KR100745046B1 - Polymer injectable detachable coil - Google Patents

Polymer injectable detachable coil Download PDF

Info

Publication number
KR100745046B1
KR100745046B1 KR1020060072497A KR20060072497A KR100745046B1 KR 100745046 B1 KR100745046 B1 KR 100745046B1 KR 1020060072497 A KR1020060072497 A KR 1020060072497A KR 20060072497 A KR20060072497 A KR 20060072497A KR 100745046 B1 KR100745046 B1 KR 100745046B1
Authority
KR
South Korea
Prior art keywords
coil
polymer
platinum
aneurysm
pusher
Prior art date
Application number
KR1020060072497A
Other languages
Korean (ko)
Inventor
성 현 김
성 권 강
Original Assignee
주식회사 에스앤지바이오텍
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 에스앤지바이오텍 filed Critical 주식회사 에스앤지바이오텍
Priority to KR1020060072497A priority Critical patent/KR100745046B1/en
Priority to PCT/KR2007/003614 priority patent/WO2008016237A1/en
Application granted granted Critical
Publication of KR100745046B1 publication Critical patent/KR100745046B1/en

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214—Coils or wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00—Dilators with or without means for introducing media, e.g. remedies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12063—Details concerning the detachment of the occluding device from the introduction device electrolytically detachable

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Surgical Instruments (AREA)

Abstract

A polymer injectable separation type embolization coil is provided to perform embolization of cerebral aneurysm even with a small number of coil by injecting liquid polymer into a hollow of the coil through a hollow of a hypo tube by connecting a separable coil with a hypo tube. A polymer injectable separation type embolization coil includes: an embolization platinum coil part(1) that a polymer coating layer(1a) is formed on the outer periphery of a platinum coil(1b) with a hollow; a coil pusher(2) that an insulation coating layer(2b) is formed on the outer periphery of a hypo tube(2a) with a hollow; a connection part(3) having a polymer injecting channel, and connecting the embolization platinum coil and coil pusher, and separating them by electrolysis; and a power supply device(4) for supplying a power for electrolyzing the connection part.

Description

폴리머 주입이 가능한 분리형 색전코일 {Polymer injectable detachable coil}Polymer injectable detachable coil {Polymer injectable detachable coil}

도 1은 액상 폴리머를 주입하지 않은 상태를 나타내는 본 발명에 따른 분리형 색전코일의 단면 개략도.1 is a schematic cross-sectional view of a separate embolic coil according to the present invention showing a state in which a liquid polymer is not injected.

도 2는 액상 폴리머를 주입한 상태를 나타내는 본 발명에 따른 분리형 색전 코일의 단면 대략도.Figure 2 is a schematic cross-sectional view of a separate embolic coil according to the present invention showing a state in which a liquid polymer is injected.

본 발명은 뇌 동맥류 치료에 사용되는 폴리머 주입이 가능한 분리형 색전코일에 관한 것이다. 뇌동맥이 비정상적으로 부풀어 생기는 뇌 동맥류는 정상적인 혈관 벽에 비해 파열의 위험이 높으며 파열이 되면 지주막하 출혈을 비롯한 심각한 뇌출혈을 일으킨다. 뇌동맥류의 치료로 개두술을 통한 동맥류 클립과 더불어 혈관을 통하여 동맥류에 접근하여 분리형 색전코일을 동맥류 내에 삽입하여 혈류에서 분리시키는 방법으로 재출혈을 방지하는 치료가 많이 시행되고 있다.The present invention relates to a separable embolic coil capable of polymer injection for the treatment of cerebral aneurysms. Cerebral aneurysms, which are caused by abnormal swelling of the cerebral arteries, have a higher risk of rupture than normal blood vessel walls, which can cause severe cerebral hemorrhage, including subarachnoid hemorrhage. In addition to the aneurysm clip through the craniotomy, an aneurysm through the blood vessels is used for the treatment of cerebral aneurysm, and a separate embolic coil is inserted into the aneurysm to prevent rebleeding.

