JPWO2014196514A1 - Blood vessel abnormality detection device - Google Patents

Abstract

The blood vessel abnormality detection device (1) is disposed in the vicinity of a pair of electrocardiogram electrodes (11, 12) for detecting an electrocardiogram signal and one of the electrocardiogram electrodes (11), and receives a first photoelectric pulse wave signal. A first photoelectric pulse wave sensor (21) to detect, a second photoelectric pulse wave sensor (22) which is disposed in the vicinity of the other electrocardiogram electrode (12) and detects a second photoelectric pulse wave signal; Peak portions (316, 326) for detecting the respective peaks of the electrocardiogram signal, the first photoelectric pulse wave signal, and the second photoelectric pulse wave signal, and the peak of the electrocardiogram signal and the first photoelectric pulse wave signal The first pulse wave propagation time is obtained from the time difference from the peak of the pulse wave, and the pulse wave propagation time measuring unit for obtaining the second pulse wave propagation time from the time difference between the peak of the electrocardiogram signal and the second photoelectric pulse wave signal ( 330) and the time difference between the first pulse wave propagation time and the second pulse wave propagation time. Comprising detection unit for the (40).

Description

  The present invention relates to a blood vessel abnormality detection device, and more particularly to a blood vessel abnormality detection device that detects a blood vessel abnormality by measuring a pulse wave propagation time.

  The speed at which the pulse wave propagates through the artery (pulse wave propagation speed) increases, for example, as arteriosclerosis progresses. In recent years, a technique has been proposed in which the pulse wave velocity (or pulse wave propagation time) is applied to, for example, arteriosclerosis, arterial stenosis, aneurysm and other blood vessel failure diagnosis using such characteristics ( For example, see Patent Document 1). Here, in Patent Document 1, the pulse wave velocity is measured almost simultaneously in two different sections of the subject, that is, the first pulse wave velocity in the first section (for example, from the heart to the upper arm) and the first section. Measure the second pulse wave velocity in the second section (for example, from the thigh to the ankle) different from, calculate the ratio of the two pulse wave velocity, and diagnose the vascular disorder based on the ratio A technique for diagnosing a vascular disorder is disclosed.

  More specifically, the vascular disorder diagnosis apparatus described in Patent Document 1 is fixed on the chest of a subject, detects a heart sound that is a heartbeat synchronization signal in the heart (upstream end of the first section), and a right-hand arm. A cuff (upper arm pulse wave sensor) that is wound around the upper arm (downstream end of the first section) and detects a cuff pulse wave signal, that is, an upper arm pulse wave, is provided. In addition, this vascular disorder diagnostic apparatus is attached to the body surface of the thigh, and includes a first ultrasonic receiving probe that detects a thigh pulse wave as a heartbeat synchronization signal in the thigh (upstream end of the second section). And a second ultrasonic receiving probe that detects an ankle pulse wave as a heartbeat synchronization signal at the ankle (downstream end of the second section).

  In the blood vessel failure diagnosis apparatus described in Patent Document 1 having the above-described configuration, the first pulse wave propagation velocity in the first section (between the heart and the upper arm) is measured based on the heart sound and the brachial pulse wave, and the femoral pulse wave. The second pulse wave propagation velocity in the second section (between the thigh and the ankle) is measured based on the ankle pulse wave. Then, when the ratio between the first pulse wave velocity and the second pulse wave velocity is calculated, and the ratio is a value outside the normal range, it is diagnosed that there is a vascular disorder in the artery in one of the sections. Is done.

Japanese Patent No. 3530892

  As described above, according to the vascular disorder diagnosis device described in Patent Document 1, the pulse wave propagation velocity is measured substantially simultaneously in two different sections (between the heart and the upper arm, and between the thigh and the ankle) of the subject, A vascular disorder can be diagnosed based on the ratio. However, in this vascular disorder diagnosis apparatus, it is necessary to include a heart sound microphone, a cuff, a first ultrasonic reception probe, and a second ultrasonic reception probe, and the apparatus becomes relatively large. In order to measure the pulse wave velocity, a heart sound microphone is fixed on the chest, a cuff is wound around the upper arm, a first ultrasonic receiving probe is attached to the thigh, and a second ultrasonic receiving probe is used. Must be attached to the ankle and connected to the electronic control unit.

  As described above, the blood vessel failure diagnosis apparatus described in Patent Document 1 requires complicated preparation for measuring the pulse wave velocity, and also requires complicated and specialized knowledge such as measurement procedures and cuff operations. For this reason, the user cannot use it easily by himself / herself.

  The present invention has been made to solve the above-described problems, and provides a blood vessel abnormality detection apparatus that can be used by a user alone and that can more easily measure a pulse wave propagation time and detect a blood vessel abnormality. The purpose is to provide.

  A blood vessel abnormality detection device according to the present invention includes a pair of electrocardiographic electrodes for detecting an electrocardiographic signal, a light emitting element and a light receiving element, which are disposed in the vicinity of one of the electrocardiographic electrodes. A first photoelectric pulse wave sensor that detects a second photoelectric pulse wave signal that has a light emitting element and a light receiving element and is disposed in the vicinity of the other electrocardiographic electrode. An electrocardiogram signal detected by the sensor and a pair of electrocardiographic electrodes, a first photoelectric pulse wave signal detected by the first photoelectric pulse wave sensor, and a second photoelectric pulse detected by the second photoelectric pulse wave sensor The first pulse wave propagation time is obtained from the time difference between the peak of the electrocardiogram signal and the peak of the first photoelectric pulse wave signal, and the peak detection means for detecting the peak of each pulse wave signal. Calculation means for obtaining the second pulse wave propagation time from the time difference from the peak of the two photoelectric pulse wave signals , Based on the time difference between the first pulse wave propagation time and the second pulse wave propagation time, characterized in that it comprises detecting means for detecting an abnormality of the blood vessels.

  According to the blood vessel abnormality detection device according to the present invention, since an electrocardiogram electrode and a photoelectric pulse wave sensor are used, an electrocardiogram signal and a photoelectric pulse wave signal can be acquired only by touching the user. In addition, the first photoelectric pulse wave sensor is disposed in the vicinity of one electrocardiographic electrode and the second photoelectric pulse wave sensor is disposed in the vicinity of the other electrocardiographic electrode. Touching the other ECG electrode and the second photoelectric pulse wave sensor with the other hand, the ECG signal, the first photoelectric pulse wave signal and the second photoelectric pulse wave sensor are touched. Pulse wave signals can be acquired simultaneously. At that time, the first pulse wave propagation time is obtained by bringing the body parts (for example, the left and right hands, the left and right legs, etc.) of the left and right bodies into contact with the electrocardiogram electrode and the photoelectric pulse wave sensor. When the time difference between the second pulse wave propagation time and the second pulse wave propagation time is large, it can be determined that there is a possibility that there is an abnormality in the blood vessel of either the left half body or the right half body. Therefore, the user can use it alone, and it is possible to more easily measure the pulse wave propagation time and detect a blood vessel abnormality.

  Note that the term “pulse wave propagation time” refers to the time during which a pulse wave propagates between two predetermined parts of a living body, and sometimes refers to the time difference between the peak of an electrocardiogram signal and the peak of the pulse wave signal. Hereinafter, in this specification, the term pulse wave propagation time is used in the latter sense.

  In the blood vessel abnormality detection device according to the present invention, the pair of electrocardiographic electrodes, the first photoelectric pulse wave sensor, and the second photoelectric pulse wave sensor are in the same housing, and the user can move the housing with the left and right hands. When one hand is in contact with one electrocardiographic electrode and the first photoelectric pulse wave sensor, the other hand is in contact with the other electrocardiographic electrode and the second photoelectric pulse wave sensor. It is preferable that it is attached to.

