JPS6150068A - Reagent distributor - Google Patents

Abstract

PURPOSE:To obtain a reagent distributor which can distribute a plurality of reagents selectively without contamination while easily handling the increase in the number of reagents, by allowing the washing of passages or the like as each reagent distribution is done. CONSTITUTION:This reagent distributor is made up of a plurality of passage switching means 1 connected to a common distribution syringe 2 and a washing liquid supply means 3 connected thereto 2. Said switching means 1 are each composed of a nozzle 5 for distributing a reagent to a container 4, a first changeover valve 8 for selecting connecting a reagent tank 6 to one end of a first common passage 7 and a second changeover valve 11 for selectively connecting the other end of said passage 7 and one of a drain passage 9 to one end of a second common passage 10 and the other end of the second common passage 10 is connected to the syringe 2 through a manifold block 12. Then, as each reagent distribution is done, a washing liquid flows via the syringe 2, the common passage 10 and the drain passage 9 by a supply means 3 to wash these passages 10 or the like.

Description

DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to a dispensing device, particularly a reagent dispensing device suitable for use in an automatic chemical analyzer.

(Prior Art) Automatic chemical analyzers generally use a wide variety of reagents to perform multi-item analysis. Conventional reagent dispensing devices that dispense such a wide variety of reagents include (1)
(2) One common dispensing syringe and dispensing nozzle for multiple reagents, and one common dispensing syringe and dispensing nozzle for multiple reagents, by moving the dispensing nozzle and dispensing multiple reagents. The one that selectively dispenses (
3) As known from Japanese Patent Application Laid-Open No. 58-76764, there is a device in which a rotary flow path switching valve is provided and a plurality of reagent discharge channels are selected by this flow path switching valve.

However, the dispensing device in (1) above requires the same number of dispensing syringes as the number of reagents, which makes the entire analyzer large. However, there are problems in that the movement mechanism is complicated and mutual contamination of reagents is likely to occur. Also,(
3) In the case of using a rotary flow path switching valve,
When quantitatively diluting reagents with a washing solution that also serves as a diluent,
Since the reagent is pushed out by the cleaning liquid, the flow path switching valve does not cause contamination between the reagents (it works effectively, but if you are trying to dispense only the reagent, in this case too, the flow path switching valve will not cause contamination between the reagents). A cleaning solution remains between the steps, and this causes contamination between the reagents, making it practically impossible to dispense only the reagents.

On the other hand, in automatic analyzers, the number of channels, ie, the number of analysis items, may be increased. However, (1) above
In the case of using the above dispensing device, it is necessary to add dispensing syringes as the number of reagents to be dispensed increases, which makes the work extremely troublesome and the structure complicated. In addition, in the case of using the dispensing device (2), if the reagent is placed on a turntable and sucked in with a dispensing nozzle at a predetermined position, it is possible to easily cope with an increase in the number of dispensed reagents. However, even in this case, there is a problem of contamination between reagents. Further, in the case of using the dispensing device (3), the flow path switching valve may be replaced, but the replacement is extremely troublesome and not easy, and the structure is also complicated.

(Objective of the Invention) The object of the present invention is to solve the various problems mentioned above, to selectively dispense only a plurality of reagents without causing contamination among them, and to make it possible to dispense only a plurality of reagents selectively without causing contamination among them. It is an object of the present invention to provide a reagent dispensing device suitably configured so as to be able to easily cope with the increase.

(Summary of the Invention) The reagent dispensing device of the present invention includes a first common channel selectively connected to a reagent dispensing nozzle and a reagent container, respectively, and a first common channel and a drainage channel. a second selectively connected to
a plurality of flow path switching means each having a common flow path;
A common suction/discharge means connected to the second common flow path of the plurality of flow path switching means, and a cleaning liquid supply means connected to the suction/discharge means, and the cleaning liquid supply means causes the suction/discharge means, the second common The present invention is characterized in that the second common flow path is cleaned by flowing the cleaning liquid through the flow path and the drainage flow path.

