JPWO2020050275A1 - Radioactivity management system - Google Patents

Abstract

The present invention is in a nuclear medicine laboratory 3 having an imaging apparatus 10 that injects a radiopharmaceutical provided by a radiopharmaceutical manufacturing facility into a subject, detects the radiation emitted from the subject, and generates image data. , A radioactivity management system that manages the radioactivity of radiopharmaceuticals administered to a subject. In the system, the reading unit 340 uses the recording medium attached to the radiopharmaceutical drug provided from the drug manufacturing facility to the nuclear medical examination facility 3 to indicate the date and time of manufacture of the radiopharmaceutical drug, the type of radioisotope, and the time of manufacture of the radiopharmaceutical drug. The radiopharmaceutical drug information including the radiopharmaceutical value in the above is read, and the calculation unit 320 injects the radiopharmaceutical drug into the subject based on the radiopharmaceutical drug information, the date and time when the radiopharmaceutical drug was injected into the subject, and the half-life of the radiopharmaceutical. Calculate the radiopharmaceutical radiopharmaceutical value. With the above configuration, it is possible to grasp the accurate value of the radioactivity of the radiopharmaceutical drug injected into the subject in the nuclear medicine examination.

Description

The present invention relates to a radioactivity management system that manages the radioactivity in the body of a radiopharmaceutical drug injected into the body (subject) of a patient, a human dock examinee, or the like for a nuclear medicine examination.

Nuclear medicine examination is one of diagnostic imaging, in which a radiopharmaceutical drug is injected into a subject by a syringe or the like, and the radiation emitted by the radiopharmaceutical drug from the body of the subject is emitted by a single photon emission tomography device (SPECT: Single Photon). A method for analyzing the presence or absence of diseases and the location of lesions based on images obtained by detecting from outside the body using a nuclear medicine examination device such as Emission Computed Tomography (Emission Computed Tomography) or Positron Emission Tomography (PET). To say.

Radiopharmaceuticals consist of a solution in which a radioisotope (RI) is bound to a compound having the property of specifically accumulating in a specific organ, tissue, or cell in a predetermined solvent. In SPECT, a single photon is used. A compound that binds RI ( ¹²³ I, ⁹⁹ MTc, etc.) that releases positron is used, and a compound that binds RI ( ¹¹ C, ¹³ N, ¹⁵ O, ¹⁸ F, etc.) that releases positron is used in PET. .. RI, which is a raw material for radiopharmaceuticals, is manufactured in RI manufacturing facilities such as nuclear reactors and cyclotrons (particle accelerators).

The radiopharmaceutical injected into the body of the subject moves in the body according to the nature of the compound and accumulates in a specific organ. Therefore, an image (cross-sectional image) showing the distribution state of the radiopharmaceutical drug in the body by injecting the radiopharmaceutical drug into the subject and measuring the radiation emitted from the body (radiopharmaceutical drug) after a predetermined time has passed. Is obtained, and information on the diagnosis of the disease, such as the functional state in the body and the position of the lesion, can be obtained from the cross-sectional image.

In nuclear medicine examinations, RI, which has a relatively short half-life of radioactivity, is used for radiopharmaceuticals in order to suppress the effects of radiation on the body. For example, technetium 99m used in SPECT ^(99m Tc), iodine 123 ⁽¹²³ I) each half-life is 6 hours, 13.3 hours, fluorine 18 ⁽¹⁸ F) or carbon 11 to be used in PET ( the half-life of ¹¹ C) is 110 minutes, respectively, 20 minutes. Since the RI contained in the radiopharmaceutical drug decreases in a short time after the RI is manufactured, it is necessary to shorten the time from the manufacture of the radiopharmaceutical drug (or RI) to the implementation of the nuclear medicine examination as much as possible.

A radiopharmaceutical manufacturing company manufactures radiopharmaceuticals in response to an order from a facility (inspection facility) equipped with a nuclear medicine inspection device and provides the radiopharmaceutical to the inspection facility. Orders from inspection facilities are now accompanied by information about the date, place, amount, and RI used of the radiopharmaceutical, and the drug manufacturer can halve this information and the radiopharmaceutical activity of the RI. Schedules such as the amount of radiopharmaceutical synthesis (RI production amount), RI production start time, radiopharmaceutical production start time, and drug delivery time are determined based on the period, and radiopharmaceutical products are manufactured according to this schedule. Provided (Patent Document 1).

Japanese Unexamined Patent Publication No. 2003-185749

It is preferable that the radiopharmaceutical drug provided to the laboratory by the drug manufacturer as described above is used immediately, but in reality, the time from the time the radiopharmaceutical drug is provided to the laboratory to the injection into the subject. In addition, there are variations in the time from the injection of the radiopharmaceutical drug into the subject until the nuclear medicine test is performed, or the time during which the nuclear medicine test is performed.

The radioactivity of radiopharmaceuticals decreases over time. In particular, RI used for radiopharmaceuticals has a short half-life of radioactivity, so that the radioactivity is greatly reduced in a short time. If the radioactivity of the radiopharmaceutical drug present in the body of the subject is low, the image quality of the image acquired by the nuclear medicine examination device deteriorates.

Therefore, it is expected that the time from the delivery of the radiopharmaceutical drug to the laboratory to the injection into the subject will be longer than planned, or it will take time to detect the radiation by the nuclear medicine testing device. In such cases, the decrease in radioactivity is compensated by increasing the injection amount of radiopharmaceutical drugs. However, when the injection amount of the radiopharmaceutical drug is increased, it is difficult to judge whether the increase amount is appropriate, and in some cases, as a result of increasing the injection amount, the exposure dose of the subject becomes excessive. There was a problem that it would end up.

An object to be solved by the present invention is to be able to grasp the accurate value of the radioactivity of the radiopharmaceutical drug injected into the subject in the nuclear medicine examination.

The present invention, which has been made to solve the above problems, injects a radiopharmaceutical drug provided by a drug manufacturing facility that manufactures a radiopharmaceutical drug into a subject, and emits radiation emitted from the subject into which the radiopharmaceutical drug is injected. It is a radioactivity management system that manages the radioactivity of the radiopharmaceutical injected into the subject in a nuclear medicine laboratory equipped with an imaging device that detects and generates image data.
For multiple types of radioisotopes used in radiopharmaceuticals, a first storage unit that stores the half-life of each radioactivity, and
The date and time of manufacture of the radiopharmaceutical drug attached to the radiopharmaceutical drug provided from the drug manufacturing facility to the nuclear medical laboratory, the type of radioisotope used in the radiopharmaceutical drug, and the time of manufacture of the radiopharmaceutical drug. A reading unit that reads the radiopharmaceutical information from a recording medium on which the radiopharmaceutical information including the radiopharmaceutical value is recorded, and
A second storage unit that stores the radiopharmaceutical drug information read by the reading unit, and
Timekeeping means to time the current date and time,
An injection time point setting unit for setting the time point at which the radiopharmaceutical drug was injected into the subject,
An injection date / time acquisition unit that acquires the date / time set by the injection time point setting unit from the timekeeping means, and an injection date / time acquisition unit.
Injection into the subject based on the half-life of radioactivity stored in the first storage unit, the radiopharmaceutical drug information stored in the second storage unit, and the injection date and time acquired by the injection date and time acquisition unit. It is characterized by including a calculation unit for calculating the radioactivity value of the radiopharmaceutical product.