  In this way, the pulse wave propagation times of the right hand and the left hand can be acquired. Therefore, it is possible to detect an abnormality in a blood vessel from the aortic arch where the artery extending from the heart branches to the left arm and the right arm to the left and right hands. In this case, since the pulse wave propagation time can be measured simultaneously with the left and right hands, it is possible to suppress variations in the left and right pulse wave propagation times due to heart rate fluctuations and blood pressure fluctuations that affect the pulse wave propagation time. A blood vessel abnormality can be detected with high accuracy.

  A blood vessel abnormality detection device according to the present invention includes a pair of electrocardiographic electrodes for detecting an electrocardiogram signal, an inversion means for inverting the polarity of the electrocardiogram signal detected by the electrocardiogram electrode, and one electrocardiogram electrode in the vicinity. One photoelectric pulse wave sensor that is disposed and has a light emitting element and a light receiving element and detects a photoelectric pulse wave signal, an electrocardiogram signal, and a peak detection means for detecting each peak of the photoelectric pulse wave signal, The first pulse wave propagation time is obtained from the time difference between the peak of the non-inverted ECG signal whose polarity is not inverted and the peak of the photoelectric pulse signal, and the peak of the ECG signal and the photoelectric pulse signal whose polarity is inverted Computation means for obtaining the second pulse wave propagation time from the time difference from the peak and detection means for detecting an abnormality of the blood vessel based on the time difference between the first pulse wave propagation time and the second pulse wave propagation time It is characterized by.

  According to the blood vessel abnormality detection device of the present invention, the first pulse wave propagation time and the second pulse wave propagation time can be measured with one photoelectric pulse wave sensor. That is, since the number of photoelectric pulse wave sensors that consume power can be reduced, the power consumption and cost of the apparatus can be reduced. Note that when the body part in contact with the electrocardiogram electrode is reversed, the polarity of the electrocardiogram signal is reversed, that is, the R wave (peak) included in the electrocardiogram signal is reversed upside down. The peak can be detected correctly by reversing the polarity of the signal. Therefore, measurement of pulse wave propagation time and detection of blood vessel abnormality can be performed more accurately.

  In the vascular abnormality detection device according to the present invention, it is preferable that the inverting means is a switch for exchanging an input signal from one electrocardiogram electrode and an input signal from the other electrocardiogram electrode.

  In this way, the polarity of the electrocardiogram signal can be reversed by the switch operation even when the portion in contact with the electrocardiogram electrode is reversed. Therefore, it is possible to correctly detect the peak of the electrocardiogram waveform.

  The blood vessel abnormality detection device according to the present invention further includes front and back detection means for detecting the surface of the housing facing the user, and the reversing means determines the polarity of the electrocardiogram signal according to the detection result by the front and back detection means. Is preferably reversed.

  In this way, by detecting the surface of the housing facing the user (that is, the front and back of the device), it is automatically determined that the user has changed the device, and the polarity of the electrocardiogram signal is determined. Since it can be reversed, a blood vessel abnormality can be detected more easily.

  The blood vessel abnormality detection device according to the present invention further comprises contact detection means for detecting the presence or absence of a user's contact, and the inversion means changes the polarity of the electrocardiogram signal according to the presence or absence of the contact detected by the contact detection means. Inversion is preferred.

  In this way, by detecting the gripping state of the device, it is possible to automatically determine whether the user has changed the device and to reverse the polarity of the electrocardiogram signal, so that it is possible to more easily detect blood vessel abnormalities. be able to.

  The blood vessel abnormality detection device according to the present invention has at least a pair of electrocardiographic electrodes for detecting an electrocardiogram signal, a light emitting element and a light receiving element, and detects a photoelectric pulse wave signal by being in contact with both hands and both feet. A pair of photoelectric pulse wave sensors, an electrocardiogram signal detected by an electrocardiogram electrode, and a peak detection means for detecting a peak of each photoelectric pulse wave signal detected by each photoelectric pulse wave sensor; The time difference between the pulse wave propagation time corresponding to the photoelectric pulse wave sensor corresponding to the calculation means for obtaining the pulse wave propagation time corresponding to each photoelectric pulse wave signal from the time difference between the peak and each peak of each photoelectric pulse wave signal And detecting means for detecting an abnormality of the blood vessel.

  According to the blood vessel abnormality detection device according to the present invention, pulse wave propagation times of the right hand, the left hand, the right foot, and the left foot can be acquired by one measurement. Therefore, for example, abnormalities in blood vessels between the aortic arch and the left and right hands and abnormalities in blood vessels between the common iliac artery and the left and right feet can be detected at a time.

  In the blood vessel abnormality detection device according to the present invention, when a user's contact is detected, an electrocardiogram signal, a first photoelectric pulse signal, and a second photoelectric pulse signal for a predetermined number of beats are acquired. It is preferable that the detection means automatically starts detecting a blood vessel abnormality when at least one of the conditions is satisfied among the payments of the compensation.

  In this way, since the detection of the vascular abnormality is automatically started, the operation for starting the measurement / detection is unnecessary, so there is no occurrence of body movement noise generated with the start operation, and relatively Measurement and detection in a resting state are possible.

  In the vascular abnormality detection device according to the present invention, when an electrocardiogram signal, a first photoelectric pulse wave signal, and a second photoelectric pulse wave signal for a predetermined number of beats are acquired, and / or detection of a vascular abnormality is started. Thereafter, it is preferable that the detection means automatically ends the detection of the blood vessel abnormality when a predetermined time has elapsed.

  In this way, when measurement of pulse wave propagation time and detection of blood vessel abnormality are completed, measurement and detection are automatically terminated. Can be detected.

  The blood vessel abnormality detection device according to the present invention includes a presentation unit that automatically presents voice and / or image guidance when the detection of the blood vessel abnormality is started and / or when the detection of the blood vessel abnormality is finished. It is preferable to further provide.

  In this way, the user can be notified of the measurement state such as the start of measurement / detection and the end of measurement / detection.

  ADVANTAGE OF THE INVENTION According to this invention, a user can use alone and it becomes possible to measure a pulse wave propagation time more easily and to detect a blood vessel abnormality.

It is a block diagram which shows the structure of the blood vessel abnormality detection apparatus which concerns on 1st Embodiment. It is a figure for demonstrating the usage method of the vascular abnormality detection apparatus which concerns on 1st Embodiment. It is a figure which shows an electrocardiogram waveform, a photoelectric pulse wave waveform (acceleration pulse wave waveform), and a pulse wave propagation time. It is a block diagram which shows the structure of the blood vessel abnormality detection apparatus which concerns on 2nd Embodiment. It is a block diagram which shows the structure of the blood vessel abnormality detection apparatus which concerns on the 1st modification of 2nd Embodiment. It is a block diagram which shows the structure of the blood vessel abnormality detection apparatus which concerns on the 2nd modification of 2nd Embodiment. It is a figure for demonstrating the usage method of the vascular abnormality detection apparatus which concerns on the 2nd modification of 2nd Embodiment. It is a block diagram which shows the structure of the blood vessel abnormality detection apparatus which concerns on 3rd Embodiment. It is a figure which shows the external appearance of the main-body part which comprises the blood vessel abnormality detection apparatus which concerns on 3rd Embodiment. It is a figure for demonstrating the usage method of the vascular abnormality detection apparatus which concerns on 3rd Embodiment.

  DESCRIPTION OF EMBODIMENTS Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the drawings. In the drawings, the same reference numerals are used for the same or corresponding parts. Moreover, in each figure, the same code | symbol is attached | subjected to the same element and the overlapping description is abbreviate | omitted.