FIG. 1 shows a diagram of the principle of the present invention. In the present invention, a plurality of flow path switching means 1, two in the illustrated example, are connected to a dispensing syringe 2 serving as a common suction and discharging means, and a cleaning liquid supply means 3 is connected to this dispensing syringe 2. Each channel switching means 1 includes a first switching device for selectively connecting a dispensing nozzle 5 for dispensing a reagent into a container 4 and a reagent tank 6 for accommodating a reagent to one end of a first common channel 7. A second switching valve 11 for selectively connecting the valve 8, the other end of the first common flow path 7, and one end of the drain flow path 9;(() to one end of the second common flow path IO. The other end of the second common flow path 10 is connected to the dispensing syringe 2 via the manifold block 12.The cleaning liquid supply means 3 includes a cleaning liquid tank 13 containing the cleaning liquid, a pump 14, and an opening/closing system. The artificial side of the pump 14 is connected to the cleaning liquid tank 13, and the outlet side is connected to the dispensing syringe 2 via the on-off valve 15.

In the present invention, a common dispensing syringe 2 is used to operate each channel switching means 1 to dispense a reagent, but each channel switching means 1 usually has a small number of (common dispensing nozzles 5 Since the flow path from the to the reagent tank 6 is filled with the reagent and the other flow paths are filled with the cleaning liquid, when dispensing the reagent, the reagent is drawn into the first
The water is sucked into the common flow path 7 of the. However, when the butterflies enter the second common flow path 71, they gradually diffuse through the second common flow path 10, causing contamination with the reagent in the flow path switching means 1 of the pond. There is a risk of it happening. Further, any one of the flow path switching means 1
If the reagent tank 6 connected to
It becomes impossible to accurately perform quantitative dispensing of reagents.

Therefore, in the present invention, for example, every time a reagent is dispensed, after the reagent is aspirated or discharged, the cleaning liquid supply means 3 passes the cleaning liquid through the dispensing syringe 2, the second common channel 10, and the drainage channel 9. to flow. In this way, the second common flow path IO is cleaned with the cleaning solution ν, and the second common flow path 10 of the empty reagent flow path switching means 1 is also filled with the cleaning liquid. Therefore, reagents can be dispensed accurately and quantitatively without causing contamination.

Further, in a preferred embodiment of the present invention, a plurality of sets of dispensing syringes each having a plurality of flow path switching means connected thereto are provided, and
Each set of corresponding flow path switching means is unitized with a common drive means for driving them simultaneously. In this way, various channel configurations can be created by providing a large number of units each having a number of flow path switching means corresponding to a predetermined number of dispensing syringes and connecting the required number of units to the dispensing syringes. It is possible to easily realize an automatic chemical analyzer having the present invention, and it is also possible to easily cope with an increase in the number of dispensing reagents without adding a dispensing syringe. Therefore, user requests can be quickly and easily met, and inspections and repairs can be easily performed. Also,
Since the units have exactly the same configuration, the manufacturing cost of the entire device can be reduced.

(Embodiment) FIG. 2 shows the configuration of essential parts of an embodiment of the present invention. This example includes four dispensing syringes 21-1 to 21-4 and two units 22-1 and 22-2. The units 22-1 and 22-2 have the same configuration, and include motors 23-1 and 23-2 that are driven independently of each other.
By each of these motors, RIK ilJ fi
Four rotary valves 25A-1 to 25D- of the same configuration are driven simultaneously via the laterals 24-1 and 24-2.
1 and 25A-2 to 25D-2. Each rotary valve corresponds to one analysis item, that is, one channel, and in this example, two types of reagents, first and second, are selectively dispensed by each rotary valve. Therefore, each rotary valve is configured with two flow path switching means. That is, as shown in an enlarged view of one rotary valve 25 in FIG. 3, long grooves 26-1 and 26-2 as the first switching valves of each flow path switching means are formed along the same circumference. In addition, a long groove 27-1a as a second switching valve runs concentrically on the inner side thereof,
27-1b; forming 27-2a, 27-2b,
A discharge port 28- connected to the dispensing nozzle so as to be selectively connected to the long grooves 26-1 and 26-2 on the outer circumference.
1; 28-2 and suction port 2 connected to the reagent tank
9-1; 29-2 and these discharge ports 28-1.28
-2 and suction port 29-1; long groove 26-1 in 29-2
; 26-2 so that the first
30-1 and 30-2 of the common flow path are formed. In addition, there are long grooves 27-1a, 27-1 on the inner circumference.
b; 27-2a; a common port 3 connected to the second common flow path so as to be selectively connected to 27-2b;
1-1; 31-2; and a drain port 32 connected to the drain channel so as to be selectively connected to the common port 31-1; 31-2 via the long groove 27-1b; 27-2b. -1;32-
2, and a long groove 27-1a; a common port 3 via 27-2a.
The connecting ports 33-1; 33-2 of the first common flow path are formed so as to be selectively connected to the connecting ports 33-1; 33-2 on the inner side. Outer connection port 30
-1; 30-2 are connected by evacuation pipes 34-1; 34-2 to form a first common flow path.