The drug manufacturing facility may be equipped with at least a device for producing a radiopharmaceutical drug, and it does not matter whether or not the facility is equipped with a device for producing a radioisotope (RI) such as a nuclear reactor or a cyclotron (particle accelerator). If the RI manufacturing device is not provided, the RI is purchased from a facility equipped with the RI manufacturing device (RI manufacturing facility), and the radiopharmaceutical is manufactured using the RI.
The nuclear medical examination facility refers to a medical institution such as a hospital or a clinic, and a research institution such as a university or a research institute. Examples of the imaging device provided in the nuclear medicine examination facility include a SPECT device, a PET device, a PET / CT (Computed Tomography) device, and the like.

In the radioactivity management system, when a radiopharmaceutical drug is provided from a drug manufacturing facility to a nuclear medicine testing facility, the reading unit reads the radiopharmaceutical drug information from the recording medium attached to the radiopharmaceutical drug, and the second storage unit. Saves this. For example, a letter representing radiopharmaceutical information, a two-dimensional code such as a QR code (registered trademark), or a bar code (one-dimensional code) is printed on a container such as a syringe or a vial (bottle) containing a radiopharmaceutical drug. In this case, or when a sticker with characters or the like indicating radiopharmaceutical information is affixed, the syringe and the container are the recording media. In this case, an OCR (Optical Character Recognition / Reader) device, a QR code reader, or a barcode reader functions as a reading unit.

When the radiopharmaceutical drug information is stored in the second storage unit, the injection date / time acquisition unit subsequently acquires the date and time when the radiopharmaceutical drug is injected into the subject, which is set by the injection time point setting unit, from the timekeeping means. ..

Radiopharmaceuticals manufactured at a drug manufacturing facility are delivered to a nuclear medicine laboratory in a syringe or vial. The radiopharmaceutical drug in the syringe is injected from the syringe into the subject, and the radiopharmaceutical drug in the vial is transferred to the syringe and then injected into the subject from the syringe. In order to reduce the exposure of workers such as doctors and radiological examination engineers, a syringe equipped with a tungsten shield or a lead shield is usually used.

When the operator manually operates the syringe to inject the radiopharmaceutical drug into the subject, the operator himself sets the injection time point by the injection time point setting unit immediately after or immediately before the injection work is performed. On the other hand, when an injection device is used in which the syringe is automatically operated to inject the radiopharmaceutical drug into the subject, the injection time setting unit may set the injection time based on the injection operation performed by the injection device. For example, when the injection time setting unit includes an injection instruction unit that outputs a start signal instructing the injection device to start the operation of injecting the radiopharmaceutical drug into the subject, and the injection instruction unit outputs the start signal. Can be configured to be set as the time of injection. Further, for example, when the injection device itself has a start button for starting the injection operation of the radiopharmaceutical drug into the subject, when the start button is pressed, the injection device sends a start signal to the injection time setting unit. At the same time as transmitting, the injection time point setting unit can be configured to receive the start signal from the injection device, and the time point at which the start signal is received can be set as the injection time point.

The time when the radiopharmaceutical drug is injected into the subject is the time when the injection is started, the time when the injection is finished, and the time when a predetermined time has elapsed from the start of the injection (typically, the middle from the start to the end). Time point).

When the administration of the radiopharmaceutical drug to the subject is completed, the calculation unit acquires the half-life of the radioactivity stored in the first storage unit, the radiopharmaceutical drug information stored in the second storage unit, and the injection date and time. The radioactivity value of the radiopharmaceutical drug injected into the subject is calculated based on the injection date and time acquired by the department.
Specifically, the calculation unit acquires the half-life of the radioactivity of the RI from the type of radioisotope (RI) included in the radiopharmaceutical information from the first storage unit. In addition, the time (elapsed time) from the manufacturing date and time of the radiopharmaceutical drug to the injection date and time is calculated from the manufacturing date and time of the radiopharmaceutical drug and the injection date and time acquired by the injection date and time acquisition unit included in the radiopharmaceutical drug information.

The radioactivity value of the radiopharmaceutical drug provided from the drug manufacturing facility to the nuclear medicine laboratory at the time of manufacture is R ₀ (unit: Bq), the elapsed time is t, and the radioisotope used in the radiopharmaceutical drug. Assuming that the half-life of (RI) is T and the value of radioactivity of the radiopharmaceutical drug injected into the subject is R ₁ , the calculation unit calculates _{R 1} from the following equation (1).
R ₁ = R ₀ × (1/2) ^{(t / T)} (1)

The above formula (1) is a formula for calculating the value of radioactivity when the entire amount of the radiopharmaceutical drug provided to the nuclear medicine laboratory is to be injected into the subject. When a part of the radiopharmaceutical drug provided to the nuclear medicine laboratory is injected into the subject, the radioactivity value R ₁ of the radiopharmaceutical drug is obtained from the following formula (2). In formula (2), L ₀ represents the amount of radiopharmaceutical drug provided to the nuclear medicine laboratory, and L _t represents the amount of radiopharmaceutical drug injected into the subject.
R ₁ = R ₀ × (1/2) ^{(t / T)} × (L _t / L ₀ ) (2)

When the calculation unit calculates the radioactivity value of the radioactivity drug injected into the subject by the above formula (2), the radioactivity management system further determines the amount of the radioactivity drug injected into the subject or An injection amount setting unit for setting the amount of the radiopharmaceutical injected into the subject is provided, and the radiopharmaceutical information includes the amount of the radiopharmaceutical, and the calculation unit is stored in the second storage unit. The stored radiopharmaceutical information, the injection date and time acquired by the injection date and time acquisition unit, the injection amount set by the injection amount setting unit, and the half-life of the radioactivity stored in the first storage unit are set. Based on this, it is preferable to calculate the radioactivity value of the radiopharmaceutical injected into the subject.

In a configuration in which an operator operates a syringe to inject a radiopharmaceutical drug into a subject, the injection amount setting unit may be provided with, for example, a numeric keypad, and the injection amount can be set by operating the numeric keypad.
In the configuration in which the injection device operates a syringe to inject the radiopharmaceutical drug into the subject, the injection amount setting unit may be configured to include a numeric keypad for setting the injection amount, but the amount injected by the injection device. The injection amount setting unit can be configured to set the injection amount based on the detection result of the detection unit.
If the injection amount setting unit has a configuration in which the injection amount is set immediately before or immediately after the injection of the radiopharmaceutical drug, the injection amount setting unit sets the time when the injection amount setting unit sets the injection amount as the injection time. You may.

In addition, the radioactivity management system further includes an inspection information acquisition unit that acquires inspection information including the date and time when the imaging device started or ended its operation from the imaging device.
The calculation unit determines the inspection information acquired by the inspection information acquisition unit, the injection date and time acquired by the injection date and time acquisition unit, the half-life of the radioactivity stored in the first storage unit, and the subject. From the injected radioactivity value of the radiopharmaceutical drug, it is preferable to calculate the radioactivity value of the radiopharmaceutical drug present in the body of the subject during the operation of the imaging device.

The image quality represented by the image data generated by the imaging device is the performance of the imaging device, the skill of the operator (setting of imaging conditions), the metabolic status of the subject, and the radioactivity of the radiopharmaceutical injected into the body of the subject. Depends on the value. Even if the performance of the imaging device and the skill of the operator are excellent, a clear image cannot be obtained if the metabolism of the subject is poor or if the radiopharmaceutical value in the body of the subject is low.
In the above-mentioned radioactivity management system, since the value of the radioactivity of the radiopharmaceutical drug in the body of the subject is obtained during the operation of the imaging device, that is, while the imaging device is detecting radiation, the image data generated by the imaging device is obtained. When the image quality of the image represented by is poor, the cause can be objectively determined. It should be noted that the operating of the photographing device may be any time when the photographing device is detecting radiation, and includes the time when the photographing operation is started and the time when the photographing operation is finished.

