JPWO2021175898A5 - - Google Patents

Claims (15)

A medical treatment device for stimulating neurons in a patient to inhibit pathologic synchronous activity of said neurons, the device being configured to simultaneously administer at least one acoustic stimulus and at least one non-acoustic stimulus to the patient's body. wherein each of said stimuli is configured to inhibit said pathologic synchronous activity when administered to said patient's body. The medical treatment device configured to be fixed to a patient's head, wherein in a fixed state of the medical treatment device fixed to the patient's head, the stimulation unit produces the acoustic stimuli. providing the patient's ears and said non-acoustic stimulus at the patient's skin in the region of the patient's forehead, particularly the first branch of the trigeminal nerve, or the occiput, particularly the C2 or C3 dermatome 11. The medical treatment device of claim 1, configured to: said acoustic stimulus is configured to inhibit pathologic synchronous activity of a first neuronal population, in particular in at least one of the patient's brain or spinal cord, when administered to said patient's body, said non-acoustic stimulus comprising: 3. The method of claim 1 or 2, adapted to inhibit pathological synchronous activity of a second population of neurons distinct from or bordering on said first population of neurons, particularly in at least one of the brain or spinal cord of a patient. medical treatment device. The medical treatment device of any one of claims 1-3, wherein the at least one non-acoustic stimulus is a vibrotactile stimulus. 11. Each one of said at least one acoustic stimulus is associated with one non-acoustic stimulus, said stimulation unit being configured to simultaneously generate one non-acoustic stimulus with its associated acoustic stimulus. 5. The medical therapeutic device according to any one of 1-4. The stimulation unit comprises at least one vibrotactile stimulation element, the vibrotactile stimulation element being vibratory or periodic on a surface of the patient's body to administer the non-acoustic stimulation to the patient's body. A medical treatment device according to any one of claims 1 to 5, adapted to act on. 7. The medical application of claim 6, wherein the stimulation unit is configured to generate the acoustic stimulus and the non-acoustic stimulus simultaneously upon vibratory or periodic actuation of the vibrotactile stimulation element. therapeutic device. Medical use according to any one of the preceding claims, wherein the vibrotactile stimulation element is operated at an operating frequency in the range 20Hz to 20kHz, in particular in the range 20Hz to 250Hz or in the range 200Hz to 600Hz. therapeutic device. the stimulation unit comprising at least two vibrotactile stimulation elements, each of the vibrotactile stimulation elements configured to generate one of the at least two non-acoustic stimuli; and the stimulation unit comprising: 9. A medical treatment device according to any one of the preceding claims, arranged to operate the at least two stimulation elements at different operating frequencies. 10. Medical treatment device according to claim 9, wherein the actuation frequencies at which the stimulation elements are to be actuated are tuned to a musical scale, in particular a pentatonic scale. wherein the stimulation unit comprises a set of different operating frequencies including frequencies at which to activate at least one stimulation element, and wherein the different set of operating frequencies is a first operating frequency and dependent on the first operating frequency. 11. A medical treatment device according to any one of claims 1 to 10, comprising at least one further operating frequency determined by or correlated to. The at least one further operating frequency of the different set of operating frequencies is added to the first operating frequency by the following formula:

wherein v ₁ refers to the first operating frequency, each one of v ₂ to v ₁₀ refers to said at least one further operating frequency, and k refers to a natural number equal to or greater than 2. 12. The medical treatment device of claim 11. said stimulation unit comprising at least one first stimulation element configured to administer said acoustic stimulus and at least one second stimulation element configured to administer said non-acoustic stimulus; one stimulation element is associated with one of said at least one second stimulation element, said association being such that said first stimulation element and said associated second stimulation element simultaneously generate said acoustic stimulus and said non-acoustic stimulus A medical treatment device according to any one of claims 1 to 12, arranged so as to be operable to generate. a control unit of the stimulation unit causing the stimulation unit to:
- a first mode of operation in which the generation of the acoustic stimulus is coupled with the generation of the non-acoustic stimulus;
- a second mode of operation in which the generation of the acoustic stimulus is decoupled from the generation of the non-acoustic stimulus;
14. A medical treatment device according to any one of claims 1 to 13 , configured to operate in a A medical method of stimulating neurons in a patient to inhibit pathologic synchronous activity of said neurons, comprising the step of non-invasively simultaneously administering at least one acoustic stimulus and at least one non-acoustic stimulus to the patient's body. and wherein each of said stimuli is configured to inhibit said pathological synchronous activity.