(First embodiment)
First, the configuration of the blood vessel abnormality detection device 1 according to the first embodiment will be described with reference to FIGS. 1 and 2 together. FIG. 1 is a block diagram showing the configuration of the blood vessel abnormality detection device 1. FIG. 2 is a diagram for explaining a method of using the vascular abnormality detection device 1.

  The blood vessel abnormality detection device 1 detects an electrocardiogram signal between the left and right hands, and a photoelectric pulse wave signal at the fingertip of the left hand and the fingertip of the right hand, and the R wave peak and photoelectric pulse of the detected electrocardiogram signal (cardiac radio wave). The pulse wave propagation times of the left hand and the right hand are acquired from the time difference from the peak (rising point) of the wave signal (pulse wave). The vascular abnormality detection device 1 then determines the left and right arms (between the aortic arch where the artery extending from the heart branches into the right arm and the left arm to the left and right hands) based on the difference between the acquired pulse wave propagation times. Detect abnormalities in blood vessels.

  Therefore, the blood vessel abnormality detection device 1 mainly includes a pair of electrocardiogram electrodes (first electrocardiogram electrode 11 and second electrocardiogram electrode 12) for detecting an electrocardiogram signal between both hands, and photoelectric pulse waves of left and right hands. Two photoelectric pulse wave sensors (first photoelectric pulse wave sensor 21 and second photoelectric pulse wave sensor 22) for detecting signals (first photoelectric pulse wave signal and second photoelectric pulse wave signal) were detected. Signal processing units 31, 32 for measuring pulse wave propagation times (first pulse wave propagation time, second pulse wave propagation time) in the left and right hands based on the electrocardiogram signal and the first and second photoelectric pulse wave signals; And the detection part 40 which detects the abnormality of the blood vessel based on the difference of the 1st pulse wave propagation time and the 2nd pulse wave propagation time is provided. Hereinafter, each component will be described in detail.

  The first electrocardiogram electrode 11 and the second electrocardiogram electrode 12 detect an electrocardiogram signal. As shown in FIG. 2, the user holds the casing 5 of the blood vessel abnormality detection device 1 with both hands. Sometimes, for example, it is attached to the left and right side surfaces of the housing 5 so as to come into contact with the index finger. That is, when the user holds the casing 5 (blood vessel abnormality detection device 1), the first and second electrocardiographic electrodes 11 and 12 are brought into contact with the left and right hands (fingertips) of the user. An electrocardiogram signal corresponding to the potential difference between the left and right hands of the user is acquired. Examples of the electrode material of the first electrocardiogram electrode 11 and the second electrocardiogram electrode 12 include metals (preferably those that are resistant to corrosion such as stainless steel and Au and less metal allergy), conductive gels, conductive rubbers, conductive cloths, and the like. Preferably used. In addition, as the electrode material of the first electrocardiogram electrode 11 and the second electrocardiogram electrode 12, for example, a conductive plastic, a capacitive coupling electrode or the like can be used. Each of the first electrocardiogram electrode 11 and the second electrocardiogram electrode 12 is connected to the signal processing units 31 and 32 through a cable, and outputs an electrocardiogram signal to the signal processing units 31 and 32 through the cable. .

  The first and second photoelectric pulse wave sensors 21 and 22 are optical sensors for detecting a photoelectric pulse wave signal by utilizing the light absorption characteristic of blood hemoglobin. Therefore, each of the first and second photoelectric pulse wave sensors 21 and 22 includes light emitting elements 211 and 221 and light receiving elements 212 and 222. Here, the first photoelectric pulse wave sensor 21 that detects the first photoelectric pulse wave signal is disposed in the vicinity of one of the electrocardiographic electrodes 11 (for example, side by side). Similarly, the second photoelectric pulse wave sensor 22 that detects the second photoelectric pulse wave signal is disposed in the vicinity of the other electrocardiographic electrode 12. That is, the pair of first and second electrocardiographic electrodes 11, 12, the first photoelectric pulse wave sensor 21, and the second photoelectric pulse wave sensor 22 are in the same housing 5 and the user can use left and right hands. When the housing 5 is gripped, one hand (for example, the left hand) contacts the first electrocardiogram electrode 11 and the first photoelectric pulse wave sensor 21, and the other hand (for example, the right hand) and the second electrocardiogram electrode. 12. It is attached at a position where the second photoelectric pulse wave sensor 22 comes into contact.

  The light emitting elements 211 and 221 emit light according to a pulsed drive signal output from the drive unit 350 of the signal processing units 31 and 32. As the light emitting elements 211 and 221, for example, an LED, a VCSEL (Vertical Cavity Surface Emitting LASER), or a resonator type LED can be used. Note that the driving unit 350 generates and outputs a pulsed driving signal for driving the light emitting element 211.

  The light receiving elements 212 and 222 are irradiated from the light emitting elements 211 and 221 and output a detection signal corresponding to the intensity of light incident through the fingertip or reflected from the fingertip, for example. As the light receiving elements 212 and 222, for example, a photodiode or a phototransistor is preferably used. In the present embodiment, photodiodes are used as the light receiving elements 212 and 222. The light receiving elements 212 and 222 are connected to the signal processing units 31 and 32, and the detection signals (photoelectric pulse wave signals) obtained by the light receiving elements 212 and 222 are output to the signal processing units 31 and 32.

  As described above, each of the first electrocardiogram electrode 11, the second electrocardiogram electrode 12, and the first photoelectric pulse wave sensor 21 is connected to the signal processing unit 31, and the detected electrocardiogram signal and the first The photoelectric pulse wave signal is input to the signal processing unit 31. Similarly, each of the first electrocardiogram electrode 11, the second electrocardiogram electrode 12, and the second photoelectric pulse wave sensor 22 is connected to the signal processing unit 32, and the detected electrocardiogram signal and the second photoelectric pulse wave sensor 22 are connected. A pulse wave signal is input to the signal processing unit 32.

  The signal processing unit 31 determines the first pulse wave propagation time (left hand) from the time difference between the R wave peak of the detected electrocardiogram signal (cardiac radio wave) and the peak (rising point) of the first photoelectric pulse wave signal (pulse wave). The pulse wave propagation time at the fingertip) is measured (see FIG. 3). Similarly, the signal processing unit 32 calculates the second pulse wave propagation time (pulse wave propagation time at the fingertip of the right hand) from the time difference between the detected R wave peak of the electrocardiogram signal and the peak of the second photoelectric pulse wave signal. measure. In addition, the signal processing units 31 and 32 process the input electrocardiogram signal and measure a heart rate, a heart beat interval, and the like. Furthermore, the signal processing units 31 and 32 process the input photoelectric pulse wave signal to measure the pulse rate, the pulse interval, and the like. Since the configuration of the signal processing unit 31 and the configuration of the signal processing unit 32 are the same, the signal processing unit 31 will be mainly described below.

  The signal processing unit 31 (32) includes amplification units 311 and 321, a first signal processing unit 310, a second signal processing unit 320, peak detection units 316 and 326, peak correction units 318 and 328, and a pulse wave propagation time measurement unit. 330. The first signal processing unit 310 includes an analog filter 312, an A / D converter 313, and a digital filter 314. On the other hand, the second signal processing unit 320 includes an analog filter 322, an A / D converter 323, a digital filter 324, and a second-order differentiation processing unit 325.

