KR101159513B1 - Device for collecting and injecting sample and biomedical data measurement set comprising the same - Google Patents

Abstract

The present invention has a sampling / injection mechanism having a structure that assists the measurement strip to better filter the red blood cell components of blood and also aids the rapid reaching of the red blood cells filtered out of the final reaction layer of the measurement strip. A set for measuring biometric data.

Description

Sampling / injection apparatus and set for measuring biological data including the same {DEVICE FOR COLLECTING AND INJECTING SAMPLE AND BIOMEDICAL DATA MEASUREMENT SET COMPRISING THE SAME}

The present invention relates to an improved sampling / injection device and a set for measuring biometric data comprising the same, in particular to assist the measurement strip to better filter the red blood cell components of the blood, and to provide the final reaction layer of the measurement strip. The present invention relates to a sampling / injection device having a structure for assisting the erythrocyte-filtered blood to reach quickly, and a biometric data set including the same.

Quantitative or qualitative analysis of analytes present in biological samples such as blood is important chemically and clinically. Typical examples include measuring cholesterol, which is a factor of various adult diseases, and measuring blood glucose in diabetics. As a technique for measuring biological data such as cholesterol and blood sugar, it is widely known to drop a biological sample such as blood on a measurement strip and to detect color change or electrochemical change resulting from an enzyme reaction in a reaction region.

To this end, biometric data measurement techniques for measuring analytes included in biological samples have been proposed. For example, if a blood glucose level is to be measured, a small amount of blood is injected into the measurement strip using a sampling / injection device, and then the biometric data of the blood component injected into the measurement strip is processed into biometric data. Techniques for analyzing by a measuring device, for example, a biodata measuring device of an enzyme decomposition method (photometry method) or a biodata measuring device of an electrode decomposition method (electrochemical method) have been proposed.

At this time, in order to calculate a reliable measurement result using a biometric data measuring device for processing biometric data, in order to prevent the sensing unit constituting the biometric data measuring device from being disturbed by red blood cell components, blood red blood cell components may be well-prepared. It is important to construct a set of biometric data measurements (including sample collection / injection instruments and measurement strips) that can be filtered.

In addition, in order to calculate the result value more quickly using a biometric data processing device that processes the biometric data, a biometric data measurement set is provided so that the biological sample can quickly reach the final reaction layer constituting the measurement strip. It is important to construct.

The present invention has been conceived in view of the above-mentioned points, wherein the measurement strip helps to better filter out the red blood cell components of the blood, and also the blood whose red blood cells have been separated in the final reaction layer of the measurement strip quickly It is an object of the present invention to provide a sampling / injection apparatus having a structure assisting to reach, and a set for measuring biological data including the same.

According to a first aspect of the present invention, there is provided a sampling / injection mechanism for taking a sample and injecting the sample into a strip for measuring biological data, the apparatus being formed on one side of the body portion and at the tip thereof with a capillary force And a sample accommodating part in which a gap for accommodating the biological sample is formed, wherein the gap is formed at a front end of the body of the sample accommodating part in a 'one' shape when the sample / injection device is viewed from the front side. And a groove having a diameter larger than the gap width of the gap is formed at the tip center portion of the body of the sample accommodating portion.

According to a second aspect of the present invention, there is provided a sampling / injection mechanism for taking a sample and injecting the sample into a strip for measuring biometric data, the apparatus being formed on one side of the body portion and at the tip thereof with a capillary force And a sample accommodating part in which a gap for accommodating the biological sample is formed, the body of the sample accommodating part is formed in a spherical shape, and the gap is viewed from the front side when the sampling / injection mechanism is viewed. It is formed in the shape which branches in at least 2 directions from the center part of the body front-end | tip part of the said sample accommodating part.

On the other hand, in the mechanism according to the second aspect, a groove having a diameter larger than the gap width of the gap can be formed in the central portion of the body tip portion of the sample receiving portion.

Further, according to a third aspect of the present invention, there is provided a biological data measuring strip having a sample receiving region into which a sample is injected, and a biological data measuring set including a sampling / injection apparatus according to the first or second aspect. Is provided.

The sampling / injection device of the present invention assists the measurement strip to better filter out the red blood cell components of the blood, and also to help the blood with the red blood cells separated to reach the final reaction layer of the measurement strip quickly.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a diagram schematically showing the configuration of a set for measuring biometric data according to the present invention.
2A and 2B are diagrams illustrating a sampling operation of a sampling / injection apparatus included in a set for measuring biological data according to the present invention.
Figure 3a is a view showing the structure of a measuring strip included in the set for measuring biometric data according to the present invention.
3B is a view showing a state in which the measuring strip of FIG. 3A is assembled;
4A shows the flow path of a biosample sample injected into a measurement strip.
4B shows an initial state when a biological sample is injected into the measurement strip.
5A shows the measurement strip state when blood injection is made along the normal F1 flow path.
5B shows the measurement strip state when blood injection is made along an abnormal F1 flow path.
6A is a perspective view showing a first embodiment of a sampling / injection apparatus included in a set for measuring biometric data according to the present invention;
6B-6D are side, front and top views of the sampling / injection device of FIG. 6A;
7A and 7B are views for explaining the advantageous effects of the sampling / injection apparatus according to the first embodiment of the present invention.
8A is a perspective view showing a second embodiment of a sampling / injection apparatus included in a set for measuring biometric data according to the present invention;
8B is a view for explaining the advantageous effect of the sampling / injection device according to the second embodiment of the present invention.
9A is a perspective view showing a third embodiment of a sampling / injection apparatus included in a set for measuring biometric data according to the present invention;
Figure 9b is a view for explaining the advantageous effect of the sampling / injection device according to the third embodiment of the present invention.
10A is a perspective view showing a fourth embodiment of a sampling / injection apparatus included in a set for measuring biometric data according to the present invention;
10B is a view for explaining the advantageous operation and effect of the sampling / injection device according to the fourth embodiment of the present invention.
11 is a perspective view showing a fifth embodiment of a sampling / injection apparatus included in a set for measuring biological data according to the present invention;
12 to 21 are perspective views showing various modified embodiments according to the spirit of the present invention.
22 is a perspective view showing a biological sample collection and injection device according to the prior art.