뇌 동맥류의 1차 치료목표는 동맥류 파열이나 재 파열에 의한 재 출혈을 방 지하는 것으로 전통적인 치료법은 개두술에 의한 동맥류의 경부 클립이다. 두개골을 열고 동맥류가 있는 혈관을 찾아 금속으로 만들어진 클립으로 동맥류의 목 부분을 잡아 혈류가 동맥류 내로 들어오지 못하도록 하는 것이다.The primary treatment goal for cerebral aneurysms is to prevent rebleeding due to aneurysm rupture or re-rupture. The traditional treatment is cervical clip of an aneurysm from craniotomy. Open the skull and look for blood vessels with an aneurysm and use metal clips to grab the neck of the aneurysm to prevent blood flow into the aneurysm.

20년전 분리형 색전코일이 개발되면서 혈관내로 가는 카테터를 삽입 동맥류에 카테터의 선단을 넣어놓고 카테터를 통해 분리형 색전코일을 동맥류 내에 충분한 양을 삽입하면 동맥류는 코일에 의해 채워지고 더 이상 혈류가 동맥류 내로 들어오지 못하게 함으로써 동맥류의 재파열에 의한 재출혈을 방지하는 치료법이 가능해 졌다.With the development of a separate embolic coil 20 years ago, a catheter leading into the blood vessel was placed in the aneurysm.The catheter's tip was inserted into the aneurysm. Preventing rebleeding due to re-rupture of an aneurysm has been possible.

분리형 색전코일의 장점은 필요시에만 코일을 코일 푸셔로부터 분리할 수 있기 때문에 필요에 따라 삽입, 제거를 반복함으로써 동맥류의 모양에 맞추어 모동맥의 혈류장애 없이 동맥류를 색전할 수 있다는 것이다.The advantage of the separate embolic coil is that the coil can be detached from the coil pusher only when necessary, so that the aneurysm can be embolized without interrupting blood flow of the mother artery by repeating insertion and removal as necessary.

그러나 동맥류 내에 코일을 삽입하는 치료는 그 자체로 동맥류 파열의 위험이 있으며 백금으로 만들어진 코일을 사용하여 동맥류를 완전히 채우는 것은 이론적으로 불가능하여 부피의 비율로 동맥류 부피의 50~60% 이상을 채우기 어렵다. However, the treatment of inserting coils in an aneurysm is itself a risk of aneurysm rupture, and it is theoretically impossible to completely fill an aneurysm using a coil made of platinum, which makes it difficult to fill more than 50-60% of the volume of an aneurysm.

이런 이유로 코일에 의한 동맥류 치료 후에도 동맥류 내로 다시 혈류가 통하는 등 재발의 가능성이 높아 처음 치료 시에 가능한 한 많은 양의 코일을 동맥류 내에 삽입하는 것이 좋은 치료법이다. 그러나 동맥류 내에 가능한 한 많은 양의 코일을 채우는 것은 동맥류의 파열, 과다삽입된 코일에 의한 모동맥의 폐색 등의 심각한 합병증의 위험도를 높여 치료를 어렵게 하고 있다. 이러한 현상은 특히 동맥류의 입구가 넓은 경우, 동맥류의 크기가 작은 경우 특히 문제가 되고 있다.For this reason, there is a high possibility of recurrence, such as blood flow back into the aneurysm after aneurysm treatment with coils. Therefore, it is a good therapy to insert as many coils into the aneurysm as possible during the initial treatment. However, filling as many coils as possible within an aneurysm increases the risk of serious complications such as rupture of the aneurysm and blockage of the mother artery by an overinserted coil, making treatment difficult. This phenomenon is particularly problematic when the inlet of the aneurysm is wide and when the size of the aneurysm is small.

