JPWO2007114447A1 - Chemical injection device - Google Patents

Abstract

The graph generation means 152 generates the injection pressure detected during the execution of the test injection in real time as a graph over time. A reference graph corresponding to the injection pressure when the test injection is properly executed is stored in the graph storage unit 153. The shape of the reference graph and the shape of the time-dependent graph are compared in real time by the graph comparison unit 156, and if the two shapes are not similar, the abnormality detection unit 157 detects the occurrence of an abnormality.

Description

The present invention relates to a chemical injection device for injecting a chemical into a subject, and in particular, a CT (Computed Tomography) scanner and an MRI (Magnetic).
The present invention relates to a chemical liquid injector that injects a contrast medium into a subject whose fluoroscopic image is captured by a fluoroscopic imaging apparatus such as a Resonance Imaging (PET) apparatus or a PET (Positron Emission Tomography) apparatus.

  Currently, there are CT scanners, MRI apparatuses, PET apparatuses, ultrasonic diagnostic apparatuses, CT angio apparatuses, MR angio apparatuses, and the like as fluoroscopic imaging apparatuses that capture a fluoroscopic image of a subject. When using the apparatus as described above, a chemical liquid such as a contrast medium or physiological saline may be injected into the subject, and a chemical liquid injection apparatus that automatically executes this injection has also been put into practical use.

  Such a chemical solution injection device has, for example, a piston drive mechanism including a drive motor and a slider mechanism, and a chemical solution syringe is detachably attached thereto. The chemical syringe includes a cylinder member and a piston member that is slidably inserted into the slider member. The cylinder member is filled with a chemical solution such as a contrast medium or physiological saline.

  When such a chemical syringe is connected to the subject via an extension tube and attached to the piston drive mechanism, the chemical injection device pushes the cylinder member into the piston member by the piston drive mechanism, whereby the contrast agent is injected from the chemical syringe to the subject. The In that case, when the operator determines the injection speed and injection volume of the contrast medium in consideration of various conditions and inputs the numerical values to the chemical liquid injection apparatus, the chemical liquid injection apparatus applies the contrast medium to the subject according to the input numerical values. Inject. Since the contrast level of the subject is changed by the injection of the contrast agent, a good fluoroscopic image is captured by the fluoroscopic imaging device.

  In addition, there exists a product which can inject a physiological saline with a contrast agent into a test subject in a chemical | medical solution injection device. In such a chemical solution injection device, a contrast agent syringe filled with a contrast agent and a physiological saline syringe filled with physiological saline are mounted in parallel as a chemical solution syringe. The contrast medium syringe and the physiological saline syringe are usually connected to the subject by one bifurcated extension tube.

  Then, if the operator inputs data to the chemical solution injection device together with the injection speed, the injection volume, and the like to inject physiological saline in conjunction with the completion of the injection of the contrast agent as desired, the chemical solution injection device responds to the input data. After injecting contrast medium into the subject, physiological saline is also automatically injected. For this reason, the contrast agent can be boosted with physiological saline to reduce the consumption of the contrast agent, and the artifact can be reduced with the physiological saline.

  In addition, when a drug solution is injected from the drug solution syringe to the subject with the extension tube using the drug solution injection apparatus as described above, a test injection is usually performed first to confirm the connection state of the extension tube. In this test injection, a small amount of chemical solution is injected at a higher pressure than the official injection, and the operator determines whether there is an abnormality.

  For example, if the extension tube is disengaged from the subject during the test injection, the detected pressure drops rapidly. Also, if the extension tube bends during the test injection, the detected pressure rises rapidly. Since the chemical injection device displays the pressure of the chemical to be injected in real time, the operator can determine the occurrence of abnormality by monitoring the pressure.

  As described above, the test injection for confirming the connection state of the extension tube is performed by injecting the contrast agent in the chemical injection device in which only the contrast medium syringe is mounted, and the chemical liquid injection in which the contrast medium syringe and the physiological saline syringe are mounted. In the apparatus, it is usually performed by injection of physiological saline from the viewpoint of cost.

  Further, as test injection executed prior to formal injection, test injection for confirming the time required for the contrast medium to reach the affected area is also executed. In this test injection, a contrast medium is injected at the same rate as the official injection, and the time required from the start of injection until the contrast medium reaches the affected area is measured.

  Moreover, in the present general chemical solution injection device, the injection head to which the chemical solution syringe is attached and the injection control unit for executing display and input operations are configured separately. For this reason, an injection | pouring head can be freely arrange | positioned in the vicinity of a test subject, and an injection | pouring control unit can be arrange | positioned in the vicinity of the imaging control apparatus of a fluoroscopic imaging device.

  In particular, when the fluoroscopic imaging apparatus is an MRI apparatus, the injection control unit having a built-in microcomputer cannot be disposed in the vicinity of the fluoroscopic imaging unit of the MRI apparatus, so that the injection head and the injection control unit are separately provided as described above. Any structure that can be placed is useful.

In addition, the applicant of the present invention has a structure in which the injection head and the injection control unit are separated as described above, and the test injection input operation and display are executed by the injection head, and the formal injection input operation and display are controlled by the injection control. A chemical injection device has been invented and applied to improve the workability between test injection and formal injection by executing the unit (see, for example, Patent Document 1).
Patent Document 1: Japanese Patent Application No. 2003-368859 (WO2005 / 039675A1)
Since the chemical injection device as described above displays the pressure of the chemical to be injected in real time, the operator can determine whether there is an abnormality by monitoring the pressure. However, in other words, if the operator does not monitor the pressure displayed by the chemical injection device, the occurrence of an abnormality will not be determined, and the burden on the operator is large and the discovery of the occurrence of the abnormality may be delayed.

  For example, it can be assumed that a predetermined allowable range is set in the chemical injection device for the test injection pressure, and that the chemical injection device detects the occurrence of abnormality when the detected pressure deviates from the allowable range. However, although it is necessary to confirm when the detected pressure changes suddenly while satisfying the allowable range, the above-described chemical solution injection device satisfies the allowable range even if the pressure changes suddenly. If so, the occurrence of an abnormality is not detected.

  It may also be desired in the medical setting to perform a test injection at a pressure that varies over time. In this case, for example, a pressure change pattern is set in the medical solution injector at the medical site. Then, the allowable range set in the chemical injection device does not correspond to the pressure detected by the test injection, and the occurrence of abnormality cannot be effectively detected.

