JPS63192705A - External agent for skin - Google Patents

Abstract

PURPOSE:To obtain an external agent for skin, giving smoothness and moist feeling to the skin, forming a fine and beautiful skin having luster and springiness and improving blood circulation in skin, by compounding an extract of a specific plant of e.g. Chenopodiaceae family. CONSTITUTION:The objective external agent for skin having the above- mentioned effects to improve chapped skin, increase blood circulation in skin, etc., can be produced by extracting one or more plants of Chenopodiaceae family, Amaranthaceae family, Mirabiliaceae family, Phytolaccaceae family, Tetragoniaceae family, Portulaceae family, Bassellaceae family and/or Cactaceae family, e.g. orache, broom cypress, Alternanthera, sessilis, SUGIMORI-KEITO, cockscomb, globe amaranth, bougainvillaea, marvel of Peru, pokeweed, sunplant, East Indian spinach, etc., and compounding the extract as essential component in an amount of 0.0001-30wt.%, preferably 0.005-20wt.% in terms of dried solid weight based on the whole agent.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to an external skin preparation containing a specific plant extract. The skin external preparation according to the present invention is a novel skin preparation that has the effect of imparting smoothness and moisturization to the skin, creating smooth and beautiful skin with gloss and firmness, and also has the effect of improving skin blood circulation. It is an external preparation for the skin.

[Prior Art] In recent years, many attempts have been made to discover useful ingredients for pharmaceuticals, quasi-drugs, or cosmetics from the natural world. From this point of view, various extracts have been reported, and there have also been cases where active ingredients have been isolated and purified from the extracts.

[Problems to be Solved by the Invention] The inventors of the present invention have been conducting intensive research to find natural ingredients that have characteristic efficacy or usefulness for the skin. They discovered that it has effects such as improving skin blood circulation, and completed the present invention.

[Means for Solving the Problems] That is, the present invention provides an extract from a Chenopodiaceae plant, an Amaranthaceae plant, a Psyllidaceae plant, a Polygonaceae plant, an Ornataceae plant, a Portulacaceae plant, a Trifoliaceae plant, or a Cactaceae plant. This is an external skin preparation characterized by containing one or more selected extracts.

These plants are known to contain a large amount of betalains. Although the mechanism of action of the external skin preparation of the present invention is not clear, it is possible that betalains may be involved in some way.

Hereinafter, the configuration of the present invention will be explained in detail.

The plant extract used in the present invention is an extract extracted from a plant of the family Chenopodiaceae, a plant of the family Amaranthaceae, a plant of the family Psyllidaceae, a plant of the family Proteaceae, a plant of the family Ornataceae, a plant of the family Portulaceae, a plant of the family Arunaceae, or a plant of the family Cactaceae. The Chenopodiaceae plants include the Amaranthaceae, the Amaranthaceae plants include the Broom tree, the Celosiaceae, the Celosia nigra, and the Celosia nigra, the Porcineaceae plants include the bougainvillea, the Polygonaceae family, the Polygonaceae family plants include the Porites, the Amaranthaceae plants, and the Purslane family plants include the Matsuba button,
Examples of plants belonging to the family Surinamedae include Tsurumarasaki and the like.

Extraction parts are arbitrary, but mainly above-ground parts such as fruits, leaves, and stems. Plant cells from these sites may be cultured to obtain an extract from the cultured cells. Extracts with more stable quality can be produced industrially.

The extraction method is not particularly limited, but a solvent such as water,
Extraction is generally carried out using an alcohol such as ethanol or methanol, or a polyhydric alcohol such as propylene glycol or 1,3-butylene glycol, with stirring at room temperature or in a cold place. The extract may be used as it is, or may be used after being concentrated, or may be used as a dry solid (hereinafter, the amount of extract is expressed in terms of dry solid weight).

In the present invention, one or more of the above-mentioned plant extracts are blended into the skin external preparation base.

