JPS6442489A - Method for crystallization and purification of 7-acylamidodeacetoxycephalosporanic acid - Google Patents

Method for crystallization and purification of 7-acylamidodeacetoxycephalosporanic acid

Info

Publication number
JPS6442489A
JPS6442489A JP20039787A JP20039787A JPS6442489A JP S6442489 A JPS6442489 A JP S6442489A JP 20039787 A JP20039787 A JP 20039787A JP 20039787 A JP20039787 A JP 20039787A JP S6442489 A JPS6442489 A JP S6442489A
Authority
JP
Japan
Prior art keywords
acid
acylamidodeacetoxycephalosporanic
crystallization
purify
followed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP20039787A
Other languages
Japanese (ja)
Inventor
Shinji Oshita
Aiichiro Kiyama
Mitsuo Kishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to JP20039787A priority Critical patent/JPS6442489A/en
Publication of JPS6442489A publication Critical patent/JPS6442489A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE:To purify the titled cephalosporanic acid useful as a starting raw material for a synthetic intermediate for producing an antibacterial agent in high yield, by adding esters into an aqueous solution of an alkaline metal salt of a cephalosporanic acid expressed by the specific formula, followed by heating thereof. CONSTITUTION:(B) Esters are added to (A) an aqueous solution of an alkaline metal salt of a 7-acylamidodeacetoxycephalosporanic acid expressed by the formula (R<1> represents phenylacetyl or phenoxyacetyl) and heated at 30-80 deg.C, followed by acid-crystallization to crystallize and purify the aimed cephalosporanic acid. Sodium 7-acylamidodeacetoxycephalosporanate, etc., are preferably used as the component (A), and ethyl acetate or butyl acetate is preferably used as the component (B).
JP20039787A 1987-08-11 1987-08-11 Method for crystallization and purification of 7-acylamidodeacetoxycephalosporanic acid Pending JPS6442489A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP20039787A JPS6442489A (en) 1987-08-11 1987-08-11 Method for crystallization and purification of 7-acylamidodeacetoxycephalosporanic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20039787A JPS6442489A (en) 1987-08-11 1987-08-11 Method for crystallization and purification of 7-acylamidodeacetoxycephalosporanic acid

Publications (1)

Publication Number Publication Date
JPS6442489A true JPS6442489A (en) 1989-02-14

Family

ID=16423642

Family Applications (1)

Application Number Title Priority Date Filing Date
JP20039787A Pending JPS6442489A (en) 1987-08-11 1987-08-11 Method for crystallization and purification of 7-acylamidodeacetoxycephalosporanic acid

Country Status (1)

Country Link
JP (1) JPS6442489A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102584853A (en) * 2011-12-14 2012-07-18 伊犁川宁生物技术有限公司 Preparation method of 7-aminodeacetoxy cephalosporanic acid
CN110105374A (en) * 2019-06-14 2019-08-09 河北科技大学 A kind of phenylacetyl -7-ADCA method for crystallising that granularity is controllable with brilliant habit

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102584853A (en) * 2011-12-14 2012-07-18 伊犁川宁生物技术有限公司 Preparation method of 7-aminodeacetoxy cephalosporanic acid
CN110105374A (en) * 2019-06-14 2019-08-09 河北科技大学 A kind of phenylacetyl -7-ADCA method for crystallising that granularity is controllable with brilliant habit

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