1 is a view showing the configuration of a set for measuring biometric data according to the present invention.

Referring to FIG. 1, a set for measuring biological data according to the present invention includes a measurement strip 1 in which a biological sample such as blood is injected to cause a color change or an electrochemical change, and a biological sample of a user, for example, blood And a sampling / injection device 2 for injecting the blood into the measuring strip 1. According to a preferred embodiment, the measuring strip 1 may be configured to be inserted into a separate biological data measuring device (not shown) for determining the result measured by the measuring strip (1).

The measurement strip 1 may include a measurement layer 110 that reacts with a biological sample to cause a color change or an electrochemical change, and an opening 121 that exposes a portion of the upper surface of the measurement layer 110 to the outside. Is formed on the upper cover 120 and the lower substrate 130 having an opening 131 for exposing a portion of the lower surface of the measurement layer 110 to the outside.

The sampling / injection mechanism 2 is formed at a main body 210 having a seating groove 211 formed therein for easy gripping, and at one end of the main body 210, and a biological sample is formed at a distal end thereof by capillary force. And a sample accommodating part 220 having a gap 221 accommodated therein. Meanwhile, a groove 223 having a structure in direct contact with the upper end of the measurement layer 110 of the measurement strip 1 is formed at the center portion of the gap 221.

2A and 2B, the sampling / injection device 2 will be described in more detail. In the sampling / injection device 2, the user grips the seating groove 211 with the thumb and index finger. When the gap 221 and the central groove 223 of the tip of the log are in contact with a biological sample (for example, blood 3), the blood 3 is received in the main body 210 side by capillary force. Device. In addition, as will be described later, the sampling / injection mechanism 2 is quick and easy to move the blood 3 ′ contained therein by the structure of the groove 223 having a relatively large area to the measurement layer 110 side. Injection device.

According to a preferred embodiment, the sampling / injection device 2 may be formed of any one of a transparent material of polymethyl methacrylate (PMMA), acrylic, polycarbonate, and transparent plastic. Accordingly, the user can directly check the state in which the biological sample (for example, blood) is accommodated in the sample collection / injection device 2 or the state in which the biological sample is injected from the sample collection / injection device 2 to the measurement layer 110 side. It can be confirmed by eye.

3A to 11, a specific embodiment of a measurement strip and a sampling / injection apparatus that can be applied or included in a biometric data measuring set according to the present invention will be described in detail.

[Measurement strip]

FIG. 3A is a cross-sectional view taken along line II ′ of FIG. 1 to illustrate the structure of a measuring strip 1 that may be applied or included in a biometric data set according to the present invention. 3B is a view showing a state in which the measuring strip 1 of FIG. 3A is assembled.

First, referring to FIG. 3A, the measurement strip 1 includes a measurement layer 110, an upper cover 120, and a lower substrate 130.

The measurement layer 110 is for measuring the reaction with a biological sample, and reacts with a biological sample such as blood to cause a color change or an electrochemical change.

The measurement layer 110 may be implemented by stacking the diffusion layer 111, the separation layer 113, and the reaction layer 115.

The diffusion layer 111 allows the biological sample such as blood or plasma to be injected to be spread quickly and uniformly. The diffusion layer 111 may be, for example, a woven material such as polyester or cotton or a nonwoven material such as fabric, gauze, or monofilament. non-woven fabric).

The separation layer 113 is provided at the bottom of the diffusion layer 111, and serves as a filter for filtering blood cells, such as erythrocytes, from the biological sample diffused from the diffusion layer 111. For example, the separation layer 113 filters blood cells in the blood flowing from the diffusion layer 111, and then only the serum from which the blood cells are filtered out flows to the reaction layer 115.

According to a preferred embodiment, the separation layer 113 may be implemented in the form of a pad containing glass fibers. However, the present invention is not limited thereto, and the isolation layer 113 may be implemented as a pad made of polyester, nitrocellulose, and poly-sulfonate.

The reaction layer 115 includes dry chemicals and reactants, and reacts with cholesterol to cause color change.

The upper cover 120 includes an opening 121 formed by a rim 121a recessed with a constant curvature, and a lower surface of the upper cover 120 includes a protrusion 123 protruding toward the lower substrate 130. The protrusion 123 presses the measurement layer 110 in the downward direction during assembly.

An opening 131 having a shape corresponding to the opening 121 of the upper cover 120 is formed on the lower substrate 130, and protrudes toward the upper cover 120 on the circumferential surface of the opening 131. The protrusion 133 is formed. The protrusion 133 presses the measurement layer 110 in the upward direction during assembly.

Next, referring to FIG. 3B, the measurement layer 110 is formed to have a convex upper end by pressing the measurement layer 110 in a form where the upper protrusion 123 and the lower protrusion 133 are staggered. Its lower end is flat.