The radiopharmaceutical control system is further provided with a detector for detecting the weight of the container containing the radiopharmaceutical drug.
The radiopharmaceutical information includes the amount of radiopharmaceutical contained in the container.
The calculation unit has the radiopharmaceutical information stored in the second storage unit, the injection date and time acquired by the injection date and time acquisition unit, and the injection date and time detected by the detector before the radiopharmaceutical drug is injected into the subject. Inject into the subject based on the weight of the container, the weight of the container after the radiopharmaceutical is injected into the subject, and the half-life of the radioactivity stored in the first storage unit. It may be configured to calculate the value of the radioactivity of the radiopharmaceutical drug.
According to the above configuration, the radioactivity value of the radiopharmaceutical injected into the subject can be accurately calculated.

According to the present invention, since it is possible to grasp the exact value of the radioactivity of the radiopharmaceutical drug administered to the subject for the nuclear medical examination, the value of the radioactivity of the radiopharmaceutical drug administered to the subject is planned. If the value of radioactivity is less than the value of radioactivity, the amount of radiopharmaceutical required to make up for the decrease can be calculated. In addition, by additionally injecting the required amount of radiopharmaceutical drug into the subject, it is possible to carry out a nuclear medicine examination in a state where an appropriate amount of radiopharmaceutical drug having an appropriate radioactivity is injected into the subject. If a nuclear medicine test is performed with the appropriate amount of radiopharmaceutical drug of the appropriate radioactivity injected into the subject, the image normally taken by the imaging device should be clear, but it is usually appropriate. Appropriate amounts of radioactivity and radiopharmaceuticals are determined based on the body weight of the subject, and the metabolic status of the subject is not taken into consideration. Therefore, it is possible to infer the metabolic status of the subject, which cannot be visually determined, from the image quality of the image captured by the imaging device (for example, when the image quality is evaluated as "good", "normal", or "bad", the subject is evaluated. It can be inferred that the metabolic status of is "good", "normal", and "bad"). In addition, if the metabolism is presumed to be good from the administration history of the subject, the radioactivity value of the radiopharmaceutical suitable for the subject can be underestimated. It can be avoided.

The schematic diagram which shows the distribution system of a radiopharmaceutical drug. The figure which shows the example of the container of the radiopharmaceutical medicine which printed the QR code. An example of radiopharmaceutical information represented by a QR code. The schematic block diagram of 1st Embodiment of the radioactivity management system which concerns on this invention. Schematic block diagram of the PET device. Schematic block diagram centered on the control unit of the injection device. Schematic block diagram of the radioactivity control device. The figure which shows the state which the injection amount is displayed on the display screen of the display device provided in the radioactivity management device. The figure which shows the state which the photographed image of a PET device is displayed on the display screen of the display device provided in the radioactivity management device. The schematic diagram which shows the structure of a part of the injection apparatus used in the radioactivity management system of 2nd Embodiment. The schematic block diagram centering on the control part of the injection apparatus used in the radioactivity management system of 3rd Embodiment. The figure which shows the state which the radioactivity value of the radiopharmaceutical drug in a container, and the radioactivity value of the radiopharmaceutical drug injected into a subject is displayed on the display screen of the display device provided in the radioactivity management device.

Hereinafter, embodiments of the radioactivity management system according to the present invention will be described with reference to the drawings.
First, prior to the description of the embodiment, the distribution system of the radiopharmaceutical drug will be described. FIG. 1 is a schematic view showing a distribution system for radiopharmaceuticals. As shown in this figure, radiopharmaceuticals are classified into a control organization 1 that manages radioisotopes, a manufacturing company (radiopharmaceutical manufacturing facility) 2 that manufactures radiopharmaceuticals, and a nuclear medicine testing facility 3 that conducts nuclear medicine testing. It is configured to circulate between. Although not shown, the distribution system includes a treatment facility for treating radioactive waste generated at the manufacturing company 2 and the nuclear medicine research facility 3.

In Japan, the distribution of radiopharmaceuticals is controlled by the Japan Radioisotope Association, which corresponds to the management organization 1.
The nuclear medicine examination facility 3 includes medical institutions such as hospitals and clinics equipped with nuclear medicine examination devices (imaging devices) such as SPECT devices, PET devices, and PET / CT devices, and research institutions. When the nuclear medicine examination facility 3 decides to carry out the nuclear medicine examination, it places an order for the radiopharmaceutical drug with the management organization 1 according to the implementation conditions (date and time of implementation, amount of radiopharmaceutical drug used, type of RI, etc.). Upon receiving the order, the management organization 1 requests the manufacturing company 2 to manufacture the radiopharmaceutical drug according to the contents of the order, and charges the nuclear medicine laboratory 3 for the cost. The manufacturing company 2 that received the request manufactures the radiopharmaceutical drug according to the content of the request and provides it to the nuclear medicine laboratory 3. The nuclear medicine laboratory 3 may place an order directly with the manufacturing company 2. In this case, the manufacturing company 2 informs the management organization 1 of the order contents and manufactures the radiopharmaceutical according to the order contents.

The management organization 1, the manufacturing company 2, and the nuclear medicine examination facility 3 each have distribution terminals 1A, 2A, and 3A that are communicably connected to each other via a network, and operate these terminals 1A to 3A, respectively. By doing so, you can order, claim, and request radiopharmaceuticals. The terminals 1A to 3A may be a so-called desktop type or notebook type personal computer (PC), or may be a portable terminal type (so-called tablet type PC).

For radiopharmaceuticals manufactured by manufacturing company 2 for management by management organization 1, the name of the manufacturing company, classification / date / time of manufacture / liquid volume of radiopharmaceuticals, type of RI used for radiopharmaceuticals, name of nuclear medicine laboratory , A recording medium on which a symbol and a number representing information including an order number (radiopharmaceutical drug information), a QR code (two-dimensional code), a bar code (one-dimensional code), etc. are recorded is attached. The recording medium may be a container or syringe containing a radiopharmaceutical drug, a seal attached to the container or syringe, or an IC chip (RF tag) attached or embedded in the container or syringe. The "liquid amount" of the radiopharmaceutical drug corresponds to the "amount" of the radiopharmaceutical drug of the present invention.

For example, FIG. 2A shows a state in which a sticker 6 on which a QR code is printed is affixed to a container 5 in which a radiopharmaceutical drug is stored. In addition to the QR code, the sticker 6 is also printed with a symbol indicating the name of the manufacturing company, characters indicating the nuclear medicine laboratory, and a number indicating the date and time of manufacture. FIG. 2B shows an example of radiopharmaceutical information represented by the QR code. Radiopharmaceutical drug information is obtained by reading the QR code printed on the sticker 6 with a QR code reader.

Affixing a sticker with a QR code printed on a container or the like of a radiopharmaceutical drug has been conventionally performed, but the QR code is exclusively used for the management of radiopharmaceutical drugs in the management institution 1 and used in the nuclear medicine laboratory 3. It never happened. The radioactivity management system according to the present invention uses such a QR code to control the radioactivity of a radiopharmaceutical drug injected into a subject, and is constructed in a nuclear medicine laboratory 3.