  The present invention has been made in view of the above-described problems, and even when the pressure of the test injection changes suddenly within a predetermined range or when the change pattern of the pressure is changed, the occurrence of abnormality occurs. It is an object of the present invention to provide a chemical injection device that can detect well.

  The chemical injection device of the present invention is a chemical injection device that performs a formal injection after a test injection of a chemical solution with an extension tube from a chemical syringe in which a piston member is slidably inserted into a cylinder member to a subject, a piston drive mechanism, A pressure detection unit, a graph generation unit, a graph storage unit, a graph comparison unit, an abnormality detection unit, and a warning notification unit;

  The piston drive mechanism pushes the piston member into the cylinder member. The pressure detection means detects the pressure of the chemical solution injected into the subject. The graph generating means generates a pressure detected during execution of the test injection in real time as a time graph. The graph storage means stores a reference graph corresponding to the pressure when the test injection is properly executed. The graph comparison means compares the shape of the graph with time with the shape of the reference graph in real time. The abnormality detection means detects the occurrence of an abnormality if the shape of the time-dependent graph is not similar to the shape of the reference graph.

  Therefore, in the chemical injection device according to the present invention, for example, the time-lapse graph and the reference graph are compared by the existing image recognition technology, and if the reference graph and the time-lapse graph are not similar, the occurrence of abnormality is detected. The occurrence of abnormality is detected regardless of whether the pressure changes rapidly within a predetermined range or when the pressure change pattern is changed.

  The various means referred to in the present invention need only be formed so as to realize the function. For example, dedicated hardware that exhibits a predetermined function, a data processing apparatus provided with a predetermined function by a computer program It can be realized as a predetermined function implemented in the data processing apparatus by a computer program, a combination thereof, or the like.

  Further, the various constituent elements referred to in the present invention do not necessarily have to be individually independent, and a plurality of constituent elements are formed as one member, and one constituent element is formed from a plurality of members. It is possible that a certain component is a part of another component, a part of a certain component overlaps a part of another component, and the like.

It is a schematic diagram which shows the logical structure of the chemical injection device by one Embodiment of this invention. It is a block diagram which shows the physical structure of a chemical injection system. It is a perspective view which shows the external appearance of a chemical injection system. It is a perspective view which shows the external appearance of a chemical injection device. It is a perspective view which shows the state which equips the injection | pouring head of a chemical | medical solution injection device with a chemical | medical solution syringe. It is typical sectional drawing which shows the internal structure of an injection | pouring head. It is a figure which shows an example of the display screen of the sub touch panel which combines the sub operation panel and the sub display panel. It is a figure which shows the state by which the schematic image of the body division and the condition screen of a blank sheet state were displayed on the main touch panel which used both the main operation panel and the main display panel. It is a figure which shows the display screen of the main touch panel in the state as which the body division was selected. It is a figure which shows the display screen of the main touch panel in the state in which the imaging region was selected and the condition image was displayed. It is a flowchart which shows the early stage part of processing operation of a chemical injection device. It is a flowchart which shows the middle part of processing operation of a chemical injection device. It is a flowchart which shows the final stage part of processing operation of a chemical injection device. It is a flowchart which shows the processing operation of the MRI apparatus which is a fluoroscopic imaging apparatus.

Explanation of symbols

DESCRIPTION OF SYMBOLS 100 Chemical solution injection apparatus 101 Injection control unit 103 Main operation panel 104 Main touch panel 110 Injection head 118 Sub touch panel 120 Computer unit 130 Piston drive mechanism 151 Pressure detection means 152 Graph generation means 153 Graph storage means 156 Graph comparison means 157 Abnormality detection means 158 Warning Notification means 159 Drive control means 161 Input operation means 162 Graph registration means 200 Chemical syringe 210 Cylinder member 220 Piston member 300 MRI apparatus

[Configuration of the embodiment]
As shown in FIGS. 1 to 3, a chemical solution injection system 1000 according to an embodiment of the present invention includes a chemical solution injection device 100, a chemical solution syringe 200, and an MRI apparatus 300 that is a fluoroscopic imaging device. As will be described later, a contrast medium or the like is injected as a drug solution into a subject (not shown).

  As shown in FIG. 3, the MRI apparatus 300 includes a fluoroscopic imaging unit 301 and an imaging control unit 302. The fluoroscopic imaging unit 301 and the imaging control unit 302 are connected to each other via a communication network 303. The fluoroscopic imaging unit 301 captures a fluoroscopic image from the subject, and the imaging control unit 302 controls the operation of the fluoroscopic imaging unit 301.

  The chemical syringe 200 has a cylinder member 210 and a piston member 220 as shown in FIG. The piston member 220 is slidably inserted into the cylinder member 210. The cylinder member 210 has a cylindrical main body portion 211, and a conduit portion 212 is formed on the closed end surface of the main body portion 211.

  The end surface of the main body 211 of the cylinder member 210 is opened, and the piston member 220 is inserted into the main body 211 from this opening. A cylinder flange 213 is formed on the outer periphery of the cylinder member 210, and a piston flange 221 is formed on the outer periphery of the piston member 220.

  As shown in FIG. 4, the chemical injection device 100 of this embodiment includes an injection control unit 101 and an injection head 110 that is an injection device main body configured separately from the injection control unit 101. The injection control unit 101 and the injection head 110 are connected by wire with a communication cable 102. The injection head 110 drives the chemical solution syringe 200 to be attached to inject the chemical solution into the subject. The injection control unit 101 controls the operation of the injection head 110.

  Therefore, as shown in FIG. 2, the injection control unit 101 includes a computer unit 120. The computer unit 120 is also connected by wire to the imaging control unit 302 of the MRI apparatus 300 via a communication network 304.

  As shown in FIG. 4, the injection control unit 101 includes a main operation panel 103, a main touch panel 104 that serves as an operation unit and a main display panel, a speaker unit 105, and the like disposed on the front surface of the main body housing 106. The controller unit 107 of the body is wired with a connection cable 108.

