JPWO2005092257A1 - Cooling sheet and cooling container - Google Patents

Abstract

Provided are a cooling sheet and a cooling container that can easily relieve pain (pain) during puncture. The cooling sheet (1) is separated into the first space (21) and the second space (22) by a partition part (23) that is formed by bending the bag body (2) and communicates when necessary. The first substance (5) is accommodated in the first space (21), and the second substance (6) that generates an endothermic reaction by contacting the first substance (5) in the second space (22). Is stored. In the cooling container (101), the container main body (128) is divided into a first space (121) on the lid (129) side and a second space (122) on the container main body (128) side by the partition part (108). A second substance that is isolated and contains an endothermic reaction when the first substance (103) is stored in the first space (121) and comes into contact with the first substance (103) in the second space (122). (104) is stored. A release member (106) is provided on the surface of the lid (129) on the first space (121) side, and the lid (129) is rotated relative to the container body (128), thereby separating the partition ( 108), the isolation state between the first space (121) and the second space (122) is released.

Description

  The present invention relates to a cooling sheet, and more particularly to a cooling sheet and a cooling container that can alleviate pain during puncturing.

  One of the indispensable actions for performing medical actions in the medical field is an action of puncturing a patient with an injection needle or the like. Examples of such actions include puncture of a vein indwelling needle, puncture for various anesthesia such as epidural anesthesia and spinal anesthesia, puncture for nerve block, and puncture for vaccination for children.

  Pain is produced at the time of puncture, and alleviating this pain is an extremely important factor in terms of releasing the patient from pain. This is also important in that medical personnel such as doctors and nurses can proceed smoothly.

  Conventionally, as means for relieving pain at the time of puncture as described above, for example, a tape preparation containing a local anesthetic is known (see, for example, JP 2000-319168 A). Prior to the puncture, such a tape is applied to the planned puncture site, and the pain at the planned puncture site is paralyzed by the anesthetic action of the local anesthetic. Thereby, when puncture is performed on a planned puncture site, pain at the puncture site during puncture is alleviated.

  However, the tape agent according to Japanese Patent Application Laid-Open No. 2000-319168 is effective in a short time because the effect (action) cannot be obtained unless the local anesthetic is permeated subcutaneously in a state of being applied to the puncture planned site. Is difficult to express. For example, in order to obtain a sufficient anesthetic action, that is, a pain relieving effect, it is necessary to apply it for 2 to 3 hours before puncturing.

  An object of the present invention is to provide a cooling sheet and a cooling container that can easily relieve pain (pain) during puncture, for example.

  Such an object is achieved by the present inventions (1) to (38) below.

(1) a bag body having a first space and a second space that are isolated from each other and communicated when necessary;
A first substance housed in the first space;
A cooling sheet having a second substance housed in the second space and causing an endothermic reaction by contacting with the first substance,
A cooling sheet, wherein the bag body is bent to form a partition portion, and the first space and the second space are separated from each other by the partition portion.

  (2) As for the said bag body, the isolation | separation state of the said 1st space and the said 2nd space is maintained by adhere | attaching or melt | bonding a part of opposing outer surfaces in the said partition part. The cooling sheet according to (1) above.

  (3) In the bag body, the partition portion is sandwiched by the sandwiching member, thereby improving the adhesion between the inner surfaces of the partition portion, thereby isolating the first space and the second space. The cooling sheet according to (1) or (2), wherein the state is maintained.

  (4) The cooling sheet according to any one of (1) to (3), wherein the bag body has a width of the partition portion narrower than other portions.

  (5) The cooling sheet according to any one of (1) to (4), wherein the partition portion is formed by folding the bag body at least twice.

  (6) The cooling sheet according to any one of (1) to (5), wherein the partition portion includes a reinforcing layer.

  (7) Any of the above (1) to (6), comprising a first pressure-sensitive adhesive layer provided on at least one of the outer surfaces facing each other in a folded state of the bag, and fixing the bag to the surface of the living body The cooling sheet as described in one.

  (8) The cooling sheet according to (7), wherein the first pressure-sensitive adhesive layer contains a drug.

  (9) The cooling sheet according to (8), wherein the drug is a disinfectant.

  (10) The cooling sheet according to (8) or (9), wherein the drug is a local anesthetic.

  (11) Said (1) said 1st adhesive layer is provided in both the outer surfaces which oppose in the state which bent the said bag body, and the said chemical | medical agent in one adhesive layer contains a hemostatic agent (8) Thru | or the cooling sheet | seat as described in any one of (10).

  (12) The cooling sheet according to any one of (7) to (11), further including a release sheet that covers at least a part of the first pressure-sensitive adhesive layer in a state before use.

  (13) The cooling sheet according to any one of (1) to (12), wherein the thickness of the first pressure-sensitive adhesive layer is substantially constant.

  (14) The cooling sheet according to any one of (1) to (13), wherein the first pressure-sensitive adhesive layer has an average thickness of 10 μm to 10 mm.

(15) The cooling sheet according to any one of (1) to (14), wherein the first pressure-sensitive adhesive layer has an area of 10 to 40 cm ² in plan view.

  (16) The above (1) to (1) having a second pressure-sensitive adhesive layer provided on at least one of the outer surface opposite to the outer surface opposed to the bag body in a folded state and for fixing the bag body in a use state. (15) The cooling sheet according to any one of (15).

  (17) The cooling sheet according to (16), further including a release sheet that covers at least a part of the second pressure-sensitive adhesive layer in a state before use.

  (18) The temperature of the living body surface can be maintained at 5 to 20 ° C. for 5 minutes or more by an endothermic reaction between the first substance and the second substance in a state of being attached to the living body surface. The cooling sheet according to any one of (1) to (17) above.

  (19) The device according to any one of (1) to (18), which is used to adhere to a puncture planned site on a living body surface, cool the living body surface, and reduce pain during puncturing. Cooling sheet.

  (20) The cooling sheet according to any one of (1) to (19), further including a fixing member that fixes the ends of the bag body in a state where the bag body is bent.

(21) A container comprising a container body and a lid body detachably mounted on the container body;
A partition that separates a space defined by the container body and the lid into a first space on the lid body side and a second space on the container body side;
A first substance housed in the first space;
A second substance housed in the second space and causing an endothermic reaction by contacting with the first substance;
Provided on the surface of the lid on the first space side, and by performing an operation of displacing the lid with respect to the container body, the first space and the second space by the partition portion And a release member capable of releasing the isolated state.

  (22) The cooling container according to (21), wherein the partition portion is configured by an easily rupturable sheet.

(23) The lid is attached to the container body by screwing,
The release member is composed of a needle body or a blade,
The above (22), wherein the release member and the easily rupturable sheet are brought close to each other by rotating the lid relative to the container body to rupture the easily rupturable sheet. The cooling container according to 1.

  (24) The cooling container according to (23), wherein an elastic member is provided at least in the vicinity of the edge of the surface of the lid on the first space side.

(25) The lid body has elasticity,
The release member is composed of a needle body,
The structure according to (22), wherein the release member and the easily rupturable sheet are brought close to each other by pressing the lid toward the container main body, and the easily rupturable sheet is ruptured. Cooling container.

  (26) The cooling container according to (21), wherein the partition portion is configured by overlapping a pair of partition plates in which through holes are formed.

(27) The lid is attached to the container body by screwing,
By rotating the lid relative to the container body, the release member rotates, and by rotating the release member, the one on the lid side of the pair of partition plates is rotated, The cooling container according to (26), wherein the through holes of the pair of partition plates are configured to communicate with each other.

(28) Of the pair of partition plates, the lid-side partition plate has a protrusion,
The cooling container according to (26), wherein the partition plate on the lid side rotates when the release member pushes the protrusion.

  (29) The cooling container according to (27) or (28), wherein an elastic member is provided at least in the vicinity of the edge of the surface of the lid on the first space side.

  (30) The cooling container according to any one of (21) to (29), including beads accommodated in at least one of the first space and the second space.

  (31) The container body according to any one of (21) to (30), further including an adhesive layer provided on a surface opposite to the lid body of the container body and fixing the container to a biological surface. Cooling container.

  (32) The cooling container according to (31), wherein the pressure-sensitive adhesive layer has a substantially constant thickness.

  (33) The cooling container according to (32), wherein the pressure-sensitive adhesive layer has an average thickness of 10 μm to 10 mm.

(34) The cooling container according to any one of (31) to (33), wherein the pressure-sensitive adhesive layer has an area in a plan view of 10 to 40 cm ² .

  (35) The cooling container according to any one of (31) to (34), wherein the pressure-sensitive adhesive layer contains a drug.

  (36) The cooling container according to (35), wherein the drug is a disinfectant.

  (37) The cooling container according to any one of (31) to (36), wherein the cooling container has a release sheet that covers the pressure-sensitive adhesive layer in a state before use.

  (38) The temperature of the living body surface can be maintained at 5 to 20 ° C. for 5 minutes or longer by an endothermic reaction between the first substance and the second substance in a state of being in contact with the living body surface. The cooling container according to any one of (21) to (37) above.

  (39) Any one of the above (21) to (38), which is used to cool the planned puncture site by bringing it into contact with the planned puncture site on the surface of the living body and relieve pain during puncture. The cooling container according to one.

  According to the present invention, the planned puncture site can be cooled prior to the puncture, and an excellent pain relieving effect can be exhibited, so that pain during puncture can be easily relieved.

  In addition, by cooling the site to be punctured, an excellent pain relieving effect can be obtained in a very short time, and pain at the time of puncturing can be alleviated.

  According to the present invention, the target portion can be efficiently cooled. For this reason, for example, prior to puncture with an injection needle or the like, the pain at the time of puncture can be relieved very effectively by cooling the planned puncture site on the surface of the living body.

  Moreover, by providing an adhesive layer, it can fix to the target site | part and can cool the site | part more easily and reliably.

  Moreover, various effects according to the kind of chemical | medical agent can also be anticipated by containing a various chemical | medical agent in this adhesive layer.

  I. Hereinafter, preferred embodiments of the cooling sheet of the present invention will be described.

<First Embodiment>
First, a first embodiment of the cooling sheet of the present invention will be described.

  FIG. 1 is a plan view (internally transparent view) showing a first embodiment of the cooling sheet of the present invention, FIG. 2 is a cross-sectional view taken along line AA in FIG. 1, and FIG. 3 is the cooling sheet shown in FIG. FIG. 4 is a plan view showing the expanded state, and FIG. 4 is a view showing a use state of the cooling sheet of FIG. 1 in a cross section corresponding to FIG. In the following, the upper side in FIG. 1 is “upper”, the lower side is “lower”, the upper side in FIG. 2 is “upper”, the lower side is “lower”, and the upper side in FIG. In the following description, the lower side is “lower”, the left side in FIG. 4 is “upper”, and the right side is “lower”.

  As shown in these drawings, the cooling sheet 1 includes a bag body 2 containing two kinds of substances, a first pressure-sensitive adhesive layer 3 and a second pressure-sensitive adhesive layer 4 provided on the outer surface of the bag body 2. have.

  Prior to puncturing the surface of the living body (hereinafter referred to as “skin”), this cooling sheet 1 is attached (attached) to the skin so as to cover the planned puncture site and its peripheral site with the first adhesive layer 3. ) To cool the puncture planned site. Thereby, the pain (pain) at the time of puncture can be relieved.