In addition, in the area of the measurement layer 110, where the upper protrusion 15 and the lower protrusion 35 are shifted from each other, a vertical pressing force by the protrusion 123 and the protrusion 133 is directly transmitted. Therefore, the diffusion layer 111, the separation layer 113, and the reaction layer 115 constituting the measurement layer 110 are in intimate contact with each other. On the contrary, since the up-down pressure applied by the protrusion 123 and the protrusion 133 is transmitted to the periphery of the region B corresponding to the center of the opening 121 in the region of the measurement layer 110, The degree of compression between the diffusion layer 111, the separation layer 113, and the reaction layer 115 constituting the measurement layer 110 is relatively inferior.

4A is a view showing a flow path of a biological sample injected into the measurement strip 1, and FIG. 4B is a view showing an initial state when the biological sample is injected into the measurement strip 1.

As shown in FIG. 4A, in the outer region of the opening 121 of the measurement strip 1 applied or included in the biometric measurement set according to the present invention, the flow of the sample sample absorbed into the lower end of the measurement layer 110. (F1) and the flow (F2) of the sample sample exiting the outside of the measurement region appear simultaneously. However, in the region of the area of the measurement layer 110 where the upper protrusion 123 and the lower protrusion 133 are shifted from each other, the F1 flows due to the strong pressing force by the protrusion 123 and the protrusion 133. This master, and the F2 flow is relatively insignificant compared to the F1 flow. In addition, although the flow F3 (vertical flow) of the sample sample absorbed to the lower end of the measurement layer 110 exists around the region B corresponding to the center portion of the opening 121, the flow rate is very small.

As shown in FIG. 4B, initially, the blood is injected through the opening 121 of the measuring strip 1, and due to the convex shape on the top of the measuring layer 110, a relatively large area is formed in the outer region of the opening 121. Sheep blood is loaded. In addition, most of the blood loaded in the outer region of the opening 121 after the blood is diffused (by the diffusion layer 111) and blood cells separation (by the separation layer 113) along the path of the F1 flow, Finally, the reaction layer 115 is reached (vertical flow).

Thereafter, the blood-separated serum finally reaching the reaction layer 115 along the path of the F1 flow is spread out into the measuring region inward or outward (horizontal flow). At this time, the area around the region where the upper protrusion 123 and the lower protrusion 133 are shifted from each other (region A in FIG. 4A) among the regions of the reaction layer 115 is formed by the protrusion 123 and the protrusion 133. Due to the strong pressing force, most of the serum is introduced into the measuring region and the amount of serum flowing out of the measuring region is very small.

On the other hand, serum is continuously introduced into the reaction layer 115 along the F1 flow path (vertical flow), and the introduced serum is continuously moved in the direction inside the measurement area (horizontal flow), so that the measurement in the reaction layer 115 is performed. When the site corresponding to the region reaches the saturation state, the serum flow (horizontal flow) toward the inside of the measurement region is stopped.

In addition, when the flow of serum in the direction of the measurement region in the reaction layer 115 is stopped, the excess serum exits in the direction outside the measurement region, and thus the portion of the reaction layer 115 corresponding to the measurement region in the reaction layer 115 is stopped. The amount of biosample accumulated is kept constant.

On the other hand, a relatively small amount of blood is loaded around the region (region B in FIG. 4A) corresponding to the central portion of the opening 121 in the measurement layer 110 (measurement layer ( 110) by the convex shape at the top), and also as described above with reference to FIG. 3B, in the region B region of the measurement layer 110 that corresponds to the central portion of the opening 121, the diffusion layer 111. Since the degree of compression between the separation layer 113 and the reaction layer 115 is relatively lower than that of the outer region (area A), the blood of the F3 flow path is affected by the serum saturation of the reaction layer 115. The contribution is very small.

As such, in the measurement strip 1 applied or included in the biometric measurement set according to the present invention, the blood of the F1 flow path contributes directly to the serum saturation of the reaction layer 115.

FIG. 5A shows the state of the measurement strip 1 when blood is injected along the normal F1 flow path, and FIG. 5B shows the state of the measurement strip 1 when blood injection is made along the abnormal F1 flow path. to be.

As shown in FIG. 5A, in the measurement strip 1, in the state in which blood is injected according to the normal method, the injected blood is diffused by the diffusion layer 111, and the diffused blood is separated from the separation layer 113. After hemocytosis, the serum only reaches the reaction layer 115.

However, the F1 flow path may be abnormally deformed, for example, when a local pressing force is applied to the opening edge portion 121a in the process of injecting blood into the measurement strip 121. For example, when the opening edge 121a is locally pushed downward and the lower measurement layer 110 is forcibly compressed, the blood cells existing in the separation layer 113 (for example, red blood cells) ) May be forced into the reaction layer 115.

FIG. 5B shows a state where a part of the opening edge portion 121a of the measurement strip 1 is pressed downward strongly by a sampling / injection mechanism or the like and an abnormality occurs in the F1 flow path. That is, during the blood injection, when a part of the opening edge 121a is strongly pressed by the sampling / injection mechanism or the like, red blood cells to be filtered in the separation layer 113 are moved toward the reaction layer 115 by the pressing force. Forced pulling in occurs. The erythrocyte component forced into the reaction layer 115 acts as a major factor causing an error in the biodata measurement result.

[Sample Collection / Injection Device]

[First Embodiment]

6A is a perspective view showing a first embodiment of a sampling / injection apparatus 2 applied or included in a biometric data measuring set according to the present invention, and FIGS. 6B to 6D are sampling / injection apparatus 2, respectively. Is a side view, a front view and a plan view. Hereinafter, the X-axis direction shown in FIG. 6A is made into the side surface direction of the sampling / injection mechanism 2, the Y-axis direction is made into the front side direction of the sampling / injection mechanism 2, and the Z-axis direction is a sample. It defines in the plane side direction of the collection / injection mechanism 2. As shown in FIG.