The blending amount is 0.0001 to 30% by weight of the total amount of the skin external preparation.
, preferably 0.005 to 20% by weight. 0.00
If it is less than 0.01% by weight, the effect of the present invention cannot be obtained, so it is not preferable. On the other hand, if it exceeds 30% by weight, it is difficult to formulate it as an external preparation for the skin, and it is also undesirable because it causes significant coloring on the skin, clothing, etc.

In addition to the above-mentioned essential ingredients, the external skin preparation of the present invention may further contain ultraviolet absorbers, antioxidants, oils, water, surfactants, humectants, as necessary and depending on the type of external skin preparation.
Ingredients commonly used in external skin preparations, such as lower alcohols, thickeners, fragrances, chelating agents, pigments, and antiseptic and antifungal agents, can be blended.

In particular, with regard to ultraviolet absorbers or antioxidants, by incorporating one or more of them, the plant extract can be stabilized and a more excellent skin preparation can be obtained.

Examples of ultraviolet absorbers include sodium 2-hydroxy 4-methoxybenzophenone 5-sulfonate (trade name: ASL-243, the same hereinafter), methyl valadimethylaminobenzoate (trade name: Escarol 506, the same hereinafter).
), urocanic acid, 2-hydroxy-4-methoxybenzophenone, 2゜2゛-dihydroxy-4.4''-dimethoxybenzophenone, and other ultraviolet absorbers that can be used in external skin preparations. There is no particular limitation on the amount used, but preferably o, ooi ~
It can be contained in an amount of 5% by weight, more preferably 0.1 to 2% by weight.

Examples of antioxidants include vitamin C, vitamin E,
Tannic acid, gallic acid, butyl hydroxyanisole,
Examples include antioxidants that can be used in external skin preparations such as erythorbic acid. There is no particular limitation on the amount of these antioxidants, but it is preferably 0.001 to 5% by weight, more preferably 0.1 to 2% by weight.

Further, the dosage form of the present invention is arbitrary, and may be a solution type, an oil type, an emulsion type, a powder dispersion type, a water-oil two-layer system, or a water-oil one-powder three-layer system.

Furthermore, the use of the skin external preparation of the present invention is arbitrary, and it can be used as a lotion,
It can be used not only in facial cosmetics such as emulsions, creams, and bags, and hair cosmetics such as hair tonics and hair liquids, but also in makeup cosmetics and body cosmetics such as foundations, lipsticks, and eye shadows.

[Example] Hereinafter, the present invention will be explained in more detail according to Examples.
It goes without saying that the technical scope of the present invention is not limited to these. The blending amount indicates weight %.

Extraction Example 1 Cultured pokeweed cells were cultured using Linsmaier
- Cultivation was carried out for 9 days in a liquid medium based on Scoog's medium containing 3% SAM and 5×10M of 2,4-dichlorophenoxyacetic acid.

After adding 39 f methanol to 3.9 kg (fresh weight) of the obtained pokeweed cultured cells and homogenizing them, the residue was immersed in 391 methanol again. After stirring overnight, the supernatant was combined with the previous supernatant, and methanol was distilled off under reduced pressure to obtain 116 g of an extract.

Extraction Example 2 After adding 70% ethanol 501 to 5 kg of the above-ground parts of dried and crushed Portulaca elegans and stirring, the residue was immersed again in 70% ethanol 501. After stirring overnight, the supernatant was combined with the previous supernatant, and ethanol was distilled off under reduced pressure to obtain 1.2 kg of extract.

Extraction example 3 70% 1 to 3 kg of the above ground part of dried and crushed Tsurumurasaki
, 3-butylene glycol aqueous solution 30j? After adding and stirring, add 30I of the residue again! 70% ethanol. After stirring overnight, the supernatant was combined with the previous supernatant, and 1,3-butylene glycol was distilled off under reduced pressure to obtain extract 582.
I got g.