In unit) 22-1, suction ports 29-1 and 29-2 of one rotary valve 25A-1 connect to corresponding first and second reagent tanks 42-1 and 42-2 stored in reagent cold storage 41. 2, and the discharge ports 28-1 and 28-2 are dispensing nozzles 44 arranged at predetermined positions to which the reaction container 43 containing the test liquid is transferred.
-1 and 44-2 respectively, and common entrance 31-1.
and 31-2 are second common flow paths 45-1 and 45-2
are connected to the four-unit manifold block 46 through the drain ports 32-1 and 32-2, respectively, and drain channels 47-1 and 47-2 are connected to the drain ports 32-1 and 32-2, respectively. The manifold block 46 is depicted as having four connecting channels 48-1 to 48-4 and a common channel 49 connected to each of these connecting channels, and the connecting channels 48-1 and 48-2 are connected to a low-resolution valve 25Δ. -1 common port 31-1 and 31-
The other ends of the second common channels 45-1 and 45-2, to which -Qmi is connected to 2, are connected to each other.

Similarly, in the unit 22-2, the suction port 29-1.
2-3.42-4, discharge port 28-1.28-2
is connected to a dispensing nozzle 44-3, 44-4 arranged at a predetermined position to which the reaction container 43 containing the test liquid is transferred, and the common port 31-1, 31-2 is connected to a second common flow path. 45-3
．． 45-4 to the connecting channel 48-3.48-4 of the manifold block 46, and also connects to the drain port 32-1.3.
Drainage channels 47-3 and 47-4 are connected to 2-2.

Uni, 7) A common flow path 49 of a manifold block 46 connecting one rotary valve 25A-1 and 25A-2 of each of 22-1 and 22-2 is connected to a dispensing syringe 21-1, and this dispensing syringe 21-1 is connected via an on-off valve 50, a branch block 51, and a pump 52 to a cleaning liquid tank 53 that stores cleaning liquid. The branch block 51 includes a main flow path 54 and four branch flow paths 55-1 to 55-4 connected to the main flow path. 1
are connected to the on-off valves 50, respectively.

The connection regarding the dispensing syringe 21-1 has been explained above, but the other rotary valves 25B-1 of the units 22-1 and 22-2 are also connected to the other dispensing syringes 21-2 to 21-4. ~250-1 and 25B-2~
250-2, for example, the rotary valves 25B-1 and 25B-2 are attached to the dispensing syringe 21-2, and the rotary valves 25C-1 and 25C are attached to the dispensing syringe 21-3.
-2 into the dispensing syringe 21-1 with the rotary valve 25.
0-1 and 250-2 respectively, and similarly connect them using a 4-unit manifold block, and connect each dispensing syringe 21-2 to 21-4 to the branch flow of the branch block 51 via an on-off valve. It is connected to roads 55-2 to 55-4.

In this way, in this example, each dispensing syringe 21-1
- 21-4 are for selectively dispensing four types of reagents, but if additional reagents are required, an additional unit is installed, and a manifold block is added or a corresponding connection port is installed for each unit. What is necessary is just to replace it with one that has one and connect it to the dispensing syringes 21-1 to 21-4.

