JPS6456614A - Maillard reaction inhibitor - Google Patents
Maillard reaction inhibitorInfo
- Publication number
- JPS6456614A JPS6456614A JP21144987A JP21144987A JPS6456614A JP S6456614 A JPS6456614 A JP S6456614A JP 21144987 A JP21144987 A JP 21144987A JP 21144987 A JP21144987 A JP 21144987A JP S6456614 A JPS6456614 A JP S6456614A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compounds expressed
- maillard reaction
- reaction inhibitor
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE:To obtain a Maillard reaction inhibitor containing a specific compound, such as thiosemicarbazide or 2-aminonicotinic acid. CONSTITUTION:A Maillard reaction inhibitor containing a compound selected from compounds expressed by formula I (R<a> is NH2, NHCH3, formula II, OCH3, etc.; X<a> is NH, O or S; R<1a> is H or CH3), e.g., 1,3-diaminoguinidine, compounds expressed by formula III (X<b> is N or CH), e.g., 3-aminopyrazine-2-carboxylic acid, compounds expressed by formula IV (R<c> is CH3, CH2COOH, formula II, etc.; X<c> is NH or O), e.g., trans-4-guanidinomethylcyclohexanecarboxylic acid, compounds expressed by formula V (R<d> and R<3d> are OH or OCH3; R<1d> and R<2d> are H or OH), e.g., tartaric acid, and compounds expressed by formula VI (R<e> is H or CH2COOH), e.g., rhodanine-3-acetate, as an active ingredient. The above-mentioned inhibitor is useful for treating and preventing various diabetic complications, diseases caused by aging and cancers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21144987A JPS6456614A (en) | 1987-08-27 | 1987-08-27 | Maillard reaction inhibitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21144987A JPS6456614A (en) | 1987-08-27 | 1987-08-27 | Maillard reaction inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6456614A true JPS6456614A (en) | 1989-03-03 |
Family
ID=16606135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP21144987A Pending JPS6456614A (en) | 1987-08-27 | 1987-08-27 | Maillard reaction inhibitor |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6456614A (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4978684A (en) * | 1987-11-13 | 1990-12-18 | The Rockefeller University | Method and agents for preventing staining of teeth |
| US4983604A (en) * | 1987-11-13 | 1991-01-08 | The Rockefeller University | Inhibitors of nonenzymatic cross-linking |
| US5422360A (en) * | 1991-08-27 | 1995-06-06 | Otsuka Pharmaceutical Co., Ltd. | Maillard reaction inhibitor |
| US5468777A (en) * | 1984-03-19 | 1995-11-21 | The Rockefeller University | Method and agents for preventing and reversing the staining of teeth |
| US5972357A (en) * | 1996-12-19 | 1999-10-26 | Kikkoman Corporation | Healthy foods and cosmetics |
| US6197806B1 (en) | 1995-12-20 | 2001-03-06 | Nippon Zoki Pharmaceutical Co., Ltd. | Eliminating agent for activated oxygen and free radicals |
| US6251929B1 (en) | 1998-11-16 | 2001-06-26 | Nippon Zoki Pharmaceuticals Co., Ltd. | Therapeutic agent for intractable vasculitis |
| US6451831B1 (en) | 2001-02-13 | 2002-09-17 | Nippon Zoki Pharmaceutical Co., Ltd. | Agent for hypoalbuminaemia |
| WO2007074346A3 (en) * | 2005-12-28 | 2007-11-29 | Merck & Co Inc | Modulation of wnt signalling pathways for treating nervous system disorders |
| DE102007004781A1 (en) * | 2007-01-31 | 2008-08-07 | Alzchem Trostberg Gmbh | Use of guanidinoacetic acid (salts) for the preparation of a health-promoting agent |
| EP2070535A1 (en) | 1998-08-24 | 2009-06-17 | Kurokawa, Kiyoshi | Drugs for relieving carbonyl stress and peritoneal dialysates |
| JP2012510959A (en) * | 2008-12-05 | 2012-05-17 | コグニス・アイピー・マネージメント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Skin lightening agent |
| JP2014062077A (en) * | 2012-09-24 | 2014-04-10 | Kyoei Kagaku Kogyo Kk | Cosmetic composition |
| JP2016504474A (en) * | 2013-01-25 | 2016-02-12 | シーライフ ファルマ ゲーエムベーハー | New bioactive polymer |
-
1987
- 1987-08-27 JP JP21144987A patent/JPS6456614A/en active Pending
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5468777A (en) * | 1984-03-19 | 1995-11-21 | The Rockefeller University | Method and agents for preventing and reversing the staining of teeth |
| US4983604A (en) * | 1987-11-13 | 1991-01-08 | The Rockefeller University | Inhibitors of nonenzymatic cross-linking |
| US4978684A (en) * | 1987-11-13 | 1990-12-18 | The Rockefeller University | Method and agents for preventing staining of teeth |
| US5422360A (en) * | 1991-08-27 | 1995-06-06 | Otsuka Pharmaceutical Co., Ltd. | Maillard reaction inhibitor |
| US6197806B1 (en) | 1995-12-20 | 2001-03-06 | Nippon Zoki Pharmaceutical Co., Ltd. | Eliminating agent for activated oxygen and free radicals |
| US5972357A (en) * | 1996-12-19 | 1999-10-26 | Kikkoman Corporation | Healthy foods and cosmetics |
| EP2070535A1 (en) | 1998-08-24 | 2009-06-17 | Kurokawa, Kiyoshi | Drugs for relieving carbonyl stress and peritoneal dialysates |
| US6251929B1 (en) | 1998-11-16 | 2001-06-26 | Nippon Zoki Pharmaceuticals Co., Ltd. | Therapeutic agent for intractable vasculitis |
| US6451831B1 (en) | 2001-02-13 | 2002-09-17 | Nippon Zoki Pharmaceutical Co., Ltd. | Agent for hypoalbuminaemia |
| WO2007074346A3 (en) * | 2005-12-28 | 2007-11-29 | Merck & Co Inc | Modulation of wnt signalling pathways for treating nervous system disorders |
| DE102007004781A1 (en) * | 2007-01-31 | 2008-08-07 | Alzchem Trostberg Gmbh | Use of guanidinoacetic acid (salts) for the preparation of a health-promoting agent |
| US8703819B2 (en) | 2007-01-31 | 2014-04-22 | Alzchem Trostberg Gmbh | Use of guanidinoacetic acid (salts) combination with betaine and/or choline to produced an agent that is beneficial to health |
| JP2012510959A (en) * | 2008-12-05 | 2012-05-17 | コグニス・アイピー・マネージメント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Skin lightening agent |
| JP2014062077A (en) * | 2012-09-24 | 2014-04-10 | Kyoei Kagaku Kogyo Kk | Cosmetic composition |
| JP2016504474A (en) * | 2013-01-25 | 2016-02-12 | シーライフ ファルマ ゲーエムベーハー | New bioactive polymer |
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