Example 1 ■ Glycerin 5.0 ■ Citric acid 0.03 ■ Sodium citrate 0.05 ■ Allantoin 0.1 ■ Ethanol (95%) 10.0 ■ POE
(*-1) (15 mol) Oleyl ether
1.0 ■ Extract of Extraction Example 1 0.5 ■
ASL-24S O, 3■
Fragrance 0.1 [phase]
Preservative 0.10 Pigment Appropriate amount @ Purified water
Remaining *-1; polyoxyethylene; the same applies hereinafter.

(Production method) Mix and melt the above components ■, ■, ■ and [phase] at room temperature,
Similarly, the components mixed and melted at room temperature■,■,■,■,■,
A lotion was obtained by stirring and adding to the contents of ①, ② and @.

On the other hand, Comparative Example 1 was carried out in the same manner as in Example 1, except that ■ Yamato burdock extract was removed from the formulation of Example 1.
I got lotion.

(Evaluation Test) A usage test was conducted on the lotions of Example 1 and Comparative Example 1 by a panel of 20 women. That is, 1 volume of the lotion of Example 1 and Comparative Example 1 was applied to the inside of the left and right forearms.
The product was used twice a day for three consecutive months, and its effects were investigated.

fl) Regarding the smoothness and moisturizing of the skin, the panel members themselves were asked to rate the results in three stages: effective, somewhat effective, and ineffective.

The results were as shown in Table 1.

(2) Regarding skin gloss and firmness, the elastic modulus of the skin of the panel (example 1 common area) was measured in the same manner as that of the comparative example.

The results were as shown in Table 2.

(3) The amount of skin blood flow in the application area was measured using a laser Doppler blood flow meter in the lotion application area of Example 1 and the lotion application area of Comparative Example 1 of the panel, and compared.

The results were as shown in Table 3.

(4) Animal experiment The hair on the back of a mouse (ICR-JCL male, weight 21-24 g) was shaved, and the lotions of Example 1 and Comparative Example 1 were applied at 0.00%.
It was applied to the back skin continuously for 2 months at 2 days/day. The back skin was collected 24 hours after the application was completed, and the amount of hyaluronic acid therein was measured (Mucopolysaccharide Experimental Method (1), 19
72. See pages 31 to 125).

The results were as shown in Table 4.

(Left below) 1st surface Skin smoothness Effective 15/20 1/20 Slightly effective 5/20 2/20 Ineffective 0/20 1? /20 Skin moist feeling Effective 16/20 0/20 Slightly effective 4/20 3/20 From the above results, it was confirmed that the skin condition of the area where Example 1 was applied was clearly improved.

There were no cases where the skin condition deteriorated.

(Margins below) Table 2 Panel Elastic modulus T (dyne 01m2XI
O8) Average value 2.17 2.38 2
．． 37 As is clear from the above results, it was confirmed that the skin elastic modulus of the area where the lotion of Example 1 was applied decreased and the firmness of the skin increased.

Table 3 Mean ± SD 112.5 ± 9.1 98.9
±4.3 As is clear from the above results, it was confirmed that the skin blood flow in the area where the lotion was applied in Example 1 was increased compared to the area where the lotion was applied in Comparative System 1.

The cause of this is thought to be the vasodilatory effect of the pokeweed extract. Incidentally, a pokeweed extract actually showed a dilating effect on isolated rabbit arteries.

Table 4 As is clear from the results of the amount of hyaluronic acid on the back skin of mice, the lotion of Example 1 was used as a control (untreated)
It was also found that compared to Comparative Example 1, the amount of hyaluronic acid in the skin was significantly increased (tested) with a risk rate of 1% or less.

When considered together with the results in Tables 1 to 3, an increase in the amount of hyaluronic acid in the skin is considered to be one of the reasons why the favorable effects on the skin regarding skin smoothness, moist feeling, and skin elasticity were revealed.

Although the mechanism behind the increase in the amount of hyaluronic acid is not clear, the present inventors have confirmed that extract of Yama burdock has an inhibitory effect on hyaluronan degrading enzymes, and this is one of the reasons why It is inferred that this may be a factor.

Next, an experimental example will be shown regarding the stability of the plant extract according to the present invention.