FIGS. 4A to 4C show the configuration of an example of the unit. In this example, four rotary valves are provided, and these four rotary valves (one rotary valve is indicated by reference numeral 25 in the figure) are held on a base 61, and each drive shaft 62 is connected to a base 61. Bearing 6 on each base 61
Valve drive shaft 64-1~ rotatably pivotally connected via 3
64-4 through drive pins 65, respectively. Note that each drive pin 65 is held by a drive pin 66, respectively. One end of levers 67-1 to 67-4 is fixed to each of the valve drive shafts 64-1 to 64-4, and the other end of each lever is connected to a connecting plate 69 via a bearing 68.
At the same time, the other end of any one of the valve drive shafts (in the figure, the valve drive shaft 64-2) is connected to the output shaft 71 of the motor 23 held on the base 61 via a coupling 70. In this way, one motor 23 can
The valve drive shafts 64-1 to 64-4, and therefore the drive shafts 62 of the four rotary valves, are connected to the levers 67-1 to 64-4.
67-4 and the connecting plate 69 at the same time. Incidentally, a stiffening spring 72 is wound between each of the levers 67-1 to 67-4 and the drive pin receiver 66, respectively.

The four rotary valves are driven by the motor 23 to be in the same state at the same time, that is, the origin state, the second reagent suction state, and
Each state is set to be a first reagent suction state, a cleaning state, a first reagent discharge state, and a second reagent discharge state. In order to detect each state, a detection plate 7 is attached to the coupling 70.
3, two cutouts 74-1 and 74-2 are formed at predetermined positions, and these cutouts are fixed to the base 61 in a predetermined positional relationship. position sensor 75, second suction sensor 76, first
Suction/pull sensor 77, cleaning sensor 78, first discharge sensor 7
9 and a second discharge sensor 80 for detection.

Next, the operation of this embodiment will be explained with reference to FIGS. 5A-F and 6.

(1) Initializing the dispensing device First, the initial setting operation of the dispensing device will be explained. -2~250-2
are in the same state at the same time, so 1 of unit)22-1
The operation will be explained focusing on the rotary valve 25A-1. In steady state, unit) 22-L 22
-2 is in the origin state where the origin position sensor 75 detects the notch 74-1 formed in the detection plate 73, and in this state, each of the rotary valves of each unit 7) is in the origin state as shown in FIG.
It is in the state shown below. First, motor 2 of Uniso) 22-1
3 to 1, and the first discharge sensor 7 is activated at No. 4N8.
9 detects the notch 74-2, the detection plate 73 is rotated counterclockwise until the notch 74-2 is detected.
i Connect the second common flow path 45-1, the evacuation pipe 34-1, and the discharge port 28-1 via 26-1 and 27-1b to bring the first reagent to the discharge state. In this state, the on-off valve 5
0 is opened to operate the pump 52, thereby pumping the cleaning liquid to the manifold block 46 and the rotary valve 25.
It is discharged from the dispensing nozzle 44-1 via A-1.

Next, the motor 23-1 is driven to rotate the detection plate 73 clockwise until the first suction sensor 77 detects the notch 74-1 in FIG. 4B. As shown, the second common flow path 45-1, the evacuation pipe 34-1, and the suction port 29- are connected via the long grooves 26-1 and 27-La.
1 is connected to set the first reagent suction state. In this state, the on-off valve 50 is closed and the reagent is sucked from the first reagent tank 42-1 into the evacuation tube 34-1 of the rotary valve 25A-1 by the suction operation of the dispensing syringe 21-1.

Thereafter, the rotary valve 25A-1 is set to the first reagent discharge state shown in FIG. 5E, and the aspirated reagent is dispensed.

The discharge operation of the ring 21-1 pushes it out toward the dispensing nozzle 44-1. By performing the above operation once or multiple times, the area from the discharge port 28-1 to the tip of the dispensing nozzle 44-1 is filled with the reagent, and the long groove 26-1, the evacuation tube 34-1, and the long groove 2
7-1a and 27-1b are filled with cleaning liquid.

Next, the motor 23-1 is driven to rotate the detection plate 73 counterclockwise from the origin position until the second discharge sensor 80 detects the notch 74-2 at No. 4N8. As shown in F, long grooves 26-2 and 27-2b
The second common flow path 45-2, the evacuation pipe 34-2, and the discharge port 2B-2 are connected to each other via the second reagent discharge state.