  Here, among the above-described units, the digital filter 314, 324, the second-order differentiation processing unit 325, the peak detection units 316, 326, the peak correction units 318, 328, and the pulse wave propagation time measurement unit 330 are CPUs that perform arithmetic processing. A ROM for storing a program and data for causing the CPU to execute each process, a RAM for temporarily storing various data such as calculation results, and the like are included. That is, the functions of the above-described units are realized by executing the program stored in the ROM by the CPU.

  The amplifying unit 311 is configured by an amplifier using an operational amplifier, for example, and amplifies the electrocardiogram signals detected by the first electrocardiogram electrode 11 and the second electrocardiogram electrode 12. The electrocardiographic signal amplified by the amplifying unit 311 is output to the first signal processing unit 310. Similarly, the amplification unit 321 is configured by an amplifier using an operational amplifier, for example, and amplifies the first (second) photoelectric pulse wave signal detected by the first (second) photoelectric pulse wave sensor 21 (22). . The photoelectric pulse wave signal amplified by the amplification unit 321 is output to the second signal processing unit 320.

  As described above, the first signal processing unit 310 includes the analog filter 312, the A / D converter 313, and the digital filter 314, and performs filtering processing on the electrocardiogram signal amplified by the amplification unit 311. This extracts the pulsation component.

  Further, as described above, the second signal processing unit 320 includes the analog filter 322, the A / D converter 323, the digital filter 324, and the second-order differentiation processing unit 325, and the first signal amplified by the amplification unit 321. (Second) A pulsation component is extracted by applying filtering processing and second-order differentiation processing to the photoelectric pulse wave signal.

  The analog filters 312 and 322 and the digital filters 314 and 324 remove components (noise) other than the frequency characterizing the electrocardiogram signal and the first (second) photoelectric pulse wave signal, and improve the S / N. Perform filtering. More specifically, a frequency component of 0.1 to 200 Hz is generally dominant for an electrocardiogram signal, and a frequency component of 0.1 to several tens of Hz is dominant for a photoelectric pulse wave signal. The S / N is improved by performing filtering using the analog filters 312 and 322 and the digital filters 314 and 324 and selectively passing only signals in the frequency range.

  If the purpose is to extract only the pulsating component (that is, when it is not necessary to acquire a waveform or the like), a component other than the pulsating component by narrowing the pass frequency range to improve noise resistance. May be blocked. The analog filters 312, 322 and the digital filters 314, 324 are not necessarily provided, and only one of the analog filters 312, 322 and the digital filters 314, 324 may be provided. Note that the electrocardiogram signal subjected to the filtering process by the analog filter 312 and the digital filter 314 is output to the peak detection unit 316. Similarly, the first (second) photoelectric pulse wave signal filtered by the analog filter 322 and the digital filter 324 is output to the second-order differentiation processing unit 325.

  The second-order differentiation processing unit 325 obtains a second-order differential pulse wave (acceleration pulse wave) signal by performing second-order differentiation on the first (second) photoelectric pulse wave signal. The acquired acceleration pulse wave signal is output to the peak detector 326. The peak (rising point) of the photoelectric pulse wave is not clearly changed and may be difficult to detect. Therefore, it is preferable to detect the peak by converting it to an acceleration pulse wave. However, a second-order differential processing unit 325 is provided. Is not essential and may be omitted.

  The peak detection unit 316 detects the peak (R wave) of the electrocardiogram signal that has been subjected to signal processing by the first signal processing unit 310 (the pulsating component has been extracted). On the other hand, the peak detector 326 detects the peak (rising point) of the first (second) photoelectric pulse wave signal (acceleration pulse wave) that has been subjected to the filtering process by the second signal processor 320. That is, the peak detection units 316 and 326 function as peak detection means described in the claims. Each of the peak detection unit 316 and the peak detection unit 326 performs peak detection within the normal range of the heartbeat interval and the pulse interval, and information on the peak time, peak amplitude, and the like for all detected peaks is stored in the RAM or the like. save.

  The peak correction unit 318 obtains the delay time of the electrocardiogram signal in the first signal processing unit 310 (analog filter 312 and digital filter 314). The peak correction unit 318 corrects the peak of the electrocardiogram signal detected by the peak detection unit 316 based on the obtained delay time of the electrocardiogram signal. Similarly, the peak correction unit 328 obtains the delay time of the photoelectric pulse wave signal in the second signal processing unit 320 (analog filter 322, digital filter 324, second-order differentiation processing unit 325). The peak correction unit 328 corrects the peak of the first (second) photoelectric pulse wave signal (acceleration pulse wave signal) detected by the peak detection unit 326 based on the obtained delay time of the photoelectric pulse wave signal. The corrected peak of the electrocardiogram signal and the corrected first (second) photoelectric pulse wave signal (acceleration pulse wave) are output to the pulse wave propagation time measurement unit 330. Note that providing the peak correction unit 318 is not essential and may be omitted.

  The pulse wave propagation time measurement unit 330 includes an R wave (peak) of the electrocardiogram signal corrected by the peak correction unit 318 and a first (second) photoelectric pulse wave signal (acceleration pulse wave) corrected by the peak correction unit 328. ) To determine the first (second) pulse wave propagation time from the interval (time difference) from the peak (rising point). That is, the pulse wave propagation time measurement unit 330 functions as a calculation unit described in the claims. Here, the pulse wave propagation time measuring unit 330 of the signal processing unit 31 acquires the first pulse wave propagation time, that is, the pulse wave propagation time at the fingertip of the left hand. Similarly, the pulse wave propagation time measuring unit 330 of the signal processing unit 32 acquires the second pulse wave propagation time, that is, the pulse wave propagation time at the fingertip of the right hand. Here, FIG. 3 shows the pulse wave propagation time obtained from the interval between the R wave (peak) of the electrocardiogram signal and the peak of the first (second) photoelectric pulse wave signal (acceleration pulse wave). In FIG. 3, the waveform of the electrocardiogram signal is indicated by a thin solid line, and the first (second) photoelectric pulse wave signal is indicated by a broken line. The waveform of the acceleration pulse wave is shown by a thick solid line.

  In addition to the first (second) pulse wave propagation time, the pulse wave propagation time measurement unit 330 calculates, for example, a heart rate, a heartbeat interval, a heartbeat interval change rate, and the like from an electrocardiogram signal. Similarly, the pulse wave propagation time measurement unit 330 calculates a pulse rate, a pulse interval, a pulse interval change rate, and the like from the photoelectric pulse wave signal (acceleration pulse wave). The signal processing units 31 and 32 output the first and second pulse wave propagation times acquired by the pulse wave propagation time measurement unit 330 to the detection unit 40.

  Based on the time difference between the first pulse wave propagation time (pulse wave propagation time at the fingertip of the left hand) and the second pulse wave propagation time (pulse wave propagation time at the fingertip of the right hand), the detection unit 40 Detect abnormalities in blood vessels (from the aortic arch to the left and right hands (fingertips)). That is, the detection unit 40 functions as a detection unit described in the claims. Incidentally, the pulse wave propagation time calculated from the electrocardiogram and the peak of the photoelectric pulse wave at the fingertip is usually 0.1 to 0.3 sec. Indicates the degree value.

  More specifically, the detection unit 40 calculates the time difference between the acquired first and second pulse wave propagation times of the left and right hands as a blood vessel abnormality due to the difference between the left and right hand pulse wave propagation times stored in the memory in advance. Compared with a suspected range, if it is out of range, it is determined that the blood vessel is abnormal. In addition, the detection unit 40 compares the calculated first and second pulse wave propagation times with a range of suspected vascular abnormalities of the pulse wave propagation time stored in advance in the memory, and when the result is out of range. Judged as vascular abnormality. Since the pulse wave propagation time is affected by the arm length, blood pressure, and heart rate, the above judgment is made by inputting the arm length, blood pressure, and heart rate of the user (measured person) before measurement. A function for correcting the reference range may be added.