이러한 코일 색전술의 불완전성 때문에 최근에는 트리셀룰로오스 아세테이트(tricellulose acetate) 등과 같이 혈류와 반응하여 중합반응을 일으켜 고체화되는 액상 폴리머를 뇌동맥류 내에 주입하는 방법이 시도되고 있으나 액상의 폴리머가 흐름이 빠른 동맥 혈류를 따라 원위부 혈관으로 날아가 혈관을 폐색시키는 심각한 합병증이 있어 아직까지는 임상에서 사용하기 어렵다. Due to the incompleteness of coil embolization, recently, a method of injecting a liquid polymer that reacts with the blood flow and solidifies by polymerization, such as tricellulose acetate, has been attempted. There is a serious complication that flies to the distal blood vessels and occludes the blood vessels, so it is still difficult to use in clinical practice.

본 발명은 이와 같은 종래의 문제점들을 해결하기 위해서 기존의 분리형 색전코일에 폴리머 코팅을 한 후 코일의 내강으로 액상 폴리머를 주입할 수 있도록 하여 기존의 색전코일로는 기대하기 어려운 뇌동맥류의 완전색전을 할 수 있게 하고 소수의 코일로도 뇌동맥류를 완전히 색전할 수 있도록 하여 안전하고 용이하게 뇌동맥류를 치료할 수 있도록 하는 것이다. In order to solve the above problems, the present invention provides a polymer coating on a conventional detachable embolic coil and injects a liquid polymer into the lumen of the coil to provide a complete embolization of cerebral aneurysm that is difficult to expect with conventional embolic coils. It is possible to completely embolize the cerebral aneurysm with a few coils so that it can be safely and easily treated.

본 발명은 분리형 색전코일을 하이포튜브와 연결함으로써 하이포튜브의 내강을 통해 코일의 내강으로 액상 폴리머를 주입할 수 있도록 하여 소수의 코일로도 뇌동맥류의 완전색전을 할 수 있는 폴리머 주입가능 분리형 색전코일을 제공하고자 한다. The present invention provides a polymer-injectable separable embolic coil capable of fully embolizing cerebral aneurysm even with a few coils by connecting a separate embolic coil with a hypotube to inject a liquid polymer into the lumen of the coil through the lumen of the hypotube. To provide.

또한, 본 발명은 분리형 색전코일의 코일파트에 폴리머를 얇게 코팅하여 주입되는 액상폴리머의 양에 따라 늘어나고 동맥의 혈류를 따라 주입된 액상 폴리머가 날아가지 않도록 하여 안전하고 효과적인 폴리머 주입가능 분리형 색전코일을 제공하고자 한다. In addition, the present invention extends according to the amount of the liquid polymer injected by coating the polymer thinly on the coil part of the separate embolic coil and prevents the liquid polymer injected along the blood flow of the artery from flying away to provide a safe and effective polymer injectable separable embolic coil. To provide.

이와 같은 과제들을 달성하기 위한 본 발명의 폴리머 주입이 가능한 분리형 색전코일은 [ⅰ] 내강을 갖는 백금코일(1b)의 외주면에 폴리머 코팅층(1a)이 형성되어 있는 색전용 백금코일부(1), [ⅱ] 내강을 갖는 하이포 튜브(2a)의 외주면에 절연 코팅층(2b)이 형성되어 있는 코일푸셔(2), [ⅲ] 폴리머 주입용 채널을 구비하고, 상기 색전용 백금코일과 코일푸셔를 연결해 주고 있다가 전기분해에 의해 상기 색전용 백금코일과 코일푸셔를 분리시켜 주는 연결부(3) 및 [ⅳ] 상기 연결부(3)를 전기분해시키기 위한 전력을 공급하는 전력공급장치(4)로 구성됨을 특징으로 한다.In order to achieve the above problems, the polymer-embedded separable embolic coil of the present invention has a platinum coil portion 1 for coloration, in which a polymer coating layer 1a is formed on the outer circumferential surface of the platinum coil 1b having a lumen. [Ii] a coil pusher (2) having an insulating coating layer (2b) formed on the outer circumferential surface of the hypotube (2a) having a lumen, and (iii) a channel for polymer injection, connecting the platinum coil for color and the coil pusher It is composed of a connecting portion (3) for separating the color-only platinum coil and the coil pusher by electrolysis and [iii] a power supply device (4) for supplying power for electrolyzing the connecting portion (3). It features.