In this state, the same cleaning liquid supply operation as described above is performed to discharge the cleaning liquid from the dispensing nozzle 44-2.

Next, the motor 23-1 is driven to rotate the detection plate 73 clockwise until the second suction sensor 76 detects the notch 74-1 in FIG. 4B. through the long grooves 26-2 and 27-2a to the second common flow path 45-2, the evacuation pipe 34-2, and the suction port 29-.
2 are connected to create a second reagent suction state. In this state, the on-off valve 50 is closed and the reagent is sucked from the second reagent tank 42-2 into the evacuation tube 34-2 of the rotary valve 258-'1 by the suction operation of the dispensing syringe 21-1.

Thereafter, the rotary valve 25A-1 is set to the second reagent discharging state shown in FIG.
It is pushed out to the dispensing nozzle 44-2 side by the discharge operation 1-1. By performing this operation once or multiple times, the discharge port 28-
2 to the tip of the dispensing nozzle 44-2 with reagent Zl: 4
In addition, the long groove 26-2, the evacuation pipe 34-2, the long groove 27
- Fill 2b with the washing 11) solution.

Next, the motor 23-1 is driven to keep the detection plate 7 until the cleaning sensor 78 detects the notch 74-1 in FIG. 4B.
3 counterclockwise from the origin position, thereby connecting the second common flow path 45-1 and the drain flow path 47-1 via the long groove 27-1'b, as shown in Figure 5. At the same time, the second common flow path 45-2 and the drainage flow path 47-2 are connected via the long groove 27-2b to achieve a cleaning state. In this state, the on-off valve 50 is opened and the pump 52 is operated, thereby transferring the cleaning liquid to the manifold block 46, the second common flow path 45-1, 45-. 2 and drainage channel 47-1;
47-2 and swept away.

Through the above operations, the flow path from the tip of the dispensing nozzle 44-1 to the discharge ports 28 to 1 is filled with the first reagent, and
The flow path from the tip of the dispensing nozzle 44-2 to the discharge port 28-2 is filled with the second reagent, and the other flow paths are filled with the cleaning liquid.

Above, the initial setting operation has been explained focusing on the rotary valve 25A-1, but the rotary valves 258-1 to 25
Since 0-1 is in the same state at the same time, similar initialization can be performed simultaneously by operating the other dispensing syringes 21-2 to 21-2 and the on-off valves attached to each of them in the same way. .

After initializing unit 22-1, each rotary valve 25A-1 of unit 22-1
~250-1 as the origin state, unit) 22-2
Perform similar initialization for .

(2) Dispensing operation of reagents into reaction containers After the initialization is completed, select units 22-1 and 22-2, and perform dispensing operations 21-1 to 21-4 via the selected units. Dispense reagents simultaneously or selectively. Hereinafter, the sequential dispensing operation of two scales of reagents using the rotary valve 25A-1 of the unit 22-1 will be described. First, with the on-off valve 50 closed, the rotary valve 25A-1 is rotated one step in the right direction from the original position shown in FIG. 5A to bring it into the second reagent suction state shown in FIG. 5B. By the suction operation of the dispensing syringe 21-1, a predetermined amount or a slightly larger amount of reagent is suctioned from the second reagent tank 42-1. As a result, the sucked amount of reagent is sucked into the evacuation tube 34-2 through the long groove 26-2. Next, the rotary valve 25A-1 is further rotated one step to the right to obtain the first reagent suction state shown in FIG. A predetermined amount or a slightly larger amount of reagent is sucked from the tank 42-2 into the evacuation pipe 34-1 through the long groove 26-1.

Thereafter, the rotary valve 25A-1 is rotated three steps to the left to bring the cleaning state shown in the fifth diagram, and in this state, the on-off valve 50 is opened to operate the pump 52, thereby dispensing the cleaning liquid into the dispensing syringe 21-. 1, manifold block 46, second common flow path 45-1; 45-2 and long groove 27-1b; drainage flow path 47-1 via 27-2b;
47-2 to clean those channels.