  The bag body 2 is formed by sealing a sheet material as described later into a desired pattern by fusing (or bonding). Thereby, a belt-like seal portion 20 is formed on the outer peripheral portion of the bag body 2 and the like.

  The bag body 2 is folded in half at the central portion from the state shown in FIG. 3 to form a partition portion 23. When not in use (before use), as shown in FIG. 1 and FIG. It is in a state.

  Thereby, as shown in FIG. 2, the interior space of the bag body 2 is divided into two by the partition portion 23, and is partitioned into the adjacent first space 21 and second space 22. That is, the bag body 2 before use is formed with a first space 21 on the left side and a second space 22 on the right side in FIG. 2, and these spaces are partition portions (folded portions) formed by the bending. 23 are isolated from each other.

In the present embodiment, as shown in FIG. 3, in the above-described seal portion 20, the width t ₁ in the partition portion 23 and the vicinity thereof is wider than the width t _{2 in} other portions. Accordingly, when the partition portion 23 is extended and the first space 21 and the second space 22 are communicated with each other, the seal portion 20 is not damaged even if a relatively large force is applied to the partition portion 23 and the vicinity thereof. Can be prevented.

  Moreover, it is preferable that the seal | sticker part 20 has higher adhesive strength in the partition part 23 and its vicinity part than another part. Also by this, the damage of the seal part 20 can be prevented as described above.

  The partition part 23 is formed by bending the bag body 2 in the upper and lower parts from the state shown in FIG. Thereby, the partition part 23 partitions the internal space of the bag body 2 into the adjacent first space 21 and second space 22. These partition states depend on the substances (first substance and second substance) stored in the first space 21 and the second space 22, but are preferably liquid-tight or air-tight.

  In this embodiment, in FIG. 1 and FIG. 2, the lower part of the bag body 2 is double-folded by the first bent part 23A and the second bent part 23B to form the partition part 23. Thereby, the airtightness (liquid tightness) between the first space 21 and the second space 22 is improved, and the first space 21 and the second space are not used (before use). 22 is prevented from communicating unintentionally.

  The partition portion 23 may be formed by bending the bag body 2 only once at the first bent portion 23A, or formed by bending the bag body 2 three times or more. It may be a thing. For example, as shown in FIG. 5, the lower portion of the bag body 2 is folded (folded) three times at the first bent portion 23A, the second bent portion 23B, and the third bent portion 23C. A partition portion can be formed. Thereby, the airtightness (liquid tightness) between the first space 21 and the second space 22 is further improved, and the first space 21 and the second space are not used (before use). 22 is more reliably prevented from communicating unintentionally. FIG. 5 is an enlarged cross-sectional view illustrating another example of the partition portion of the bag body 2.

  Moreover, as for the partition part 23, the inner surfaces which the bag body 2 opposes may be sealed supplementarily by the weak seal | sticker etc. FIG. Such an auxiliary seal can be easily broken by hitting the bag body 2 and the like, and the first space 21 and the second space 22 can be communicated with each other.

  Such a bag body 2 is changed from the state shown in FIG. 1 and FIG. 2 to the state shown in FIG. 3 in use, so that the isolation by the partition portion 23 is released, and the first space 21 and the first space 21 The two spaces 22 communicate with each other.

  Moreover, such a bag body 2 can once again be in an isolated state after the first space 21 and the second space 22 are brought into communication. That is, communication and isolation between the first space 21 and the second space 22 can be performed reversibly.

  For this reason, for example, when it is desired to stop the cooling operation once, before the first substance 5 and the second substance 6 described later are completely mixed, the first space 21 and the second space 22 By returning to the isolation state, the cooling operation (puncture operation) can be restarted later, which is convenient.

  The first material 21 is stored in the first space 21, and the second material 6 is stored in the second space 22.

  The first substance 5 and the second substance 6 cause an endothermic reaction when brought into contact with each other. The present invention uses this endothermic reaction as a cooling means to cool the puncture site.

  The cooling sheet 1 is preferably capable of maintaining the temperature of the skin (scheduled puncture site) at 5 ° C. to 20 ° C. for 5 minutes or more by an endothermic reaction, and at 7 ° C. to 18 ° C. for 7 minutes or more. What can hold | maintain during this is more preferable. By satisfying such conditions, it is possible to effectively cool the planned puncture site and effectively relieve pain due to puncture even after the cooling sheet 1 is peeled off from the planned puncture site.

  If the cooling temperature is too low, the puncture site may be excessively cooled, causing frostbite, and may cause pain due to excessive cooling. On the other hand, if the cooling temperature is too high, there is a possibility that the pain relieving effect at the time of puncture cannot be obtained sufficiently.

  In addition, if the duration (holding time) is too short, the planned puncture site is not sufficiently cooled, and the pain relief effect at the time of puncture may not be sufficiently obtained.

The first substance (water solution) 5 is not particularly limited as long as it is in contact with the second substance 6 and causes an endothermic reaction. In addition to water, for example, microencapsulated water or sodium carbonate 10 Hydrate, sodium sulfate decahydrate, sodium phosphate 12 hydrate, sodium hydrogen phosphate 12 hydrate, sodium sulfite heptahydrate, sodium silicate 9 hydrate, sodium tetraborate decahydrate Water, aluminum sulfate 18 hydrate, aluminum nitrate 9 hydrate, calcium chloride hexahydrate, barium hydroxide octahydrate, chromium nitrate 9 hydrate, iron (III) nitrate 9 hydrate, etc. A compound etc. are mentioned, Among these, it can use combining 1 type (s) or 2 or more types. Among these, in particular, the first substance 5 is preferably composed mainly of water and barium hydroxide octahydrate, more preferably composed mainly of barium hydroxide octahydrate. By using the first substance 5, the cooling effect can be expressed in a shorter time.

  Moreover, as a form of the 1st substance 5, what kind of things, such as a liquid form, a solid form, and a gel form, may be sufficient, for example.

  When a solid substance or the like is used as the first material 5, it is not used even if the space between the first space 21 and the second space 22 is not completely sealed (airtight). At times (before use), an unintentional reaction between the first substance 5 and the second substance 6 can be prevented.

  Further, when a solid or gel-like material is used as the first substance 5, if the first substance 5 is made into a powder, flakes, or a small lump (pellet), the second substance is used at the time of use. 6 can be easily mixed and the dissolution rate can be increased. As a result, the cooling effect can be exhibited in a shorter time. From this point, it is particularly preferable that the first substance 5 is powdered.

  When the first substance 5 is in a powder form, the average particle diameter is not particularly limited, but is preferably 1 μm to 3 mm, and more preferably 50 μm to 1 mm. When the average particle diameter of the first substance 5 is less than the lower limit value, the scattering property is increased and the adjustment becomes complicated. On the other hand, if the average particle size of the first substance 5 exceeds the upper limit, the mixing with the second substance 6 becomes low, and a sufficient cooling effect (pain relieving effect) cannot be obtained, or the cooling sheet It takes a long time for the pain relief effect to be expected after sticking, and the immediate effect may not be expected.

  When a liquid substance is used as the first substance 5, it can be easily mixed with the second substance 6 at the time of use, and the dissolution rate can be increased. As a result, a cooling effect can be exhibited in a shorter time. be able to.

  On the other hand, the second substance (freezing agent) 6 is not particularly limited as long as it is in contact with the first substance 5 and gives an endothermic reaction. For example, ammonium nitrate, potassium nitrate, sodium nitrate, silver thiocyanate, boron Acid, ammonium chloride, ammonium carbonate, ammonium azide, ammonium nitrite, ammonium cyanate, ammonium phosphate trihydrate, ammonium thiocyanate, sodium tetraborate decahydrate, sodium hydrogen phosphate dodecahydrate, l -Aspartic acid, salicylic acid, oxalic acid dihydrate, guanidine nitrate, urea nitrate, sodium nitrite, urea, ammonium carbamate, ammonium carbonate, calcium nitrate, crystalline calcium chloride, magnesium sulfate, potassium thiocyanate, potassium carbonate, sulfuric acid Sodium, ammonium sulfate, Examples thereof include diammonium hydrogenate, ammonium metavanadate, ammonium bromide, and ammonium iodide. Among these, the second substance 6 is mainly composed of ammonium nitrate, ammonium chloride, and ammonium thiocyanate. Those having ammonium nitrate as a main component are more preferable. By using the second substance 6, the cooling effect can be exhibited in a shorter time.

  In addition, the form (shape) of the second substance 6 may be any solid form such as powder, flakes, or a small lump (pellet), but in particular a powder form. Is preferably used. Thereby, mixing with the 1st substance 5 becomes easy, a dissolution rate can be raised, As a result, a cooling effect can be expressed further in a short time.

  When the second substance 6 is in a powder form, the average particle diameter is not particularly limited, but is preferably 1 μm to 3 mm, and more preferably 50 μm to 1 mm. When the average particle size of the second substance 6 is less than the lower limit value, the scattering property is increased and the adjustment becomes complicated. On the other hand, when the average particle size of the second substance 6 exceeds the upper limit, the mixing with the first substance 5 becomes low, and a sufficient cooling effect (pain relieving effect) cannot be obtained, or a cooling sheet. After sticking, it takes a long time until the pain relief effect can be expected, or the immediate effect cannot be expected.

  Further, a gelling agent, a polymer, or the like may be added to the first substance 5 and the second substance 6 for the purpose of, for example, improving the feeling of use or obtaining a sustained cooling effect. Good.

  Although it does not specifically limit as a gelatinizer, For example, the polymer crosslinked material which uses the repeating unit of an amide type compound as the main repeating unit is used suitably.

  Examples of the amide compound include N-vinylformamide, N-vinylacetamide, N-methyl-N-vinylformamide, N-methyl-N-vinylacetamide and the like.

  On the other hand, the polymer is not particularly limited. , Dextrin, amylose, gelatin, collagen, pullulan, pectin, amylopectin, starch, amylopectin sodium semiglycolate, natural polymers such as chitin, albumin, casein, polyglutamic acid, polyaspartic acid, methylcellulose, hydroxypropylmethylcellulose, hydroxy Propyl starch, carboxymethyl starch, alkali metal carboxymethyl cellulose, alkali metal cellulose sulfate , Cellulose rough polymer, crosslinked gelatin, cellulose acetate phthalate, starch-acrylic acid graft polymerization, phthalic anhydride modified gelatin, succinic acid modified gelatin and other semi-synthetic polymers, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl methyl ether, methyl vinyl ester , Polyacrylic acid salt (for example, sodium polyacrylate) carboxyvinyl polymer, vinylpyrrolidone-ethyl acrylate copolymer, vinylpyrrolidone-styrene copolymer, vinylpyrrolidone-vinyl acetate copolymer, polyvinyl acetate- (meth) acrylic Acid copolymer, polyvinyl acetate-crotonic acid copolymer, vinyl acetate- (meth) acrylic acid copolymer, N-vinylacetamide homopolymer, vinyl acetate-crotonic acid copolymer, polyvinyl And synthetic polymers such as acid, polyitaconic acid, polyhydroxyethyl acrylate, polyacrylamide, styrene-maleic anhydride copolymer, acrylamide-acrylic acid copolymer, etc. Two or more kinds can be used in combination.