  The injection head 110 is attached to the upper end of the caster stand 111 via a movable arm 112. As shown in FIG. 5, the injection head 110 has a head main body 113, and a semi-cylindrical groove-shaped concave portion 114 that holds the chemical syringe 200 is formed on the upper surface of the head main body 113. .

  A cylinder holding mechanism 116 that holds the cylinder flange 213 of the chemical syringe 200 is formed at the front of the recess 114. A piston drive mechanism 130 that holds and slides the piston flange 221 is disposed behind the recess 114. The cylinder holding mechanism 116 has a concave groove formed on the inner surface of the concave portion 114, and the cylinder flange 213 engages with the concave groove.

  The two concave portions 114 of the injection head 110 are individually mounted with a contrast medium syringe 200C filled with a contrast medium as a chemical solution and a physiological saline syringe 200P filled with a physiological saline solution as the chemical liquid. The piston drive mechanism 130 is disposed corresponding to each recess 114. The two recesses 114 and the two piston drive mechanisms 130 constitute a contrast medium injection mechanism 130C for injecting a contrast medium into a subject and a physiological saline injection mechanism 130P for injecting physiological saline.

  As shown in FIG. 6, the piston drive mechanism 130 includes a slide rod 131 that is elongated in the front-rear direction as a slider member. The slide rod 131 is supported by the head body 113 so as to be slidable in the front-rear direction while being unable to rotate about the axis.

  A piston pressing member 132 is integrally formed at the front end of the slide rod 131. A pair of engaging claws 133 are mounted on the piston pressing member 132 so as to be freely opened and closed. A screw hole 134 is formed in the slide rod 131 from the center of the rear surface to the front. A male screw 136 that engages with the screw hole 134 is formed on a screw shaft 137 that is a rotating member.

  The screw shaft 137 is rotatably supported by the head main body 113 by a radial bearing 138 and is supported by the thrust bearing 139 in the axial direction in a rotatable state. More specifically, an annular flange portion 141 is formed in the vicinity of the rear end of the screw shaft 137, and an annular thrust bearing 139 is in contact with the rear surface of the flange portion 141.

  A load cell 142 having the same shape is in contact with the rear surface of the thrust bearing 139 as a pressure detecting element. Although the load cell 142 is fixed to the head main body 113, the thrust bearing 139 is supported by the head main body 113 in a state that can be slightly displaced in the front-rear direction.

  The piston drive mechanism 130 has an ultrasonic motor 143 as a drive motor as shown in FIG. 2, and this ultrasonic motor 143 is connected to the screw shaft 137 by a belt mechanism 144 as shown in FIG. ing. More specifically, a belt wheel 145 is integrally attached to the rear end of the screw shaft 137, and a belt wheel is also integrally attached to the rotor member of the ultrasonic motor 143 (not shown). An endless belt 146 is stretched around the belt wheel 145.

  In this embodiment, each part of the injection head 110 is formed of a non-magnetic material, and portions that cannot be formed of a non-magnetic material are shielded. For example, the ultrasonic motor 143 is phosphor bronze alloy (Cu + Sn + P), titanium alloy (Ti-6Al-4V), magnesium alloy (Mg + Al + Zn), etc. so as not to generate a magnetic field during operation. It is made of a nonmagnetic metal. Similarly, the load cell 142, the screw shaft 137 and the like are formed of a nonmagnetic metal. The belt mechanism 144, the head main body 113, and the like are formed of a nonmagnetic resin.

  In the chemical injection device 100 of this embodiment, the main operation panel 103, the load cell 142, and the like are connected to the computer unit 120, and the computer unit 120 performs integrated control of each unit corresponding to the computer program that is installed. For this reason, the computer unit 120 controls the operation of the piston drive mechanism 130 of the injection head 110 in response to the input operation of the main operation panel 103, the main touch panel 104, and the controller unit 107 of the injection control unit 101. The computer unit 120 displays various data on the main touch panel 104.

  As shown in FIG. 5, a sub-touch panel 118 serving as both a sub-operation panel and a sub-display panel is attached to the side of the injection head 110. The computer unit 120 also controls the operation of the piston drive mechanism 130 of the injection head 110 and displays various data related to this control on the sub-touch panel 118 even in the input operation from the sub-touch panel 118.

  However, as will be described in detail later, the sub-touch panel 118 has a smaller screen size and a smaller number of pixels than the main touch panel 104, so that the amount of data that can be displayed is small. For this reason, all the various data that needs to be displayed is displayed on the main touch panel 104, but only a part is displayed on the sub touch panel 118.

In the chemical injection device 100 of this embodiment, as shown in FIG. 2, the computer unit 120 includes a CPU (Central Processing Unit) 121, a ROM (Read Only Memory) 122, a RAM (Random
Access Memory) 123, I / F (Interface) 124, and the like.

  In the computer unit 120, a dedicated computer program is mounted as firmware on an information storage medium such as the ROM 122, and the CPU 121 executes various processing operations corresponding to the computer program.

  Since the computer unit 120 recognizes data input from the main touch panel 104 and the sub touch panel 118 and controls the display, in the chemical injection device 100 of this embodiment, various data for formal injection are input and operated on the main touch panel 104. Displayed on the touch panel 104, various test injection data are input on the sub touch panel 118 and displayed on the sub touch panel 118.

  More specifically, in the computer unit 120, control data of the piston drive mechanism 130 specialized for confirming the connection state of the extension tube 230 is registered as various data of test injection, and the test data is stored in the sub-touch panel 118. When an injection start command is input, the operation of the ultrasonic motor 143 of the physiological saline injection mechanism 130P is controlled corresponding to the test injection control data.

  As described above, the chemical injection device 100 according to the present embodiment is operated by the computer unit 120 corresponding to the computer program and the control data of the test injection, so that the pressure detection unit 151, the graph generation unit 152, the graph storage unit 153, Various means such as display means 154, graph comparison means 156, abnormality detection means 157, warning notification means 158, drive control means 159, input operation means 161, and graph registration means 162 are logically provided.

  Each of these means uses hardware such as the load cell 142 and the sub-touch panel 104 as necessary, but basically corresponds to the function of the CPU 121 executing predetermined data processing corresponding to the computer program in the ROM 122. To do.