[First Embodiment]
Next, the radioactivity management system of the first embodiment will be described with reference to FIGS. 3 to 8.
[1. Radioactivity management system configuration]
As shown in FIG. 3, the radiological control system 100 includes a nuclear medicine examination device (imaging device) 10, an injection device 20 for injecting a radiopharmaceutical drug into a subject, a radiological control device 30, and a chart management device. HIS (Hospital Information System) 40, RIS (Radiology Information System) 50, which is a device for managing information related to nuclear medicine examination, and PACS (PACS), which is a device for managing image data generated by the nuclear medicine examination device 10. Picture Archiving and Communication Systems) 60, an image viewing device 70, a printer 80, and the like are provided. As will be described in detail later, the method of injecting the radiopharmaceutical drug into the subject includes a method in which the injection device 20 operates a syringe filled with the radiopharmaceutical drug to inject the radiopharmaceutical drug into the subject (automatic injection). There is a method of injecting into the subject by operating a syringe (manual injection).

The nuclear medicine examination device 10, the injection device 20, the radioactivity management device 30, the HIS40, the RIS50, the PACS60, the image viewing device 70, and the printer 80 are connected via a network 90 such as a wired LAN or a wireless LAN. In FIG. 3, the radioactivity management system 100 includes one nuclear medicine examination device 10, one injection device 20, one image viewing device 70, and one printer 80, but each of them is not limited to one, and a plurality of devices are provided. You may have it.

The nuclear medicine examination device 10 and the injection device 20 are installed in a room of the nuclear medicine examination facility 3 which is configured by using a partition wall or the like that does not leak radioactivity to the outside. Normally, the nuclear medicine examination device 10 and the injection device 20 are installed in the same room, but both devices may be installed in different rooms. The radioactivity control device 30, HIS40, RIS50, PACS60, image viewing device 70, and printer 80 are installed in a room of the nuclear medicine examination facility 3 different from the room in which the nuclear medicine examination device 10 and the injection device 20 are installed. ing. The radioactivity management device 30, HIS40, RIS50, PACS60, the image viewing device 70, and the printer 80 may all be installed in the same room, or one by one or a plurality of them may be installed in different rooms. ..

The HIS 40 is composed of a paperwork system such as examination reception work and accounting work at the nuclear medicine examination facility 3, an electronic medical record management system, and the like. The electronic medical record includes data such as a medical record ID, a subject ID, personal data such as the subject's name, gender, age, and weight, and chart data related to the subject's disease.

The RIS50 creates and manages test condition data for performing a nuclear medicine test. The RIS50 acquires an electronic medical record from the HIS40 and creates inspection condition data based on the electronic medical record. The test condition data includes the work ID of the nuclear medicine test, the type of the nuclear medicine test and the identification information of the nuclear medicine test device, the subject ID, the date and time of the nuclear medicine test (start and end date and time), the type and use of the radiopharmaceutical drug. Data such as quantity is included. The distribution terminal 3A described above acquires test condition data from RIS50 and orders a radiopharmaceutical drug based on the test condition data.

The PACS 60 receives, stores, and manages image data generated by the nuclear medicine examination device 10 (modality) through the network 90.

The HIS40, RIS50, and PACS60 are each composed of a computer on which a dedicated computer program is implemented.
Further, the communication protocol between the HIS40, RIS50, PACS60, the nuclear medicine examination device 10, the injection device 20, and the radioactivity control device 30 is typically DICOM (digital imaging and communication in medicine). It is not limited to.

[2. Configuration of nuclear medicine examination equipment]
The nuclear medicine examination device 10 is a device mainly used for diagnosing a disease in a medical facility such as a hospital or a clinic, and an imaging device such as a PET device, a SPECT device, or a PET / CT device is exemplified. Hereinafter, in order to explain the case where the PET device is used as the nuclear medicine test device 10 as an example, the nuclear medicine test device 10 will be read as the PET device.

As shown in FIG. 4, the PET apparatus 10 includes a PET scanner 11, an image generation unit 12 that generates image data based on the detection result of the PET scanner 11, and for setting shooting conditions and inputting each command. It includes an operation unit 13, an output unit 14 for outputting image data and other data generated by the image generation unit 12, and a display unit 15 for displaying an image or the like represented by the image data.

The PET scanner 11 detects the radiation emitted from the radioisotope contained in the radiopharmaceutical injected into the body of the subject.
The image generation unit 12 is configured based on a computer, and is composed of basic hardware such as a CPU (Central processing unit) 121, a memory 122, and an HDD (Hard disk drive) 123. The CPU 121 is interconnected to each hardware component via a signal transmission line. The CPU 121 executes a program stored in the memory 122 in response to an operation via the operation unit 13. As a result, the CPU 121 functions as a scan control unit 126, an image data processing unit 127, a display control unit 128, and the like.

The image data processing unit 127 generates image (internal image) data inside the subject by processing the signal supplied from the PET scanner 11. The image data generated by the image data processing unit 127 includes text data (setting conditions of the scanner 11 during scanning operation, radiation dose data, subject ID, identification information of PET device 10 (manufacturer name, model number, etc.)). The software name used in the PET device 10, the version of the software, etc.) is attached, and the information (inspection information) obtained by the inspection is transmitted from the output unit 14 to the PACS 60, and also to the radioactivity management device 30. Will be sent.

[3. Injection device configuration]
As shown in FIGS. 3 and 5, the injection device 20 independently presses the injection head 200 having two recesses 201 for mounting the syringe 21 and the piston of the syringe 21 mounted in the recess 201. The piston drive mechanism 210 and the control panel 220 are provided.
The control panel 220 is provided with a control unit 221 that controls the piston drive mechanism 210, an operation unit 222, a display unit 223, a camera 224, and a communication I / F 225.

The control unit 211 drives the piston drive mechanism 202 when the operation unit 211 is operated to set the injection amount and the start of the injection operation is instructed. In response to this, the piston of each syringe 21 is pushed by the piston drive mechanism 202, and the radiopharmaceutical drug in the syringe 21 set in the recess 201 is injected into the subject.

The camera 224 is for photographing the QR code attached to the container 5 containing the radiopharmaceutical drug provided by the manufacturing company 2. When the container 5 is a syringe, the QR code is photographed by the camera 224, and then the syringe is set in the injection device 20. If the container 5 is a vial, the QR code is photographed with a camera 224, then a part or all of the radiopharmaceutical in the vial is transferred to a syringe, and the syringe is set in the injection device 20. The image data taken by the camera 224 is transmitted to the radioactivity management device 30 through the communication I / F 225.

[4. Radioactivity management device configuration]
As shown in FIG. 6, the radioactivity management device 30 includes a CPU 301, a main storage device 302, an auxiliary storage device 303 including a storage unit 350, a communication I / F 304, and an input device (keyboard, mouse (pointing device)). , Touch panel, etc.) 305, display device 306, camera 307, and time server (time measuring means) 308. The radioactivity management device 30 loads the various processing programs stored (installed) in the auxiliary storage device 303 into the main storage device 302 and executes the information processing function of the information processing unit 320 and the data reception unit 330. Data reception function and reading function of QR code reader 340 are realized. The storage unit 350 stores information on the half-lives of various RIs.

The data receiving unit 330 receives the data sent from the PET device 10 and the injection device 20 through the communication I / F 304, or the data input by operating the input device 305. The QR code reader 340 reads the radiopharmaceutical drug information represented by the QR code from the image of the QR code taken by the camera 307 or the image of the QR code sent from the injection device 20. Therefore, the QR code reader 340, the camera 307, and the camera 224 constitute the reading unit of the present invention. The radiopharmaceutical information data read by the QR code reader 340 and the data received by the data receiving unit 330 are stored in the storage unit 350, respectively. In the storage unit 350, data related to the same nuclear medicine test is linked based on the subject ID, the work ID of the nuclear medicine test, the nuclear medicine test device (PET device), the product code of the radiopharmaceutical drug, etc. included in each data. Be done.