The bag body 2 (preferably the entire bag body 2) preferably has a water vapor barrier property. Here, the water vapor barrier property means that the water vapor permeability is preferably 30 g / m ² · 24 hrs · 25.
μm thickness ・ 40 ℃ ・ 90% RH or less, more preferably 10g / m ²・ 24hrs ・ 25μm
Thickness 40 ° C 90% RH or less, more preferably 1 g / m ² · 24 hrs · 25 µm thickness ·
It says that it is 40 degrees C and 90% RH or less. This water vapor permeability is measured by the method described in JIS K7129 (Method A).

  Combinations of the first substance 5 and the second substance 6 include liquid-solid, solid-solid, and gel-solid combinations. Of these, the solid is most preferably powder.

  In addition, the filling amount of the first substance 5 into the first space 21 may be filled in the entire first space 21 or may be partially filled.

  Similarly, the filling amount of the second substance 6 into the second space 22 may be filled in the entire second space 22 or may be partially filled. When the entire space is filled, the amount of the first substance and the second substance can be increased, so that the cooling effect is large or can be maintained for a long time. On the other hand, if it is partially filled, the first substance and the second substance are likely to be mixed, and rapid cooling becomes possible.

  Since the bag body 2 has the water vapor barrier property as described above, the first space is used when water vapor enters the bag body 2 or when the first substance 5 is mainly composed of water. The transpiration of moisture from 21 can be prevented.

  As a result, it is possible to prevent an endothermic reaction from occurring between the second substance 6 and moisture due to the penetration of water vapor into the second space 22 when not in use (before use).

  Further, in the case where the first substance 5 containing water as a main component is used, the reduction and concentration can be prevented, and the amount of the first substance 5 can be minimized and the cooling sheet 1 can be used. The overall volume and mass can be reduced. Further, it is possible to prevent water vapor from entering the second space 22 from the outside of the bag body 2.

  The sheet material (film) constituting the bag body 2, particularly the sheet material having the water vapor barrier property, is not particularly limited as long as it has a flexible and sufficient strength and does not leak a substance contained therein. However, for example, styrene resin (eg, polystyrene, butadiene-styrene copolymer, acrylonitrile-styrene copolymer, acrylonitrile-butadiene-styrene copolymer), ABS resin, AES resin, AAS resin, polyethylene, polypropylene , Ethylene-propylene resin, ethylene-ethyl acrylate resin, polyvinyl chloride, polyvinylidene chloride, polybutene, polycarbonate, polyacetal, polyphenylene oxide, polymethyl methacrylate, saturated polyester resin (for example, hydroxy Boric acid condensate, diol and dicarboxylic acid condensate such as polybutylene succinate), polyamide resin, fluororesin, polysulfone, polyethersulfone, polyarylate, polyetheretherketone, thermoplastic such as liquid crystal polymer Resin, urethane resin, epoxy resin, phenolic resin, urea resin, melamine resin, single layer film such as thermosetting resin such as unsaturated polyester resin, etc., those obtained by vapor-depositing aluminum, silica, etc. A metal foil such as an aluminum film or an aluminum laminate film or a film containing a metal foil can be used. Furthermore, what laminated | stacked these each film 2 layers or more can also be used. Thereby, the softness | flexibility etc. of the bag body 2 can be improved.

  In selecting a sheet material, it is preferable to select a sheet material that is excellent in flexibility even in a low temperature state. Furthermore, it is preferable to select one that has heat sealability and can be easily fused (heat fusion, ultrasonic fusion, high frequency fusion).

  The thickness of the sheet material (single layer or multilayer laminate) constituting the bag body 2 is appropriately determined according to the layer configuration and the characteristics of the material used (flexibility, strength, water vapor permeability, heat resistance, etc.). Although it is not particularly limited, it is usually preferably about 10 to 1000 μm, more preferably about 60 to 700 μm, and still more preferably about 100 to 500 μm.

  Examples of the sheet material constituting the bag body 2 include an inflation method, a T-die method, a blow molding method, a dry lamination method, a hot melt lamination method, a co-extrusion inflation method, a co-extrusion T-die method, a hot press method, It can be manufactured by various methods.

  The shape of the bag body 2 in plan view is not particularly limited, and can be appropriately set according to various purposes. For example, in addition to a square (substantially square) as shown in FIG. 1, for example, a rectangle (substantially rectangular) , Circular, oval and the like.

  When the shape of the bag body 2 in plan view is a square, the length of one side is preferably about 32 to 63 mm. For example, when the shape is a circle, the diameter is preferably 35 to 71 mm. It is said to be about.

  One of the opposing outer surfaces of the bag body 2 when not in use (before use), that is, one of the opposing outer surfaces in the folded state of the bag body 2 (the outer surface on the right side of the bag body 2 in FIG. 2) has a first The pressure-sensitive adhesive layer 3 is fixed (fixed) by, for example, fusion or bonding with an adhesive. The first pressure-sensitive adhesive layer 3 has a function of fixing the cooling sheet 1 to the skin during use. This prevents the cooling sheet 1 from being unintentionally detached from the skin during use.

  Moreover, in this embodiment, the 1st adhesive layer 3 has reached even the lowest part of one of the said opposing outer surfaces of the bag body 2 in FIG. That is, the first pressure-sensitive adhesive layer 3 is not only a portion corresponding to the first space 21 and the second space 22 on one of the opposed outer surfaces of the bag body 2, but also the partition portion 23. The part corresponding to is reached. This ensures that the partition 23 is bent when not in use (before use).

  The means for holding the partition portion 23 in a folded state is the first space by bonding or fusing part of the opposing surfaces in the folded portion (partition portion 23) of the bag body 2. If the isolation state of 21 and the 2nd space 22 is maintained, it will not be restricted to the above-mentioned thing. Here, “adhesion” refers to the state where two surfaces are bonded by chemical or physical force or both through an adhesive, and a slight force is applied at room temperature without using heat or solvent. This means a concept including “adhesion” which is a state of being bonded together. “Fusion” refers to a state in which the materials themselves are melted and bonded.

  For example, the outer surface of the bag body 2 opposite to the first pressure-sensitive adhesive layer 3, that is, the left side with respect to the first space 21 and the right side with respect to the second space 22 with the bag body 2 folded in FIG. It is also possible to hold the partition portion 23 in a folded state by attaching an adhesive, an adhesive, or the like to the outer surface. It is preferable that the adhesion and the fusion are those that can be easily released (weak adhesion or weak seal). That is, it is preferable that the adhesion or the fusion is such that the folded state is released by gripping and pulling both ends of the bag body 2.

  The first pressure-sensitive adhesive layer 3 is not particularly limited as long as the first pressure-sensitive adhesive layer 3 has an adhesive force capable of exhibiting the above functions. However, when the cooling sheet 1 is peeled off from the skin, the first adhesive layer 3 has an adhesive force that does not cause pain. Those are preferably used.

  The pressure-sensitive adhesive used for the first pressure-sensitive adhesive layer 3 is not particularly limited as long as it has such pressure-sensitive adhesive properties. For example, acrylic acid ester polymer, sodium carboxymethyl cellulose, styrene-isoprene-styrene block Examples thereof include pressure sensitive adhesives having a base polymer of one or more selected from copolymers, natural rubber, vinyl ether copolymers, sodium polyacrylate, polydimethylsiloxane, and methacrylic ester polymers. 1 type or 2 types or more can be used in combination.

  Moreover, since the 1st adhesive layer 3 contacts skin directly, it is preferable that there is little irritation | stimulation with respect to skin and it is excellent in safety | security. In particular, the first pressure-sensitive adhesive layer 3 is preferably one that does not easily remain on the skin after peeling from the skin.

  The first pressure-sensitive adhesive layer 3 is selected from necessary additives such as stabilizers, tackifiers, pigments, dyes and the like for the purpose of adjusting tackiness (adhesiveness) and improving safety. You may contain 1 type, or 2 or more types.

  Such a first pressure-sensitive adhesive layer 3 preferably has a substantially constant thickness. Thereby, the puncture scheduled site can be cooled uniformly.

  Specifically, the average thickness of the first pressure-sensitive adhesive layer 3 is not particularly limited, but is preferably about 10 μm to 10 mm, and more preferably about 100 μm to 5 mm. Thereby, it is possible to prevent unintentional detachment of the cooling sheet 1 from the skin while improving the cooling effect on the planned puncture site.

  In addition, by making the thickness of the 1st adhesive layer 3 comparatively thick, the effect which prevents that a puncture plan site | part is cooled more than necessary (overcooling) can also be exhibited.

The area in plan view of the first adhesive layer 3 (the contact area of the skin) is preferably in the range of about ² 10 to 40 cm, and more preferably ² about 15 to 30 cm. By setting the size of the first pressure-sensitive adhesive layer 3 within the above range, it is possible to sufficiently cool the puncture planned site and to simplify the handling.

  Such a 1st adhesive layer 3 may contain the chemical | medical agent. There are various kinds of these drugs, and in particular, a bactericidal / disinfectant and a local anesthetic are suitable, and at least one of them can be used.

  When a sterilizing / disinfecting agent is used as a medicine, an effect of preventing infection at a site to be punctured at the time of puncturing is exhibited, and sterilization / disinfecting before puncturing can be simplified.

  Examples of the disinfectant / disinfectant include chlorobutanol, ethyl alcohol, benzalkonium chloride, acrinol, isopropanol, geraniol-modified alcohol, sodium thiosulfate, chlorhexidine gluconate, popidone iodine, and iodine tincture. Among these, chlorhexidine gluconate or a combination of sodium thiosulfate and a gelanine-modified alcohol is particularly preferable.

  When a local anesthetic is used as a drug, the pain relieving effect at the time of puncture is more effectively exhibited.

  Examples of the local anesthetic include lidocaine, procaine, tetracaine, dibucaine, mepivacaine, prilocaine, bupivacaine, ethyl aminobenzoate and the like, and lidocaine is particularly preferable.

  Furthermore, the 1st adhesive layer 3 may contain other chemical | medical agents other than the chemical | medical agent mentioned above from a viewpoint of improving a pain relieving effect. Such a drug is not particularly limited as long as it effectively contributes to the achievement of the object of the present invention.

  In the above description, one of the opposing surfaces in the folded state of the bag body 2 (the outer surface on the right side with respect to the first space 21 of the bag body 2 in FIG. 2 and the outer surface on the left side with respect to the second space 22). The first pressure-sensitive adhesive layer 3 is provided, but a pressure-sensitive adhesive layer may be provided on both of the opposing surfaces.

  When an adhesive layer is provided on both of the opposing surfaces, it is preferable that one adhesive layer contains a hemostatic agent as a medicine. Thereby, hemostasis can be performed while cooling the puncture site | part by making the adhesive layer containing a hemostatic agent contact the skin after puncture. In such a case, the other pressure-sensitive adhesive layer (first pressure-sensitive adhesive layer 3) does not contain a hemostatic agent and contains the above-mentioned disinfectant and local anesthetic, and this pressure-sensitive adhesive is used before puncturing. A cooling sheet may be used with the layer in contact with the planned puncture site.

  Examples of the hemostatic agent include gelatin, cellulose, thrombin or thrombin-like substance, fibrin monomer, fibrinogen, vitamin K, blood coagulation factor VIII, blood coagulation factor IX, hemocoagulase (snake venom preparation) and the like.

  Furthermore, the cooling sheet 1 has a release sheet 7 that protects the first pressure-sensitive adhesive layer 3 when it is not used (before use).

  By providing this release sheet 7, the function of protecting the first pressure-sensitive adhesive layer 3 from microorganisms such as bacteria and viruses and the function of preventing the lowering of the adhesiveness of the first pressure-sensitive adhesive layer 3 until use. Demonstrated.