  The pressure detection means 151 detects the pressure of the chemical solution injected into the subject from the detection pressure of the load cell 142, as will be described in detail later. The graph generating means 152 generates the pressure detected during execution of the test injection in real time as a time graph. The graph storage unit 153 corresponds to a storage area of the RAM 123 constructed so as to be recognized by the CPU 121, and stores a reference graph corresponding to the pressure when the test injection is properly executed.

  As shown in FIG. 7, the graph display unit 154 displays the stored reference graph on the sub-touch panel 118 and also displays the generated time-lapse graph in real time. The graph comparison unit 156 compares the shape of the time-dependent graph with the shape of the reference graph in real time using an existing image recognition technique or the like. The abnormality detection unit 157 detects the occurrence of an abnormality if the shape of the time graph and the reference graph are not similar.

  When the abnormality detection unit 157 detects the occurrence of an abnormality, the warning notification unit 158 displays a warning that the abnormality has occurred on the main touch panel 104 and the sub touch panel 118 and outputs a warning as a sound from the speaker unit 105. The drive control means 159 controls the operation of the piston drive mechanism 130 corresponding to the reference graph when the test injection is executed, and forcibly stops the piston drive mechanism 130 when an abnormality is detected by the abnormality detection means 157.

  The input operation unit 161 sets the abnormality detection unit 157 to detect the occurrence of an abnormality in response to a predetermined input operation to the sub touch panel 118. The graph registration unit 162 registers the time-lapse graph as a reference graph in the graph storage unit 153 by a predetermined input operation on the sub-touch panel 118.

  Various means of the chemical liquid injector 100 as described above are realized by using hardware such as the main touch panel 104 as necessary. The main body corresponds to a computer program stored in an information storage medium such as the ROM 122. This is realized by the function of the CPU 121 as hardware.

  Such a computer program stores, for example, a reference graph corresponding to the pressure when the test injection is properly executed in the RAM 123, and the piston drive mechanism 130 corresponding to the reference graph when the test injection is executed. Controlling the operation of the liquid crystal, detecting the pressure of the chemical solution injected into the subject during the test injection from the detection pressure of the load cell 142, generating the detected pressure in real time as a graph over time, Display a graph and display a time graph in real time, compare the shape of the time graph with the shape of the reference graph in real time using existing image recognition technology, etc., abnormal if the shape of the time graph and the reference graph are not similar Detection of occurrence, predetermined input to the sub-touch panel 118 If an abnormality is detected in response to the operation, if an abnormality is detected, a warning is issued by the display on the main touch panel 104 and the sub-touch panel 118 and the sound of the speaker unit 105, and if an abnormality is detected. Information storage medium such as RAM 123 as software for causing the CPU 121 to execute processing operations such as forcibly stopping the piston drive mechanism 130 and registering a time-dependent graph as a reference graph by a predetermined input operation to the sub-touch panel 118 Stored in

[Operation of the embodiment]
In the configuration as described above, when the chemical injection device 100 of this embodiment is used, the injection head 110 of the chemical injection device 100 is arranged in the vicinity of the fluoroscopic imaging unit 301 of the MRI apparatus 300 as shown in FIG. The injection control unit 101 is arranged at a predetermined position away from the fluoroscopic imaging unit 301.

  In such a state, for example, the operator moves to the vicinity of the injection head 110, and two chemical liquid syringes 200 (contrast medium syringe 200 </ b> C) are connected to a subject (not shown) located in the fluoroscopic imaging unit 301 with a bifurcated extension tube 230. And physiological saline syringe 200P). And the cylinder member 210 of these chemical | medical solution syringes 200 is hold | maintained at the recessed part 114 of the injection | pouring head 110, and the piston member 220 is made to hold | grip to the piston drive mechanism 130. FIG.

  Next, the operator moves from the vicinity of the injection head 110 to the vicinity of the injection control unit 101, and activates the chemical injection device 100 by an input operation of the main operation panel 103 or the like. Then, as shown in FIG. 8 and FIG. 11, a schematic image of a plurality of body sections is displayed on the upper part of the main touch panel 104 corresponding to the human body shape, and below it is injected with the injection speed of the drug solution as the vertical axis. A horizontally long condition screen with time as the horizontal axis is displayed (step S1).

  Therefore, when one of the schematic images of a plurality of body sections displayed on the main touch panel 104 is selected by the operator touching with a finger (step S2), as shown in FIG. 9, the selected body section is displayed. Only the schematic image is brightened and the other schematic images are darkened, and the schematic image of the scanner mechanism is displayed above the schematic image of the selected body section.

  At the same time, a schematic image of a plurality of imaging regions related to the selected body segment is read and displayed at the bottom (steps S3 and S4), and the operator touches one of them with a finger. When selected (step S5), as shown in FIG. 10, only the selected one schematic image is brightened and the other schematic images are darkened.

  When an imaging region is selected as described above, in the liquid injector 100 of this embodiment, it is confirmed whether or not a plurality of types of chemical syringes 200 are registered in the RAM 123 corresponding to the imaging region (step S6). When the chemical syringe 200 is registered, the product name, capacity, and the like serving as identification data are displayed in a list on the main touch panel 104 and the sub touch panel 118 (step S7).

  That is, in the liquid injector 100 of this embodiment, since a plurality of types of contrast medium syringe 200C and physiological saline syringe 200P are used, various data of the contrast medium syringe 200C and physiological saline syringe 200P to be used are stored in advance. It is registered. Furthermore, since various data of the chemical syringe 200 are registered in association with the imaging region, the product name of the corresponding chemical syringe 200 is displayed in a list when the imaging region is selected as described above.

  Therefore, when the operator selects and operates the chemical syringe 200 on the sub-touch panel 118, various data of the selected chemical syringe 200 are read (step S9). At this time, for example, the display data of the unselected drug solution syringe 200 is erased, and the display data of only the selected drug solution syringe 200 is enlarged, so that the operator can surely confirm the selection result of the drug solution syringe 200. it can.

  In addition, the chemical injection device 100 according to the present embodiment stores the chemical syringe 200 that was used last time, and the chemical syringe 200 that was used last time is displayed by blinking or reversal when the list is displayed. When the chemical syringe 200 to be used is the same as the previous one, the selection operation can be easily performed.

  In addition, since the selection operation of the chemical syringe 200 can be performed also on the sub-touch panel 118 of the injection head 110, the selection is performed on the sub-touch panel 118 while confirming the contrast medium syringe 200C and the physiological saline syringe 200P actually mounted on the injection head 110. The operation can also be executed reliably.