  In addition to detected vascular abnormality information (that is, detection results such as the presence or absence of vascular abnormality), the calculated pulse wave propagation time, heart rate, heart rate interval, pulse rate, pulse interval, cardiac radio wave, photoelectric pulse wave, and acceleration Measurement data such as a pulse wave is output to the display unit 50 and the like. The acquired measurement data such as the pulse wave propagation time, heart rate, and pulse rate are accumulated and stored in, for example, the above-described RAM and the like and stored in a personal computer (PC) after the measurement is completed. You may make it output and confirm.

  The display unit 50 includes, for example, a liquid crystal display (LCD) or the like, and displays the detected blood vessel abnormality information and measurement data (measurement results) such as the acquired pulse wave transmission time, heart rate, and pulse rate in real time. . In addition, the information may be transmitted to the PC, a portable music player having a display, a smartphone, or the like via the communication unit 60 and displayed. In this case, it is preferable to transmit data such as measurement date and time in addition to the measurement result and detection result.

  Next, a method of using the blood vessel abnormality detection device 1 will be described with reference to FIG. FIG. 2 is a diagram for explaining a method of using the vascular abnormality detection device 1. When detecting a blood vessel abnormality using the electrocardiogram signal measuring apparatus 1, first, the user holds the casing 5 (blood vessel abnormality detecting apparatus 1) with both hands, and the fingertip of the left hand is the first electrocardiographic electrode 11. The finger tip of the right hand is brought into contact with the second electrocardiographic electrode 12 and the second photoelectric pulse wave sensor 22.

  By doing so, an electrocardiogram signal between both hands, a first photoelectric pulse wave signal at the fingertip of the left hand, and a second photoelectric pulse wave signal at the fingertip of the right hand are acquired. Then, the first pulse wave propagation time at the fingertip of the left hand and the second pulse wave propagation time at the fingertip of the right hand are acquired. In addition, since it is as having mentioned above about the acquisition method of the 1st, 2nd pulse wave propagation time, detailed description is abbreviate | omitted here. Then, a blood vessel abnormality is detected from the time difference between the first pulse wave propagation time and the second pulse wave propagation time. As a result, a blood vessel abnormality between the aortic arch where the artery extending from the heart branches into the right arm and the left arm and the left and right hands is detected.

  In this way, the user grasps the housing 5 (blood vessel abnormality detection device 1), touches the first electrocardiogram electrode 11 and the first photoelectric pulse wave sensor 21 with the fingertip of the left hand, and the first fingertip with the fingertip of the right hand. By simply touching the two electrocardiographic electrodes 12 and the second photoelectric pulse wave sensor 22, it is possible to detect a blood vessel abnormality.

  As described above, according to the present embodiment, since the first and second electrocardiographic electrodes 11 and 12 and the first and second photoelectric pulse wave sensors 21 and 22 are used, an electrocardiogram signal can be obtained only by touching the user. A photoelectric pulse wave signal can be acquired. In addition, since the first photoelectric pulse wave sensor 21 is disposed in the vicinity of the first electrocardiogram electrode 11 and the second photoelectric pulse wave sensor 22 is disposed in the vicinity of the second electrocardiogram electrode 12, for example, Touching the first electrocardiogram electrode 11 and the first photoelectric pulse wave sensor 21 with one hand (left hand) and touching the second electrocardiogram electrode 12 and the second photoelectric pulse wave sensor 22 with the other hand (right hand), the heart The electric signal, the first photoelectric pulse wave signal, and the second photoelectric pulse wave signal can be acquired simultaneously. In particular, according to the present embodiment, since the pulse wave propagation times (first pulse wave propagation time and second pulse wave propagation time) of the left hand and the right hand can be acquired, the arteries extending from the heart are separated into the left arm and the right arm. It is possible to detect a blood vessel abnormality between the branching aortic arch and the left and right hands. Therefore, the user can use it alone, and it is possible to more easily measure the pulse wave propagation time and detect a blood vessel abnormality.

  In addition, according to the present embodiment, since the first and second pulse wave propagation times can be measured simultaneously with the left and right hands, the left and right pulse wave propagation times due to heart rate fluctuations and blood pressure fluctuations that affect the pulse wave propagation time can be measured. Variations can be suppressed, and abnormalities in blood vessels can be detected with higher accuracy.

(Second Embodiment)
The blood vessel abnormality detection device 1 according to the first embodiment described above includes two photoelectric pulse wave sensors (a first photoelectric pulse wave sensor 21 and a second photoelectric pulse wave sensor 22), and photoelectric pulses of left and right hands (fingertips). Wave signal (first photoelectric pulse wave signal, second photoelectric pulse wave signal) was acquired at the same time, but one photoelectric pulse wave sensor (first photoelectric pulse wave sensor) arranged only at the location where the left or right hand of the user contacts A pulse wave sensor 21), a storage unit 340, and a changeover switch 70 that reverses the polarity of the electrocardiogram signal, and the first photoelectric pulse wave signal (first pulse wave propagation time) with one hand (for example, the left hand). After acquiring the signal, the apparatus can be changed, the second photoelectric pulse wave signal (second pulse wave propagation time) is acquired with the other hand (for example, the right hand), and the time difference between the two can be calculated.

  Therefore, next, the configuration of the blood vessel abnormality detection device 2 according to the second embodiment will be described with reference to FIG. Here, the description of the same or similar configuration as that of the blood vessel abnormality detection device 1 according to the first embodiment described above will be simplified or omitted, and different points will be mainly described. FIG. 4 is a block diagram illustrating a configuration of the blood vessel abnormality detection device 2 according to the second embodiment. In FIG. 4, the same or equivalent components as those in the first embodiment are denoted by the same reference numerals.

  The blood vessel abnormality detection device 2 detects a second photoelectric pulse wave sensor 22 that detects a second photoelectric pulse wave signal, and calculates a pulse wave propagation time (second pulse wave propagation time) based on the second photoelectric pulse wave signal. It differs from the blood vessel abnormality detection device 1 described above in that it does not include the signal processing unit 32 to measure. The blood vessel abnormality detection device 2 is different from the blood vessel abnormality detection device 1 in that it includes a switch 70 and a storage unit 340. Other configurations are the same as or similar to those of the blood vessel abnormality detection device 1 described above, and thus detailed description thereof is omitted here.

  The housing 5B of the blood vessel abnormality detection device 2 has a thin, substantially rectangular parallelepiped shape, and a display unit 50 is attached to the front and back surfaces thereof. The 1st electrocardiogram electrode 11 (and the 1st photoelectric pulse wave sensor 21) and the 2nd electrocardiogram electrode 12 are arrange | positioned in the substantially symmetrical position with respect to the front and back of the housing 5B. Therefore, if the casing 5B is gripped in an inverted state, the hands contacting the first and second electrocardiographic electrodes 11, 12 and the first photoelectric pulse wave sensor 21 are reversed, and the electrocardiogram signal and the photoelectric pulse wave signal are It will be acquired with the reverse index finger. Here, since the electrocardiogram waveform is inverted when the left and right hands are switched, in order to measure the left and right pulse wave propagation times, it is necessary to invert the electrocardiogram waveform with respect to the left and right shift. Therefore, the switch 70 is detected by the first and second electrocardiographic electrodes 11 and 12 by switching the input signal from the first electrocardiographic electrode 11 and the input signal from the second electrocardiographic electrode 12 to each other. Inverts the polarity of the ECG signal. That is, the switch 70 functions as the inverting means described in the claims.