  Various types of release sheet 7 can be used, and are not particularly limited. For example, a film such as aluminum, cellulose, polyester, polyethylene, or polypropylene, or a multilayer film in which these are laminated is used. Can do.

  Further, the release sheet 7 has a surface treatment with the first pressure-sensitive adhesive layer 3 side (the right surface in FIG. 2), for example, surface treatment with silicon, surfactant, fluorocarbon, or uneven processing (embossing). Or a necessary additive may be added to the release sheet 7. Thereby, the peelability from the 1st adhesive layer 3 of the peeling sheet 7 can be adjusted to a desired thing.

  Although the average thickness of the release sheet 7 is not particularly limited, for example, it is preferably about 10 to 100 μm, and more preferably about 25 to 75 μm.

  In addition, without providing the release sheet 7, the first surface of the opposite outer surface of the bag body 2 when not in use (before use) is opposite to the surface on which the first pressure-sensitive adhesive layer 3 is provided. The pressure-sensitive adhesive layer 3 may be adhered. In this case, it is preferable to provide the surface of the bag body 2 with peelability like the release sheet 7 described above. Thereby, while the said surface exhibits the function similar to the peeling sheet 7, the bag body 2 can be hold | maintained in a bending state as shown to FIG. 1 and FIG. 2 at the time of unused (before use).

  Moreover, the 2nd adhesive layer 4 is attached to the outer surface on the opposite side to the outer surface which opposes when the bag body 2 is unused (before use). The second pressure-sensitive adhesive layer 4 is fixed (fixed) to the outer surface of the bag body 2 by, for example, fusion or bonding with an adhesive.

  When the second pressure-sensitive adhesive layer 4 is used (when the cooling sheet 1 is attached to the puncture planned site), the bag body 2 is bent oppositely to the unused state (before use) to fold the first adhesive layer 1 described above. In a state where the pressure-sensitive adhesive layer 3 is on the outside, the outer surfaces on the opposite sides of the bag body 2 are bonded to each other so that the state is maintained.

  As the 2nd adhesive layer 4, the thing similar to the above-mentioned 1st adhesive layer 3 can be used, However, The thing which has the adhesive force of the grade which exhibits the said function is used suitably especially.

  Furthermore, the cooling sheet 1 has a release sheet 8 that protects the second pressure-sensitive adhesive layer 4 when not in use (before use).

  By providing this release sheet 8, the function of preventing a decrease in the adhesiveness of the second pressure-sensitive adhesive layer 4 is exhibited until use.

  As such a release sheet 8, the thing similar to the above-mentioned release sheet 7 can be used.

  Furthermore, the cooling sheet 1 is provided with a fixing member 10 for fixing the bag body 2 in a folded state as shown in FIGS. 1 and 2 when not in use (before use). The fixing member 10 can be easily removed during use. Thereby, the bent state at the time of use can be canceled.

  In this embodiment, an adhesive tape is used as the fixing member 10, and this adhesive tape fixes the end portions (upper end portions in FIGS. 1 and 2) of the bag body 2 to each other. The fixing member 10 is not limited to the above-described adhesive tape as long as it exhibits the above-described fixing function, and may be, for example, a sandwiching member 9 described later.

  In the above-described sheet or the cooling container described later, the partition portion 23 of the bag body 2 may be further reinforced by lamination for the purpose of maintaining an isolated state and obtaining an easy restoring force. . That is, a reinforcing layer may be provided in the partition portion 23 of the bag body 2. In this case, the reinforcing layer is provided on one or both of the two sheet materials constituting the bag body 2. The two sheets constituting the bag body 2 are composed of an inner sheet material in contact with the skin and an outer sheet material on the opposite side, but from the viewpoint of heat retention, the reinforcing layer is provided on the outer sheet material. It is preferable.

  In addition, in order to reduce the thickness of the sheet material of the bag body 2 and increase the thermal conductivity for the purpose of obtaining a rapid cooling effect, the laminated reinforcing layer should be orthogonal to the partition portion 23 as well as the partition portion 23. Band-shaped reinforcement may be applied to both ends of the bag body 2. Or you may provide a reinforcement layer so that not only the partition part 23 but the four corners of the bag body 2 may be tied with a diagonal line. Furthermore, you may provide in the sheet | seat material whole surface of the bag body 2. FIG.

  As the film used for the reinforcing layer, a film having higher strength than the sheet material of the bag body 2 can be used. The material is not particularly limited, and examples thereof include a polyester resin film, a polyamide resin film, a polypropylene resin film, a polyolefin film, a polyvinyl chloride film, and an acetal resin film. In particular, in view of restoration properties, a polyester resin film and a polyamide resin film are preferable. The thickness of the film is arbitrary, but is usually preferably 5 to 100 μm, and particularly preferably 10 to 30 μm.

  As the adhesive for laminating, commonly used ones can be used, including vinyl (meth) acrylic, polyamide, polyester, polyether, polyurethane, epoxy, rubber, etc. Urethane type is preferred.

  The cooling sheet 1 as described above can be used as follows, for example.

  First, both end portions (upper portions in FIGS. 1 and 2) of the bag body 2 are respectively gripped, and the bag body 2 is changed from the state shown in FIGS. 1 and 2 to the state shown in FIG. Thereby, the first space 21 and the second space 22 of the bag body 2 are communicated with each other.

  Next, the 1st substance 5 and the 2nd substance 6 are fully contacted, and these are made to react.

  Next, after confirming the occurrence of an endothermic reaction between the first substance 5 and the second substance 6, the release sheet 8 is peeled off.

  Next, as shown in FIG. 4, the bag body 2 is bent to the opposite side before use, and the outer surfaces of the bag body 2 are bonded to each other by the second adhesive layer 4. Thereby, the bag body 2 is hold | maintained in a state as shown in FIG.

  Next, the release sheet 7 is peeled off, and the first pressure-sensitive adhesive layer 3 covers the planned puncture site S1 and is attached to the skin S so as to contact the planned puncture site S1. Thereby, the puncture planned site S1 is cooled by the endothermic reaction between the first substance 5 and the second substance 6.

  Next, after confirming that the planned puncture site S1 is sufficiently cooled, the cooling sheet 1 is peeled from the skin S.

  Thereafter, puncture such as an injection needle is performed on the cooled planned puncture site S1. At this time, the planned puncture site S1 is sufficiently cooled, and the pain sensation in the planned puncture site S1 is paralyzed, so that the pain (pain) associated with the puncture is alleviated.

  Thus, the use of the cooling sheet 1 can relieve pain during puncturing.

  In addition, since only the planned puncture site can be selectively cooled, it is possible to prevent unnecessary sites from being cooled.

  Furthermore, by impregnating the first pressure-sensitive adhesive layer 3 with various drugs, an effect based on the type of drug is exhibited, and pain during puncture can be more effectively alleviated.

  Further, by reducing the size of the bag body 2 (particularly, making it thinner), the bag body 2 can be made more compact and the cost can be reduced.

  Also, compared to cooling the puncture planned site with cooling spray, the puncture planned site can be slowly cooled, so that the risk of shock due to sudden cooling can be avoided and safety is high .

  When using the cooling spray method, the duration of the cooling effect is relatively short, and the coolant (gas component) often has flammability or anesthetic action. There are many inconveniences such as that it is necessary to check, it is difficult to confirm the remaining amount of the coolant in the spray can, and that the processing of the empty can is troublesome after use.

  On the other hand, according to the present invention, these disadvantages do not occur, and there is an advantage that pain at the time of puncture can be relieved very easily.

  In the cooling sheet 1 as described above, the configuration of the partition portion 23 is limited to the configuration shown in the drawing as long as the first space and the second space can be separated from each other by bending the bag body 2. However, various modifications and configuration additions are possible.

Second Embodiment
Next, a second embodiment of the cooling sheet according to the present invention will be described.

  FIG. 6 is a plan view showing a second embodiment of the cooling sheet of the present invention, and FIG. 7 is a sectional view taken along line BB in FIG. In the following description, the upper side in FIG. 6 is “upper”, the lower side is “lower”, the upper side in FIG. 7 is “upper”, and the lower side is “lower”.

  Hereinafter, although the cooling sheet of 2nd Embodiment is demonstrated, it demonstrates centering around difference with the cooling sheet of the said 1st Embodiment, and the description is abbreviate | omitted about the same matter.

  The cooling sheet 1 ′ of the second embodiment is different in the shape of the bag body 2 ′ from the position where the second pressure-sensitive adhesive layer 4 is provided, and has a configuration for holding the folded state of the bag body 2 ′. Otherwise, it is the same as the cooling sheet of the first embodiment.

  In the cooling sheet 1 ′ shown in FIGS. 6 and 7, the folded portion of the bag body 2 ′ is narrower than the other portions.

  That is, in the lower portion of the bag body 2 ′, the width of the communication path between the first space 21 and the second space 22 is narrower than other portions. Then, the communication path of the bag body 2 ′ is bent to form a partition portion 23 ′, thereby separating the first space 21 and the second space 22 from each other.

  Thereby, the 1st substance 5 and the 2nd substance 6 can be made to contact gradually, a cooling effect can be maintained for a long time, a cooling temperature can be adjusted, etc.

  Further, the partition portion 23 ′ is sandwiched between the both sides by the sandwiching member 9. Thereby, the adhesiveness of the inner surfaces in the partition part 23 'of the bag body 2' is improved. As a result, the isolated state between the first space 21 and the second space 22 is maintained, and unintentional communication between the first space 21 and the second space 22 before use is prevented.

  The holding member 9 is detachable from the bag body 2 so that it can be easily removed from the bag body 2 in use. Thereby, at the time of use, the 1st space 21 and the 2nd space 22 can be made into a communication state easily.

  In the present embodiment, the sandwiching member 9 has a U-shaped cross section parallel to the paper surface in FIG. 7 and can sandwich the partition portion 23 ′ of the bag body 2 ′. Specifically, the partition portion 23 ′ is sandwiched by the sandwiching member 9 by inserting the partition portion 23 ′ of the bag body 2 ′ into the sandwiching member 9 from below.

  The configuration of the holding member 9 is not limited to the above-described one as long as the partition 23 ′ of the bag body 2 can be held and the state can be maintained. For example, the holding member may be such that the bag body 2 ′ is inserted from the left-right direction in FIG. 6. Further, the sandwiching member may be a member that sandwiches a part of the partition portion 23 ′ instead of the entire left and right direction of the partition portion 23 ′ in FIG. 6.

  Further, in the cooling sheet 1 ′ shown in FIGS. 6 and 7, the second adhesive layer 4 and the release sheet 8 are attached to the upper part of the bag body 2. Thereby, at the time of use, the bag body 2 ′ can be more stably held in a state where the bag body 2 ′ is bent to the opposite side to that before use.

In the present embodiment, as shown in FIG. 6, the seal portion 20 ′ of the bag body 2 ′ has a width T _{1 at} the partition portion 23 ′ and the vicinity thereof that is wider than the width T ₂ of other portions. . Accordingly, when the partition 23 'is extended to communicate the first space 21 and the second space 22, or when the substances in these spaces are mixed, the partition 23' and the vicinity thereof are compared. Even if an excessively large force is applied, it is possible to prevent the seal portion 20 'from being damaged. In particular, in the present embodiment, the width of the partition portion 23 ′ of the bag body 2 ′ is narrower than other portions, and a relatively large load is applied to the partition portion 23 ′ and the vicinity thereof during the mixing. Such a configuration is effective.