The sampling / injection mechanism 2 is formed at a main body portion 210 having a seating groove 211 formed in a concave shape so as to be easily gripped, and at the front side end portion of the main body portion 210, and at the front end thereof is subjected to capillary force. By the biological sample, for example, the sample receiving portion 220 is formed a gap 221 is accommodated.

The sample accommodating part 220 is formed in a concave shape with the upper surface 220-1 in the planar direction and the lower surface 220-2 in the opposite direction, and has an upper surface 220-1 and a lower surface 220. The outer circumferential surface 220-3 connecting -2) is formed as a curved surface having a predetermined curvature.

As for the sample accommodating part 220, both width | variety W1 of the outer peripheral surface 220-3 is formed in the dimension larger than the center width W2 when it sees from the front side direction (refer FIG. 6C).

In addition, in the present embodiment, the curvature of the outer circumferential surface 220-3 constituting the sample accommodating part 220 is formed to have a dimension corresponding to the curvature constituting the edge portion 121a of the opening 121. Accordingly, when blood is to be injected into the measurement layer 110 of the measurement strip 1 through the sampling / injection mechanism 2, the outer circumferential surface 220-3 of the sample accommodating part 220 is stably opened. It can be seated on the edge portion 121a of the fart 121 (see FIG. 7A).

The gap 221 formed at the front end of the sample accommodating part 220 is dug in a 'one' shape from the left end to the right end when viewed from the front side direction. In particular, the gap 221 of the sample accommodating portion 220 is formed in a 'V' shape in which the width gradually decreases toward the inside when viewed from the side surface side direction. Accordingly, in collecting and accommodating blood through the sampling / injection mechanism 2, the blood may be sucked further into the sample accommodating part 220 without being buried around the outer circumferential surface 220-3. On the other hand, the V-shaped shape has the advantage that the ease of molding when the injection molding of the sample receiving portion is large.

In addition, a groove 223 having a diameter larger than the gap width of the gap 221 is formed in the central portion of the tip of the sample accommodating portion 220. The groove 223 is in direct contact with the top of the measuring layer 110 of the measuring strip 1. Accordingly, in the case of injecting blood through the sampling / injection device 2, the blood contained in the gap 221 of the sample accommodating part 220 passes through the groove 223 having a relatively large area. It can quickly flow into the measurement layer 110 of 1). According to a preferred embodiment, the groove 223 may be formed in a conical shape, the diameter of the sample receiving portion 220 toward the end portion from the end portion side.

7A and 7B are diagrams for explaining the advantageous effects of the sampling / injection apparatus according to the present embodiment.

First, referring to FIG. 7A, the sampling / injection mechanism 2 according to the present embodiment has a groove 223 having a diameter larger than the gap width of the gap 221. Since the sample is directly in contact with the upper end of the measurement layer 110 of the measurement strip 1, the blood contained in the sample accommodating part 220 flows out to the measurement strip 1 (measurement layer 110) more smoothly and quickly. can do. Thus, for example, when the measurement result of the measurement strip 1 is calculated using a biometric data measuring device (not shown), the measured result value can be derived more quickly.

In addition, in the sampling / injection mechanism 2 according to the present embodiment, the curvature of the outer circumferential surface 220-3 constituting the sample accommodating portion 220 is the curvature of the edge portion 121a constituting the opening 121. Since it has a corresponding dimension, it is very easy to mount the outer peripheral surface 220-3 of the sample accommodating part 220 to the edge part 121a of the opening 121. As shown in FIG. For example, even if the user approaches the sampling / injection device 2 from the direction toward the opening 121 side of the measurement strip 1, the curvature of the edge 121a of the opening 121 is matched. Through the outer circumferential surface 220-3 of the sample accommodating part 220 having a curvature, the sample accommodating part 220 may be mounted on the edge portion 121a of the opening 121 in a very stable manner.

Next, FIG. 7B illustrates a state in which the sample accommodating part 220 (its outer circumferential surface 220-3) of the sampling / injection mechanism 2 is seated on the edge portion 121a of the opening 121. Drawing. For reference, the region C of FIG. 7B is a portion where the groove 223 of the sampling / injection apparatus 2 and the measurement layer 110 of the measurement strip 1 come into contact with each other, and the region D of FIG. 7B is sampling / injection. It is a site where the outer circumferential surface 220-3 of the instrument 1 and the edge portion 121a of the measurement strip 1 come into contact with each other.

Referring to FIG. 7B, in the sampling / injection mechanism 2 according to the present embodiment, both side end widths W1 of the outer circumferential surface 220-3 when the sample accommodating part 220 is viewed from the front side direction are formed in the center part. Since it is formed with a dimension larger than the width W2, the pressing force transmitted from the outer circumferential surface 220-3 of the sampling / injection mechanism 2 to the edge portion 121a is almost full of the edge portion 121a. It is uniformly dispersed in the area. That is, as described above with reference to FIG. 5B, when partial pressure is applied to the edge portion 121a of the opening 121, the region of the partially pressed edge portion 121a is pressed downward, As a result, abnormalities may occur in the F1 flow path that directly contributes to the serum saturation of the reaction layer 115 of the measurement strip 1. However, in the case of using the sampling / injection mechanism 2 according to the present embodiment, the pressing force transmitted from the outer circumferential surface 220-3 of the sampling / injection mechanism 1 to the lower edge portion 121a is the opening edge portion. Since it is uniformly distributed over almost the entire area of 121a, the phenomenon in which only a part of the edge portion 121a is locally pressed can be effectively excluded.

Second Embodiment

8A is a perspective view showing a second embodiment of a sampling / injection apparatus applied or included in a biometric data measuring set according to the present invention, and FIG. 8B is an advantageous operation of the sampling / injection apparatus according to the second embodiment. It is a figure for demonstrating an effect.

