JPS6135972Y2 - - Google Patents

Description

[Detailed explanation of the idea] The present invention relates to an automatic analyzer.

Conventionally, a sample solution, such as serum or urine, and the reagents necessary to analyze the desired components contained in the sample are dispensed into a reaction container to create a test solution. Various automatic analyzers for quantitatively analyzing desired components contained in a sample by colorimetric measurement are known. However, in conventional automatic analyzers, when setting analysis items, the operator generally has to set the reagents to be used, and separately from this operation, set the analysis conditions, such as the amount of sample dispensed, the amount of reagent dispensed, the photometric wavelength, etc. It is necessary to set various conditions depending on the analysis item, such as a concentration conversion coefficient, or to call up analysis conditions corresponding to the analysis item that have been input in advance. Therefore, the operations are complicated and there is a risk that the set reagents and analysis conditions may not correspond to each other.

In addition, in Japanese Patent Publication No. 54-5713, a plurality of rods are arranged in parallel, each having its length memorized with various operation timing information, i.e., analysis conditions, etc. required for measurement according to various types of measurement. A combination of keys is prepared, the key corresponding to the measurement item is selected from these keys, and the key is attached to the control mechanism of the analyzer to set the measurement item and its analysis conditions. is disclosed.

However, when the measurement item and its analytical conditions are set by using a key in this way, since the key is not actually necessary for the analysis, in addition to the operation of setting the reagent according to the measurement item, the operation of selecting the corresponding key and attaching it to the control mechanism is added, which makes the operation more complicated and causes mistakes such as the reagent set not corresponding to the attached key. In addition, it is necessary to prepare various keys in advance according to various measurement items, and each key needs to be connected in parallel with rods each having various analytical conditions required for that measurement stored according to their length, which makes it extremely difficult to manufacture the keys. Furthermore, since the control mechanism mechanically detects each rod of the attached key, there is a disadvantage that the detection mechanism becomes complicated and the entire device becomes expensive.

Furthermore, Japanese Patent Laid-Open No. 54-5791 discloses that a calibration container is provided at the head of each group of sample containers grouped according to necessary analysis items, and a means for identifying analysis items is provided in this calibration container. A system has been disclosed in which analysis items are set by detecting this.

However, when setting analysis items by providing a calibration container with an identification function for analysis items in this way, the calibration container is not originally necessary for the analysis, so
In addition to the operation of setting reagents according to the analysis item, the operation of setting the corresponding calibration container is added, which makes the operation complicated as in the case above, and also makes it difficult for the set reagents and the calibration container to be connected. The drawback is that mistakes can be made by not responding.

The object of the present invention is to eliminate the various drawbacks mentioned above, to provide an automatic analyzer that can be easily and inexpensively constructed, and that is suitably constructed so that analysis items can be reliably set with simple operations.

The automatic analyzer of the present invention includes: a reagent container mounting section to which a reagent container containing a predetermined reagent can be detachably mounted; a detector that photoelectrically identifies the reagent container mounted on the reagent container mounting section; A storage device that stores in advance analysis conditions such as sample dispensing amount, reagent dispensing amount, photometric wavelength, concentration conversion coefficient, etc. according to the analysis item, and identification from the storage device based on the identification signal from the detector. It is equipped with a control device that reads the analysis conditions for the analysis item corresponding to the reagent and controls the analysis operation, and is configured so that quantitative analysis of the desired analysis item can be automatically performed by attaching the required reagent container. It is characterized by the fact that

The present invention will be described in detail below with reference to the drawings.

FIG. 1 is an external perspective view diagrammatically showing the configuration of an example of the automatic analyzer of the present invention. A sampler 2 and a reaction disk 3 are rotatably mounted on the apparatus main body 1 so as to rotate intermittently at a constant period. The sampler 2 holds a plurality of sample cups 4 containing collected samples such as serum or urine on the same circumference, and the reaction disk 3 holds a plurality of cuvettes 5 on the same circumference. The apparatus body 1 is further provided with a reagent container mounting part 6, into which a reagent container 7 containing a predetermined reagent required for a desired analysis item is removably mounted, and the mounted reagent container is identified. A detector described later is provided. Further, the device main body 1 is provided with a probe 8 connected to a dispenser (not shown), and this probe allows the sampler 2 to
The sample in each sample cup 4 held in the sample cup 4 is aspirated at a predetermined suction position, and the reagent in a predetermined reagent container set in the reagent container mounting portion 6 is used as a diluent, and the sample is added to the reaction disk 3 together with this diluent. The configuration is such that a predetermined amount is sequentially dispensed into each cuvette 5 held at a predetermined discharge position. Furthermore, a probe 9 connected to a dispenser (not shown) is provided around the reaction disk 3, and at a position where each cuvette 5 is transported after a predetermined time has elapsed from the discharge position of the probe 8, a reagent container mounting portion 6 is provided. The second reagent is configured to dispense a predetermined amount of a reagent in another predetermined reagent container set as a second reagent. In this way, a test liquid is prepared by dispensing the sample and the second reagent into the cuvette 5, and after a predetermined period of time has elapsed, the test liquid is heated to a predetermined wavelength according to the analysis item at a position where it is transported. The configuration is such that the colorimetric measurement is performed through a filter that transmits the data, and required analysis data can be extracted from the output printer 10 based on the measured value and a density conversion coefficient according to the analysis item. Furthermore, the apparatus main body 1 includes an input keyboard for storing analysis conditions such as sample dispensing amount, reagent dispensing amount, photometric wavelength, concentration conversion coefficient, etc. in advance in a storage device, which will be described later, according to each analysis item. 11, and a monitor CRT 12 for displaying input information, analysis data, etc. using this keyboard. Furthermore, a control device (to be described later) that controls analysis operations according to analysis conditions for each analysis item is provided, and this control device allows data to be read from the above-mentioned storage device based on an identification signal from a detector provided in the reagent container mounting section 6. It is configured to read out the analysis conditions for the analysis item corresponding to the identified reagent and control the analysis operation for the required analysis item.