  Further, it is preferable that the seal portion 20 ′ has higher adhesive strength at the partition portion 23 ′ and the vicinity thereof than other portions. This also prevents damage to the seal portion 20 'as described above.

  As mentioned above, although the cooling sheet | seat of this invention was demonstrated based on embodiment of illustration, this invention is not limited to this.

  For example, in the present invention, the configurations of the first embodiment and the second embodiment can be combined. That is, in the first embodiment, similarly to the second embodiment, the partition portion 23 may be sandwiched by a sandwiching member, and the second pressure-sensitive adhesive layer 4 is disposed on the upper portion of the bag body 2. May be provided.

  Moreover, each part which comprises the cooling sheet | seat of this invention can be substituted by the thing of the arbitrary structures which exhibit the same function, and arbitrary structures can also be added.

  In the first embodiment and the second embodiment described above, an example in which the bag body is bent to the opposite side to that before use has been described. However, after communication between the first space and the second space, the bag body is again used before use. It is also possible to use a cooling sheet by bending in the same manner. In this case, the first pressure-sensitive adhesive layer is provided on the surface of the bag body on the side where the cooling sheet comes into contact with the skin during use.

  In the first embodiment and the second embodiment described above, the cooling sheet has been described as the main purpose of alleviating pain at the time of injection needle puncture, but as an application target of the cooling sheet of the present invention, an injection is used. The type, injection site, etc. are not particularly limited, and the present invention can alleviate the pain of various injections.

  Examples of the type of injection targeted by the present invention include vein indwelling needle puncture, epidural anesthesia, spinal anesthesia, nerve block, various vaccinations, and insulin self-injection.

  In recent years, local cooling has also been used to reduce various pains such as menstrual cramps, headaches, joint pain, bruises, hair loss, abrasion treatments, and fascia trigger point therapy. It is also possible to apply the cooling sheet of the present invention to these. Furthermore, it can be used not only for pain prevention but also for anesthetic level check and bleeding prevention.

  II. Hereinafter, preferred embodiments of the cooling container of the present invention will be described.

<First Embodiment>
FIG. 8 is a plan view (internal perspective view) showing the first embodiment of the cooling container of the present invention, FIG. 9 is a cross-sectional view taken along the line CC in FIG. 8, and FIG. It is a longitudinal cross-sectional view which shows the state which was displaced. In the following, the front side of the page in FIG. 8 is “upper”, the back side of the page is “lower”, the upper side in FIG. 9 is “upper”, the lower side is “lower”, and the upper side in FIG. The description will be made assuming that “upper” and lower side are “lower”.

  As shown in these drawings, the cooling container 101 includes a storage container 102 that stores two kinds of substances, and an adhesive layer 105 provided on the lower surface of the storage container 102.

  The cooling container (cooling body) 101 cools a planned puncture site on the surface of a living body (hereinafter, referred to as “skin”) prior to, for example, a puncture operation, thereby causing pain (pain) during puncture. It is used for the purpose of relieving.

  The storage container 102 includes a container main body 128 and a lid body 129 that is mounted so as to be accessible (displaceable) to the container main body 128.

  The container main body 128 is configured by a bottomed cylindrical member. The side wall portion of the container main body 128 has a substantially cylindrical shape, and a screw groove 281 is formed on the upper outer surface thereof. The screw groove 281 and a screw thread 291 of the lid body 129 described later are screwed together, and the lid body 129 is attached to the container main body 128.

  In addition, a first protrusion 282 and a second protrusion 283 are provided on the inner surface of the side wall of the container main body 128 in the middle in the height direction and at the upper end, respectively. Each of the protrusions 282 and 283 is formed in a ring shape, for example. An easy-rupture sheet (partition) 108 described later is fixed (adhered) to the first protrusion 282.

  The lid body 129 is also composed of a bottomed cylindrical member. The side wall of the lid 129 has a substantially cylindrical shape, and a screw thread 291 that is screwed into the screw groove 281 is formed on the lower inner surface thereof.

  With such a configuration, the lid body 129 can be moved closer to the container body 128 by rotating the lid body 129 relative to the container body 128.

  A fixing portion 292 for fixing the needle body (release member) 106 is provided at the center portion on the inner surface of the ceiling portion of the lid 129 (the surface on the first space 121 side described later). The needle body 106 is fixed to the fixing portion 292 by a method such as fusion, bonding with an adhesive, fitting, or caulking.

  The needle body 106 has a sharp needle tip at the tip (lower end in FIG. 9), and the easily rupturable sheet 108 can be ruptured (broken) by bringing the needle tip into contact with the easily rupturable sheet 108. it can.

  The needle body 106 may be formed integrally with the lid body 129.

  In addition, an elastic member 129 is provided on the edge of the inner surface of the ceiling of the lid 129 (the surface on the first space 121 side described later). The elastic member 129 is formed in a ring shape, for example. With such a configuration, the lid 129 is rotated relative to the container main body 128, and the liquid tightness or airtightness of the storage container 102 when the lid 129 and the container main body 128 come close to each other. Can be increased.

  As shown in FIG. 9, the edge portion of the easily rupturable sheet (partition portion) 108 is fixed (fixed) to the first projecting portion 282 described above. Thereby, the internal space 120 of the storage container 102 is partitioned into the adjacent first space 121 and second space 122. These partition states depend on the substances (the first substance 103 and the second substance 104) stored in the first space 121 and the second space 122, but are preferably liquid-tight or air-tight. The material constituting such an easy-rupture sheet 108 is not particularly limited, and well-known materials can be appropriately used. For example, films such as aluminum, cellulose, polyester, polyethylene, and polypropylene, and these are laminated. A multilayer film or the like can be used.

  When such a container main body 128 is changed from the state shown in FIG. 9 to the state shown in FIG. 10 in use, the isolation by the easily rupturable sheet 108 is released, and the first space 121 and the second space The space 122 communicates.

  The first material 121 is stored in the first space 121, and the second material 104 is stored in the second space 122.

  The first substance 103 and the second substance 104 cause an endothermic reaction when brought into contact with each other. The present invention uses this endothermic reaction as a cooling means to cool the puncture site. In the present specification, the endothermic reaction is not limited to the one accompanied by a change in chemical structure, but includes one caused by dissolution or the like.

  This cooling container 101 is preferably capable of holding the temperature of the skin (scheduled puncture site) at 5 ° C. to 20 ° C. for 5 minutes or more by an endothermic reaction, and at 7 ° C. to 18 ° C. for 7 minutes or more. What can hold | maintain during this is more preferable. By satisfying such conditions, it is possible to effectively cool the planned puncture site and effectively relieve pain due to puncture even after the cooling container 101 is peeled from the planned puncture site.

  If the cooling temperature is too low, the puncture site may be excessively cooled, causing frostbite, and may cause pain due to excessive cooling. On the other hand, if the cooling temperature is too high, there is a possibility that the pain relieving effect at the time of puncture cannot be obtained sufficiently.

  In addition, if the duration (holding time) is too short, the planned puncture site is not sufficiently cooled, and the pain relief effect at the time of puncture may not be sufficiently obtained.

  The first substance (freezing agent) 103 is not particularly limited as long as it is in contact with the second substance 104 described later and gives an endothermic reaction. For example, ammonium nitrate, potassium nitrate, sodium nitrate, silver thiocyanate, boron Acid, ammonium chloride, ammonium carbonate, ammonium azide, ammonium nitrite, ammonium cyanate, ammonium phosphate trihydrate, ammonium thiocyanate, sodium tetraborate decahydrate, sodium hydrogen phosphate dodecahydrate, l -Aspartic acid, salicylic acid, oxalic acid dihydrate, guanidine nitrate, urea nitrate, sodium nitrite, urea, ammonium carbamate, ammonium carbonate, calcium nitrate, crystalline calcium chloride, magnesium sulfate, potassium thiocyanate, potassium carbonate, sulfuric acid Sodium, ammonium sulfate Arm, ammonium phosphate dibasic, ammonium metavanadate, ammonium bromide, and ammonium iodide. Among these may be used alone or in combination. Among these, in particular, the first substance 103 preferably includes ammonium nitrate, ammonium chloride, and ammonium thiocyanate as main components, and more preferably includes ammonium nitrate as a main component. By using the first substance 103, the cooling effect can be exhibited in a shorter time.

  In addition, when two or more kinds of the first substance 103 are used, one of them has a high immediate effect as a cooling effect and the other has a high sustainability, so that a cooling effect can be achieved in a short time. It is possible to maintain the expression and the cooling effect for a long time.

  In addition, the form (shape) of the first substance 103 may be any form such as powder, flakes, and a small lump (pellet), but in particular, a powder form is used. Is preferred. Thereby, mixing with the second substance 104 is facilitated, and the dissolution rate can be increased. As a result, the cooling effect can be exhibited in a shorter time.

  In the case where the first substance 103 is in a powder form, the average particle size is not particularly limited, but is preferably 1 μm to 3 mm, and more preferably 50 μm to 1 mm. When the average particle size of the first substance 103 is less than the lower limit value, the scattering property becomes high and the adjustment becomes complicated. On the other hand, when the average particle size of the first substance 103 exceeds the upper limit, the mixing with the second substance 104 becomes low, and a sufficient cooling effect (pain alleviation effect) cannot be obtained, or the cooling container After sticking, it takes a long time until the pain relief effect can be expected, or the immediate effect cannot be expected.

  On the other hand, the second substance (liquid agent) 104 is not particularly limited as long as it is in contact with the first substance 103 described above and causes an endothermic reaction. In addition to water, for example, microencapsulated water or Sodium carbonate decahydrate, sodium sulfate decahydrate, sodium phosphate 12 hydrate, sodium hydrogen phosphate 12 hydrate, sodium sulfite heptahydrate, sodium silicate 9 hydrate, tetraborate Sodium decahydrate, aluminum sulfate 18 hydrate, aluminum nitrate 9 hydrate, calcium chloride hexahydrate, barium hydroxide octahydrate, chromium nitrate 9 hydrate, iron (III) nitrate 9 hydrate Examples thereof include water-containing compounds such as products, and one or more of them can be used in combination. Among these, in particular, the second substance 104 is preferably a substance mainly composed of water and barium hydroxide octahydrate, and more preferably a substance mainly composed of barium hydroxide octahydrate. By using the second substance 104, the cooling effect can be exhibited in a shorter time.

  Moreover, as a form of the 2nd substance 104, what kind of liquid, a solid form, a gel form etc. may be sufficient, for example.

  For example, when a solid material or the like is used as the second substance 104, even if the space between the first space 121 and the second space 122 is not completely sealed (airtight), Unintentional reaction between the first substance 103 and the second substance 104 can be prevented when not used (before use).

  Further, for example, when a solid substance or a gel substance is used as the second substance 104, if the second substance 104 is in the form of powder, flakes, or a small lump (pellet), the first substance 104 is used at the time of use. Mixing with the substance 3 can be facilitated, and the dissolution rate can be increased. As a result, the cooling effect can be exhibited in a shorter time. In view of this, it is particularly preferable that the second substance 104 is powdered.

