JPS646271A - Carbostyril derivative - Google Patents
Carbostyril derivativeInfo
- Publication number
- JPS646271A JPS646271A JP62060770A JP6077087A JPS646271A JP S646271 A JPS646271 A JP S646271A JP 62060770 A JP62060770 A JP 62060770A JP 6077087 A JP6077087 A JP 6077087A JP S646271 A JPS646271 A JP S646271A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- formulas
- halogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formulas I-III (R is residue of unsaturated heterocyclic ring bearing 1-4 heteroatoms (O, N), which may be substituted; R<1> is H, alkyl, phenylalkyl; R<2> is H, halogen, alkylsulfonyloxy, alkoxy, hydroxyl; Z is O, S, CO, formula IV, formula V (R<3> is H, alkyl), NH; A is alkylene; X is O, S, SO, SO2; Z' is Z except O] or its salt. EXAMPLE:6-[2-(1-Phenyl-2-imidazolyl)thioacetyl-3,4-dihydrocarbostyril. USE:It has action to inhibit blood platelets from adhering and is useful as a remedy or prophylactic for arteriosclerosis, ischemic cardiopathy, acute or chromic nephritis. PREPARATION:For example, the reaction of a compound of formula VI (Za is O, S, NH) with another compound of formula VII (X<1> is halogen, alkanesulfonyl; n is 0, 1) gives a corresponding compound of formulas I through III.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62060770A JPH0681752B2 (en) | 1986-04-02 | 1987-03-16 | Carbostyril derivative |
DK167187A DK167187A (en) | 1986-04-02 | 1987-04-01 | CARBOSTYRIC DERIVATIVES AND SALTS THEREOF, PROCEDURE FOR THE PREPARATION OF SUCH COMPOUNDS AND MEDICINAL CONTAINING THESE |
EP87104873A EP0240015B1 (en) | 1986-04-02 | 1987-04-02 | Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use |
DE3750913T DE3750913T2 (en) | 1986-04-02 | 1987-04-02 | Carbostyril derivatives, processes for their preparation, pharmaceutical compositions containing them and their use. |
KR1019870003141A KR940000785B1 (en) | 1986-04-02 | 1987-04-02 | Process for the preparation of carbostyril derivatives and salts thereof |
ES87104873T ES2068807T3 (en) | 1986-04-02 | 1987-04-02 | CARBOESTIRILE DERIVATIVES, PROCEDURE TO PREPARE THEM, PHARMACEUTICAL COMPOSITION, AND USE. |
US07/232,524 US5008274A (en) | 1986-04-02 | 1988-08-16 | Carbostyril derivatives and salts thereof and pharmaceutical composition for inhibiting adhesion of thrombocytes |
US07/958,489 US5434164A (en) | 1986-04-02 | 1992-10-08 | Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7608986 | 1986-04-02 | ||
JP61-76089 | 1986-04-02 | ||
JP62-43458 | 1987-02-25 | ||
JP4345887 | 1987-02-25 | ||
JP62060770A JPH0681752B2 (en) | 1986-04-02 | 1987-03-16 | Carbostyril derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS646271A true JPS646271A (en) | 1989-01-10 |
JPH0681752B2 JPH0681752B2 (en) | 1994-10-19 |
Family
ID=27291551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP62060770A Expired - Lifetime JPH0681752B2 (en) | 1986-04-02 | 1987-03-16 | Carbostyril derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0681752B2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0733765A (en) * | 1993-05-19 | 1995-02-03 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
US5892190A (en) * | 1988-01-29 | 1999-04-06 | Hitachi, Ltd. | Method and system of controlling elevators and method and apparatus of inputting requests to the control system |
JP2006501243A (en) * | 2002-08-23 | 2006-01-12 | カイロン コーポレイション | A pyrrole-based inhibitor of glycogen synthase kinase 3 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50142576A (en) * | 1974-04-25 | 1975-11-17 | ||
JPS5430183A (en) * | 1977-08-10 | 1979-03-06 | Otsuka Pharmaceut Co Ltd | 3,4-dihydrocarbostyril derivative |
JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
JPS5649378A (en) * | 1979-08-25 | 1981-05-02 | Otsuka Pharmaceut Co Ltd | Tetrazolylalkoxycarbostyril derivative |
JPS579780A (en) * | 1980-06-21 | 1982-01-19 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS57159778A (en) * | 1981-03-27 | 1982-10-01 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS57183761A (en) * | 1981-04-30 | 1982-11-12 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
-
1987
- 1987-03-16 JP JP62060770A patent/JPH0681752B2/en not_active Expired - Lifetime
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50142576A (en) * | 1974-04-25 | 1975-11-17 | ||
JPS5430183A (en) * | 1977-08-10 | 1979-03-06 | Otsuka Pharmaceut Co Ltd | 3,4-dihydrocarbostyril derivative |
JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
JPS5649378A (en) * | 1979-08-25 | 1981-05-02 | Otsuka Pharmaceut Co Ltd | Tetrazolylalkoxycarbostyril derivative |
JPS579780A (en) * | 1980-06-21 | 1982-01-19 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS57159778A (en) * | 1981-03-27 | 1982-10-01 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS57183761A (en) * | 1981-04-30 | 1982-11-12 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5892190A (en) * | 1988-01-29 | 1999-04-06 | Hitachi, Ltd. | Method and system of controlling elevators and method and apparatus of inputting requests to the control system |
JPH0733765A (en) * | 1993-05-19 | 1995-02-03 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JP2006501243A (en) * | 2002-08-23 | 2006-01-12 | カイロン コーポレイション | A pyrrole-based inhibitor of glycogen synthase kinase 3 |
Also Published As
Publication number | Publication date |
---|---|
JPH0681752B2 (en) | 1994-10-19 |
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