JPS6442489A - Method for crystallization and purification of 7-acylamidodeacetoxycephalosporanic acid - Google Patents
Method for crystallization and purification of 7-acylamidodeacetoxycephalosporanic acidInfo
- Publication number
- JPS6442489A JPS6442489A JP20039787A JP20039787A JPS6442489A JP S6442489 A JPS6442489 A JP S6442489A JP 20039787 A JP20039787 A JP 20039787A JP 20039787 A JP20039787 A JP 20039787A JP S6442489 A JPS6442489 A JP S6442489A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- acylamidodeacetoxycephalosporanic
- crystallization
- purify
- followed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
PURPOSE:To purify the titled cephalosporanic acid useful as a starting raw material for a synthetic intermediate for producing an antibacterial agent in high yield, by adding esters into an aqueous solution of an alkaline metal salt of a cephalosporanic acid expressed by the specific formula, followed by heating thereof. CONSTITUTION:(B) Esters are added to (A) an aqueous solution of an alkaline metal salt of a 7-acylamidodeacetoxycephalosporanic acid expressed by the formula (R<1> represents phenylacetyl or phenoxyacetyl) and heated at 30-80 deg.C, followed by acid-crystallization to crystallize and purify the aimed cephalosporanic acid. Sodium 7-acylamidodeacetoxycephalosporanate, etc., are preferably used as the component (A), and ethyl acetate or butyl acetate is preferably used as the component (B).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20039787A JPS6442489A (en) | 1987-08-11 | 1987-08-11 | Method for crystallization and purification of 7-acylamidodeacetoxycephalosporanic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20039787A JPS6442489A (en) | 1987-08-11 | 1987-08-11 | Method for crystallization and purification of 7-acylamidodeacetoxycephalosporanic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6442489A true JPS6442489A (en) | 1989-02-14 |
Family
ID=16423642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP20039787A Pending JPS6442489A (en) | 1987-08-11 | 1987-08-11 | Method for crystallization and purification of 7-acylamidodeacetoxycephalosporanic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6442489A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102584853A (en) * | 2011-12-14 | 2012-07-18 | 伊犁川宁生物技术有限公司 | Preparation method of 7-aminodeacetoxy cephalosporanic acid |
CN110105374A (en) * | 2019-06-14 | 2019-08-09 | 河北科技大学 | A kind of phenylacetyl -7-ADCA method for crystallising that granularity is controllable with brilliant habit |
-
1987
- 1987-08-11 JP JP20039787A patent/JPS6442489A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102584853A (en) * | 2011-12-14 | 2012-07-18 | 伊犁川宁生物技术有限公司 | Preparation method of 7-aminodeacetoxy cephalosporanic acid |
CN110105374A (en) * | 2019-06-14 | 2019-08-09 | 河北科技大学 | A kind of phenylacetyl -7-ADCA method for crystallising that granularity is controllable with brilliant habit |
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