification module and the peripheral vascular resistance index classification module Combining the results of the classification judgment of both, if it is normal, it is judged as healthy normal, and other high blood pressure group and peripheral vascular resistance index is normal, lifestyle, such as drug therapy, diet therapy, exercise therapy that can lower blood pressure When prescribed as an improvement target, normal blood pressure and the peripheral vascular resistance index, it can be prescribed as a lifestyle improvement target, such as diet, exercise therapy (see Figure 3).

In addition, since NICOM can measure changes in cardiovascular fluid volume, the cardiovascular fluid volume data is stored in a database so that the cardiovascular fluid volume data drawn from the database can be classified into two groups, normal and abnormal. Set and save the upper limit of the normal group, and further include the cardiovascular fluid volume classification module for judging the cardiovascular fluid volume data into any one of the above two groups in the second judgment module, which is not normal among non-risk groups. Investigate whether the group corresponds to an abnormally excessive group of cardiovascular fluid volume, and if so, may be classified as a diuretic prescription subject (see FIG. 4).

In particular, in the prescription of drugs of non-risk patients, if the index of peripheral vascular resistance belongs to the higher side, ACE inhibitors, angiotension II receptor antagonists, calcium antagonists, which are vasodilators, are prescribed. If the cardiac output is high, it is preferable to further include a module for prescribing a β-blocking agent in the second judgment module.

In addition, since the NICOM can inform the stroke volume data, the NICOM stores the data in the database and calculates the value obtained by dividing the single-stroke volume data by the difference between the highest blood pressure and the lowest blood pressure as a vascular stiffness index. The upper and lower limits of the normal group are set and stored so as to be classified into two groups, and the vascular stiffness classification determination module for classifying and determining the vascular stiffness data into any one of the two groups is further included in the secondary determination module. Prescription can be performed.

Among the groups classified as non-risk in the first judgment module, when blood pressure belongs to the normal group and the peripheral vascular resistance index belongs to an abnormally excessive group, when the vascular stiffness is an abnormal group, an ACE inhibitor as a vasodilator Prescriptions such as angiotension II receptor antagonists and calcium antagonists can be prescribed for prescribing and atherosclerosis screening, and if the vascular stiffness is a normal group, it can be classified as a retesting subject after a period of time (see FIG. 5). ).

In addition, since the NICOM can measure the inflammation index data, the upper and lower limits of the normal group to store the inflammation index data in the database, retrieve the inflammation index data from the database and classify it into abnormal and normal 2 groups Set and save, and further comprises an inflammation classification determination module in the secondary determination module for determining and classifying the extracted inflammation index data into any one of the two groups.

Accordingly, if the blood pressure belongs to the normal group and the peripheral vascular resistance index belongs to an abnormally excessive group among the groups classified as non-risk groups in the primary judgment module, the inflammation index is examined. And the atherosclerosis examination subject, and if the inflammatory index is a normal group, it may be classified and classified as a subject after relapse examination (see FIG. 6).

In addition, when prescribed in consideration of the HDL index that can be measured relatively easily, more accurate diagnosis is possible, it is possible to store the patient's HDL (High Density Lipoprotein) level in the database. The HDL index can be measured on the fly or separately, if the patient already knows it.

Accordingly, the upper and lower limits of the normal group are set and stored so that the HDL numerical data drawn from the database can be classified into abnormal and normal two groups, and the HDL numerical value is determined and classified into one of the two groups. The classification determination module is further included in the secondary determination module.

Among the groups classified as the non-risk group in the primary judgment module, if the blood pressure belongs to the normal group and the peripheral vascular resistance index belongs to the abnormally excessive group, and the HDL level is the abnormal group, drug prescription and atherosclerosis screening are included. In the case where the HDL level is a normal group, it may be determined to classify as a re-examination subject after a period of time (see FIG. 7).

A database that stores HDL (High Density Lipoprotein) levels can be built separately or can be included in a database that stores and builds data from NICOM.

Although the above embodiment has been described with respect to NICOM, other non-invasive impedance cardiography equipment for the intensive care unit may be used, for example, osypkamed's AESCULON, ICON, General Electric's impedance cardography, and COVIDIEN's products. Can be implemented.

The above-described health check-up system of the present invention, in particular, when a large number of health check-ups are used for a national health checkup that is performed in a short time, the checkup can be carried out accurately and at low cost, using medical equipment and computer systems such as NICOM. As a result, even a small number of medical staff can perform real-time medical examinations, which is very efficient.

It is to be understood that the invention is not limited to the disclosed embodiment, but is capable of many modifications and variations within the scope of the appended claims. It is self-evident.