The sampling / injection mechanism 2a according to the present embodiment differs from the sampling / injection mechanism 2 of the first embodiment only in the structure of the sample accommodating portion 220a, and the rest of the structure is the first embodiment. Same as the example.

On the other hand, in FIG. 8A, the X-axis direction is the side surface direction of the sampling / injection device, the Y-axis direction is the front side direction of the sampling / injection device, and the Z-axis direction is the plane side direction of the sampling / injection device. It is prescribed by.

The sampling / injection mechanism 2a is formed at a main body portion 210 having a seating groove 211 formed in a concave shape so as to be easily gripped, and at the front end side of the main body portion 210, and at the distal end thereof, a capillary force is applied. This includes a sample accommodating part 220a in which gaps 221a and 221b for receiving a biological sample, for example, blood, are formed.

As shown in Fig. 8A, the body of the sample accommodating portion 220a is formed in a shape in which the body branches in three directions at the central portion of the front end of the body when viewed from the front side direction. According to a preferred embodiment, the body of the sample accommodating portion (220a) can be configured in the shape of '十' when viewed from the front side direction.

In more detail, the body of the sample accommodating part 220a includes a first body 220a-1 and a first body 220a-1 having a gap 221a for accommodating a biological sample by capillary force. It consists of the 2nd body 220a-2 formed in the shape which rotated 90 degrees about the axis | shaft of the front side direction of the collection / injection mechanism 2a.

In addition, the curvature of the outer peripheral surfaces 220a-1a and 220a-2a constituting the first body 220a-1 and the second body 220a-2 corresponds to the curvature of the edge 121a of the opening 121. It is formed to have a dimension to become. Accordingly, when blood is to be injected into the measurement layer 110 of the measurement strip 1 through the sampling / injection mechanism 2a, the outer circumferential surfaces 220a-1a and 220a-2a of the sample accommodating portion 220a are formed. It can be stably seated on the edge portion 121a of the opening 121.

The gaps 221a and 221b formed at the ends of the first body 220a-1 and the second body 220a-2 are dug into a 'V' shape in which the width gradually decreases toward the inside when viewed from the lateral side direction. have. Accordingly, in collecting and accommodating blood through the sampling / injection mechanism 2a, the blood can be sucked further into the sample accommodating portion 220a without getting around the outer circumferential surfaces 220a-1a and 220a-2a. have.

In addition, a groove 223 having a diameter larger than the gap width of the gaps 221a and 221b is formed in the central portion of the front end of the body of the sample accommodating portion 220a. The groove 223 is in direct contact with the measurement layer 110 of the measurement strip 1. Accordingly, in the case of injecting blood through the sampling / injection mechanism 2a, the blood contained in the gaps 221a and 221b of the sample accommodating part 220 is measured through the groove 223 having a relatively large area. It can be introduced quickly into the measuring layer 110 of the strip 1. According to a preferred embodiment, the groove 223 may be formed in a conical shape, the diameter of the sample receiving portion 220a toward the end portion toward the end portion.

8B is a view for explaining the advantageous effect of the sampling / injection mechanism according to the present embodiment.

In the sampling / injection apparatus according to the present embodiment, a groove 223 having a diameter larger than the gap width of the gaps 221a and 221b is formed, and the groove 223 is the measurement layer 110 of the measurement strip 1. Since it is in direct contact with the upper end, the blood contained in the sample accommodating part 220a may flow out to the measurement layer 110 of the measurement strip 1 more smoothly and quickly. As a result, for example, when the measurement result of the measurement strip 1 is calculated using a biometric data measurement device (not shown), the measurement result value can be derived more quickly.

In addition, in the sampling / injection mechanism 2a according to the present embodiment, the curvature of the outer circumferential surfaces 220a-1a and 220a-2a constituting the sample accommodating portion 220a is determined by the edge portion 121a of the opening 121. Since it has the dimension corresponding to curvature, it is easy to mount the outer peripheral surfaces 220a-1a and 220a-2a of the sample accommodating part 220a to the edge part 121a of the opening 121. As shown in FIG. For example, even if the user approaches the sampling / injection device 2a from the direction toward the opening 121 side of the measuring strip 1, the curvature of the edge 121a of the opening 121 is matched. Through the outer circumferential surfaces 220a-1a and 220a-2a of the sample accommodating part 220a having the curvature, the sample accommodating part 220a can be mounted to the edge portion 121a of the opening 121 very stably.

In addition, the sample taking / injecting mechanism (2a) according to the present embodiment is formed in the shape of a 'twist' shape when the body is extended up, down, left and right when the sample receiving portion (220a) is viewed from the front side direction, the sample receiving portion ( The pressing force transmitted to the edge portion 121a through the outer circumferential surfaces 220a-1a and 220a-2a of the 220a is uniformly distributed in the up, down, left, and right directions. That is, as described above with reference to FIG. 5B, when a partial pressure is applied to the edge portion 121a of the opening 121, the partially pressed edge portion 121a is pressed downward, thereby Abnormalities could occur in the F1 flow path directly contributing to the serum saturation of the reaction layer 130 of the measurement strip 1. However, in the case of using the sampling / injection mechanism 2a according to the present embodiment, the edge portion is formed from the outer circumferential surfaces 220a-1a and 220a-2a of the sample receiving portion 220a constituting the sampling / injection mechanism 2a. Since the pressing force transmitted to the 121a side is uniformly distributed in the up, down, left, and right directions, a phenomenon in which a part of the edge portion 121a is pressed downward can be effectively excluded.