  The memory | storage part 340 is comprised from RAM mentioned above etc., and memorize | stores temporarily the pulse wave propagation time (1st pulse wave propagation time) acquired based on the electrocardiogram signal and the 1st photoelectric pulse wave signal.

  In addition, the detection part 40 is the 1st pulse wave propagation time memorize | stored in the memory | storage part 340 (for example, the pulse wave propagation time in a left fingertip), and the 2nd pulse acquired after that (after changing the housing | casing 5B). Based on the time difference from the wave propagation time (pulse wave propagation time at the right hand fingertip), an abnormality in the blood vessels of the left and right arms (between the aortic arch and the left and right hands) is detected. When the display units 50 are arranged on both the front and back surfaces of the blood vessel abnormality detection device 2, the display on the front side display unit 50 is turned off and the display on the back side display unit 50 is turned on in conjunction with the inversion of the electrocardiogram signal. To do.

  When detecting a blood vessel abnormality using the electrocardiogram signal measuring apparatus 2, the user holds the casing 5B (blood vessel abnormality detecting apparatus 2), and for example, the fingertip of the left hand is placed on the first electrocardiographic electrode 11 and the first electrocardiogram electrode 11. While making contact with the photoelectric pulse wave sensor 21, the fingertip of the right hand is in contact with the second electrocardiographic electrode 12. By doing so, an electrocardiogram signal between both hands (a non-inverted electrocardiogram signal whose polarity is not inverted) and a first photoelectric pulse wave signal at the fingertip of the left hand are acquired. Then, the first pulse wave propagation time at the fingertip of the left hand is acquired and stored in the storage unit 340.

  Subsequently, after switching the switch 70 so as to reverse the polarity of the electrocardiogram signal, the case 5B (blood vessel abnormality detection device 2) is changed, and the fingertip of the right hand is placed on the first electrocardiogram electrode 11 and the first photoelectric pulse wave sensor. 21, and the fingertip of the left hand is in contact with the second electrocardiographic electrode 12. By doing so, an electrocardiogram signal between the two hands (an electrocardiogram signal with the polarity reversed) and a second photoelectric pulse wave signal at the fingertip of the right hand are acquired, and the second pulse wave propagation time is measured. The

  Then, a blood vessel abnormality is detected from the time difference between the first pulse wave propagation time stored in the storage unit 340 and the second pulse wave propagation time measured thereafter. As a result, a blood vessel abnormality between the aortic arch where the artery extending from the heart branches into the right arm and the left arm and the left and right hands is detected.

  According to the present embodiment, the first pulse wave propagation time and the second pulse wave propagation time can be measured with one photoelectric pulse wave sensor 21. That is, since the number of photoelectric pulse wave sensors that consume power can be reduced, the power consumption and cost of the apparatus can be reduced. In addition, when the body part which contacts the 1st, 2nd electrocardiogram electrodes 11 and 12 is reversed, the polarity of the electrocardiogram signal is reversed. That is, the R wave (peak) included in the electrocardiogram signal is inverted upside down, but the peak can be detected correctly by inverting the polarity of the electrocardiogram signal. Therefore, measurement of pulse wave propagation time and detection of blood vessel abnormality can be performed more accurately.

  Moreover, according to this embodiment, the polarity of an electrocardiogram signal can be reversed by switch operation. Furthermore, according to the present embodiment, since the display of the display unit 50 is switched in conjunction with the inversion of the electrocardiogram signal, when the inversion of the electrocardiogram signal is not correctly performed when the casing 5B is turned over. Since the display unit 50 on the back surface is not turned on, it is possible to prevent measurement / detection errors due to the electrocardiogram signal not being inverted.

(First Modification of Second Embodiment)
In the vascular abnormality detection device 2 described above, the polarity of the electrocardiogram signal is switched by the operation of the switch 70. However, the polarity of the electrocardiogram signal may be automatically switched by detecting the gripping state of the housing 5B.

  Then, next, the configuration of the blood vessel abnormality detection device 2B according to the first modification of the second embodiment will be described with reference to FIG. Here, the description of the same or similar configuration as that of the blood vessel abnormality detection device 2 according to the second embodiment described above will be simplified or omitted, and different points will be mainly described. FIG. 5 is a block diagram illustrating a configuration of the vascular abnormality detection device 2 according to a first modification of the second embodiment. In FIG. 5, the same or equivalent components as those in the second embodiment are denoted by the same reference numerals.

  The blood vessel abnormality detection device 2B includes a front / back detection unit 71 that detects a surface (that is, a surface facing upward) of the blood vessel abnormality detection device 2B (housing 5B) facing the user, and Instead of the switch 70 described above, it differs from the blood vessel abnormality detection device 2 described above in that it includes an inversion unit 315 that inverts the polarity of the electrocardiogram signal according to the detection result by the front / back detection unit 71. Other configurations are the same as or similar to those of the blood vessel abnormality detection device 2 described above, and thus detailed description thereof is omitted here.

  Here, as the front / back detection unit 71, for example, an acceleration sensor, a tilt sensor, an illuminance sensor, or the like can be used. The front / back detector 71 functions as a front / back detector described in the claims.

  The inversion unit 315 is disposed between the digital filter 314 and the peak detection unit 316 and inverts the polarity of the electrocardiogram signal according to the detection result by the front / back detection unit 71. That is, the heart wave is inverted upside down. That is, the reversing unit 315 functions as reversing means described in the claims. In this way, when the part of the living body (left and right hands) in contact with the first and second ECG electrodes 11 and 12 is reversed, the peak is correctly detected by reversing the polarity of the ECG signal. The pulse wave propagation time can be accurately measured.

  According to this modification, by detecting the surface of the housing 5B facing the user (that is, the front and back of the blood vessel abnormality detection device 2B), it is automatically determined that the user has changed the device 2B. Since the polarity of the electrocardiogram signal can be reversed, a blood vessel abnormality can be detected more easily.

(Second Modification of Second Embodiment)
By the way, with the form mentioned above, although the 1st electrocardiogram electrode 11 (and 1st photoelectric pulse wave sensor 21) and the 2nd electrocardiogram electrode 12 were arrange | positioned in the substantially symmetrical position with respect to the front and back of the housing 5B. The first photoelectric pulse wave sensor 21 is disposed at a location where the thumb contacts, for example, and the first electrocardiogram electrode 11 (and the first photoelectric pulse wave sensor 21) and the second electrocardiogram electrode 12 are shown in FIG. As shown, it may be arranged so as to be substantially symmetric with respect to the central axis of the housing 5B. In addition, FIG. 7 is a figure for demonstrating the usage method of the vascular abnormality detection apparatus 2B which concerns on the 2nd modification of 2nd Embodiment.

  In this case, for example, after the first photoelectric pulse wave signal is measured in a state where the first photoelectric pulse wave sensor 21 is in contact with the left thumb, the blood vessel abnormality detection device 2B is rotated 180 ° and the right thumb is used. A second photoelectric pulse wave signal is measured. Here, the gripping state of the housing 5B (the rotation state of the blood vessel abnormality detection device 2B) is detected by including a contact detection unit 72 that detects the presence or absence of the user's contact in place of the front / back detection unit 71 described above. (See FIG. 6). The contact detection unit 72 functions as contact detection means described in the claims. Here, as the contact detection unit 72, for example, a proximity sensor, a pressure sensor, a switch, or the like can be used. That is, as shown in FIG. 7, the contact detection unit 72 detects the contact / proximity of the base of the thumb or the palm, thereby determining the gripping direction (holding) of the housing 5B and automatically generating an electrocardiogram signal. Can be reversed. In this case, the display on the display unit 50 is rotated 180 ° (that is, upside down) in conjunction with the inversion of the electrocardiogram signal.