이하, 첨부한 도면 등을 통하여 본 발명을 상세하게 설명한다.Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

먼저, 본 발명은 도 1 및 도 2에 도시된 바와 같이 백금코일(1b)의 외주면에 폴리머 코팅층(1a)이 형성되어 있는 색전용 백금코일부(1), 하이포튜브(2a)의 외주면에 절연코팅층(2a)이 되어 있는 코일 푸셔(2), 코일과 코일 푸셔를 연결하며 전기분해에 의해 이들을 분리시키며 폴리머 주입용 채널이 있는 연결부(3), 상기 연결부(3)를 전기분해시키기 위한 전력공급장치(4)로 구성된다. 그로인해 본 발명은 동맥류내에 삽입된 코일의 내강으로 액상 폴리머를 주입할 수 있어 소수의 코일로 동맥류의 완전색전을 할 수 있다. First, the present invention is insulated on the outer circumferential surface of the color-only platinum coil portion 1, the hypotube 2a in which the polymer coating layer 1a is formed on the outer circumferential surface of the platinum coil 1b, as shown in FIGS. Coil pusher 2 with coating layer 2a, connecting coil and coil pusher, separating them by electrolysis, connecting part 3 with polymer injection channel, supplying power for electrolyzing the connecting part 3 It consists of the device (4). Therefore, the present invention can inject the liquid polymer into the lumen of the coil inserted into the aneurysm, so that a small number of coils allow complete embolization of the aneurysm.

도 1은 액상 폴리머를 주입하지 않은 상태를 나타내는 본 발명에 따른 분리형 색전코일의 단면개략도 이고, 도 2는 액상 폴리머를 주입한 상태를 나타내는 본 발명에 따른 분리형 색전코일의 단면 개략도이다.1 is a cross-sectional schematic view of a separate embolic coil according to the present invention showing a state in which a liquid polymer is not injected, and FIG. 2 is a cross-sectional schematic view of a separate embolic coil according to the present invention showing a state in which a liquid polymer is injected.

상기의 색전용 백금코일부(1)는 액상 폴리머가 주입되는 내강을 갖고, 상기 내강내로 주입되는 액상 폴리머(1c)가 혈류를 따라 날아가지 않도록 백금코일(1b)의 외주면에 얇은 폴리머 코팅층(1a)이 형성되어 있으며, 액상 폴리머(1c)가 주입되면 백금코일에 코팅된 얇은 폴리머 막이 백금코일(1b)에서 떨어서 액상 폴리머(1c)의 양에 따라 부풀어 오른다. 또한 액상 폴리머(1c)가 백금코일 내강으로부터 균일하게 새어 나올 수 있도록 미세한 구멍이 백금코일(1b) 전장에 걸쳐 뚫려 있다.The color-only platinum coil part 1 has a lumen into which a liquid polymer is injected, and a thin polymer coating layer 1a on the outer circumferential surface of the platinum coil 1b so that the liquid polymer 1c injected into the lumen does not fly along the blood stream. ) Is formed, and when the liquid polymer 1c is injected, a thin polymer film coated on the platinum coil falls from the platinum coil 1b and swells according to the amount of the liquid polymer 1c. In addition, fine holes are drilled through the entire length of the platinum coil 1b so that the liquid polymer 1c can be uniformly leaked from the platinum coil lumen.

다음으로, 코일 푸셔(2)는 하이포튜브(2a)로 만들어져 있어 하이포 튜브의 내강을 통하여 액상 폴리머(1c)를 주입할 수 있으며, 상기 하이포튜브(2a)의 외주면에는 절연 코팅층(2b)이 형성되어 있다. 코일 푸셔(2)의 근위부 끝에는 표지자(5)와 주사기 등을 연결할 수 있는 허브(6)가 부착되어 있어 이를 통하여 액상 폴리머(1c)를 주입할 수 있다.Next, the coil pusher 2 is made of a hypotube 2a to inject the liquid polymer 1c through the lumen of the hypotube, and an insulating coating layer 2b is formed on the outer circumferential surface of the hypotube 2a. It is. At the proximal end of the coil pusher 2, a hub 6 may be attached to the marker 5 and a syringe to inject the liquid polymer 1c.