  When only one type of contrast medium syringe 200C and physiological saline syringe 200P is registered corresponding to the imaging region (step S6), various data of the drug solution syringe 200 are automatically read out. The product name, capacity, and the like are enlarged and displayed on the main touch panel 104 and the sub touch panel 118 (step S9).

  In the liquid injector 100 of this embodiment, for each contrast medium syringe 200C and physiological saline syringe 200P used, the inner diameter of the cylinder member 210, the stroke of the piston member 220, the frictional force between the cylinder member 210 and the piston member 220, and the filling Since various kinds of data such as the volume of the medicinal solution and the viscosity of the medicinal solution are registered, these various data are read out corresponding to the selection operation of the contrast medium syringe 200C and the physiological saline syringe 200P.

  When the imaging region and the chemical syringe 200 are selected as described above, in the chemical injection device 100 of the present embodiment, the previous injection conditions of the formal injection are registered in the RAM 123 corresponding to the imaging region and the chemical syringe 200. If not registered, the default injection condition is read (step S11). If registered, the previous injection condition is read (step S12).

  In the chemical injection device 100 of the present embodiment, since the contrast medium and the physiological saline are sequentially injected in the formal injection, the injection conditions of the contrast medium and the physiological saline are registered so that the injection is executed. ing. Since the injection time and the injection rate are set as data for the injection conditions read out in this way, the injection time and the injection speed are multiplied to calculate the injection volume for each injection condition (step S13). .

  Then, a condition image having a horizontal width corresponding to the injection time and an injection speed and an injection volume provided as text data is generated for each injection condition (step S14). As shown in FIG. Are displayed and output on the condition screen at a vertical position corresponding to the horizontal position and a horizontal position corresponding to the injection time (step S17).

  At this time, since the condition image is generated from the injection conditions of the contrast medium and the physiological saline as described above, for example, the condition image is displayed and output in green and blue and arranged in order in the horizontal direction. Display output. Further, it is determined whether or not the injection speed exceeds the upper limit speed for each injection condition (step S15), and for the injection condition that exceeds the condition, the condition image is flashed in red and a speed warning is output (step S15). S16).

  As shown in FIG. 12, the chemical injection device 100 according to the present embodiment can change the injection conditions displayed on the main touch panel 104 as described above by operating the main touch panel 104 (steps S18 and S19). . For example, it is possible to increase / decrease the injection speed of the injection condition by bringing the finger into contact with the center of the condition image displayed on the main touch panel 104 and sliding the contacted finger up and down on the condition image.

  Further, the injection time and the injection volume of the injection condition can be increased or decreased by bringing the finger into contact with at least one of the left and right ends of the displayed condition image and sliding the contacted finger to the left and right. Furthermore, when the finger touches the numerical value of the injection speed and injection volume of the displayed condition image, an operation image of the numeric keypad is displayed there (not shown). The injection volume can be increased or decreased.

  When the injection condition for formal injection is input through the condition image displayed on the main touch panel 104 as described above (step S18), this is stored as the current injection condition (step S12), and the condition corresponding to the injection condition is set. Image generation and the like are also executed in real time (steps S13 to S19).

  In the chemical injection device 100 of the present embodiment, when the injection conditions for formal injection are determined as described above, the time chart of the test injection is used as a reference corresponding to the imaging region and the chemical syringe 200 selected as described above. It is confirmed whether it is registered in the RAM 123 as a graph (step S20).

  If the time graph is not registered, the reference graph set as default corresponding to the imaging region and the chemical syringe 200 is read and displayed on the sub-touch panel 118 (step S23). On the other hand, when a time-dependent graph is registered corresponding to the imaging region and the chemical syringe 200, the time-dependent graph is read and displayed as a reference graph on the sub-touch panel 118 (step S21).

  In this case, for example, a default reference graph and a time chart registered as a reference graph are displayed on the sub-touch panel 118 together with a guidance message such as “Do you want to perform test injection with user settings? Y / N”. Is done. Therefore, the operator can select and operate the sub-touch panel 118 to use the registered time graph or the default reference graph (step S22).

  Therefore, when the operator selects a desired reference graph, only the reference graph is displayed on the sub-touch panel 118. Therefore, when the operator inputs a test start to the sub-touch panel 118 in this state (step S24) Initial setting and test injection are executed (steps S25 to S25).

  In that case, first, the computer unit 120 obtains an electrical resistance as an electrical signal from the load cell 142 in a state where the ultrasonic motor 143 of the physiological saline injection mechanism 130P and the contrast injection mechanism 130C is not operated (step S25). Initial setting is executed assuming that a pressure of "0" is indicated (step S26).

  Next, the computer unit 120 executes test injection by operating the ultrasonic motor 143 only for the physiological saline injection mechanism 130P corresponding to the reference graph (step S27). At this time, as shown in FIG. 6, the screw shaft 137 connected by the ultrasonic motor 143 and the belt mechanism 144 is rotationally driven. This screw shaft 137 is thrust by the load cell 142 fixed to the head body 113. Since it is supported in the axial direction via the bearing 139, the slide rod 131 connected to the screw shaft 137 by the screw mechanism is slid.

  Therefore, the piston member 220 is pushed into the cylinder member 210 by the slide rod 131, and a chemical solution is injected from the cylinder member 210 to the subject. At this time, since the pressure acting on the slide rod 131 that presses the piston member 220 also acts on the screw shaft 137, the pressure acting on the screw shaft 137 acts on the load cell 142 via the thrust bearing 139.

  Therefore, as shown in FIG. 12, the computer unit 120 obtains the pressure detected by the load cell 142 during the execution of the chemical solution injection as described above (step S28), and the viscosity and cylinder of the chemical solution initially set by the syringe selection Corresponding to the inner diameter of the member 210 and the like, the pushing pressure of the piston member 220 is converted into the injection pressure of the chemical liquid (step S29).

  For this reason, in the chemical injection device 100 of this embodiment, the operator does not need to infer the injection pressure of the chemical from the pressure acting on the piston member 220, and can easily check the injection pressure of the chemical. Moreover, since various data necessary for converting the pressure of the piston member 220 into the injection pressure of the chemical solution is set only by selecting and operating the chemical solution syringe 200 displayed as a list as described above (steps S8 and S9). The operator is not required to enter complicated data.