100: NICOM
150: disposable sensor
200: computer

Claims (7)

Impedance cardiography capable of measuring pulse pressure, stroke volume, and peripheral vascular resistance index (TPRI) of the patient, including a disposable sensor that adheres non-invasively to the patient's body. cardiography);
A computer system connected with the impedance cardiography,
A database for storing respective data obtained from the impedance cardiography;
A blood pressure classification module for setting and storing an upper limit and a lower limit of the normal group so as to classify the blood pressure data drawn from the database into two groups of high blood pressure and normal, and classify the blood pressure data into any one of the two groups;
Peripheral for setting and storing the upper limit of the normal group and judging the peripheral vascular resistance index data to any one of the two groups so that the peripheral vascular resistance index data drawn from the database can be classified into two groups of normal and abnormal excess Vascular resistance index classification module; and
In the cardiovascular disease caused by non-invasive, characterized in that it comprises a; primary judgment module for determining the classification of the risk and non-risk group by combining the determination classification result of the blood pressure classification module and the determination classification result of the peripheral vascular resistance index classification module For medical examination device. The method according to claim 1, further comprising combining the results of the judgment classification of the blood pressure classification module with the results of the classification determination of the peripheral vascular resistance index classification module for a group classified as a non-risk group. Health screening device for non-invasive cardiovascular disease, characterized in that it further comprises; a second judgment module to classify the drug prescription. According to claim 2, The impedance cardiography (impedance cardiography) measures the change in the amount of fluid in the cardiovascular the database further comprises cardiovascular fluid volume data,
The upper limit of the normal group is set and stored so that the cardiovascular fluid volume data drawn from the database can be classified into two groups of normal and abnormal excess, and the cardiovascular fluid volume data is classified into one of the two groups. Cardiovascular fluid volume classification module; further comprising in the second judgment module,
In the first judgment module, in the case of a group with abnormality in cardiovascular fluid volume for the lifestyle improvement prescription group and the lifestyle improvement and drug prescription group among the groups judged as non-risk groups, the classification is made as a diuretic prescription target group. Health screening device for non-invasive cardiovascular disease, characterized in that. The method of claim 2, wherein the impedance cardiography measures the stroke volume data, and the database further includes the single-stroke volume data.
The upper limit and the lower limit of the normal group are set and stored so that one-time cardiac output data drawn from the database can be classified into two groups, the abnormal vascular stiffness according to the value divided by the difference between the highest blood pressure and the lowest blood pressure, and the vascular stiffness data is stored. And further including the blood vessel stiffness classification determination module to classify and determine any one of the groups in the secondary determination module.
Among the groups classified as the non-risk group in the primary judgment module, when blood pressure belongs to the normal group and the peripheral vascular resistance index belongs to the abnormally excessive group, when the vascular stiffness is an abnormal group, drug prescription and atherosclerosis examination are included. , Health screening device for non-invasive cardiovascular disease, characterized in that if the normal vascular stiffness group to be classified as a re-examination subject after the period elapsed. The method of claim 2, wherein the impedance cardiography measures inflammation index data, and the database further includes inflammation index data.
Inflammation classification determination module for setting and storing the upper and lower limits of the normal group so that the inflammation index data drawn from the database can be classified into abnormal and normal 2 groups, and classifying the inflammation index data into any one of the 2 groups. And further included in the secondary determination module,
Among the groups determined as non-risk in the primary judgment module, if blood pressure belongs to the normal group and peripheral vascular resistance index belongs to the abnormally excessive group, if the inflammatory index is the abnormal group, drug prescription and atherosclerosis screening are included. , Health screening device for non-invasive cardiovascular disease, characterized in that if the inflammatory index is a normal group, after the period elapsed to be classified as subject to re-examination. The method of claim 2, wherein the database further comprises a database for storing a patient's HDL (High Density Lipoprotein) levels,
HDL numerical classification determination to set and store the upper and lower limits of the normal group so that HDL numerical data drawn from the database can be classified into abnormal and normal two groups, and to classify the HDL numerical data into any one of the two groups. A module; further included in the secondary determination module,
Among the groups classified as the non-risk group in the primary judgment module, if the blood pressure belongs to the normal group and the peripheral vascular resistance index belongs to the abnormally excessive group, and the HDL level is the abnormal group, drug prescription and atherosclerosis screening are included. , Health screening device for non-invasive cardiovascular disease, characterized in that if the HDL level is normal group to be classified as a re-examination subject after the passage of time. 7. The non-invasive method of claim 6, wherein the database for storing High Density Lipoprotein (HDL) levels is integrated with a database for storing respective data obtained therefrom, coupled with impedance cardiography. Health screening device for cardiovascular disease by.

Images