  When the second substance 4 is in a powder form, the average particle diameter is not particularly limited, but is preferably 1 μm to 3 mm, and more preferably 50 μm to 1 mm. When the average particle size of the second substance 104 is less than the lower limit value, the scattering property is increased and the adjustment becomes complicated. On the other hand, when the average particle size of the second substance 104 exceeds the upper limit, the mixing property with the first substance 103 becomes low, and a sufficient cooling effect (pain relief effect) cannot be obtained, or the cooling container It takes a long time for the pain relief effect to be expected after sticking, and the immediate effect may not be expected.

  When a liquid substance is used as the second substance 104, it can be easily mixed with the first substance 103 at the time of use, and the dissolution rate can be increased. As a result, a cooling effect can be exhibited in a shorter time. be able to.

  In addition, a gelling agent, a polymer (polymer), or the like is added to the first substance 103 and the second substance 104 for the purpose of, for example, improving the feeling of use or obtaining a sustained cooling effect. May be.

  Although it does not specifically limit as a gelatinizer, For example, the polymer crosslinked material which uses the repeating unit of an amide type compound as the main repeating unit is used suitably.

  Examples of the amide compound include N-vinylformamide, N-vinylacetamide, N-methyl-N-vinylformamide, N-methyl-N-vinylacetamide and the like.

  On the other hand, the polymer is not particularly limited. , Dextrin, amylose, gelatin, collagen, pullulan, pectin, amylopectin, starch, amylopectin sodium semiglycolate, natural polymers such as chitin, albumin, casein, polyglutamic acid, polyaspartic acid, methylcellulose, hydroxypropylmethylcellulose, hydroxy Propyl starch, carboxymethyl starch, alkali metal carboxymethyl cellulose, alkali metal cellulose sulfate , Cellulose rough polymer, crosslinked gelatin, cellulose acetate phthalate, starch-acrylic acid graft polymerization, phthalic anhydride modified gelatin, succinic acid modified gelatin and other semi-synthetic polymers, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl methyl ether, methyl vinyl ester , Polyacrylic acid salt (for example, sodium polyacrylate) carboxyvinyl polymer, vinylpyrrolidone-ethyl acrylate copolymer, vinylpyrrolidone-styrene copolymer, vinylpyrrolidone-vinyl acetate copolymer, polyvinyl acetate- (meth) acrylic Acid copolymer, polyvinyl acetate-crotonic acid copolymer, vinyl acetate- (meth) acrylic acid copolymer, N-vinylacetamide homopolymer, vinyl acetate-crotonic acid copolymer, polyvinyl And synthetic polymers such as acid, polyitaconic acid, polyhydroxyethyl acrylate, polyacrylamide, styrene-maleic anhydride copolymer, acrylamide-acrylic acid copolymer, etc. Two or more kinds can be used in combination.

  In the present embodiment, beads 110 are accommodated in the second space 122 in addition to the second substance 104. Thereby, at the time of use, the 1st substance 103 and the 2nd substance 104 can be mixed more rapidly, As a result, a cooling effect can be expressed in a further short time.

  The material constituting the beads 110 is not particularly limited, but it is preferable to use a resin material. Thereby, the 1st substance 103 and the 2nd substance 104 can be mixed more rapidly, without damaging the inside of the storage container 102. FIG.

  The resin material constituting the beads 110 is not particularly limited as long as it does not react with the first substance 103 and the second substance 104 described above and can be easily molded into a bead shape. For example, styrene resin (for example, polystyrene, butadiene / styrene copolymer, acrylonitrile / styrene copolymer, acrylonitrile / butadiene / styrene copolymer, etc.), ABS resin, AES resin, AAS resin, polyethylene, polypropylene, ethylene- Propylene resin, ethylene-ethyl acrylate resin, polyvinyl chloride, polyvinylidene chloride, polybutene, polycarbonate, polyacetal, polyphenylene oxide, polymethyl methacrylate, saturated polyester resin (for example, hydroxycarboxylic acid condensate such as polylactic acid, Diol and dicarboxylic acid condensate such as ribylene succinate), polyamide resin, fluororesin, polysulfone, polyethersulfone, polyarylate, polyetheretherketone, thermoplastic polymer such as liquid crystal polymer, urethane resin, Examples thereof include thermosetting resins such as epoxy resins, phenol resins, urea resins, melamine resins, and unsaturated polyester resins, and one or more of them can be used in combination.

  The shape of such a bead 110 is not particularly limited, but is preferably a spherical shape. Thereby, the 1st substance 103 and the 2nd substance 104 can be mixed more rapidly.

  When the beads 110 have a spherical shape, the average particle diameter of the beads 110 is not particularly limited, but is preferably 100 μm to 5 mm. Thereby, the 1st substance 103 and the 2nd substance 104 can be mixed more efficiently.

  The content of the beads 110 is not particularly limited, but is preferably 1 to 50 parts by mass when the entire substance accommodated in the cooling container 101 is 100 parts by mass. If the content of the beads 110 is less than the lower limit, the mixing speed of the first substance 103 and the second substance 104 may not be sufficiently improved. On the other hand, when the content of the beads 110 exceeds the upper limit, the mixing of the first substance 103 and the second substance 104 may be hindered.

  In the present embodiment, the beads 110 have been described as being housed in the second space 122. However, the beads 110 may be housed in the first space 121, and the first space 121 and It may be stored in both the second spaces 122. That is, the beads 110 may be mixed with the first substance 103, may be mixed with the second substance 104, or may be mixed with both.

The storage container 102 (container main body 128, lid 129) as described above preferably has a water vapor barrier property. Here, the water vapor barrier property means that the water vapor permeability is preferably 30 g / m ² · 24 hrs · 25 μm thickness · 40 ° C. · 90% RH or less, more preferably 10 g / m ² · 24 hrs · 25 μm thickness · 40 ° C. 90% RH or less, more preferably 1 g / m ² · 24 hrs · 25 µm thickness · 40 ° C · 90% RH or less. This water vapor permeability is measured by the method described in JIS K7129 (Method A).

  Since the storage container 102 has a water vapor barrier property as described above, the second space is used when water vapor enters the storage container 102 or when the second substance 104 is mainly composed of water. Moisture transpiration from 122 can be prevented. Further, when not in use (before use), it is possible to prevent an endothermic reaction from occurring between the first substance 103 and moisture due to intrusion of water vapor into the first space 121.

  In addition, in the case where a substance containing water as a main component is used as the second substance 104, reduction and concentration can be prevented, and the amount of the second substance 104 can be the minimum necessary amount. The overall volume and mass can be reduced. In addition, it is possible to prevent water vapor from entering the first space 121 from the outside of the storage container 102.

  The material constituting the storage container 102, particularly the material having the water vapor barrier property is not particularly limited as long as it is flexible and has sufficient strength and does not leak out the substance stored therein. Styrenic resin (eg, polystyrene, butadiene / styrene copolymer, acrylonitrile / styrene copolymer, acrylonitrile / butadiene / styrene copolymer, etc.), ABS resin, AES resin, AAS resin, polyethylene, polypropylene, ethylene-propylene resin , Ethylene-ethyl acrylate resin, polyvinyl chloride, polyvinylidene chloride, polybutene, polycarbonate, polyacetal, polyphenylene oxide, polymethyl methacrylate, saturated polyester resin (for example, hydroxycarboxylic acid condensation such as polylactic acid) Diol and dicarboxylic acid condensate such as polybutylene succinate), polyamide resin, fluororesin, polysulfone, polyethersulfone, polyarylate, polyetheretherketone, thermoplastic polymer such as liquid crystal polymer, urethane resin , Epoxy resins, phenol resins, urea resins, melamine resins, unsaturated polyester resins, and other thermosetting resins, and one or more of these can be used in combination.

  Further, as the storage container 102, for example, in addition to those composed of the materials as described above, those obtained by vapor-depositing aluminum, silica, or the like can be used. Thereby, the liquid tightness of the storage container 102, airtightness, etc. can be improved.

  Although the average thickness of the wall surface of the container main body 128 and the lid body 129 is not particularly limited, it is usually preferably about 0.1 to 2 mm. Further, the diameter of the storage container 102 when viewed in plan is preferably about 35 to 71 mm.

  An adhesive layer 105 is provided on the lower surface of the storage container 102, that is, the surface opposite to the lid 129 of the container main body 128.

  The adhesive layer 105 has a function of fixing the cooling container 101 to the skin during use. This prevents the cooling container 101 from being unintentionally detached from the skin during use.

  The pressure-sensitive adhesive layer 105 is not particularly limited as long as it has an adhesion force that can exert the above-mentioned function, but preferably has a pressure-sensitive adhesive strength that does not cause pain when the cooling container 101 is peeled off from the skin. used.

  Moreover, it is preferable that such an adhesive layer 105 changes a shape along the shape of the surface to stick. Thereby, unintentional detachment of the cooling container 101 from the skin can be prevented.

  Although it does not specifically limit as an adhesive used for the adhesive layer 105, For example, an acrylic ester polymer, sodium carboxymethylcellulose, a styrene-isoprene-styrene block copolymer, natural rubber, a vinyl ether copolymer, sodium polyacrylate , Pressure-sensitive adhesives based on one or more selected from polydimethylsiloxane, methacrylic acid ester polymers, and the like, and a combination of one or more of them can be used. .

  Moreover, since the adhesive layer 105 is in direct contact with the skin, it is preferable that the adhesive layer 105 has little irritation to the skin and is excellent in safety. In particular, the pressure-sensitive adhesive layer 105 is preferably one that hardly remains on the skin after peeling from the skin.

  In addition, the pressure-sensitive adhesive layer 105 is one kind selected from necessary additives such as stabilizers, tackifiers, pigments, dyes, etc. for the purpose of adjusting tackiness (adhesiveness) and improving safety. You may contain 2 or more types.

  The pressure-sensitive adhesive layer 105 preferably has a substantially constant thickness. Thereby, the puncture scheduled site can be cooled uniformly.

  Specifically, the average thickness of the pressure-sensitive adhesive layer 105 is not particularly limited, but is preferably about 10 μm to 10 mm, and more preferably about 100 μm to 5 mm. Thereby, it is possible to prevent the cooling container 101 from being unintentionally detached from the skin while improving the cooling effect on the planned puncture site.

  In addition, by making the thickness of the pressure-sensitive adhesive layer 105 relatively large, it is possible to exert an effect of preventing the planned puncture site from being cooled more than necessary (overcooling).

The area in plan view of the pressure-sensitive adhesive layer 105 (contact area with the skin) is preferably in the range of about ² 10 to 40 cm, and more preferably ² about 15 to 30 cm. By setting the size of the pressure-sensitive adhesive layer 5 within the above range, the puncture planned site can be sufficiently cooled and the handling becomes simple.

  Such an adhesive layer 105 may contain a medicine. There are various kinds of these drugs, and in particular, a bactericidal / disinfectant and a local anesthetic are suitable, and at least one of them can be used.

  When a sterilizing / disinfecting agent is used as a medicine, an effect of preventing infection at a site to be punctured at the time of puncturing is exhibited, and sterilization / disinfecting before puncturing can be simplified.

  Examples of the disinfectant / disinfectant include chlorobutanol, ethyl alcohol, benzalkonium chloride, acrinol, isopropanol, geraniol-modified alcohol, sodium thiosulfate, chlorhexidine gluconate, popidone iodine, and iodine tincture. Among these, chlorhexidine gluconate or a combination of sodium thiosulfate and a gelanine-modified alcohol is particularly preferable.