When the data receiving unit 330 receives the injection start signal of the radiopharmaceutical drug, the arithmetic processing unit 320 sets the receiving time as the injection time, acquires the date and time from the time server 308, and stores the date and time in the storage unit 350 as the injection date and time. do. Then, when the input device 305 is operated to instruct the start of the calculation processing of the radioactivity value, the calculation processing unit 320 extracts the data stored in the storage unit 350 and injects the radiopharmaceutical drug into the subject. Calculate the value of radioactivity in. Therefore, the storage unit 350 corresponds to the first storage unit and the second storage unit of the present invention, and the arithmetic processing unit 320 corresponds to the injection time point setting unit, the injection date / time acquisition unit, and the arithmetic unit.

The result calculated by the arithmetic processing unit 320 is displayed on the display device 306. Further, this result may be sent to HIS40 by communication I / F304.

[5. Procedure for executing a nuclear medicine examination] Next, a procedure for executing a nuclear medicine examination using the PET apparatus 10 will be described. First, a case where a worker manually injects a radiopharmaceutical drug will be described.
[5.1 Injection of radiopharmaceutical drug into subject (manual)]
When the test condition data for carrying out the nuclear medicine test is created in the RIS50, the worker of the nuclear medicine test prepares the radiopharmaceutical drug according to the test conditions. Then, the operator operates the input device 305 of the radioactivity management device 30 to take a picture of the QR code attached to the container 5 containing the radiopharmaceutical drug with the camera 307. The data of the image of the QR code taken by the camera 307 is sent to the QR code reader 340, and the radiopharmaceutical drug information represented by the QR code is read. The read radiopharmaceutical drug information is stored in the storage unit 350.

Subsequently, when the container 5 is a syringe, the operator operates the syringe to inject the radiopharmaceutical in the vial into the subject. When the container 5 is a vial, the operator transfers the radiopharmaceutical drug to a syringe and then operates the syringe to inject the radiopharmaceutical drug into the subject. Then, when the injection of the radiopharmaceutical drug into the subject is completed, the operator operates the input device 305 (numeric keypad) to input the injection amount. That is, in this example, the input device 305 functions as the injection amount setting unit of the present invention. The input injection amount data is received by the data receiving unit 330 and stored in the storage unit 350. When the data receiving unit 330 receives the injection amount data, the arithmetic processing unit 320 acquires the received date and time from the time server 308 and stores it in the storage unit 350 as the injection date and time. Information represented by various data stored in the storage unit 350 can be displayed on the display device 306. For example, FIG. 7 shows the display screen 306A of the display device 306 at the time when “35 (ml)”, which is the injection amount of the radiopharmaceutical drug, is input. On this display screen 306A, in addition to the injection amount display area 306B, the numeric keypad 306C, the QR code image display area 306D taken by the camera 307, information on each subject (test conditions, physical characteristics of the subject, etc.) ) Is included in the display area 306E and the like. The injection date and time acquired from the time server 308 is displayed in the display area 306E.

[5.2 Calculation of the radioactivity value of the radiopharmaceutical injected into the subject]
Next, when the input device 305 is operated to instruct the start of the arithmetic processing of radioactivity, the arithmetic processing unit 320 injects the data stored in the storage unit 350, specifically, the injection date and time, and the injection of the radiopharmaceutical drug. Data on the amount, the half-life of RI used in the radiopharmaceutical drug, the date and time of manufacture of the radiopharmaceutical drug, the value of radioactivity at the time of manufacture, and the liquid volume of the radiopharmaceutical drug were extracted, and the radiation of the radiopharmaceutical drug injected into the subject was extracted. Calculate the value of the ability. The above-mentioned equation (2) can be used to calculate the value of radioactivity. The calculated radioactivity value is stored in the storage unit 350. The calculated radioactivity value is displayed on the display screen 306A by a predetermined operation.

[5.3 Injection of radiopharmaceutical drug into subject (automatic)]
The procedure for automatically injecting a radiopharmaceutical drug by the injection device 20 is as follows. First, the QR code attached to the container 5 containing the radiopharmaceutical is photographed by the camera 224. The QR code image data taken by the camera 224 is stored in the memory 221a. Subsequently, when the container 5 is a syringe, the syringe is transferred, and when the container 5 is a vial, the radiopharmaceutical drug is transferred to the syringe, and then the syringe is set in the injection device 20. Then, the operation unit 222 is operated to set the injection amount of the radiopharmaceutical drug and instruct the start of the injection operation. The set injection amount is stored in the memory 221a. Further, the control unit 221 operates the piston drive mechanism 210 so that the radiopharmaceutical drug is injected into the subject by the set injection amount.

When the start of the injection operation is instructed by the operation of the operation unit 222, the operation signal (injection start signal), the image data of the QR code stored in the memory 221a, and the injection amount data are transmitted to the radioactivity management device 30. It is accepted by the data reception unit 330. When the data receiving unit 330 receives the injection start signal, the arithmetic processing unit 320 acquires the date and time at the time of acceptance from the time server 308, and stores the date and time as the injection date and time in the storage unit 350. Further, the image data of the QR code received by the data reception unit 330 is sent to the QR code reader 340, and the radiopharmaceutical drug information represented by the QR code is read. Since the calculation process of radioactivity is the same as that of manual injection, the description thereof will be omitted.

In both the manual injection and the automatic injection, when the injection of the radiopharmaceutical drug into the subject is completed, a nuclear medicine examination using the PET device 10 is performed. In the PET device 10, the subject is scanned by the PET scanner 11 within a period from the start to the end of taking an internal image of the subject, and radiation emitted from various parts of the subject is detected. The detection result of the PET scanner 11 is processed by the image generation unit 12, and image data of a plurality of in-vivo images is created. When the acquisition of the internal image by the PET device 10 is completed, the inspection information data including the image data, the imaging start date and time and the imaging end date and time data is sent to the radioactivity management device 30 and received by the data receiving unit 330. That is, in this example, the data receiving unit 330 functions as the inspection information acquisition unit of the present invention. The inspection information data received by the data receiving unit 330 is stored in the storage unit 350. The inspection information data is also sent to PACS60.

In the radioactivity management device 30, when the input device 305 is operated to instruct the start of the radioactivity arithmetic processing, the arithmetic processing unit 320 receives the data stored in the storage unit 350, specifically, the injection date and time. Data on the start date and time of imaging, the end date and time of imaging, the half-life of RI used in the radiopharmaceutical drug, and the radioactivity at the time of injection are extracted, and the radioactivity of the radiopharmaceutical drug at a predetermined time during the imaging operation of the PET device 10. Calculate the value of. The predetermined time point can be obtained from the shooting start date and time and the shooting end date and time, and can be, for example, an intermediate time point between the shooting start date and time and the shooting end date and time. Further, the shooting start date and time, or a time point when a certain time has passed from the shooting start date and time may be set as a predetermined time point, and a time point which is advanced by a certain time from the shooting end date and time or the shooting end date and time may be set as a predetermined time point. .. The above-mentioned equation (1) can be used to calculate the value of radioactivity. The calculated radioactivity value is stored in the storage unit 350. The calculated radioactivity value is displayed on the display screen 306A by a predetermined operation.