액상 폴리머로는 트리셀룰로오스 아세테이트(Tricellulose acetate) 등이 사용될 수 있다.Tricellulose acetate may be used as the liquid polymer.

다음으로, 코일과 코일 푸셔의 연결부(3)는 절연 폴리머 튜브로 만들어져 있어 백금코일 분리를 위해 인가되는 전류가 백금코일로 통하지 않도록 한다. 또한 백금코일부(1)와 하이포튜브(2a)를 단단히 연결하여 액상 폴리머 주입시 압력에 의해 분리되지 않는다. 상기 연결부(3)는 전기분해 가능한 폴리머 튜브이다.Next, the connection portion 3 of the coil and the coil pusher is made of an insulating polymer tube so that the current applied for the platinum coil separation does not pass through the platinum coil. In addition, the platinum coil part 1 and the hypotube 2a are firmly connected so that they are not separated by pressure during injection of the liquid polymer. The connection part 3 is an electrolytic polymer tube.

본 발명은 폴리머가 코팅된 색전용 백금코일부(1)에 내강이 있는 금속 튜브인 하이포튜부(2a)로 만들어진 코일푸셔(2)를 연결함으로써 액상 폴리머를 주입할 수 있도록 하였으며, 전기분해를 통하여 코일과 푸셔 사이를 전기분해를 통해 분리 할 수 있도록 하였다. The present invention allows the injection of a liquid polymer by connecting a coil pusher (2) made of a hypotube part (2a), which is a metal tube with a lumen, to a polymer-coated platinum coil part (1) coated with a polymer. The separation between the coil and the pusher can be achieved by electrolysis.

동맥류 내에 분리형 백금코일부(1)을 삽입한 후 액상 폴리머를 하이포튜브(2a) 내강을 통해 주입하여 백금코일의 내강을 채우고 백금코일 루프 사이로 새 나오는 액상 폴리머가 도 2에 도시된 바와 같이 미리 백금코일 외주면에 코팅 있는 폴리머 주머니 내로 주입되어 동맥류 내에 삽입되어 있는 코일의 부피를 늘이고 액체인 액상 폴리머가 백금코일 사이의 공간을 완전히 채워 한 두개의 백금코일로 동맥류의 완전 색전을 얻을 수 있도록 하였다.After inserting the separate platinum coil part 1 into the aneurysm, the liquid polymer is injected through the lumen of the hypotube 2a to fill the lumen of the platinum coil, and the liquid polymer that emerges between the platinum coil loops is previously platinum, as shown in FIG. 2. Injected into the polymer bag coated on the outer circumference of the coil to increase the volume of the coil inserted into the aneurysm, and liquid liquid polymer completely filled the space between the platinum coils to obtain complete embolization of the aneurysm with one or two platinum coils.

백금코일의 외주면에 미리 코팅되어 있는 폴리머에 의해 주입된 액상 폴리머의 움직임이 제한되며 동맥류 내에 삽입되어 있는 백금코일이 프레임 역할을 하여 주입된 액상 폴리머가 동맥혈류를 타고 원위부 동맥으로 날라가는 것을 방지할 수 있으며, 백금코일 프레임을 따라 액상폴리머가 주입됨으로써 동맥류만 선택적으로 색전할 수 있는 장점이 있다. The movement of the liquid polymer injected by the polymer coated on the outer surface of the platinum coil is limited and the platinum coil inserted into the aneurysm acts as a frame to prevent the injected liquid polymer from flying into the distal artery through the arterial blood flow. In addition, since the liquid polymer is injected along the platinum coil frame, only an aneurysm can be embolized selectively.