  When a local anesthetic is used as a drug, the pain relieving effect at the time of puncture is more effectively exhibited.

  Examples of the local anesthetic include lidocaine, procaine, tetracaine, dibucaine, mepivacaine, prilocaine, bupivacaine, ethyl aminobenzoate and the like, and lidocaine is particularly preferable.

  Furthermore, from the viewpoint of improving the pain relieving effect, the pressure-sensitive adhesive layer 105 may contain a drug other than the drugs described above. Such a drug is not particularly limited as long as it effectively contributes to the achievement of the object of the present invention.

  In the above description, the pressure-sensitive adhesive layer 105 is provided on the surface of the container body 128 opposite to the lid 129, but the pressure-sensitive adhesive layer is also provided on the surface of the lid 129 opposite to the container body 128. It may be done. That is, an adhesive layer may be provided on both opposing surfaces of the cooling container 101.

  When an adhesive layer is provided on both of the opposing surfaces, it is preferable that one adhesive layer contains a hemostatic agent as a medicine. Thereby, hemostasis can be performed while cooling the puncture site | part by making the adhesive layer containing a hemostatic agent contact the skin after puncture. In such a case, the other pressure-sensitive adhesive layer (pressure-sensitive adhesive layer 105) does not contain a hemostatic agent, but contains the above-mentioned disinfectant or local anesthetic, and punctures this pressure-sensitive adhesive layer before puncturing. It is good to use a cooling container in contact with a predetermined site.

  Examples of the hemostatic agent include gelatin, cellulose, thrombin or thrombin-like substance, fibrin monomer, fibrinogen, vitamin K, blood coagulation factor VIII, blood coagulation factor IX, hemocoagulase (snake venom preparation) and the like.

  Furthermore, the cooling container 101 has a release sheet 7 that protects the pressure-sensitive adhesive layer 105 when it is not used (before use).

  By providing the release sheet 107, the function of protecting the pressure-sensitive adhesive layer 105 from microorganisms such as bacteria and viruses and the function of preventing the pressure-sensitive adhesive layer 105 from being deteriorated until use are provided.

  Various materials can be used as the release sheet 107, and the release sheet 107 is not particularly limited. For example, a film such as aluminum, cellulose, polyester, polyethylene, or polypropylene, or a multilayer film in which these are laminated is used. Can do.

  In addition, the release sheet 107 is subjected to surface treatment with silicon, a surfactant, fluorocarbon, or the like, uneven processing (embossing), or the like on the surface on the pressure-sensitive adhesive layer 105 side (right surface in FIG. 9). A necessary additive may be added to the release sheet 107. Thereby, the peelability from the adhesive layer 105 of the peeling sheet 107 can be adjusted to a desired thing.

  The average thickness of the release sheet 107 is not particularly limited, but is preferably about 10 to 100 μm, and more preferably about 25 to 75 μm, for example.

  The cooling container 101 as described above can be used as follows, for example.

  First, the lid body 109 is rotated with respect to the container body 128 to change the storage container 102 from the state shown in FIG. 9 to the state shown in FIG. 10, and the needle body 106 formed on the inner surface of the ceiling portion of the lid body 129. Thus, the easily breakable sheet 108 is ruptured (broken). As a result, the first space 121 and the second space 122 of the storage container 102 communicate with each other.

  Next, the first substance 103 and the second substance 104 are sufficiently brought into contact with each other to react with each other.

  Next, after confirming the occurrence of an endothermic reaction between the first substance 103 and the second substance 104, the release sheet 107 is peeled off to expose the adhesive layer 105.

  Next, the cooling container 101 is stuck to the skin by the adhesive layer 105 so as to contact the planned puncture site. Thereby, the planned puncture site is cooled by the endothermic reaction between the first substance 103 and the second substance 104.

  Next, after confirming that the planned puncture site has been sufficiently cooled, the cooling container 101 is peeled from the skin.

  Thereafter, puncture with an injection needle or the like is performed on the cooled planned puncture site. At this time, the planned puncture site is sufficiently cooled, and the pain sensation at the planned puncture site is paralyzed, so that the pain (pain) associated with the puncture is alleviated.

  Thus, by using the cooling container 101, pain during puncture can be alleviated.

  In addition, since only the planned puncture site can be selectively cooled, it is possible to prevent unnecessary sites from being cooled.

  Furthermore, by impregnating the adhesive layer 105 with various drugs, an effect based on the type of the drug is exhibited, and pain at the time of puncture can be more effectively alleviated.

  Further, by reducing the size of the storage container 102, it is possible to make it more compact and to reduce the cost.

  Also, compared to cooling the puncture planned site with cooling spray, the puncture planned site can be slowly cooled, so that the risk of shock due to sudden cooling can be avoided and safety is high .

  When using the cooling spray method, the duration of the cooling effect is relatively short, and the coolant (gas component) often has flammability or anesthetic action. There are many inconveniences such as that it is necessary to check, it is difficult to confirm the remaining amount of the coolant in the spray can, and that the processing of the empty can is troublesome after use.

  On the other hand, according to the present invention, these disadvantages do not occur, and there is an advantage that pain at the time of puncture can be relieved very easily.

  In the cooling container 101 as described above, the configuration of the storage container 102 is such that the first space and the second space by the partition 108 are formed by performing an operation of displacing the lid 129 with respect to the container main body 128. As long as the isolated state can be canceled, the present invention is not limited to the illustrated configuration, and various modifications and configuration additions are possible.

Second Embodiment
Next, a second embodiment of the cooling container according to the present invention will be described.

  FIG. 11 is a longitudinal sectional view showing a second embodiment of the cooling container of the present invention. In the following description, the upper side in FIG. 11 will be described as “upper” and the lower side as “lower”.

  Hereinafter, although the cooling container of 2nd Embodiment is demonstrated, it demonstrates centering around difference with the cooling container of the said 1st Embodiment, The description is abbreviate | omitted about the same matter.

  The cooling container 101 ′ of the second embodiment is different from the first embodiment except that the shape and material of the lid body 129 ′ are different and the operation for displacing the lid body 129 ′ with respect to the container body 128 is different. This is the same as the cooling container.

  In the cooling container 101 ′ of the present embodiment, the lid 129 ′ has elasticity.

  As shown in FIG. 11, the lid body 129 ′ has a shape curved upward.

  The lid 129 'is fixed to the container main body 128 at the edge thereof.

  When the lid body 129 ′ has such a configuration, the needle body 106 formed on the inner surface of the ceiling portion of the lid body 129 ′ is pressed against the easily-breakable sheet 108 by pressing the lid body 129 ′ toward the container main body 128. The easily breakable sheet 108 can be ruptured (broken). Thereby, the 1st substance 103 and the 2nd substance 104 are mixed, and the cooling effect is exhibited.

  The material constituting the lid 129 'having such elasticity is not particularly limited, and examples thereof include various metal materials such as aluminum, spring steel, and stainless steel, and the above-described thermoplastic resin and thermosetting resin. It is done.

  Such a lid body 129 ′ is configured with a thickness that can impart appropriate elasticity to the lid body 129 ′.

<Third Embodiment>
Next, a third embodiment of the cooling container according to the present invention will be described.

  FIG. 12 is a plan view showing a partition portion in the third embodiment of the cooling container of the present invention, and FIG. 13 is a sectional view taken along the line DD in FIG. 12 in the third embodiment of the cooling device of the present invention. In the following description, the front side of the page in FIG. 12 is “upper”, the back side of the page is “lower”, the upper side in FIG. 13 is “upper”, and the lower side is “lower”.

  Hereinafter, although the cooling container of 3rd Embodiment is demonstrated, it demonstrates centering around difference with the cooling container of the said 1st Embodiment, The description is abbreviate | omitted about the same matter.

  In the cooling container 101 ″ of the third embodiment, the partition portion 108 ′ is configured by overlapping a partition plate 181 in which a through hole 811 is formed and a partition plate 182 in which a through hole 821 is formed. When the cooling container 101 ″ is not used (before use), the through hole 811 and the through hole 821 are configured not to overlap each other as shown in FIG. Thereby, the first space 121 and the second space 122 described above are partitioned.

  Of the pair of partition plates constituting the partition portion 108 ′, on the partition plate 181 disposed on the lid 129 ″ side, a protruding portion 812 is provided at a portion off the central portion of the partition plate 181. The protrusion 812 has a function of transmitting a displacement of a release member 106 ′ described later to the partition plate 181.

  Of the pair of partition plates constituting the partition portion 108 ′, the partition plate 182 disposed on the container body 128 side is fixed (fixed) to the protruding portion 282.

  The lid body 129 ″ is attached to the container main body 128 by screwing as in the first embodiment.

  On the surface of the lid 129 ″ on the first space 121 side, a release member 106 ′ is provided at a position corresponding to the protrusion 812. This release member 106 ′ is the same as in the first embodiment. Thus, the lid body 129 ″ is fixed.

  The tip of the release member 106 ′ is configured to be caught by the protrusion 812 when the lid 129 ″ rotates.

  With such a configuration, when the lid 129 ″ is rotated (displaced) relative to the container main body 128, the protrusion 812 moves with the movement of the release member 106 ′, and the partition plate 181 rotates. 12B, the through hole 811 and the through hole 821 are communicated, and the first substance 103 in the first space 121 and the second substance in the second space 122 are connected. Mixing with the substance 104 is started, so that the cooling container 101 ″ exhibits a cooling effect.

  In addition, the reaction can be stopped once by rotating the partition plate 181 again before releasing the communication between the through holes before the first substance 103 and the second substance 104 are completely mixed. it can. Further, by adjusting the degree of overlap of the through holes, the cooling effect can be maintained for a long time, the cooling temperature can be adjusted, and the like.

  As a material constituting the partition plates 181 and 182, the same material as that constituting the container main body 128 and the lid 129 ″ can be used.

  Moreover, it is preferable that the average thickness of the partition plates 181 and 182 is about 0.1 to 1.5 mm.

  Moreover, it is preferable that the average diameter of the through-holes 811 and 821 is about 3 to 10 mm. Accordingly, the first space 121 and the second space 122 can be reliably partitioned when not used, and the first substance 103 and the second substance 104 are more reliably separated when used. Can be mixed.

  Other configurations are the same as those in the first embodiment.

  As mentioned above, although the cooling container of this invention was demonstrated based on embodiment of illustration, this invention is not limited to this.

  For example, each part which comprises the cooling container of this invention can be substituted by the thing of the arbitrary structures which exhibit the same function, and arbitrary structures can also be added.

  Moreover, although embodiment mentioned above demonstrated the case where a cryogen was accommodated as a 1st substance and a liquid medicine was accommodated as a 2nd substance, it is not limited to this, The reverse may be sufficient.

  Further, in the above-described embodiment, the cylindrical container has been described as the cooling container. However, the cooling container is not limited to this and may be a box-shaped container.

  In the above-described embodiment, the description has been given on the assumption that the beads are stored in the second space. However, the present invention is not limited to this, and the beads may be omitted, or the beads are stored in the first space. Alternatively, it may be stored in both the first space and the second space.

  In the first embodiment and the second embodiment described above, the case where the needle body is used as the release member has been described. However, the present invention is not limited to this. For example, a blade may be used.

  In the third embodiment described above, the description has been given assuming that one through hole is provided in the partition plate. However, the present invention is not limited to this, and the number of through holes may be two. There may be more than one.