[Third Embodiment]

9A is a perspective view showing a third embodiment of a sampling / injection apparatus applied or included in a biometric data set according to the present invention, and FIG. 9B is an advantageous operation of the sampling / injection apparatus according to the third embodiment. It is a figure for demonstrating an effect.

The sampling / injection mechanism 2b according to the present embodiment has only the structure of the sample accommodating portion 220b different from the sampling / injection mechanism 2 of the first embodiment described above, and the rest of the structure is the first embodiment. Same as the example.

On the other hand, in FIG. 9A, the X-axis direction is the side surface direction of the sampling / injection device, the Y-axis direction is the front side direction of the sampling / injection device, and the Z-axis direction is the plane side direction of the sampling / injection device. It is prescribed by.

The sampling / injection mechanism 2b is formed at a main body portion 210 having a seating groove 211 formed in a concave shape so as to be easily gripped, and at the front side end portion of the main body portion 210, and at the front end thereof is subjected to capillary force. This includes a sample accommodating part 220b in which gaps 221a 'and 221b' for receiving a biological sample, for example, blood, are formed.

As shown in Fig. 9A, the body of the sample accommodating portion 220b is formed in a shape in which the body branches in three directions at the central portion of the front end of the body when viewed from the front side direction. According to a preferred embodiment, the body of the sample accommodating portion 220b may be formed in a 'double' shape when viewed from the front side direction.

More specifically, the body of the sample accommodating part 220b includes a first body 220b-1 and a first body 220b-1 having a gap 221a 'for accommodating a biological sample by capillary force. It is comprised by the 2nd body 220b-2 formed in the shape which rotated 90 degrees about the axis of the front side direction of the sample collection / injection mechanism 2b.

In addition, the curvature of the outer peripheral surfaces 220b-1a and 220b-2a constituting the first body 220b-1 and the second body 220b-2 corresponds to the curvature of the edge 121a of the opening 121. It is formed to have a dimension to become. Accordingly, when blood is to be injected into the measurement layer 110 of the measurement strip 1 through the sampling / injection device 2b, the outer circumferential surfaces 220b-1a and 220b-2a of the sample accommodating part 220b are disposed. It can be stably seated on the edge portion 121a of the opening 121.

9B is a view for explaining the advantageous effect of the sampling / injection mechanism according to the present embodiment.

In the sampling / injection mechanism 2b according to the present embodiment, the curvatures of the outer circumferential surfaces 220b-1a and 220b-2a constituting the sample accommodating portion 220b are equal to the curvature of the edge portion 121a of the opening 121. Since it has a corresponding dimension, it is easy to mount the outer peripheral surfaces 220b-1a and 220b-2a of the sample accommodating part 220b to the edge part 121a of the opening 121. As shown in FIG. For example, even if the user approaches the sampling / injection device 2b toward the opening 121 side of the measurement strip 1 from any direction, the curvature of the edge 121a of the opening 121 is matched. Through the outer circumferential surfaces 220b-1a and 220b-2a of the sample accommodating part 220b having a curvature, the sample accommodating part 220b can be mounted on the edge portion 121a of the opening 121 very stably.

In addition, the sample taking / injecting mechanism (2b) according to the present embodiment is formed in the shape of a 'double' shape when the body of the sample accommodating portion (220b) when viewed from the front side direction, spread up, down, left and right, the sample accommodating part ( The pressing force transmitted to the edge portion 121a through the outer circumferential surfaces 220b-1a and 220b-2a of 220b is uniformly distributed in the vertical, horizontal, and horizontal directions. That is, as described above with reference to FIG. 5B, when a partial pressure is applied to the edge portion 121a of the opening 121, the partially pressed edge portion 121a is pressed downward, thereby Abnormalities could occur in the F1 flow path directly contributing to the serum saturation of the reaction layer 130 of the measurement strip 1. However, in the case of using the sampling / injection mechanism 2b according to the present embodiment, the edge portion is formed from the outer circumferential surfaces 220b-1a and 220b-2a of the sample accommodating portion 220b constituting the sampling / injection mechanism 2b. Since the pressing force transmitted to the (121a) side is uniformly distributed in the up, down, left and right directions, only a part of the edge portion 121a may be effectively excluded from being pushed downward.

[Fourth Embodiment]

10A is a perspective view showing a fourth embodiment of a sampling / injection apparatus applied or included in a biometric data set according to the present invention, and FIG. 10B is an advantageous operation of the sampling / injection apparatus according to the fourth embodiment. It is a figure for demonstrating an effect.

The sampling / injection mechanism 2c according to this embodiment only differs from the sampling / injection mechanism 2 of the first embodiment described above only in the structure of the sample accommodating portion 220c, and the rest of the structure is the first embodiment. Same as the example.

On the other hand, in Fig. 10A, the X-axis direction is toward the side of the sampling / injection mechanism 2c, the Y-axis direction is toward the front side of the sampling / injection mechanism 2c, and the Z-axis direction is about the sampling / injection mechanism. It defines in the plane side direction of (2c), respectively.

The sampling / injection mechanism 2c is formed at a main body portion 210 having a seating groove 211 formed in a concave shape to facilitate gripping, and at the front side end portion of the main body portion 210, and at the front end thereof is subjected to capillary force. It includes a sample receiving portion 220c formed with a gap for receiving a biological sample, for example, blood.

The body of the sample accommodating part 220c is comprised in spherical shape.

In addition, the curvature of the outer circumferential surface 220c-1 constituting the spherical body is formed to have a dimension corresponding to the curvature of the edge portion 121a of the opening 121. Accordingly, when blood is to be injected into the measurement layer 110 of the measurement strip 1 through the sampling / injection mechanism 2c, the outer peripheral surface 220c-1 of the sample accommodating portion 220c is stably opened. It can be seated on the edge part 121a of (1).