또한 한 두 개의 소수의 백금코일로 뇌동맥류의 완전색전을 기대할 수 있기 때문에 많은 수의 백금코일을 삽입해야 하는 거대 동맥류나 여러 개의 코일을 삽입하기 어려운 작은 동맥류를 안전하게 색전할 수 있는 장점이 있다.In addition, one or two platinum coils can be expected to fully embolize cerebral aneurysms, so they can safely embolize large aneurysms that require a large number of platinum coils or small aneurysms that are difficult to insert into multiple coils.

본 발명은 뇌동맥류의 치료에 사용되는 분리형 색전코일의 내강에 액상 폴리머를 동맥류의 크기와 모양에 맞게 주입하여 소수의 코일로 동맥류를 완전히 색전할 수 있어 뇌동맥류의 치료에 관련된 합병증의 감소와 재발을 줄일 수 있다. The present invention is to inject the liquid polymer into the lumen of the separate embolic coil used in the treatment of cerebral aneurysm in accordance with the size and shape of the aneurysm to completely embolize the aneurysm with a small number of coils to reduce the recurrence and recurrence of complications associated with the treatment of cerebral aneurysm Can be reduced.

Claims (6)

[ⅰ] 내강을 갖는 백금코일(1b)의 외주면에 폴리머 코팅층(1a)이 형성되어 있는 색전용 백금코일부(1), [ⅱ] 내강을 갖는 하이포 튜브(2a)의 외주면에 절연 코팅층(2b)이 형성되어 있는 코일푸셔(2), [ⅲ] 폴리머 주입용 채널을 구비하고, 상기 색전용 백금코일과 코일푸셔를 연결해 주고 있다가 전기분해에 의해 상기 색전용 백금코일과 코일푸셔를 분리시켜 주는 연결부(3) 및 [ⅳ] 상기 연결부(3)를 전기분해시키기 위한 전력을 공급하는 전력공급장치(4)로 구성됨을 특징으로 하는 폴리머 주입이 간으한 분리형 색전코일.[Iii] Platinum coil part 1 for color, in which polymer coating layer 1a is formed on the outer circumferential surface of platinum coil 1b having lumen, and [ii] Insulation coating layer 2b on the outer circumferential surface of hypotube 2a having lumen. ) Is provided with a coil pusher (2) and a channel for polymer injection, and the platinum coil and the coil pusher for color are connected, and the platinum coil and coil pusher for color separation are separated by electrolysis. The main injection part 3 and the embroiderable embolic coil of the polymer injection characterized in that it consists of a power supply (4) for supplying power for electrolysis of the connection (3). 1항에 있어서, 코일퓨셔(2)의 후단부에 표지자(5)와 허브(6)가 차례로 설치되어 있는 것을 특징으로 하는 폴리머 주입이 가능한 분리형 색전코일.2. The detachable embolic coil as claimed in claim 1, wherein a marker (5) and a hub (6) are sequentially provided at the rear end of the coil pusher (2). 1항에 있어서, 백금코일(1b)에는 전장에 걸쳐 미세한 구멍이 형성되어 있는 것을 특징으로 하는 폴리머 주입이 가능한 분리형 색전코일.2. The detachable embolic coil as claimed in claim 1, wherein the platinum coil (1b) is formed with fine pores over its entire length. 1항에 있어서, 연결부(3)는 절연 폴리머 튜브인 것을 특징으로 하는 폴리머 주입이 가능한 분리형 색전코일.2. The detachable embolic coil as claimed in claim 1, wherein the connection part is an insulated polymer tube. 3. 1항에 있어서, 백금코일(1b)의 외주면에 형성된 폴리머 코팅층(1a)은 백금코일 내강내로 액상 폴리머(1c)가 주입되면 백금코일(1b)로부터 분리되면서 주입된 액상 폴리머(1c)에 의해 주머니 모양으로 부풀어 오르는 것을 특징으로 하는 폴리머 주입이 가능한 분리형 색전코일.The polymer coating layer (1a) formed on the outer circumferential surface of the platinum coil (1b) is a pocket by the liquid polymer (1c) injected while being separated from the platinum coil (1b) when the liquid polymer (1c) is injected into the platinum coil lumen. A detachable embolic coil capable of injecting polymers, characterized by swelling into a shape. 1항에 있어서, 연결부(3)는 전기분해 가능한 폴리머 튜브인 것을 특징으로 하는 폴리머 주입이 가능한 분리형 색전코일.2. The polymer implantable separable embolic coil according to claim 1, wherein the connection part is an electrolytic polymer tube.
KR1020060072497A 2006-08-01 2006-08-01 Polymer injectable detachable coil KR100745046B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020060072497A KR100745046B1 (en) 2006-08-01 2006-08-01 Polymer injectable detachable coil
PCT/KR2007/003614 WO2008016237A1 (en) 2006-08-01 2007-07-27 Polymer injectable detachable coil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020060072497A KR100745046B1 (en) 2006-08-01 2006-08-01 Polymer injectable detachable coil