Next, the rotary valve 25A-1 is rotated one more step to the left to bring it into the first reagent discharging state shown in FIG.
1 is discharged and the sucked first reagent is transferred to the dispensing nozzle 44.
A predetermined amount is discharged into the reaction container 43 that has been conveyed directly below from -1. Next, rotary valve 25A-1
Rotate one step further to the left to obtain the second position shown in Figure 5F.
The reagent is discharged, and in this state, the dispensing syringe 21-1 is further discharged, and the aspirated second reagent is transferred to the dispensing nozzle 44.
A predetermined amount is discharged from -2 into the reaction container 43 that has been conveyed directly below it. After that, rotary valve 25A-1
is rotated three steps to the right to return to the original position shown in FIG. 5A.

FIG. 6 is a time chart showing the operations of the dispensing syringe 21-1, the rotary valve 25A-1, the on-off valve 50, and the pump 52 in the sequential reagent dispensing process regarding the rotary valve 25A-1.

As described above, in this embodiment, after suctioning the reagent, the cleaning liquid is passed through the dispensing syringe 21-1, the manifold block 46, and the second common flow path 45-1; 45-2 to the drainage flow path 4.
7-1; Since the flow from 47-2 cleans those channels, it is possible to effectively prevent contamination due to diffusion of the reagent into the second common channel as described above. Even if a sample tank becomes empty, the second common flow path is filled with the washing liquid, so that there is no adverse effect on the quantitative dispensing of other reagents.

7A to 7F show configuration examples of an automatic chemical analyzer equipped with the reagent dispensing device of the present invention. FIG. 7A is composed of one analysis unit 81 with 24 channels, and FIG. 7B is 1
2 channels of 2 analysis units) 83-1.83-2
7C consists of three analysis units (85-1 to 85-3) with 8 channels, each of which analyzes up to 24 items. In addition, the 7th diagram is 32
Analysis was performed up to the item, and Figure 7 E and F were 4 each.
Channel 6 analysis units) 89-1 to 89-6
Eight analysis units 89-1 to 89-8 perform analysis on up to 24 items and 32 items, respectively. In each configuration example, several MI racks 92 each holding 1Jlii sample cups 92 are set in the rack feeding section 91, and under the control of a controller 94, the racks 93 are sequentially moved through a predetermined path 95 into the racks. While stored in the storage section 96, the sample in each sample cup 92 is dispensed into a reaction container provided in the reaction line 97 of each analysis unit according to the number of channels of that analysis unit, and a predetermined analysis operation is performed. It is about to be done.

Each analysis unit is equipped with four dispensing syringes. Therefore, in the analysis unit 81 shown in FIG. 7A, as shown in FIG. 22-6, two manifold blocks 101-1 and 101-2 for 6 units are associated with each of the four dispensing syringes 21-1 to 21-4, and each of the rotary valves of each unit is It is connected to each dispensing syringe via a manifold block and configured in the same manner as shown in FIG. In this way, one dispensing syringe can be equipped with six loaf IJ-valves to selectively dispense up to 12 types of reagents. In addition, in FIG. 7B, each of the analysis units 83-1 and 83-2 has 12 channels, so each analysis unit has three units 22 as shown in FIG. 8B. -1 to 22-3,
Dispensing each rotary valve of each unit with syringe 2
Each dispensing syringe 21 is connected via one manifold block 101 for 6 stations corresponding to each of syringes 1-1 to 21-4.
-1 to 21-4.

Moreover, since each analysis unit shown in FIGS. 7C and D has eight channels, each analysis unit 7) has two units) 22-1.22 as shown in FIG. 8C. −
2, and may be configured in the same manner as in FIG. Furthermore, in Figures 7E and F, each analysis unit has four channels, so each of the four rotary valves in one unit 22 is connected to a double-channel receiver, as shown in Figure 8. What is necessary is just to connect to each of the dispensing syringes 21-1 to 21-4 via the manifold block 102.

As shown in the configuration example above, by connecting the required number of units to the dispensing syringes, the units having four rotary valves corresponding to the four dispensing syringes can be connected to An automatic chemical analyzer having a channel configuration can be easily realized.Therefore, user requests can be quickly and easily met, and inspection and repair can be easily performed.

Furthermore, since the configurations of the units are exactly the same, the installation cost of the entire device can be reduced.