  Then, as shown in FIG. 7, a time-lapse graph is generated in real time from this injection pressure and displayed on the sub-touch panel 118 (step S30), so that the operator can use the injection pressure of the chemical solution actually injected as a reference. It can be easily confirmed in real time whether it corresponds to the graph.

  In addition, in the chemical injection device 100 of the present embodiment, the upper limit pressure of the test injection is also set by default corresponding to the imaging part and the chemical syringe 200, so that the injection pressure does not exceed the upper limit pressure during the test injection. Is constantly monitored (step S31). If the injection pressure exceeds the upper limit pressure, the occurrence of abnormality is output by the display on the main touch panel 104 and the sub touch panel 118 and the sound output of the speaker unit 105 (step S35), and the operation of the physiological saline injection mechanism 130P is forced. Stopped (step S36). For this reason, the operator can quickly and surely recognize that an abnormal pressure is generated in the test injection, and the test injection is automatically prevented from continuing while the abnormal pressure is generated.

  Moreover, since the chemical injection device 100 according to the present embodiment performs the test injection by driving the physiological saline injection mechanism 130P corresponding to the reference graph, the shape of the time-dependent graph is displayed when the test injection is normally executed. It will be similar to the shape of the reference graph. Therefore, for example, the computer unit 120 compares the shape of the time-dependent graph with the shape of the reference graph in real time using an existing image recognition technique (step S32), and detects the occurrence of an abnormality if the shapes of the two graphs are not similar.

  For example, when the injection needle (not shown) of the extension tube 230 is removed from the blood vessel but remains in the muscle during the test injection, the time-lapse graph rapidly decreases in a short time. However, when the time-dependent graph is originally higher in pressure than the reference graph, the occurrence of abnormality may not be detected from the difference from the pressure of the reference graph even if the pressure of the time-dependent graph decreases.

  On the other hand, if the extension tube 230 is bent during the test injection, the time graph rises rapidly in a short time, but if the time graph is originally at a lower pressure than the reference graph, the increased pressure The occurrence of abnormality may not be detected from the difference from the pressure in the reference graph.

  However, in the chemical injection device 100 according to the present embodiment, the occurrence of an abnormality is detected if the shape of the reference graph is not similar to the shape of the time-dependent graph. it can. Note that when a sufficient pressure difference is generated between the reference graph and the time-lapse graph, it is determined that the shapes are not similar, so that the occurrence of an abnormality is also detected. As described above, for example, a recognition technique used in OCR (Optical Character Reader) or the like can be used as the technique for determining the similarity in shape between the reference graph and the time-dependent graph.

  Furthermore, in the chemical injection device 100 of the present embodiment, for example, by touching the upper or lower portion of the reference graph displayed on the sub-touch panel 118 with fingers during execution of the test injection (step S32), the test injection pressure is set. It is also possible to adjust in real time (step S27). Since the time graph manually operated in this manner is not compared with the reference graph (step S33), the test injection can be executed in a state where the time graph is not similar to the reference graph as desired by the operator. .

  Furthermore, in the chemical injection device 100 of the present embodiment, since the time-lapse graph is displayed in real time together with the reference graph as described above, the occurrence of abnormality can be input to the sub-touch panel 118 according to the operator's judgment (step S34). . Also in this case, since the operation of the physiological saline injection mechanism 130P is forcibly stopped (step S36), the time-lapse graph determined to be abnormal by the operator is not registered as the reference graph.

  If the test injection is interrupted due to the occurrence of an abnormality as described above, the operator will investigate the cause of the abnormality and deal with it. In that case, the chemical syringe 200 may need to be replaced, but usually there is no need to change the imaging region. Therefore, in the chemical injection device 100 of this embodiment, when the test injection is interrupted due to the occurrence of an abnormality (step S36), the operation can be resumed from the state where the imaging region is selected as shown in FIG. In step S6), the test injection can be resumed quickly without the need for unnecessary input operations.

  Then, until the completion of the injection is detected from the working distance of the physiological saline injection mechanism 130P (step S37), the above-described test injection operation is repeated (steps S27 to S37). When this test injection is completed without any problem (step S37), as shown in FIG. 13, the operation of the physiological saline injection mechanism 130P is stopped (step S38).

  Then, the sub-touch panel 118 displays a guidance message such as “Do you want to register the current injection graph as the next or subsequent reference graph? Y / N” while the reference graph and the time-lapse graph are displayed. Therefore, when the operator determines that the time chart of the current test injection is more appropriate than the current reference graph and wants to register, the operator manually operates “Y” (step S39).

  Then, since the current time graph is registered as the reference graph (step S40), the time graph registered from the next time can be used as the reference graph (steps S20 to S23). For this reason, a time-lapse graph that is confirmed to be similar to the current reference graph without exceeding the upper limit pressure (steps S31 and S33) can be registered as a new reference graph as desired by the operator (step S40). .

  Moreover, even when a time-dependent graph similar to the reference graph is generated by the manual operation of the operator (step S32), the time-dependent graph can be registered as a new reference graph as desired by the operator (step S40). . In particular, even when the test injection is manually operated as desired by the operator, the injection pressure is limited to a range that does not exceed the upper limit pressure (step S31), so that the test injection is executed at an abnormal pressure. There is no (Step S36), and the dangerous time-lapse graph is not registered as the reference graph.

  And even when an original time chart is registered as a new reference graph in this way, the next test injection is executed corresponding to the reference graph, and by comparing the waveform of the reference graph with the new time chart, The presence or absence of abnormality is determined. For this reason, in the chemical injection device 100 of this embodiment, even if the reference graph is changed according to the operator's request, it is possible to detect the occurrence of abnormalities in the test injection well.

  Further, the time-series graph registered as the reference graph is registered corresponding to the imaging region and the chemical syringe 200, and if the imaging region and the chemical syringe 200 are selected and operated as described above (steps S1 to S8), it corresponds. Since the reference graph is automatically read (steps S20 to S23), the reference graph corresponding to the imaging region and the drug solution syringe 200 can be easily registered and read.