  In the third embodiment described above, the description has been made assuming that the two partition plates are provided. However, the present invention is not limited to this, and the number may be three, or may be four or more.

  In the above-described third embodiment, the through hole has been described as having a circular shape. However, the present invention is not limited thereto, and may be, for example, an elliptical shape or a polygonal shape such as a quadrangle.

  In the third embodiment described above, the partition plate rotates when the release member pushes the projection. However, the present invention is not limited to this. For example, the release member and the projection are integrally formed. It may be a configured.

  In the above-described embodiment, the cooling container has been described as the main purpose of alleviating pain at the time of needle puncture. However, as the application target of the cooling container of the present invention, the type of injection, the injection site, etc. The present invention is not particularly limited, and the present invention can alleviate the pain for various injections.

  Examples of the type of injection targeted by the present invention include vein indwelling needle puncture, epidural anesthesia, spinal anesthesia, nerve block, various vaccinations, and insulin self-injection.

  Also, in recent years, local cooling has been used to reduce various pains such as menstrual cramps, headaches, joint pain, bruises, hair loss, abrasions, sunburn, and fascia trigger point therapy. Therefore, the cooling container of the present invention can be applied to these. Furthermore, it can be used not only for pain prevention but also for anesthesia level check, bleeding prevention, and eye strain.

  Hereinafter, specific examples of the present invention will be described.

(Example 1)
A cooling sheet as shown in FIGS. 1 and 2 was produced.

  The specifications of this cooling sheet are as shown below.

・ Bag sheet material: Two-layer rubber of polyethylene and aluminum-deposited polyester
Minate film (3M Scotchpak 1109 Backing
Polyester Film Laminate (1109 SPAK 1.34 MIL HEAT
SEALABLE POLYESTER FILM))
Average thickness of sheet material: 33 μm
Water vapor permeability of sheet material: 1g / m ² · 24hrs · 25µm thickness · 40 ° C · 90% R
H or less Shape in plan view: <Bent state> Square (length of one side 60 mm)
<Stretched state> Rectangular (length 130mm x width 60mm)
First substance: Barium hydroxide octahydrate (4g)
Second substance: ammonium nitrate (4 g)
First pressure-sensitive adhesive layer: Ny stack (NW-40, normal adhesive strength, Nichiban Co., Ltd.)
(Made by company)
Second adhesive layer: Ny stack (NW-40, normal adhesive strength, Nichiban Co., Ltd.)
(Made by company)
Then, by pulling both ends of the cooling sheet, the first space and the second space are brought into communication, and after the first substance and the second substance are reacted for 30 seconds, the release sheet is peeled off. A cooling sheet was attached to the planned puncture site of the lower arm of the subjects (10 persons) for 1 minute. Thereafter, the cooling sheet was peeled off from the puncture planned site, and a von Frey type pain test was performed every predetermined time.

  In the von Frey-type pain test, the number 6.10 von Frey-type stimulating hair (made of nylon, 8 mm in diameter, manufactured by North Coast Medical, USA) was pressed against the skin with a force of 126 g to draw pain close to that of a normal needle puncture. Woke up. Then, with respect to the degree of pain, the pain at the time of non-cooling was used as a reference (initial stimulus), and the subject was interviewed according to the following four-stage criteria.

◎: Pain is not felt ○: It is not painful than the initial stimulus △: It is the same as the initial stimulus ×: It is painful than the initial stimulus Pain measurement is 15 seconds, 30 seconds, 60 seconds after peeling of the cooling sheet, After 90 seconds, 120 seconds and 180 seconds. The number of people for each degree of pain at each time was summarized.

  The results are shown in Table 1.

  As can be seen from Table 1, the pain relieving effect was significant in 1 minute after the cooling sheet was peeled off (that is, a time sufficient to complete the puncture operation).

  Moreover, the partition part as shown in FIG. 5 was formed in the bag body of the above-mentioned Example, and as a result of performing the same test as the above, the same result as the above was obtained. Moreover, as a result of producing the cooling sheet as shown in FIGS. 6 and 7 and conducting the same test as described above, the same result as described above was obtained.

(Example 2)
A cooling sheet as shown in FIGS. 1 and 2 was produced.

  The specifications of this cooling sheet are as shown below.

・ Bag sheet material: Two-layer rubber of polyethylene and aluminum-deposited polyester
Minate film (3M Scotchpak 1109 Backing
Polyester Film Laminate (1109 SPAK 1.34 MIL HEAT
SEALABLE POLYESTER FILM))
Average thickness of sheet material: 33 μm
Water vapor permeability of sheet material: 1g / m ² · 24hrs · 25µm thickness · 40 ° C · 90% R
H or less Shape in plan view: <Bent state> Square (length of one side 70 mm)
<Stretched state> Rectangular (length 150mm x width 70mm)
First substance: Water (8g)
Second substance: ammonium nitrate (12 g)
First pressure-sensitive adhesive layer: Ny stack (NW-40, normal adhesive strength, Nichiban Co., Ltd.)
(Made by company)
Second adhesive layer: Ny stack (NW-40, normal adhesive strength, Nichiban Co., Ltd.)
(Made by company)
Then, by pulling both ends of the cooling sheet, the first space and the second space are communicated, and after the first substance and the second substance are reacted for 5 seconds, the release sheet is peeled off. A cooling sheet was attached to the planned puncture site of the lower arm of the subjects (10 persons) for 1 minute. Hereinafter, the same von Frey type pain test as in Example 1 was performed.

  The results are shown in Table 2.

◎: No pain ○: Less pain than initial stimulus △: Same as initial stimulus ×: More pain than initial stimulus As can be seen from Table 2, 1 minute after removing the cooling sheet (ie, puncture operation completed) The pain relieving effect was significant at a sufficient time).

(Example 3)
A cooling sheet as shown in FIGS. 1 and 2 was produced.

  The specifications of this cooling sheet are as shown below.

・ Bag sheet material: Two-layer rubber of polyethylene and aluminum-deposited polyester
Minate film (3M Scotchpak 1109 Backing
Polyester Film Laminate (1109 SPAK 1.34 MIL HEAT
SEALABLE POLYESTER FILM))
Average thickness of sheet material: 33 μm
Water vapor permeability of sheet material: 1g / m ² · 24hrs · 25µm thickness · 40 ° C · 90% R
H or less Shape in plan view: <Bent state> Square (length of one side 70 mm)
<Stretched state> Rectangular (length 150mm x width 70mm)
First substance: Water (8g)
Second substance: ammonium nitrate (12 g)
First pressure-sensitive adhesive layer: Ny stack (NW-40, normal adhesive strength, Nichiban Co., Ltd.)
(Made by company)
Second adhesive layer: Ny stack (NW-40, normal adhesive strength, Nichiban Co., Ltd.)
(Made by company)
・ Fixing member clip: Alligator clip
Then, after removing the fixing member and pulling both ends of the cooling sheet, the first space and the second space are communicated, and the first substance and the second substance are reacted for 5 seconds. The release sheet was peeled off, and a cooling sheet was attached to the planned puncture site of the lower arm of the subjects (10 persons) for 1 minute. Hereinafter, the same von Frey type pain test as in Example 1 was performed. As a result, the same results as in Table 2 were shown.

  The cooling sheet and cooling container of the present invention can be mainly used in the medical field.

It is a top view (internal permeation | transmission figure) which shows embodiment of the cooling sheet | seat of this invention. It is the sectional view on the AA line in FIG. It is a top view which shows the state which expanded the cooling sheet | seat shown in FIG. It is a figure which shows the use condition of the cooling sheet | seat of FIG. 1 in the cross section corresponding to FIG. 6 is an enlarged cross-sectional view showing another example of the partition portion of the bag body 2. FIG. It is a top view which shows other embodiment of the cooling sheet | seat of this invention. It is a BB sectional view of the cooling sheet of FIG. It is a top view (internal perspective view) which shows 1st Embodiment of the cooling container of this invention. It is CC sectional view taken on the line in FIG. It is a longitudinal cross-sectional view which shows the state which the cover body displaced with respect to the container main body. It is a longitudinal cross-sectional view which shows 2nd Embodiment of the cooling container of this invention. It is a top view which shows the partition part in 3rd Embodiment of the cooling container of this invention. It is the DD sectional view taken on the line in FIG. 12 in 3rd Embodiment of the cooling device of this invention.

Claims (17)

A bag body having a first space and a second space that are isolated from each other and communicated when necessary;
A first substance housed in the first space;
A cooling sheet having a second substance housed in the second space and causing an endothermic reaction by contacting with the first substance,
A cooling sheet, wherein the bag body is bent to form a partition portion, and the first space and the second space are separated from each other by the partition portion.   The said bag body maintains the isolation | separation state of the said 1st space and the said 2nd space by adhere | attaching or melt | bonding a part of opposing outer surfaces in the said partition part. The cooling sheet according to 1.   The bag body improves the adhesion between the inner surfaces of the partition portion by holding the partition portion by a sandwiching member, and maintains the isolation state between the first space and the second space. The cooling sheet according to claim 1 or 2.   The cooling sheet according to any one of claims 1 to 3, wherein the bag body has a width of the partition portion narrower than other portions.   The cooling sheet according to any one of claims 1 to 4, wherein the partition portion is formed by folding the bag body at least twice or more.   The cooling sheet according to any one of claims 1 to 5, wherein the partition portion has a reinforcing layer.   7. The device according to claim 1, further comprising a first pressure-sensitive adhesive layer that is provided on at least one of the outer surfaces facing each other in a state in which the bag body is bent, and fixes the bag body to a living body surface. Cooling sheet.   The cooling sheet according to claim 7, wherein the first pressure-sensitive adhesive layer contains a drug.   The cooling sheet according to claim 8, wherein the drug is a disinfectant. A container body;
A container comprising a lid body detachably mounted on the container body;
A partition that separates a space defined by the container body and the lid into a first space on the lid body side and a second space on the container body side;
A first substance housed in the first space;
A second substance housed in the second space and causing an endothermic reaction by contacting with the first substance;
Provided on the surface of the lid on the first space side, and by performing an operation of displacing the lid with respect to the container body, the first space and the second space by the partition portion And a release member capable of releasing the isolated state.   The cooling container according to claim 10, wherein the partition portion is configured by an easily rupturable sheet. The lid is attached to the container body by screwing,
The release member is composed of a needle body or a blade,
The structure according to claim 11, wherein the release member and the easily rupturable sheet are brought close to each other by rotating the lid relative to the container body to rupture the easily rupturable sheet. The cooling container as described.   The cooling container according to claim 12, wherein an elastic member is provided at least in the vicinity of the edge of the surface of the lid on the first space side. The lid body has elasticity,
The release member is composed of a needle body,
The cooling according to claim 11, wherein the release member and the easily rupturable sheet are brought close to each other by pressing the lid toward the container main body, and the easily rupturable sheet is ruptured. container.   The cooling container according to claim 10, wherein the partition portion is configured by overlapping a pair of partition plates in which through holes are formed. The lid is attached to the container body by screwing,
By rotating the lid relative to the container body, the release member rotates, and by rotating the release member, the one on the lid side of the pair of partition plates is rotated, The cooling container according to claim 15, wherein the through holes of the pair of partition plates are configured to communicate with each other. Of the pair of partition plates, the partition plate on the lid side has a protrusion,
The cooling container according to claim 16, wherein the partition plate on the lid side rotates when the release member pushes the protrusion.

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