The gap 221 formed at the tip of the body of the sample accommodating part 220c is dug into a 'V' shape, the width of which is gradually narrowed toward the inner side when viewed from the lateral side direction. Accordingly, in collecting and accommodating blood through the sampling / injection mechanism 2c, blood can be sucked further into the sample accommodating portion 220c without being buried around the outer circumferential surface 220c-1.

In addition, a groove 223 having a diameter larger than the gap width of the gap 221 is formed in the central portion of the body tip of the sample accommodating part 220c. The groove 223 is in direct contact with the measurement layer 110 of the measurement strip 1. Accordingly, in the case of injecting blood through the sampling / injection mechanism 2c, the blood contained in the gap 221 of the sample accommodating part 220c passes through the groove 223 having a relatively large area. Can be quickly introduced into the measurement layer (110). According to a preferred embodiment, the groove 223 may be formed in a conical shape, the diameter of the sample accommodating portion 220c toward the end portion from the end portion side.

10B is a view for explaining the advantageous effect of the sampling / injection device according to the present embodiment.

In the sampling / injection mechanism 2c according to the present embodiment, since the groove 223 having a diameter larger than the gap width of the gap 221 is formed, the blood stored in the sample accommodating portion 220c is more smoothly. And quickly flows to the measurement layer 110 of the measurement strip 1. As a result, for example, when the measurement result of the measurement strip 1 is calculated using a biometric data measurement device (not shown), the measurement result value can be derived more quickly.

In addition, in the sampling / injection mechanism 2c according to the present embodiment, the curvature of the spherical body outer circumferential surface 220c-1 constituting the sample accommodating portion 220c is an opening of the measurement strip 1 ( Since it has dimensions corresponding to the curvature of the edge portion 121a constituting 121, it is necessary to mount the outer peripheral surface 220c-1 of the body of the sample accommodating portion 220c to the edge portion 121a of the opening 121. It is easy.

In addition, since the body of the sample collection / injection mechanism 220c according to the present embodiment is formed in a spherical shape when the sample receiving portion 220c is viewed from the front side direction, the outer circumferential surface of the sample collection / injection mechanism 2c ( The downward pressing force transmitted from 220c-1 to the edge portion 121a side of the opening 121 is uniformly distributed to the entire area of the edge portion 121a. That is, as described above with reference to FIG. 5B, when a partial pressure is applied to the edge portion 121a of the opening 121, the partially pressed edge portion 121a is pressed downward, thereby Abnormalities could occur in the F1 flow path directly contributing to the serum saturation of the reaction layer 115 of the measurement strip 1. However, when using the sampling / injection mechanism 2c according to the present embodiment, the outer peripheral surface 220c-1 of the sample accommodating portion 220c constituting the sampling / injection mechanism 2c is moved toward the edge portion 121a. Since the pressing force transmitted is uniformly distributed over the entire surface of the edge portion 121a, only a portion of the edge portion 121a may be strongly pressed downward.

[Fifth Embodiment]

11 is a perspective view showing a fifth embodiment of a sampling / injection apparatus applied or included in a set for measuring biometric data according to the present invention.

The sample collection / injection mechanism 2d according to the fifth embodiment has a structure in which at least two sample receiving portions of any of the first to fourth embodiments are formed in the main body 210 having the concave groove 211. to be. 11 illustrates a structure in which two sample collection / injection mechanisms 220 of the first embodiment are formed in one main body 210 for convenience of description, but the sample / injection mechanism 2d of the present embodiment necessarily has such a shape. It is not limited only.

In the case of using the sampling / injection device 2d according to the present embodiment, it is possible to simultaneously inject a biological sample into each opening 121 of the measurement strip 1 in which two or more openings 121 are formed. .

)으로 하는 등의 실시예가 가능하다.The above description is merely illustrative of the technical idea of the present invention, and those skilled in the art to which the present invention pertains may make various modifications and variations without departing from the essential characteristics of the present invention. For example, the shape of the sample accommodating part 220 of FIG. 6A, the shape of the sample accommodating part 220a of FIG. 8A, the shape of the sample accommodating part 220b of FIG. 9A, and the sample accommodating part 220b of FIG. The shape is only for illustration of the present invention, in addition, the cross-shaped shape when viewed from the front side direction (

Examples such as) are possible.

On the other hand, in the above description, the technique for measuring biometric data is limited to measuring color change or electrochemical change due to enzymatic reaction.However, the biometric data measuring method to which the present invention is applied uses a fluorescent material or a method using radioactivity. There are various ways. Therefore, it is obvious that the field of use of the present invention is not limited to the method of measuring the optical color change or the electrochemical change by the enzymatic reaction.

In addition, other various modified embodiments that can achieve the object of the present invention are shown in Figs. How these modified embodiments achieve the object of the present invention will be described briefly with reference to the accompanying drawings.

First, FIG. 12 shows a strip in which a groove is placed in the middle of a? -Shaped gap in the first sampling and injection device disclosed in Patent Application No. 2009-48804, filed on June 2, 2009, filed by the applicant on June 2, 2009. This is an embodiment in which the contact area with the reaction region is increased, and the injection speed of the sample is increased to pursue the promptness of the measurement. For reference, FIG. 22 illustrates a sampling and injection mechanism disclosed in the patent application previously filed by the present application as described above.

FIG. 13 is formed in a 'V' shape in which the gap between the sample accommodating portions in the configuration of FIG. 12 is gradually narrowed toward the inner side when viewed from the side side direction thereof. Accordingly, in collecting and accommodating the blood through the sampling / injection mechanism, the blood can be sucked further into the sample accommodating part without getting around the outer circumferential surface. In addition, this V-shape has the advantage that the moldability at the time of injection molding is easy.