In the radioactivity management device 30, by operating the input device 305, the internal image taken by the PET device 10 can be displayed on the display device 306. FIG. 8 shows an example in which four cross-sectional images and one longitudinal image are displayed on the display screen 306A. In addition to the image display area 306F, the display screen 306A displays a display area 306G for displaying an index for evaluating image quality, and information on each subject (subject ID, physical characteristics of the subject, etc.). The display area 306H and the like to be displayed are included.

In the display area 306G, in addition to the image quality evaluation index such as NEC (noise equivalent count) patient, the value of the radioactivity in the subject during the photographing operation stored in the storage unit 350 is also displayed. Therefore, the operator injects the radiopharmaceutical drug into the subject based on the photographed image displayed on the display screen 306A, the physical characteristics of the subject, the image quality evaluation index, the value of radioactivity in the subject during the imaging operation, and the like. The validity of the quantity can be judged.

Generally, the amount of radiopharmaceutical injection is determined from the body weight of the subject. Therefore, when the amount of the radiopharmaceutical drug determined from the body weight is injected into the subject and the imaging is performed by the PET device 10 as scheduled, the radioactivity in the subject during the imaging operation becomes an appropriate value. In addition, when a metabolic disorder is observed in the subject, the radiopharmaceutical injected into the subject is not uniformly distributed in the body of the subject, and the image quality deteriorates.

From this, if the radioactivity in the subject during the imaging operation is smaller than the appropriate value, the imaging was started later than the scheduled imaging date and time, or the wrong amount of radiopharmaceutical was used as the subject. It can be judged that it was injected into. In addition, if the image quality of the photographed image is good even though the radioactivity is smaller than the appropriate value, it can be inferred that the metabolic condition of the subject is good, and even if the injection amount of the radiopharmaceutical drug is reduced. It can be determined that the image quality of the captured image does not deteriorate. In addition, when the image quality of the internal image is poor and the radioactivity is an appropriate value, it can be inferred that the cause of the poor image quality is that the setting of the imaging conditions is not appropriate, or that the metabolic condition of the subject is poor. can. Further, for example, when the image quality evaluation index of the internal image exceeds the reference value, it can be determined that the injection amount of the radiopharmaceutical drug is excessive.

In this way, in the radioactivity management system, since the value of the radioactivity in the body of the subject at the time of taking a picture with the PET device 10 can be known, the radiopharmaceutical injected into the subject is examined from the image quality of the image taken by the PET device 10. It is possible to objectively judge whether or not the amount of is appropriate.

[Second Embodiment]
The radioactivity management system of the second embodiment will be described with reference to FIG. The same or corresponding parts as those in the first embodiment are designated by the same reference numerals, and the description thereof will be omitted as appropriate. In this embodiment, the radioactivity management system 100 includes a QR code scanner 260 instead of the injection device 20, and the injection device 20 exists as a so-called stand-alone device independent of the radioactivity management system 100. ..

The injection device 20 includes a touch panel 230 in which a display unit and an operation unit are integrated, and a printer 250. The touch panel 230 includes a screen 240 having an operation area 241 and a display area 242. A detector (not shown) for detecting a touch operation on the screen is provided inside the operation area 241 according to the operator touching an image of an operation button displayed in the operation area 241. The touch signal is output to the control unit 221. The display area 242 includes an information display area 243 for displaying information (subject information) and the like related to the subject, and an image display area 244 for displaying the image of the QR code printed on the container 5 containing the radiopharmaceutical drug. Have.

The QR code scanner 260 is a handy type scanner that is generally commercially available, and is connected to the radioactivity management device 30 via a network such as a wired LAN or a wireless LAN (for example, Bluetooth®). The QR code scanner 260 corresponds to the reading unit of the present invention.

In this embodiment, before the radiopharmaceutical drug is automatically injected by the injection device 20, the operator first operates the operation area 241 of the touch panel 230 to input the subject information. When the subject information is input, the injection device 20 stores it in the memory 221a and displays it in the information display area 243.

Further, the operator takes a picture of the QR code attached to the container 5 containing the radiopharmaceutical drug with the camera 224 of the injection device 20. The image data of the QR code taken by the camera 224 is stored in the memory 221a, and the image of the QR code is displayed in the image display area 244. Next, the operator uses the QR code scanner 260 to read the image of the QR code displayed in the image display area 244. When the QR code scanner 260 reads the image of the QR code, it reads the radiopharmaceutical drug information represented by the QR code and transmits it to the radioactivity management device 30. Further, the QR code scanner 260 sends the read data of the radiopharmaceutical drug information to the printer 250. As a result, the printer 250 prints the radiopharmaceutical drug information on the paper 251 and outputs it. FIG. 9 shows an example of a paper 251 on which radiopharmaceutical information is printed.

As described above, when the work of inputting the subject information by the operator and the work of reading the QR code using the QR code scanner 260 are completed, the work operates the touch panel 230 to instruct the start of the injection operation of the radiopharmaceutical drug. As a result, the piston drive mechanism 210 operates, and the radiopharmaceutical drug is injected into the subject by the set injection amount.

The data receiving unit 330 of the radioactivity management device 30 receives the data of the radiopharmaceutical drug information sent from the QR code scanner 260 and stores it in the storage unit 350. Further, when the data receiving unit 330 receives the radiopharmaceutical information data from the QR code scanner 260, the arithmetic processing unit 320 acquires the date and time at the time of acceptance from the time server 308, and uses that date and time as the injection date and time in the storage unit 350. Remember.

After that, in the radioactivity management device 30, the calculation process of the radioactivity of the radiopharmaceutical drug injected into the subject is executed as in the first embodiment. In addition, a nuclear medicine examination using the PET device 10 is performed, and a calculation process of the radioactivity of the radiopharmaceutical drug is executed at a predetermined time point during the imaging operation of the PET device 10.

As described above, in the second embodiment, the radioactivity management system 100 includes the QR code scanner 260, and the QR code scanner 260 is connected to the radioactivity management device 30 by a wireless LAN or the like. Therefore, unlike the first embodiment, the injection device 20 does not have a communication I / F. Further, in the present embodiment, the QR code reader 340 provided in the radioactivity management device 30 of the first embodiment can be omitted.

[Third Embodiment]
The radioactivity management system of the third embodiment will be described with reference to FIGS. 10 and 11. The same or corresponding parts as those in the first embodiment are designated by the same reference numerals, and the description thereof will be omitted as appropriate. In this embodiment, the injection device 20 includes a weight sensor 226. The weight sensor 226 is for detecting the weight of the syringe set in the injection device 20. Since the syringe contains the radiopharmaceutical, the weight sensor 226 detects the weight of the radiopharmaceutical together with the syringe.

In this embodiment, when the syringe is set in the injection device 20, its weight is detected by the weight sensor 226. The detected weight (weight before injection) is stored in the memory 221a. After that, when the start of the injection operation is instructed by the operation of the operation unit 222, the piston drive mechanism 210 operates, and the injection operation of the radiopharmaceutical drug into the subject is executed. Then, when the set injection amount of the radiopharmaceutical drug is injected into the subject, the operation of the piston drive mechanism 210 is stopped, and the injection operation of the radiopharmaceutical drug is completed. At this timing, the weight of the syringe set in the injection device 20 is detected again by the weight sensor 226. The detected weight (weight after injection) is stored in the memory 221a.

When the operation unit 222 is operated and the transmission of the data stored in the memory 221a is instructed, the control unit 221 reads the pre-injection weight and post-injection weight data from the memory 221a and reads the data through the communication I / F 225. It is transmitted to the radioactivity management device 30. The pre-injection weight and post-injection weight data sent from the injection device 20 to the radioactivity management device 30 are received by the data receiving unit 330 and stored in the storage unit 350.

