JPS6445350A - Production of n-substituted-l-amino acid derivative - Google Patents

Production of n-substituted-l-amino acid derivative

Info

Publication number
JPS6445350A
JPS6445350A JP62200865A JP20086587A JPS6445350A JP S6445350 A JPS6445350 A JP S6445350A JP 62200865 A JP62200865 A JP 62200865A JP 20086587 A JP20086587 A JP 20086587A JP S6445350 A JPS6445350 A JP S6445350A
Authority
JP
Japan
Prior art keywords
formula
acid derivative
compound
amino acid
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62200865A
Other languages
Japanese (ja)
Inventor
Sei Kondo
Genji Iwasaki
Rieko Kimura
Osanori Numao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP62200865A priority Critical patent/JPS6445350A/en
Publication of JPS6445350A publication Critical patent/JPS6445350A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE:To obtain the titled compound useful as a synthetic intermediate for angiotensinase inhibitor, in high yield, by reacting an L-amino acid derivative with a 2-(R)-halogeno-4-phenylbutyric acid derivative in the presence of a base. CONSTITUTION:The objective compound of formula III is produced by reacting an L-amino acid derivative of formula I (R is lower alkyl; R<1> is H or carboxyl- protecting group) with a 2-(R)-halogeno-4-phenylbutyric acid derivative of formula II (R<2> is H or carboxyl-protecting group; X is Br or Cl) in the presence of a base (e.g. ammonium carbonate) in a solvent (e.g. nitromethane-water) at room temperature - 100 deg.C. The amount of the base is >=1mol. per 1mol. of the compound of formula I. The starting compound of formula I is easily available or producible. The compound of formula II can be easily induced from an optically inactive hydantoin derivative as a starting raw material via an optically active N-carbamoyl-2-amino-4-phenylbutyric acid.
JP62200865A 1987-08-13 1987-08-13 Production of n-substituted-l-amino acid derivative Pending JPS6445350A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62200865A JPS6445350A (en) 1987-08-13 1987-08-13 Production of n-substituted-l-amino acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62200865A JPS6445350A (en) 1987-08-13 1987-08-13 Production of n-substituted-l-amino acid derivative

Publications (1)

Publication Number Publication Date
JPS6445350A true JPS6445350A (en) 1989-02-17

Family

ID=16431508

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62200865A Pending JPS6445350A (en) 1987-08-13 1987-08-13 Production of n-substituted-l-amino acid derivative

Country Status (1)

Country Link
JP (1) JPS6445350A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002074728A1 (en) * 2001-03-19 2002-09-26 Kaneka Corporation Purification method of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanine
US6518434B2 (en) 2000-02-07 2003-02-11 Astrazeneca Ab Coupling process

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6518434B2 (en) 2000-02-07 2003-02-11 Astrazeneca Ab Coupling process
WO2002074728A1 (en) * 2001-03-19 2002-09-26 Kaneka Corporation Purification method of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanine
US7071349B2 (en) 2001-03-19 2006-07-04 Kanaka Corporation Purification method of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine

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