JPS62275456A - Wound protective material - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

Detailed Description of the Invention 3. Detailed Description of the Invention (Industrial Field) The present invention provides water repellency and adhesion to a wound.
Relating to a wound protection material that promotes wound repair and healing. [This article relates to a wound protection material that is mainly composed of lume and promotes repair and healing of a wound.

<Prior art> Wounds are caused by burns, physical injuries, skin peeling, etc. When treating these, for example, a therapeutic agent such as silver nitrate or a topical antibiotic is applied to the wound, and then Methods such as applying medicated gauze and wrapping a bandage over it, or applying a therapeutic agent to medicated gauze, applying it to the wound, and then wrapping a bandage over it are adopted.

1. However, in these methods, the medicated gauze sticks to the wound due to blood, pus, etc. in the wound. When the medicated gauze is removed, the medicated gauze sticks and the skin (scabs, etc.) on the wound area peels off, causing damage to the wound area.

In addition, bandages are usually made of gauze, which absorbs water, so when they come into contact with water, the affected area gets wet, which can lead to the influx and proliferation of bacteria, making the bandage, which is supposed to protect the wound, counterproductive.

In recent years, in order to improve these shortcomings, for example, Japanese Patent Application Laid-open No.
As seen in Publication No. 20935, there is a method of vapor-depositing a metal on one side of medicated gauze to make medicated gauze that does not stick to the wound, and as seen in Publication No. 181158/1980, there is a method of depositing metal on one side of medicated gauze. Wound coverings using water-repellent, microporous films that prevent water or bacteria from entering have been proposed. It wasn't.

<Problems to be solved by the invention> The present inventors have conducted intensive studies on the structure of an excellent wound protection material that can repair and heal wounds quickly. fiber aggregate for absorbing
It is surprising that a wound protection material made of aluminum-deposited and aluminum-deposited fiber aggregates significantly promotes repair and healing of the wound.
The present invention was achieved by discovering this fact.

<Means for Solving the Problems> That is, the present invention provides a body fluid made of fiber aggregates on which metal is vapor-deposited.
To fit in! This is a wound protection material mainly consisting of R fiber aggregates and a water-repellent microporous film.

The f&fiber used in the metal-deposited fiber aggregate constituting the wound protection material of the present invention may be of any commonly used type (specific examples include natural fibers such as cotton and cotton, and polyester fibers). Examples include fibers such as synthetic fibers such as Nysterle cellulose ester in the form of woven fabrics, non-woven fabrics, and knitted fabrics.In the present invention, gold, platinum, silver, balanum, etc. are coated on one or both sides of such fiber aggregates. , aluminum, titanium, copper, if , nickel, zinc,
A material on which one or more of these alloys, stainless steel, etc. is deposited is used. Such a fiber aggregate has a property that the metal-deposited surface and the wound part do not stick together even if blood or pus generated from the wound part coagulates.

The fiber aggregate for absorbing body fluids according to the present invention is not particularly limited as long as it absorbs body fluids coming out of a wound, and specific examples thereof include natural HR fibers such as wood M, cotton, polyester, cellulose ester, etc. Examples include synthetic fibers and other fibers made into planar shapes as they are, and those made into woven fabrics, nonwoven fabrics, knitted fabrics, and the like.

The water-repellent microporous film of the present invention is one that has countless micropores that do not allow water or bacteria to enter from the outside and have a sufficient pore size to release moisture from the wound surface. For example, microporous polymer films such as microporous fluororesin films, microporous polyurethane resin films, microporous polyolefin resin films, microporous polyamide films, and microporous polysulfone resin films are used. The pore diameter of the micropores in the microporous polymer film is usually 100A'' to 100μm, preferably 1000μm.
It is in the range of 10 μm to 10 μm, and 100 A or less is preferable because it inhibits moisture evaporation (and 100 μm or more is unfavorable because water etc. enter. Of course, it is not only the pore size that is important, but also the so-called pore size). The ratio is also an important factor and is usually about 5 to 90%, preferably about 20 to 85%.

In addition to these microporous film forms, non-woven fabrics, woven fabrics, and those combined with 451 Physical Properties 9 paper-like planar bodies are also included. Further, the microporous film preferably has moisture permeability and air permeability.

The wound protection material of the present invention is usually obtained by laminating in this order a water-repellent microporous film, a fiber aggregate for absorbing body fluids, and then a metal-deposited fiber H1 aggregate.

This is a must-have for wound protection materials that are mainly composed of a metal-deposited fiber aggregate, a fiber aggregate for absorbing body fluids, and a water-repellent microporous film! In accordance with this, it is also an aspect of the present invention to incorporate a drug into the metal-deposited fiber assembly 9 for absorbing body fluids, in order to expect the effect of promoting wound healing. Examples of such drugs are eg penicillin, tetracycline, gentamicin, fradiomycin.

Antibiotics and chemotherapeutic agents such as bacitracin, fosfomycin, minocycline, methicillin, norfloxacin;
Hydroflutidine, hydrocortisone acetate, prednisolone, dexamethasone.