 Fig. 14 shows that the sample receiving portion is formed in a spherical shape when viewed from the front side, so that the downward pressing force transmitted from the outer circumferential surface of the sample collection / injection mechanism to the edge portion of the opening is uniform to the entire area of the edge portion. Disperse That is, as described above with reference to FIG. 5B, when a partial pressure is applied to the edge portion of the opening, the partially pressed edge portion is pressed downward, and thus the reaction layer 115 of the measurement strip 1 is applied. Abnormalities could occur in the F1 flow pathway, which directly contributes to serum saturation. However, in the case of using the sampling / injection mechanism in this case, only a part of the edge portion is downward since the pressing force transmitted from the outer circumferential surface of the sample accommodating portion constituting the sampling / injection mechanism is uniformly distributed throughout the edge portion. Strong crushing can be completely ruled out. In addition, since the gap is formed in a Y shape as compared with FIG. 10A, the time taken to inject the collected sample into the strip is reduced. In this way, the speed of sample data measurement can be achieved.

FIG. 15 is further provided with a groove formed in the middle of the Y-shaped branch of FIG. 14 above, so that the area in contact with the sample application region of the strip may be larger, thereby further facilitating the rapidity of sample data measurement.

FIG. 16 is different from the one branched in three directions in FIG. 14, but has a branch branched in four directions, and the effect of the configuration is similar to that of FIG. 14.

FIG. 17 is a groove formed at the center of the gap branched in the four directions in FIG. 16, and its structural effect is similar to that of FIG. 15.

FIG. 18 differs from the configuration of FIG. 14 in that the gap in which the sample is accommodated in FIG. 14 is not smaller toward the inside of the sample accommodating portion but is constant, and its structural effect is similar to that of FIG.

FIG. 19 differs from the configuration of FIG. 15 in that the gap in which the sample is accommodated in FIG. 15 is not smaller toward the inside of the sample accommodating portion, but is constant, and its structural effect is similar to that of FIG.

FIG. 20 differs from the configuration of FIG. 16 in that the gap in which the sample is accommodated in FIG. 16 is not smaller toward the inside of the sample accommodating portion, but is constant, and its structural effect is similar to that of FIG.

FIG. 21 differs from the configuration of FIG. 17 in that the gap in which the sample is accommodated in FIG. 17 is not smaller toward the inside of the sample accommodating portion, but is constant, and its structural effect is similar to that of FIG.

In addition, although not shown in the drawings, the sampling / injection apparatus disclosed in FIGS. 12 to 21 described above may be provided as a biometric data measurement set together with a measurement strip used to measure biometric data.

In addition, although not shown in the drawings, the process and principle of injecting the sample on the measuring strip by the sampling / injection apparatus disclosed in FIGS. 12 to 21 described above are substantially similar to those disclosed in FIGS. 6 to 10.

In addition, in Fig. 12, the groove of the sample accommodating portion is formed to have a constant diameter toward the inside of the body of the sample accommodating portion, but as shown in Fig. 13, the groove of the sample accommodating portion has a diameter toward the inner side of the body of the sample accommodating portion. It may be formed in a shape that becomes smaller. In addition, in Fig. 13, the groove of the sample accommodating part is formed in a shape that the diameter decreases toward the inside of the body of the sample accommodating part, but the diameter of the groove of the sample accommodating part is toward the inner side of the body of the sample accommodating part as shown in Fig. 12. It may be formed in this constant shape. This same principle can be equally applied to FIGS. 15, 17, 19, and 21 in which grooves are formed in the central portion.

1: measuring strip 2,2a, 2b, 2c, 2d: sampling / injection device
110: measurement layer 111: diffusion layer
113: Separation layer 115: Reaction layer
120: upper cover 121: opening
121a: edge portion 130: lower substrate
210: body portion 211: concave groove
220,220a, 220b, 220c: sample accommodating part 221: gap
223: home

Claims (6)

A sampling / injection device for taking a biological sample and injecting the biological sample into a strip for measuring biological data,
A main body portion and a sample accommodating portion formed at one side of the main body portion, the tip end portion having a gap for accommodating the biological sample by capillary force;
The gap at the front end of the body of the sample accommodating portion, when viewed from the front side direction of the sample collection / injection mechanism 'twist' shape or cross shape (

),
And a groove having a diameter larger than the gap width of the gap is formed at the center portion of the distal end of the body of the specimen accommodating portion. A sampling / injection device for taking a biological sample and injecting the biological sample into a strip for measuring biological data,
A main body portion and a sample accommodating portion formed at one side of the main body portion, the tip end portion having a gap for accommodating the biological sample by capillary force;
The body of the sample accommodating portion is composed of a sphere (球) shape,
And the gap is formed so as to branch in at least two directions from a central portion of the body tip portion of the sample accommodating portion when the sample / injection mechanism is viewed from the front side. The method of claim 2,
And a groove having a diameter larger than the gap width of the gap is formed at the central portion of the body tip portion of the sample accommodation portion. The method according to any one of claims 1 to 3,
The gap between the sample accommodating part is excavated in a 'V' shape, the width of which is gradually narrowed toward the inside of the body of the sample accommodating part when viewed from the side of the sample accommodating / injection device. Injection apparatus. The method according to claim 1 or 3,
And said groove is formed in a shape such that the diameter of the sample accommodating part becomes smaller toward the inner side of the body of the sample accommodating part. A biological data measuring strip having a sample receiving region into which a sample is injected;
A biometric data set comprising a sampling / injection instrument according to any one of claims 1 to 3.

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