In the radioactivity management device 30, when the input device 305 is operated to instruct the start of the arithmetic processing of the radioactivity, the arithmetic processing unit 320 receives the data stored in the storage unit 350, specifically, the radiopharmaceutical. Data on the pre-injection weight and post-injection weight, the date and time of injection, the half-life of RI used in the radiopharmaceutical drug, the date and time of manufacture of the radiopharmaceutical drug and the value of radioactivity at the time of manufacture, and the liquid volume of the radiopharmaceutical drug were extracted. Calculate the radioactivity value of the radiopharmaceutical injected into the sample. Further, the result calculated by the arithmetic processing unit 320 is displayed on the display device 306.

FIG. 11 shows an example of the display screen 306A of the display device 306 on which the result calculated by the arithmetic processing unit 320 is displayed. The display screen 306A displays areas 316A to 316D in which radiopharmaceutical information, pre-injection weight and post-injection weight of the radiopharmaceutical drug, and a calculation result (radioactivity value of the radiopharmaceutical drug injected into the subject) are displayed. ing. Note that FIG. 11 shows an example in which the radiopharmaceutical information of the two radiopharmaceuticals, the pre-injection weight and the post-injection weight of the radiopharmaceutical, and the calculation result display areas 316A to 316D are displayed in two upper and lower stages. , The number of radiopharmaceuticals displayed on the display screen 306A may be one or three or more.

According to this embodiment, it is possible to obtain the radioactivity value of the radiopharmaceutical drug actually injected into the subject.

[Modification example]
The present invention is not limited to the above-described embodiment, and the following modifications can be made.
In the first and second embodiments, both the radioactivity value of the radiopharmaceutical injected into the subject (the radioactivity value at the time of injection) and the radioactivity value during the imaging operation are obtained. However, it is also possible to obtain only the value of radioactivity at the time of injection of the radiopharmaceutical drug. Normally, imaging by the PET device 10 is started as soon as the injection of the radiopharmaceutical drug is completed, so that there is no problem even if the radioactivity value at the time of injection is regarded as the radioactivity value during the imaging operation.

In the first and second embodiments, the container or syringe on which the QR code is printed, or the sticker on which the QR code is printed has been described as a recording medium on which the radiopharmaceutical information is recorded, but the QR code is printed. A tag may be attached to the container or syringe. In this case, the tag is the recording medium. It is also possible to use an IC chip (RF tag) on which radiopharmaceutical information is recorded as a recording medium. In this case, the radioactivity management system includes an IC tag reader (RFID reader) as a reading unit.

In the first embodiment, the inspection information data transmitted from the PET device 10 to the radioactivity management device 30 includes the data of the shooting start date and time by the PET device 10, but the PET device 10 starts shooting to the radioactivity management device 30. It may be configured so that a signal is transmitted. In this configuration, the radioactivity management device 30 that has received the shooting start signal receives the shooting start signal at the data receiving unit 330, and the date and time when the arithmetic processing unit 320 receives the shooting start signal at the data receiving unit 330 is received from the time server 308. It is acquired and the date and time is stored in the storage unit 350 as the shooting start date and time.

In the first embodiment, information on the half-life of radioactivity of various RIs and radiopharmaceutical information are stored in a common storage unit 350, but they are stored in separate storage units (first storage unit and second storage unit). ) May be saved.

In the first embodiment, the operation of the operation unit 222 of the injection device 20 is instructed to start the injection operation of the injection device 20 itself, and the injection start signal is transmitted to the radioactivity management device 30. The injection start signal may be transmitted to the injection device 20 by the operation of the input device 305 of the radioactivity management device 30, and the injection device 20 that has received the injection start signal may start the injection operation. In this configuration, the arithmetic processing unit 320 acquires the date and time when the injection start signal is transmitted from the time server 308, and stores the date and time as the injection date and time in the storage unit 350.

In the second embodiment, the operator operates the touch panel 230 to input the subject information, but instead, the electronic medical record is received from the HIS 40 and the subject information is acquired from the electronic medical record. You may. Further, instead of receiving the electronic medical record from the HIS 40, the electronic medical record may be received from the RIS 50 or the radioactivity management device 30 that has acquired the electronic medical record from the HIS 40. In this configuration, the injection device 20 is connected to the HIS40, RIS50, or radioactivity management device 30 by a network such as a wireless LAN.

In the second embodiment, when the injection device 20 includes a QR code scanner having a wireless communication function such as Bluetooth, this QR code scanner is used as a reading unit of the radioactivity management system 100. Can be done. In this configuration, the QR code scanner directly reads the QR code attached to the container 5 and transmits the radiopharmaceutical drug information represented by the QR code to the radioactivity management device 30.

In the second embodiment described above, the injection device 20 includes a touch panel and a printer. However, the radioactivity management system 100 includes a touch panel and a printer as peripheral devices of the injection device 20, and the touch panel is an image of a QR code. You may have a camera to shoot the image. In this configuration, the touch panel and printer are not included in the injection device 20.

In either case where the touch panel and the printer are included in the injection device 20 or not, the operator may operate the touch panel to input radiopharmaceutical information. Further, for example, when the nuclear medicine examination facility 3 owns a radiopharmaceutical drug manufacturing facility, the radiopharmaceutical drug is directly provided to the injection device 20 via a transport tube or the like and is not contained in the container. In such a case, the touch panel may receive the radiopharmaceutical drug information sent from the radiopharmaceutical drug manufacturing facility. The touch panel includes a tool for converting the input radiopharmaceutical drug information or the received radiopharmaceutical drug information into a QR code, and displays the image of the QR code converted by the tool in the image display area. In this configuration, the touch panel functions as a recording medium on which radiopharmaceutical information is recorded.

Generally, medical radioactivity measuring instruments called curie meters and dose calibrators are used in nuclear medicine laboratories. This radioactivity measuring instrument is a device that measures the radioactivity of the container after the radiopharmaceutical is sucked from the container into the syringe, the radioactivity of the syringe after the radiopharmaceutical in the syringe is injected into the subject, and the like. Yes, it has a display for displaying the measured radioactivity value. Therefore, instead of the injection device 20 of the second embodiment, a QR code representing radiopharmaceutical information may be displayed on the display of the medical radioactivity measuring device.

In addition, the medical radioactivity measuring instrument usually has a wireless communication function such as Bluetooth. Therefore, the medical radioactivity measuring device may be provided with a camera for taking a QR code image, and the QR code image taken by the camera may be transmitted from the medical radioactivity measuring device to the radioactivity management device. ..

1 ... Management organization 2 ... Radiopharmaceutical manufacturing company 3 ... Nuclear medicine testing facility 10 ... Nuclear medicine testing equipment (imaging equipment, PET equipment)
20 ... Injection device 224 ... Camera 260 ... QR code scanner 30 ... Radioactivity management device 305 ... Input device 306 ... Display device 308 ... Time server 320 ... Arithmetic processing unit 340 ... QR code reader 350 ... Storage unit 40 ... HIS
50 ... RIS
60 ... PACS
90 ... Network 100 ... Radioactivity management system

The control unit 221 drives the piston drive mechanism 210 when the operation unit 222 is operated to set the injection amount and the start of the injection operation is instructed. In response to this, the piston of each syringe 21 is pushed by the piston drive mechanism 210 , and the radiopharmaceutical drug in the syringe 21 set in the recess 201 is injected into the subject.