FIG. 2 is a diagram showing the configuration of essential parts of the automatic analyzer shown in FIG. 1. In FIG. 2, the same reference numerals as those shown in FIG. 1 indicate the same members. The output shaft of a pulse motor 15 is fixed to the sampler 2, and is configured to rotate intermittently at a constant period when driven by the pulse motor. The reaction disk 3 forms a gear on its periphery, and a pulse motor 16 is connected to this gear.
A fixed gear is meshed with the output shaft of the sampler 2, and the sampler 2 is driven by the pulse motor to rotate intermittently at a constant period in synchronization with the sampler 2. In this example, an opening is formed at the center of rotation of the reaction disk 3, and a photometric device for colorimetrically measuring the test liquid prepared in the cuvette 5 is provided in this opening.
This photometry device guides light emitted from a polychromatic light source 17 placed on the rotational center line of the reaction disk 3 onto the rotational center line through a lens 18 as a parallel light beam, and passes this photometric light beam through a prism 19 to a predetermined value. The light is projected onto the cuvette 5 in the radial direction of the reaction disk 3 at the photometry position, and the transmitted light of the cuvette 5 and the test liquid contained therein is received by the light receiver 20.
A filter 21 that transmits light of a predetermined wavelength depending on the analysis item is selectively interposed in the photometric optical path between the two. In this example, filters that transmit light of different wavelengths used in various analysis items are held on the same circumference by a filter holding member 22.
2 is rotated by a pulse motor 23, so that a filter that transmits light of a desired wavelength is interposed in the photometric optical path. This pulse motor 23 is driven via a driver 25 by the control device 24 explained in FIG. Also,
The output of the photodetector 20 is transmitted through an amplifier 26 and a logarithmic amplifier 27.
and is supplied to the control device 24 via the A/D converter 28.

The probe 8 passes through a switching valve 29 to a dispenser (syringe) 30 and a reagent container mounting portion 6 in FIG.
Among the reagent containers 7 set in the reagent container 7, the reagent container 7 is connected to a reagent container containing a reagent to be used as a diluent. The reagent container 7 set in the reagent container mounting section 6 is identified by the detector 31, and this identification signal is supplied to the control device 24 via the interface 32. In this example, each reagent container used in various analysis items is provided with a label 33 as shown in FIG. Detector 3
1 was configured to be read photoelectrically. In FIG. 2, the dispensing operation using the syringe 30 is performed by driving a pulse motor 34, and the dispensing amount of the sample and diluent can be controlled according to the analysis item. Drive control of the pulse motor 34 is performed by the control device 24 via a driver 35. In addition, in FIG. 1, the probe 9 for dispensing the second reagent into the cuvette 5 is also connected to a syringe and another predetermined reagent container set in the reagent container mounting part 6 through a switching valve, similarly to the probe 8. At the same time, the dispensing amount can also be controlled by the control device 24 according to the analysis item.
Similarly, the reagent container connected to the probe 9 is also identified by a detector, and the identification signal is supplied to the control device 24.

On the other hand, the storage device 36 stores in advance the analysis conditions of all analyzable items using the input keyboard 11, and supplies the analysis conditions of predetermined analysis items to the control device 24 in response to instructions from the control device 24. That is, the control device 24 reads the analysis conditions for the analysis item corresponding to the reagent identified by the detector 31 from the storage device 36, and controls the operation of the above-mentioned parts such as the pulse motors 23 and 34 based on the analysis conditions. At the same time, a predetermined concentration conversion coefficient is selected to control the analysis operation of the required analysis item.

As mentioned above, in the present invention, the reagent containers essential for analysis are identified.
By simply setting the reagent container corresponding to the desired analysis item, analysis of the desired item can be performed automatically and accurately. Also,
Since the reagent containers are identified photoelectrically,
The identification mechanism can be easily configured, and the entire device can be made inexpensive.

[Brief explanation of the drawing]

FIG. 1 is an external perspective view diagrammatically showing the configuration of an example of the automatic analyzer of the present invention, FIG. 2 is a diagram showing the configuration of the main parts of the automatic analyzer shown in FIG. 1, and FIG. FIG. 2 is an external perspective view showing the configuration of an example of a reagent container used in the invented automatic analyzer. 1... Main body, 2... Sampler, 3... Reaction disk, 4... Sample container, 5... Cuvette, 6
...Reagent container mounting part, 7...Reagent container, 8, 9...
... Probe, 17 ... Multicolor light source, 20 ... Light receiver, 21 ... Filter, 22 ... Filter holding member, 23 ... Pulse motor, 24 ... Control device, 30 ... Dispenser (syringe), 31...Detector, 33...Label, 34...Pulse motor, 3
6...Storage device.

Claims (1)

[Scope of utility model registration request] A reagent container mounting part to which a reagent container containing a predetermined reagent can be detachably mounted, a detector that photoelectrically identifies the reagent container mounted to the reagent container mounting part, and a sample dispensing device according to the analysis item. amount, reagent dispensing amount,
A storage device in which analysis conditions such as photometric wavelengths and concentration conversion coefficients are stored in advance, and analysis conditions for analysis items corresponding to the identified reagent are read out from the storage device based on the identification signal from the detector and analyzed. 1. An automatic analyzer comprising a control device for controlling operations and configured to automatically perform quantitative analysis of a desired analysis item by attaching a necessary reagent container.