  If the operator determines that the time chart of the current test injection is not more appropriate than the current reference graph, the operator manually operates “N”, so the current time graph is registered as the reference graph. The current reference graph will be used again next time.

  And the chemical | medical solution injection | pouring apparatus 100 of this form will be in the state which can perform formal injection | pouring (step S41-), when test injection is completed as mentioned above (step S39, S40). In that case, the operator moves from the vicinity of the injection head 110 to the vicinity of the injection control unit 101 and inputs an operation start of formal injection to the main touch panel 104. Then, the chemical injection device 100 that has detected this (step S41) transmits a work start to the MRI apparatus 300 (step S44).

  As shown in FIG. 14, the MRI apparatus 300 that has received the work start from the chemical injection device 100 in this way (step T2) returns the work start to the chemical injection device 100 and executes the imaging operation (step T8). For this reason, in the chemical injection system 1000 of the present embodiment, the imaging of the MRI apparatus 300 follows the chemical injection of the chemical injection apparatus 100.

  In the chemical injection system 1000 of this embodiment, as described above, when the chemical injection device 100 is ready for formal injection (steps S41 to S43), as shown in FIG. 14, the start of imaging is input to the MRI apparatus 300. Even when operated (step T1), the chemical injection of the chemical injection device 100 follows the imaging of the MRI apparatus 300 (steps T4, T6˜, S42, S47˜).

  As shown in FIG. 13, when the chemical injection device 100 performs a series of chemical injection operations (step S 48-), the elapsed time is measured from the start of injection (step S 48), and the elapsed time and readout are performed. The contrast medium injection mechanism 130C and the physiological saline injection mechanism 130P are controlled in sequence in real time in accordance with the injection conditions that have been set (step S49).

  Also at this time, the computer unit 120 obtains the pressure detected by the load cell 142 (step S50), and converts the piston pressure into the injection pressure in accordance with the initially set viscosity of the chemical solution and the inner diameter of the cylinder member 210 ( Step S51), it is confirmed whether this injection pressure is normal (Step S52).

  The chemical injection device 100 and the MRI apparatus 300 according to the present embodiment detect the occurrence of abnormality in the above-described preparation completion state (steps S43 and T3), or detect the occurrence of abnormality during operation execution (step S52, T9), the occurrence of the abnormality is output (steps S55 and T16), and the operation is stopped (steps S58 and T18).

  Furthermore, since the abnormality occurrence is also transmitted to the other (steps S54, T15), the abnormality occurrence is also output (steps T16, S46) even on the other side (steps T10, S44). In addition, since one operation stop is also transmitted to the other (steps S56 and T17), the other operation (steps T13 and S53) receives the operation stop (steps T18 and S57).

  Even when the operation stop is input on one side (steps S58 and T11), the operation stop is executed (steps S57 and T18) and transmitted to the other side (steps S56 and T17). On the other side of receiving (steps T13 and S60), the operation is stopped (steps T18 and S57).

  When the operation completion is detected on the one hand (steps S61 and T14), the operation end is executed (steps S62 and T19), and the operation end is transmitted to the other side (steps S63 and T20). On the other side (steps T12 and S59), the operation is stopped (steps T18 and S57).

  In the drug solution injection system 1000 of this embodiment, the drug solution injection of the drug solution injection device 100 and the image capturing of the MRI apparatus 300 are automatically linked as described above, so that the contrast agent and the physiological saline are sequentially placed at appropriate timing. A fluoroscopic image can be taken from the subject to be injected at an appropriate timing.

  In the chemical injection device 100 of the present embodiment, as described above, various data of formal injection are input and displayed on the large and high-resolution main touch panel 104 mounted on the injection control unit 101. Complex input operations and displays can be executed accurately.

  Nevertheless, since various data of the test injection are input and displayed on the small and low resolution sub-touch panel 118 mounted on the injection head 110, one operator can use the extension tube 230 in the vicinity of the injection head 110. It is possible to easily execute the test injection input operation and confirmation while visually observing the above.

  In the chemical injection device 100 of this embodiment, the piston drive mechanism 130 is supported by the head body 113 so as to be displaceable, and the load cell 142 that detects the pressure acting on the piston drive mechanism 130 is fixed to the head body 113. Yes. For this reason, since the load cell 142 is not disposed in the movable part of the piston drive mechanism 130, the structure is simple and the productivity and reliability are good.

[Modification of Embodiment]
The present invention is not limited to the above embodiment, and various modifications are allowed without departing from the scope of the present invention. For example, in the above embodiment, the chemical injection device 100 having the contrast medium injection mechanism 130C and the physiological saline injection mechanism 130P is illustrated as injecting the contrast medium and the physiological saline. A chemical liquid injection device (not shown) for injecting only the liquid can be implemented.

  In the above embodiment, the chemical injection device 100 having the contrast medium injection mechanism 130C and the physiological saline injection mechanism 130P performs the test injection with the physiological saline. However, it is also possible to perform a test injection with a contrast agent. In that case, for example, the control data of the piston drive mechanism 130 specialized for confirming the time required for the contrast medium to reach the affected part where the fluoroscopic image is captured is registered in the computer unit 120 as various types of test injection data. In addition, the operation of the piston drive mechanism 130 can be controlled in accordance with the control data.

  Further, in the above embodiment, the case where the input operation and display of formal injection and test injection are executed on the main touch panel 104 and the sub touch panel 118 is illustrated. However, for example, it is also possible to separately execute the input operation and display of formal injection and test injection on the independent main touch panel and sub display panel and the main operation panel and sub operation panel (not shown). .

  Moreover, in the said form, it illustrated that the various data of the chemical | medical solution syringe 200 required in order to convert the pressure of the piston member 220 into the injection pressure of a chemical | medical solution were registered into the chemical | medical solution injection apparatus 100 in advance. However, for example, an RFID tag in which various data is recorded is attached to the chemical syringe 200, and an RFID reader that acquires various data recorded from the RFID tag is mounted in the chemical injection device. Possible (not shown). In this case, even if the new chemical syringe 200 is shipped, the chemical injection device 100 can acquire the various data.

  Further, the chemical injection device 100 is connected online with a host computer of the manufacturer of the chemical syringe 200, and various data are provided online to the chemical injection device 100 each time a new chemical syringe 200 is shipped. It is also possible (not shown).