[4. Radioactivity management device configuration]
As shown in FIG. 6, the radioactivity management device 30 includes a CPU 301, a main storage device 302, an auxiliary storage device 303 including a storage unit 350, a communication I / F 304, and an input device (keyboard, mouse (pointing device)). , Touch panel, etc.) 305, display device 306, camera 307, and time server (time measuring means) 308. The radioactivity management device 30 is executed by the CPU 301 loading various processing programs stored (installed) in the auxiliary storage device 303 into the main storage device 302, thereby executing the information processing function of the arithmetic processing unit 320 and the data receiving unit 330. Data reception function and reading function of QR code reader 340 are realized. The storage unit 350 stores information on the half-lives of various RIs.

Subsequently, the container 5 is in the case of the syringe to inject the morphism radiopharmaceutical release by operating the syringe the operator to the subject. When the container 5 is a vial, the operator transfers the radiopharmaceutical drug to a syringe and then operates the syringe to inject the radiopharmaceutical drug into the subject. Then, when the injection of the radiopharmaceutical drug into the subject is completed, the operator operates the input device 305 (numeric keypad) to input the injection amount. That is, in this example, the input device 305 functions as the injection amount setting unit of the present invention. The input injection amount data is received by the data receiving unit 330 and stored in the storage unit 350. When the data receiving unit 330 receives the injection amount data, the arithmetic processing unit 320 acquires the received date and time from the time server 308 and stores it in the storage unit 350 as the injection date and time. Information represented by various data stored in the storage unit 350 can be displayed on the display device 306. For example, FIG. 7 shows the display screen 306A of the display device 306 at the time when “35 (ml)”, which is the injection amount of the radiopharmaceutical drug, is input. On this display screen 306A, in addition to the injection amount display area 306B, the numeric keypad 306C, the QR code image display area 306D taken by the camera 307, information on each subject (test conditions, physical characteristics of the subject, etc.) ) Is included in the display area 306E and the like. The injection date and time acquired from the time server 308 is displayed in the display area 306E.

1 ... management engine 2 ... Manufacturing Company 3 ... nuclear medicine inspection facility 10 ... nuclear medicine inspection apparatus (imaging apparatus, PET apparatus)
20 ... Injection device 224 ... Camera 260 ... QR code scanner 30 ... Radioactivity management device 305 ... Input device 306 ... Display device 308 ... Time server 320 ... Arithmetic processing unit 340 ... QR code reader 350 ... Storage unit 40 ... HIS
50 ... RIS
60 ... PACS
90 ... Network 100 ... Radioactivity management system

Claims (9)

Nuclear medicine having an imaging device that injects a radiopharmaceutical provided by a drug manufacturing facility that manufactures radiopharmaceuticals into a subject, detects the radiation emitted from the subject into which the radiopharmaceutical is injected, and generates image data. A radioactivity management system that manages the radioactivity of radiopharmaceuticals injected into the subject at a testing facility.
For multiple types of radioisotopes used in radiopharmaceuticals, a first storage unit that stores the half-life of each radioactivity, and
The date and time of manufacture of the radiopharmaceutical drug attached to the radiopharmaceutical drug provided from the drug manufacturing facility to the nuclear medical laboratory, the type of radioisotope used in the radiopharmaceutical drug, and the time of manufacture of the radiopharmaceutical drug. A reading unit that reads the radiopharmaceutical information from a recording medium on which the radiopharmaceutical information including the radiopharmaceutical value is recorded, and
A second storage unit that stores the radiopharmaceutical drug information read by the reading unit, and
Timekeeping means to time the current date and time,
An injection time point setting unit for setting the time point at which the radiopharmaceutical drug is injected into the subject,
An injection date / time acquisition unit that acquires the date / time set by the injection time point setting unit from the timekeeping means, and an injection date / time acquisition unit.
Injection into the subject based on the half-life of the radioactivity stored in the first storage unit, the radiopharmaceutical drug information stored in the second storage unit, and the injection date and time acquired by the injection date and time acquisition unit. A radioactivity management system including a calculation unit for calculating the radioactivity value of the radiopharmaceutical product. In the radioactivity management system according to claim 1,
The injection time setting unit outputs a start signal instructing the injection device that automatically injects the radiopharmaceutical drug into the subject in the container containing the radiopharmaceutical drug to start the operation of injecting the radiopharmaceutical drug into the subject. A radioactivity management system that includes an injection instruction unit to be used, and sets a time point at which the injection instruction unit outputs the start signal as a time point at which the radiopharmaceutical drug is injected into a subject. The calculation unit determines the date and time of manufacture of the radiopharmaceutical drug, the value of radioactivity at the time of manufacture of the radiopharmaceutical drug, the date and time of injection of the radiopharmaceutical drug, and the half-life of the radioisotope used in the radiopharmaceutical drug. The radioactivity management system according to claim 1 or 2, which calculates the radioactivity value of the radiopharmaceutical drug injected into the subject. In the radioactivity management system according to claim 1 or 2, further
Equipped with an injection amount setting unit for setting the amount of radiopharmaceutical injection into the subject,
The radiopharmaceutical information includes the amount of the radiopharmaceutical and
The calculation unit stores the radiopharmaceutical information stored in the second storage unit, the injection date and time acquired by the injection date and time acquisition unit, the injection amount set by the injection amount setting unit, and the first storage unit. A radioactivity management system that calculates the radioactivity value of the radiopharmaceutical drug injected into the subject based on the stored radioactivity half-life. In the radioactivity management system according to claim 1 or 2, further
It is provided with an inspection information acquisition unit that acquires inspection information including the date and time when the photographing device starts or ends the operation from the photographing device.
The calculation unit determines the inspection information acquired by the inspection information acquisition unit, the injection date and time acquired by the injection date and time acquisition unit, the half-life of the radioactivity stored in the first storage unit, and the subject. A radioactivity management system that calculates the radioactivity value of the radiopharmaceutical present in the body of the subject during the operation of the imaging device from the injected radioactivity value of the radiopharmaceutical drug. In the radioactivity management system according to claim 1,
The injection time setting unit is configured to receive a start signal for starting the injection operation of the radiopharmaceutical drug from an injection device that automatically injects the radiopharmaceutical drug into a subject in a container containing the radiopharmaceutical drug. A radioactivity management system that sets the time when the start signal is received as the time when the radiopharmaceutical drug is injected into the subject. In the radioactivity management system according to claim 1,
The recording medium comprises a medium on which an image of a one-dimensional code or a two-dimensional code representing the radiopharmaceutical drug information is drawn.
The reading unit has a code photographing unit that captures an image of the one-dimensional code or a two-dimensional code, and a radiopharmaceutical information acquisition unit that acquires the radiopharmaceutical drug information from the image captured by the code photographing unit. Management system. In the radioactivity management system according to claim 7.
The code photographing unit is a device that automatically injects the radiopharmaceutical drug into a subject from a container containing the radiopharmaceutical drug, and captures an image of the one-dimensional code or a two-dimensional code and displays the image. A radioactivity management system that captures an image of the one-dimensional code or two-dimensional code from an injection device having a unit. In the radioactivity management system according to claim 1, further
Equipped with a detector to detect the weight of the container containing the radiopharmaceutical
The radiopharmaceutical information includes the amount of radiopharmaceutical contained in the container.
The calculation unit has the radiopharmaceutical information stored in the second storage unit, the injection date and time acquired by the injection date and time acquisition unit, and the injection date and time detected by the detector before the radiopharmaceutical drug is injected into the subject. Inject into the subject based on the weight of the container, the weight of the container after the radiopharmaceutical is injected into the subject, and the half-life of the radioactivity stored in the first storage unit. A radioactivity management system that calculates the radioactivity value of the radiopharmaceutical product.

Images