Note that the present invention is not limited to the above-mentioned example, and can be modified or changed in many ways.

For example, if the capacity of the dispensing syringe is large enough for the amount of reagent to be dispensed, multiple reagents may be suctioned into the rotary valves of multiple units connected to the syringe in sequence and then discharged one after another. can. Further, the rotary valve can be configured to handle one reagent or three or more reagents, and other suction/discharge means such as a rotary pump can be used instead of the dispensing syringe. Furthermore, the number of rotary valves to be made into a unit can also be set according to the number of suction/exhaust means. Also,
Second Common Flow Path C] Cleaning can also be performed after the reagent is discharged.

(Effects of the Invention) As described above, according to the present invention, quantitative dispensing of only a plurality of reagents can be performed selectively and accurately at all times without causing contamination among them, and also The increase can also be easily dealt with by adding suction/exhaust means.

[Brief explanation of the drawing]

Fig. 1 is a diagram for explaining the present invention in detail, Fig. 2 is a diagram showing essential parts of an embodiment of the invention, Fig. 3 is an enlarged view of the rotary valve shown in Fig. 2, Fig. 4 A-C are diagrams showing the configuration of an example of the unit shown in FIG. 2, FIGS. 5A-F and 6 are diagrams for explaining the operation, and FIGS. 7A-F are diagrams showing the reagent portion according to the present invention. FIGS. 8A to 8D are diagrams showing a configuration example of an automatic chemical analyzer equipped with a dispensing device. FIGS. 1...Flow path switching means 2...Dispensing syringe 3.
... Cleaning liquid supply means 4 ... Container 5 ... Dispensing nozzle 6 ... Reagent tank 7 ... First common flow path 8 ... First switching valve 9 ... Drainage flow path
lO...Second common flow path 11...Second switching valve
12... Manifold block 13... Cleaning liquid tank 14... Pump 15... Open/close valve
21-1 to 21-4...Dispensing syringe 22-1.2
2-2...Unit 23-1.23-2...
Motor 24-1.24-2... Drive mechanism 258-1 to 250-1.258-2 to 250-2 ・
...Rotary hull 34-1.34-2...Evacuation tube 42-1 to 42-4...Reagent tank 43...Reaction container 44-1 to 44-4...Dispensing nozzle 45-1 ~115-4...Second common flow path 46...
Manifold blocks 47-1 to 47-4... Drain flow path 50... On-off valve 51... Branch block 52... Pump 53.
・Cleaning liquid tank. 4, )” , Relationship with the case of the person making the amendment Patent applicant (037) Olympus Optical Industry Co., Ltd. 4, Agent 1, Changed "koru yo na" to "kono shi" in lines 8-9 of page 2 of the specification. correct. 2. On page 6, line 12 of the same page, "diffused through the second common channel 10" is corrected to "diffused into the second common channel 10." 3. On page 18, lines 7 to 9, [the channel is...filled]
] is filled with the first reagent, and the flow path from the first reagent tank 42-1 to the suction port 29-1 is filled with the first reagent, and the flow path from the tip of the dispensing/spool 44-2 to the discharge port 28-2 is The flow path and the flow path from the second reagent tank 42-2 to the suction port 29-2 are filled with the second reagent.'' 4. Correct "initial setting operation" on page 14, line 15 of the same page to "initial setting operation."

Claims (1)

[Claims] 1. A first common flow path selectively connected to the reagent dispensing nozzle and the reagent container, respectively, and selectively connected to the first common flow path and the drainage flow path. a plurality of flow path switching means each having a second common flow path, and a common suction/discharge means connected to the second common flow path of the plurality of flow path switching means;
a cleaning liquid supply means connected to the suction/drainage means, and the cleaning liquid supply means causes the cleaning liquid to flow through the suction/drainage means, the second common flow path, and the drainage flow path;
A reagent dispensing device characterized in that it is configured to clean a common flow path of. 2. A patent characterized in that a plurality of sets of suction/exhaust means are provided in which the plurality of flow path switching means are connected, and the corresponding flow path switching means of each set are unitized together with a common driving means for simultaneously driving them. A reagent dispensing device according to claim 1.