Publications (1)

Publication Number Publication Date
KR100745046B1 true KR100745046B1 (en) 2007-08-01

Family

ID=38601598

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020060072497A KR100745046B1 (en) 2006-08-01 2006-08-01 Polymer injectable detachable coil

Country Status (2)

Country Link
KR (1) KR100745046B1 (en)
WO (1) WO2008016237A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032337A2 (en) * 2002-07-23 2005-04-14 Micrus Corporation Vasoocclusive coil with enhanced therapeutic strand structure

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5702361A (en) * 1996-01-31 1997-12-30 Micro Therapeutics, Inc. Method for embolizing blood vessels
JP4352673B2 (en) * 2002-09-13 2009-10-28 株式会社カネカ Bioluminal embolization device
US6923996B2 (en) * 2003-05-06 2005-08-02 Scimed Life Systems, Inc. Processes for producing polymer coatings for release of therapeutic agent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032337A2 (en) * 2002-07-23 2005-04-14 Micrus Corporation Vasoocclusive coil with enhanced therapeutic strand structure

Also Published As

Publication number Publication date
WO2008016237A1 (en) 2008-02-07

Similar Documents

Publication Publication Date Title
CN110996805B (en) Adhesive closure system
Debrun et al. Detachable balloon and calibrated-leak balloon techniques in the treatment of cerebral vascular lesions
US6383174B1 (en) Detachable aneurysm neck bridge (II)
US5263964A (en) Coaxial traction detachment apparatus and method
US7128736B1 (en) Detachable aneurysm neck closure patch
US5895385A (en) Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE38972E1 (en) Intravascular device
AU673502B2 (en) Endovascular electrolytically detachable wire for thrombus formation
ES2215334T3 (en) METAL SHEET ANEURISM NECK BRIDGE.
US20030040733A1 (en) Device and method for controlling injection of liquid embolic composition
EP1925258A2 (en) Mechanism for the deployment of endovascular implants
US20140012307A1 (en) Detachable metal balloon delivery device and method
AU2002214623A1 (en) Mechanism for the deployment of endovascular implants
WO1999049930A9 (en) Flow arrest, double balloon technique for occluding aneurysms or blood vessels
Debrun et al. Two different calibrated-leak balloons: experimental work and application in humans.
CN211460357U (en) Conveying and releasing system for embolic coil
CN108939257B (en) Balloon microcatheter with releasable head end
CN108434580B (en) Releasable microcatheter with double-coating at head end
KR100745046B1 (en) Polymer injectable detachable coil
CN216535404U (en) Blood vessel occlusion device and blood vessel occlusion system
CN210990516U (en) Arteriovenous malformation embolism microcatheter
Chiriac et al. Multimodal tretment of intracranial aneurysm
SU995800A1 (en) Occlusion device
Byrne et al. Treatment by endosaccular packing with the Guglielmi detachable coil
SU1635963A1 (en) Method for treatment false traumatic aneurysms in cavernous section of carotid artery

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20110601

Year of fee payment: 5

LAPS Lapse due to unpaid annual fee