Corticosteroids such as betamethasone valerate; iodine;
povidone iodine, acrinol mercuric chloride, silver nitrate,
Antibacterial or antifungal agents such as Macup Copm, Sulfamethizole, Pentamycin, Mifnazole, Trifmycin, Cimazole Hydrochloride; Lidocaine, Pensicaine, Ethyl Aminobenzoate, Bucaine Hydrochloride, Nbrocaine,
Local anesthetics such as Procotylin; 7 Subirin.

Salicylic acid, l-menthol salicylate, 7-minovirine, phenylphytazone, cabsaicin.

Piroxicam, indomethacin, g? Anti-inflammatory analgesics or agents for skin diseases such as Ya7zuren, ketoprofenfuenguen, tinoridine hydrochloride, prednisolone, and their derivatives; antihistamines such as diphenhydramine, diphenhydramine hydrochloride; drugs such as nido-glycerin, insorbide nitrate, nifedipine, nicardipine, etc. Vasodilators; mucopolysaccharides such as fundroitin sulfate and hyaluronic sulfate; hemostatic agents such as tranexamic acid; and the like, and these may be used in combination or in combination of two or more.

The wound protection material according to the present invention can be cut into a desired shape and fixed to the wound site with external adhesive tape, or it can be fixed by forming an adhesive in the form of an edge, for example, on the main periphery of the wound protection material piece in advance. It is used as such.

As such adhesives, Nisder acrylate-acrylic acid copolymer systems, ethyl-vinyl acetate copolymer systems, acrylic ester systems, polybutene systems, polyvinyl alcohols, natural rubbers, synthetic rubbers, etc. can be used.

These adhesives themselves need to be non-irritating to the skin. It also adheres to the skin surface with light pressure. Normal activities require sufficient adhesion to be retained on the skin. In addition, apply wound protection material A.
It is preferable that the adhesive does not leave any skin ffK adhesive or cause pain when removed from the lj-promoting area.

The wound protection material of the present invention will be explained based on the drawings. The figure shows one embodiment of the wound protection material of the present invention. In the figure, ■ is a fiber aggregate on which metal is vapor-deposited, 2 is a fiber aggregate for absorbing body fluids, 3 is a water-repellent microporous film, and 4 is an adhesive.

<Effects of the Invention> The wound protection material of the present invention as detailed above does not stick to the wound area, so it does not damage the wound area, and there is no infiltration of water or bacteria from the outside. . Furthermore, it also has the effect of significantly promoting wound repair and healing.

<Examples> The present invention will be further specifically explained below with reference to Examples, but the present invention is not limited only to the Examples.

Examples and Comparative Examples 1.2 As examples, the thickness was 1100p and the average pore diameter was 1. Microporous film with Oμm water repellency (Tanesui Kagaku: Cervo 7)
Cut into 453IIX4511111, 15m from the edge.
An adhesive (Siden Chemical; Cypinol AT-301) was applied to the inside in a frame shape. Place a 15m x 15m square piece of absorbent cotton on the area where the adhesive is not applied, and then
A wound protection material as shown in Figure 1 was prepared by covering one side of a 511I x 25 fl square piece with a polyester filament cloth coated with aluminum.

Comparative Example 1 was prepared in the same manner as in the example except that the aluminum-deposited polyester filament cloth of the example was replaced with medicated gauze.

We created a wound protection material without fiber aggregates that was coated with metal.

As Comparative Example-2, the water-repellent microporous film of the example was used as a commercially available Kizoku IF (Sanso, manufactured by Kirin Co., Ltd., size 45
A wound protection material without a water-repellent microporous film was prepared in the same manner as in Example except that the gauze and absorbent cotton were removed from X 45 y ) and replaced with a sheet only.

The wound protection materials prepared in Examples and Comparative Examples 1 and 2 were tested using six domestic rabbits.

In the test, after cutting the hair on the back of a domestic rabbit and disinfecting it with alcohol, three skin abrasion wounds with a l cMX lα angle and a thickness of 6 nm were made, and the samples of Example and Comparative Example -1゜2 were treated with ethylene oxide. It was sterilized with gas and pasted. In this state, soak in running water for 30 seconds once a day, 3, 6.
After 12 days, the state of healing of the wound and the state of adhesion to the wound surface were visually observed. The results are shown in Table IK.

As is clear from Table 1, the wound protection material of the example significantly promoted repair and healing of the wound area.

[Brief explanation of the drawing]

The figure shows one embodiment of the wound protection material of the present invention.
This is an example of its cross section. In the figure, 1 represents a fiber aggregate on which metal is vapor-deposited, 2 represents a fiber aggregate for absorbing body fluids, 3 represents a microporous film having water repellency, and 4 represents an adhesive. times

Claims (1)

[Claims] A wound protection material mainly comprising a fiber aggregate on which a metal is vapor-deposited, a fiber aggregate for absorbing body fluids, and a water-repellent microporous film.