  Moreover, in the said form, converting the pressure of the piston member 220 into the injection pressure of a chemical | medical solution by the various data of the chemical | medical solution syringe 200 was illustrated. However, for example, by installing a load cell inside the cylinder member 210 or the extension tube 230 (not shown), it is possible to directly detect the injection pressure of the chemical solution.

  Furthermore, in the said form, at least 1 chemical | medical solution syringe 200 was registered for every imaging region | part, and when the registered chemical | medical solution syringe 200 was multiple, it displayed as a list and made the operator perform selection operation. However, only one chemical syringe 200 is registered for each imaging region, and syringe data can be automatically read when an imaging region is selected.

  In the above embodiment, the MRI apparatus 300 is used as the fluoroscopic imaging apparatus, and the chemical solution injection apparatus 100 injects the MR contrast agent. However, for example, it is also possible to use a CT scanner or a PET apparatus as a fluoroscopic imaging apparatus and inject a contrast agent for the CT scanner or PET apparatus.

  Furthermore, in the above embodiment, it is exemplified that various means are logically realized as various functions of the chemical injection device 100 by operating the CPU 121 corresponding to the computer program stored in the RAM 123 or the like. However, each of these various means can be formed as unique hardware, and a part can be stored in the RAM 123 or the like as software and a part can be formed as hardware.

Claims (10)

A chemical solution injection device for performing a formal injection after a test injection of a chemical solution from a chemical solution syringe into which a piston member is slidably inserted into a cylinder member via an extension tube,
A piston drive mechanism for pushing the piston member into the cylinder member;
Pressure detecting means for detecting an injection pressure of a chemical solution injected into the subject;
A graph generating means for generating the injection pressure detected during execution of the test injection in real time as a time graph;
Graph storage means for storing a reference graph corresponding to the injection pressure when the test injection is properly executed;
A graph comparison means for comparing the shape of the time graph with the shape of the reference graph in real time;
An abnormality detection means for detecting occurrence of an abnormality when the shape of the time-dependent graph and the shape of the reference graph are not similar;
A chemical injection device. Graph display means for displaying the time graph in real time;
Input operation means for setting the abnormality detection means to a state in which the abnormality occurrence is detected by an input operation;
The chemical injection device according to claim 1, further comprising: Graph display means for displaying the time graph together with the reference graph;
The drug solution injection device according to claim 1, further comprising: a graph registration unit that registers the temporal graph as the reference graph in the graph storage unit by an input operation. A computer unit that controls the operation of the piston drive mechanism and functions as at least the graph generation means, the graph storage means, and the graph comparison means;
A main display panel for displaying various data by the computer unit;
A main operation panel for accepting various data input operations to the computer unit;
A sub-display panel that is smaller than the main display panel and displays various data by the computer unit;
A sub-operation panel that is smaller than the main operation panel and accepts various data input operations to the computer unit;
An injection control unit on which at least the computer unit, the main display panel, and the main operation panel are mounted;
An injection head configured separately from the injection control unit and having at least the piston drive mechanism, the sub display panel, and the sub operation panel mounted thereon;
At least a part of the formal injection data is input on the main operation panel and displayed on the main display panel,
The chemical injection device according to any one of claims 1 to 3, wherein at least a part of data of the test injection is input on the sub operation panel and displayed on the sub display panel. The computer unit stores a schematic image of a plurality of body sections of a human body and a large number of imaging parts in association with each other and stores the reference graph for each imaging part,
The main display panel displays a plurality of schematic images of the body sections corresponding to the human body shape,
The main operation panel accepts an input operation for selecting one of the plurality of displayed body sections,
The main display panel displays a schematic image of at least one of the imaging regions corresponding to the selected body segment,
The main operation panel accepts an input operation for selecting one of the displayed imaging parts,
The chemical injection device according to claim 4, wherein the reference graph corresponding to the selected imaging region is read and displayed on the sub display panel. There are multiple types of the drug solution syringe,
A pressure detection element for detecting in real time the pressure with which the piston member is pushed into the cylinder member;
The computer unit stores various data of the chemical syringe for each imaging region, reads various data of the chemical syringe corresponding to the selected imaging region, and uses the read various data of the chemical syringe The chemical injection device according to claim 5, wherein the pressure detected by the pressure detection element is converted into the injection pressure of the chemical in real time. There are multiple types of the drug solution syringe,
A pressure detection element for detecting in real time the pressure with which the piston member is pushed into the cylinder member;
The computer unit stores various data of at least one type of the chemical syringe for each imaging region,
The computer unit reads various data of the drug solution syringe corresponding to the selected imaging region,
At least one of the main display panel and the sub display panel displays identification data of at least one kind of the liquid syringe corresponding to the selected imaging region,
At least one of the main operation panel and the sub operation panel accepts an input operation for selecting one from the displayed identification data,
The chemical solution injection device according to claim 5, wherein the computer unit converts a pressure detected by the pressure detection element from various data of the selected chemical solution syringe into an injection pressure of the chemical solution in real time. From an RFID (Radio Frequency Identification) tag in which various data is recorded and attached to the chemical syringe, further includes an RFID reader that acquires the recorded various data,
The pressure detection means includes a pressure detection element that detects in real time a pressure at which the piston member is pushed into the cylinder member, and a pressure detected by the pressure detection element based on the various data acquired from the RFID tag. The chemical solution injection device according to any one of claims 1 to 5, further comprising pressure conversion means for converting the injection pressure into real time in real time. A data processing method using the chemical injection device according to claim 1,
A reference graph corresponding to the injection pressure when the test injection is properly executed is stored,
Generating the injection pressure detected during the test injection in real time as a graph over time;
Compare the shape of the time graph with the shape of the reference graph in real time,
A data processing method for detecting occurrence of an abnormality when the shape of the time-dependent graph is not similar to the shape of the reference graph. A computer program for the chemical injection device according to claim 1,
Storing a reference graph corresponding to the injection pressure when the test injection is properly performed;
Generating in real time the injection pressure detected during execution of the test injection as a time graph;
Comparing the shape of the time graph with the shape of the reference graph in real time, and detecting the occurrence of an abnormality if the shape of the time graph and the shape of the reference graph are not similar,
Is a computer program for causing the medicinal solution injection device to execute.

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