  Also according to this modification, since the grasping state of the blood vessel abnormality detection device 2B is detected, it is possible to automatically determine whether the user has changed the device and to reverse the polarity of the electrocardiogram signal. Abnormality can be detected.

(Third embodiment)
In the first embodiment described above, the first electrocardiogram electrode 11, the second electrocardiogram electrode 12, the first photoelectric pulse wave sensor 21, and the second photoelectric pulse wave sensor 22 are provided, and the pulse wave propagation time from the fingertips of the left and right hands. However, in addition to both hands, it is also possible to acquire the pulse wave propagation time of both feet and detect a blood vessel abnormality in both feet.

  Next, the configuration of the blood vessel abnormality detection device 3 according to the third embodiment will be described with reference to FIGS. Here, the description of the same or similar configuration as that of the blood vessel abnormality detection device 1 according to the first embodiment described above will be simplified or omitted, and different points will be mainly described. FIG. 8 is a block diagram showing a configuration of the blood vessel abnormality detection device 3. FIG. 9 is a diagram showing an external appearance of the main body 6 constituting the vascular abnormality detection device 3. FIG. 10 is a diagram for explaining a method of using the vascular abnormality detection device 3. 8, 9, and 10, the same reference numerals are given to the same or equivalent components as in the first embodiment.

  The blood vessel abnormality detection device 3 includes an electrocardiogram electrode (third electrocardiogram electrode 13 and fourth electrocardiogram electrode 14) for detecting an electrocardiogram signal, and a left and right foot photoelectric pulse wave signal (third photoelectric pulse wave signal). , Four photoelectric pulse wave sensors (third photoelectric pulse wave sensor 23, fourth photoelectric pulse wave sensor 24) for detecting the fourth photoelectric pulse wave signal), the detected electrocardiogram signal and the third and fourth Signal processing units 33 and 34 for measuring pulse wave propagation times (third pulse wave propagation time and fourth pulse wave propagation time) in the left and right legs based on the photoelectric pulse wave signals of It further includes a detection unit 40B that detects a blood vessel abnormality between both hands and both feet based on the difference between the second pulse wave propagation time and the difference between the third pulse wave propagation time and the fourth pulse wave propagation time. This is different from the blood vessel abnormality detection device 1 described above. Other configurations are the same as or similar to those of the blood vessel abnormality detection device 1 described above, and thus detailed description thereof is omitted here.

  The blood vessel abnormality detection device 3 includes a main body 6 that is used by being placed on a floor surface or the like, and a grip-type measurement probe 7 that is electrically connected to the main body 6 by a cable 8 and that a user holds with both hands. ing. Here, the first and second photoelectric pulse wave sensors 21, 22 and the first and second electrocardiographic electrodes 11, 12 are installed at the portions of the grip-type measurement probe 7 that are in contact with the left and right hands. The third and fourth photoelectric pulse wave sensors 23 and 24 and the third and fourth electrocardiographic electrodes 13 and 14 are disposed in portions of the main body 6 that are in contact with the left and right soles (note that The third electrocardiogram electrode 13 and the fourth electrocardiogram electrode 14 are short-circuited). By arranging the first to fourth photoelectric pulse wave sensors 21 to 24 in this way, photoelectric pulse wave signals are acquired by the left hand and the right hand, and the left sole and the right sole. The measurement site is preferably the palm or the ventral side of the big toe, but may be the forearm, the back of the foot, the lower leg, or the like. In addition, as described above, the first to fourth electrocardiographic electrodes 11 to 14 are disposed, so that an electrocardiographic signal is acquired between both hands or between one hand and the sole.

  The detection unit 40B includes an electrocardiogram signal measured between both hands, or between the hands and feet (especially when the electrocardiogram amplitude is small and cannot be measured stably between both hands), and the left foot, right foot, left hand, Measure the pulse wave propagation times of the left hand, right hand, left foot, and right foot from the photoelectric pulse wave signals measured with the right hand, respectively, the time difference between the pulse wave propagation times of the left hand and right hand, and the pulse of the left foot and right foot. From the time difference in wave propagation time, vascular abnormalities of the arm (from the aortic arch to the hand) and the leg (from the common iliac artery to the foot) are detected.

  By the way, the pulse wave propagation time calculated from the peak of the electrocardiogram signal and the peak of the photoelectric pulse wave signal on the sole is usually 0.1 to 0.4 sec. It becomes a value of about, and is larger than the value by hand. For this reason, also regarding the pulse wave propagation time of the foot, the range in which the blood vessel abnormality is suspected in the pulse wave propagation time alone and the range in which the blood vessel abnormality is suspected regarding the time difference between the pulse wave propagation times in the left and right legs (determination reference range) ) And stored in the storage unit 340 in advance. Based on a total of four pieces of data of the pulse wave propagation time of the left and right hands and the pulse wave propagation time of the left and right feet, the detection unit 40B performs vascular abnormality determination of a single body and a left-right difference. Here, just as the pulse wave propagation time of the arm is affected by the length of the arm, the pulse wave propagation time of the leg is affected by the length of the trunk and legs, blood pressure, and heart rate. A function of correcting the determination reference range by inputting the body data, blood pressure, and heart rate of the user (the person to be measured) may be added.

  According to the present embodiment, the pulse wave propagation time of the left hand, right hand, left foot, and right foot can be acquired by one measurement. Therefore, for example, abnormalities in blood vessels between the aortic arch and the left and right hands and abnormalities in blood vessels between the common iliac artery and the left and right feet can be detected at a time.

(Fourth embodiment)
By the way, the acquisition of the pulse wave propagation time and the start / end of the blood vessel abnormality detection described above may be automatically performed. Moreover, it is good also as a structure which performs the guidance by an audio | voice or an image | video when starting automatically and / or ending.

  In this embodiment, for example, when a user's contact is detected, an electrocardiogram signal, a first photoelectric pulse wave signal, and a second photoelectric pulse wave signal for a predetermined number of beats (for example, several beats) are acquired. When at least one of the conditions is satisfied when the compensation is paid, the detection unit 40 automatically starts detecting a blood vessel abnormality.

  In the present embodiment, when an electrocardiogram signal, a first photoelectric pulse wave signal, and a second photoelectric pulse wave signal for a predetermined number of beats (for example, 30 beats) are acquired, and / or blood vessel abnormality When a predetermined time (for example, 30 seconds) elapses after the start of the detection, the detection unit 40 automatically ends the detection of the blood vessel abnormality.

  Furthermore, in the present embodiment, voice and / or image guidance is presented by the speaker 73 and the display unit 50 when the detection of the blood vessel abnormality is automatically started and / or when the detection of the blood vessel abnormality is finished. Is done. That is, the speaker 73 and the display unit 50 correspond to the presenting means described in the claims.

  According to the present embodiment, since the detection of the blood vessel abnormality is automatically started, the operation for starting the measurement / detection is unnecessary, so there is no occurrence of body motion noise that occurs with the start operation, and the comparison Measurement and detection in a quiet state is possible.

  Further, according to the present embodiment, when the measurement of the pulse wave propagation time and the detection of the blood vessel abnormality are completed, the measurement / detection is automatically terminated. Therefore, the pulse wave propagation time can be measured more easily. It becomes possible to detect vascular abnormalities.

  Furthermore, according to the present embodiment, the user can be notified of the measurement state such as the start of measurement / detection and the end of measurement / detection.

  Although the embodiment of the present invention has been described above, the present invention is not limited to the above embodiment, and various modifications can be made. For example, in the above embodiment, the first and second electrocardiographic electrodes 11 and 12 and the first and second photoelectric pulse wave sensors 21 and 22 are brought into contact with the fingertips of both hands of the user. It may be an approximately target portion of the half body and the right half body, and instead of the fingertips of both hands, for example, the left and right palms, the forearm portion, the upper arm portion, and the like may be contacted. In the second embodiment, the first and second electrocardiographic electrodes 11 and 12 and the first photoelectric pulse wave sensor 21 are arranged on the upper surface of the housing 5B. You may arrange | position in the location where a person's middle finger etc. contact.

  In the third embodiment, the third electrocardiogram electrode 13 and the fourth electrocardiogram electrode 14 for acquiring an electrocardiogram signal between both feet are provided, but the third electrocardiogram electrode 13 and the fourth electrocardiogram electrode 14 are omitted. You can also Further, for example, a body composition meter function may be added to the blood vessel abnormality detection device 3 according to the third embodiment. In that case, since the electrocardiogram electrode can also be used as the measurement electrode of the body composition meter, a function can be added without greatly changing the mechanism design.

  As described above, the obtained measurement data such as the heart rate and the pulse rate may be output and displayed on a PC, a portable music player having a display, a smartphone, or the like. In that case, blood vessel abnormality determination or the like may be performed on the PC or smartphone side. Furthermore, it can also be set as the structure which transmits data to a server and processes on the server side. In such a case, data such as the above-mentioned range of suspected vascular abnormalities of the pulse wave propagation time and the range of suspected vascular abnormalities of the difference between the pulse wave propagation times of the left and right arms are stored on the PC, smartphone, or server side. Remembered.

1, 2, 2B, 3 Blood vessel abnormality detection device 5, 5B Case 6 Body portion 7 Measurement probe 8 Cable 11 First electrocardiogram electrode 12 Second electrocardiogram electrode 13 Third electrocardiogram electrode 14 Fourth electrocardiogram electrode 21 First 1 photoelectric pulse wave sensor 22 second photoelectric pulse wave sensor 23 third photoelectric pulse wave sensor 24 fourth photoelectric pulse wave sensor 201 light emitting element 202 light receiving element 31, 32, 33, 34 signal processing unit 310 first signal processing unit 320 first 2 signal processing section 311 ECG signal amplification section 321 Pulse wave signal amplification section 312, 322 Analog filter 313, 323 A / D converter 314, 324 Digital filter 315 Inversion section 325 Second-order differentiation processing section 316, 326 Peak detection section 318, 328 Peak correction unit 330 Pulse wave propagation time measurement unit 340 Storage unit 350 Drive unit 40 Detection unit 50 Display unit 60 Communication unit 0 switch 71 front and back detector 72 contact detecting unit 73 speaker

Claims (10)

A pair of ECG electrodes for detecting ECG signals;
A first photoelectric pulse wave sensor disposed in the vicinity of one of the electrocardiographic electrodes, having a light emitting element and a light receiving element, and detecting a first photoelectric pulse wave signal;
A second photoelectric pulse wave sensor disposed in the vicinity of the other electrocardiographic electrode, having a light emitting element and a light receiving element, and detecting a second photoelectric pulse wave signal;
An electrocardiographic signal detected by the pair of electrocardiographic electrodes, a first photoelectric pulse wave signal detected by the first photoelectric pulse wave sensor, and a second photoelectric sensor detected by the second photoelectric pulse wave sensor. Peak detection means for detecting the peak of each pulse wave signal;
The first pulse wave propagation time is obtained from the time difference between the peak of the electrocardiogram signal and the peak of the first photoelectric pulse wave signal, and the peak of the electrocardiogram signal and the peak of the second photoelectric pulse wave signal are calculated. Calculating means for obtaining the second pulse wave propagation time from the time difference;
A blood vessel abnormality detection device comprising: a detecting unit that detects a blood vessel abnormality based on a time difference between the first pulse wave propagation time and the second pulse wave propagation time.   The pair of electrocardiographic electrodes, the first photoelectric pulse wave sensor, and the second photoelectric pulse wave sensor are placed in the same casing and when the user holds the casing with left and right hands, The hand is attached at a position where one electrocardiographic electrode and the first photoelectric pulse wave sensor are in contact with each other, and the other hand is connected with the other electrocardiographic electrode and the second photoelectric pulse wave sensor. The blood vessel abnormality detection device according to claim 1. A pair of ECG electrodes for detecting ECG signals;
Reversing means for reversing the polarity of the electrocardiographic signal detected by the electrocardiographic electrode;
One photoelectric pulse wave sensor disposed near one of the electrocardiographic electrodes, having a light emitting element and a light receiving element, and detecting a photoelectric pulse wave signal;
Peak detection means for detecting the peak of each of the electrocardiogram signal and the photoelectric pulse wave signal;
The first pulse wave propagation time is obtained from the time difference between the peak of the non-inverted ECG signal whose polarity is not inverted and the peak of the photoelectric pulse signal, and the peak of the ECG signal whose polarity is inverted and the photoelectric pulse Calculating means for obtaining the second pulse wave propagation time from the time difference from the peak of the wave signal;
A blood vessel abnormality detection device comprising: a detecting unit that detects a blood vessel abnormality based on a time difference between the first pulse wave propagation time and the second pulse wave propagation time.   The blood vessel abnormality detection device according to claim 3, wherein the inverting means is a switch for switching an input signal from one of the electrocardiographic electrodes and an input signal from the other of the electrocardiographic electrodes. . It further comprises front and back detection means for detecting the surface of the housing facing the user,
The blood vessel abnormality detection device according to claim 3, wherein the reversing unit reverses the polarity of the electrocardiogram signal according to a detection result by the front and back detection unit. It further comprises contact detection means for detecting the presence or absence of user contact,
The blood vessel abnormality detection device according to claim 3, wherein the reversing unit reverses the polarity of the electrocardiogram signal according to the presence or absence of the contact detected by the contact detection unit. At least a pair of electrocardiographic electrodes for detecting an electrocardiographic signal;
Two pairs of photoelectric pulse wave sensors, each having a light emitting element and a light receiving element, which are in contact with both hands and both feet to detect a photoelectric pulse wave signal;
Peak detection means for detecting the respective ECG signals detected by the ECG electrodes and the respective photoelectric pulse wave signals detected by the respective photoelectric pulse wave sensors;
From the time difference between the peak of the electrocardiogram signal and the peak of each of the photoelectric pulse wave signals, calculation means for obtaining a pulse wave propagation time corresponding to each photoelectric pulse wave signal,
A blood vessel abnormality detection device comprising: a detecting unit that detects a blood vessel abnormality based on a time difference between pulse wave propagation times corresponding to a pair of photoelectric pulse wave sensors.   When a user's contact is detected, an electrocardiogram signal for a predetermined number of beats, a first photoelectric pulse wave signal, a second photoelectric pulse wave signal are acquired, and when compensation is paid The blood vessel abnormality according to any one of claims 1 to 7, wherein when at least one of the conditions is satisfied, the detection unit automatically starts detecting a blood vessel abnormality. Detection device.   When an electrocardiogram signal for a predetermined number of beats, a first photoelectric pulse wave signal, a second photoelectric pulse wave signal are acquired, and / or when a predetermined time has elapsed after the start of detection of a vascular abnormality, The blood vessel abnormality detection device according to claim 1, wherein the detection unit automatically ends detection of a blood vessel abnormality. 2. A display unit for automatically presenting voice and / or image guidance when automatically detecting vascular abnormality and / or ending detection of vascular abnormality. The vascular abnormality detection apparatus of any one of -9.

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