The sample was irradiated with light using a xenon lamp in an environment of 50° C. (461×10′ J/m), and the absorbance at the large absorption wavelength (λ max) was measured for 5 hours and 30 hours.

The results are shown in Table 5.

(The following is the margin) Table 5*-3: Polyoxyethylene (60 mol) Hydrogenated castor oil (The following is the margin) As mentioned above, the color fading was significant for the pokeweed extract alone or with the addition of a surfactant. By adding ultraviolet absorbers and/or antioxidants,
The fading caused by light could be improved very well.

Example 2 ■ Glycerin 5.0 ■ Polyethylene glycol 2.0 (molecular weight 4
00) ■ Glycyrrhizic acid 0.1 monoammonium salt ■ Allantoin 0.1 ■
Extract of Extract Example 2 1.0 ■ Setanol 4.0 ■ Squalane 5.0 ■ Stearic acid 1.0 ■ Beeswax
1.0 [phase] Vaseline
1.00 POE (25 mol) Cetyl ether 2.00 Glyceryl monostearate 1.50 Preservative
0.10 fragrance
0.15■ASL-24S
O,3 [phase] Gallic acid 1.00 Purified water
Residue (manufacturing method) Ingredients (1) to [phase] were mixed and dissolved, and stirred and mixed into the similarly mixed and dissolved components (2), (2), (2), (2), and (3) to emulsify. Emulsified particles were prepared by homogenization, and then cooled to room temperature using a heat exchanger to obtain W10 type cream.

Example 3 ■ Polyvinyl alcohol 10. O■
Polyethylene glycol 0.4 (molecular weight 400) ■ Glycerin 3.0 ■ Ethanol (95%) 8.0 0 Extract of Extraction Example 1 0.5 ■ A
SL-24S O, 5■
Preservative 0.1■ Fragrance 0.1■ Purified water Remaining (manufacturing method) Mix and dissolve ingredients ■～■ at room temperature, and add this to ingredients ■, ■, ■
and (2) were added to the mixed and melted mixture with stirring, and the mixture was cooled to room temperature to obtain a pack.

Example 4 ■ Squalane 5.0 ■
Vaseline 2.0 ■ Beeswax 0.5 ■ Sorbitan sesquioleate 0.8 ■ POE (
20 mol) Oleyl ether 1.2■ Propylene glycol 5.0■ Extract of Extraction Example 3 0.5■ Escarol 5o60
．． 2 ■ Tannic acid 0.3 [phase] Ethanol 10.00
Fragrance amount @ Preservative amount 0 Purified water
Residue (manufacturing method) The above components (1), (2), (2), (2), (2), (2) and @ were stirred and dissolved at 70°C to form an oil phase. On the other hand, components (1), (2), (2) and (2) were dissolved in component 0 to form an aqueous phase and maintained at 70°C. Immediately before, component (1) was mixed into the aqueous phase, and then the oil phase was further mixed to obtain an emulsion.

Example 5 ■ Castor oil 20.0 ■
Cetyl alcohol 20. O■ Beeswax 5.0■ Candelilla wax 30. O■ Extract of Extraction Example 1 0.5■, A S
L -2430,5 ■ Squalane 13.0■
Carnauba wax 5.0 ■ Pigment 5.0 [phase] Fragrance i! Amount I (manufacturing method) Ingredients (1) to [phase] were mixed and dissolved at 80°C, poured into a mold, allowed to cool to room temperature, and then taken out from the mold to obtain a lipstick stick.

〔Effect of the invention〕

The external skin preparation of the present invention gives a smooth and moist feeling to the skin, increases skin blood flow, revitalizes the skin, gives firmness and luster to the skin, and is extremely useful for preventing and improving skin roughness. It is a topical skin preparation.

Claims (1)

[Claims] (1) Contains one or more extracts selected from the extracts of Chenopodiaceae, Amaranthaceae, Alocataceae, Proteaceae, Trunaceae, Portulaceae, Trifoliaceae, or Cactaceae. A skin external preparation characterized by: