JPS61164562A - Apparatus and method for treatment of body fluid component - Google Patents
Apparatus and method for treatment of body fluid componentInfo
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- JPS61164562A JPS61164562A JP60006341A JP634185A JPS61164562A JP S61164562 A JPS61164562 A JP S61164562A JP 60006341 A JP60006341 A JP 60006341A JP 634185 A JP634185 A JP 634185A JP S61164562 A JPS61164562 A JP S61164562A
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- processing device
- body fluid
- small processing
- small
- blood
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Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
「産業上の利用分野」
本発明は、血球成分及び血漿成分からなる血液をはじめ
として、リンパ液、腹水等、体内に存在する総ての体液
成分に対して、有害物質や不要成分の除去、薬効物質の
添加、不足成分の補充、他の体液成分との置換等、各種
の処理を加える体液成分処理回路において、その中枢部
となる体液成分処理装置に関するものである。Detailed Description of the Invention "Field of Industrial Application" The present invention is designed to eliminate harmful substances from all body fluid components present in the body, including blood consisting of blood cells and plasma components, lymph fluid, ascites, etc. The present invention relates to a body fluid component processing device, which is the central part of a body fluid component processing circuit that performs various processes such as removal of fluids and unnecessary components, addition of medicinal substances, replenishment of deficient components, and replacement with other body fluid components.
尚、本明−書においては、主として、体液が血液である
場合及び体液成分処理が血液内から低密度リポ蛋白質及
び極低密度リポ蛋白質（以下ＬＤＬと仮称する）を除去
するものである場合について説明する。In this specification, the case where the body fluid is blood and the case where the body fluid component treatment is to remove low density lipoproteins and very low density lipoproteins (hereinafter tentatively referred to as LDL) from the blood will be mainly discussed. explain.
「従来技術とその問題点」
第２図は、従来の体液成分処理装置（血漿用ＬＤＬ除去
装置）９を正面視した半断面図である。"Prior art and its problems" FIG. 2 is a half sectional view of a conventional body fluid component processing device (plasma LDL removal device) 9 viewed from the front.
同図に示すように体液成分処理装置９は、両端部に血漿
の流入口１９ａ及び流出口１９ｂを備えたカラム１６内
に、微粒子状のＬＤＬ吸着剤１７が封入されてなる。前
記カラム１６には、その流入口１９ａ及び流出口１９ｂ
を遮るようにメンブレンフィルター１８゜１８が収嵌さ
れており、前記ＬＤＬ吸着剤１７が漏れ出るのを遮断し
ている。As shown in the figure, the body fluid component processing device 9 includes a column 16 having an inlet 19a and an outlet 19b for plasma at both ends thereof, and a particulate LDL adsorbent 17 sealed therein. The column 16 has an inlet 19a and an outlet 19b.
A membrane filter 18° 18 is fitted so as to block the LDL adsorbent 17 from leaking out.
前記ＬＤＬ吸着剤１７の吸着能力は、該ＬＤＬ吸着剤１
７の乾燥体積がカラム１６の内容積に対して約５〜２５
％程度を占めるように分布しているときに最も効率よく
作用することが判明している。また、一般的体型を有す
る患者の体内から、−回の処理によって適量のＬＤＬを
除去するためのＬＤＬ吸着剤１７の吸着能力は、該ＬＤ
Ｌ吸着剤エフの量に換算すると約２０〜１００ｃｃとな
る。従って該ＬＤＬ、吸着剤１７を機能的な最良状態に
保つために、カラム１６の内容積は約２５０〜４００−
とされているのが普通であって、当初、残る２００〜３
８０ｃｃには、人体に無害な生理食塩水等の初期流通液
が満たされている。このようにしてなる従来の体液成分
処理装置９は、その内部を血漿成分が通過流通すること
によって、該血漿成分内のＬＤＬを、前記ＬＤＬ吸着剤
１７が選択的に吸着する。そして、その流通過程中には
、カラム１６内が血漿成分とＬＤＬ吸着剤１７とによっ
て充満される。The adsorption capacity of the LDL adsorbent 17 is the same as that of the LDL adsorbent 1.
The dry volume of column 7 is about 5 to 25 with respect to the internal volume of column 16.
It has been found that it works most efficiently when it is distributed so that it accounts for about %. Furthermore, the adsorption capacity of the LDL adsorbent 17 for removing an appropriate amount of LDL from the body of a patient with a typical body type through the treatment is as follows:
When converted to the amount of L adsorbent F, it is approximately 20 to 100 cc. Therefore, in order to maintain the LDL and adsorbent 17 in the best functional condition, the internal volume of the column 16 is approximately 250 to 400 -
Initially, the remaining 200 to 3
The 80cc is filled with an initial circulating fluid such as physiological saline that is harmless to the human body. In the conventional body fluid component processing device 9 constructed as described above, the LDL adsorbent 17 selectively adsorbs LDL in the plasma component as the plasma component flows through the interior thereof. During the flow process, the column 16 is filled with plasma components and the LDL adsorbent 17.
上記した体液成分処理装置９の使用例を第３図に示す。An example of the use of the above-mentioned body fluid component processing device 9 is shown in FIG.
同図は、血液の血漿成分内からＬＤＬを除去すべく構成
された血液成分処理用の回路図であって、該血液成分処
理回路の構成を血液の流れに沿って簡単に説明する。This figure is a circuit diagram for blood component processing configured to remove LDL from the plasma component of blood, and the configuration of the blood component processing circuit will be briefly explained along the flow of blood.
採血端１から採血圧力異常検出器２及び体液ポンプ３を
経て流れる血液は、ヘパリンポンプ４からのヘパリンと
混合されつつドリッパ−５へ至る。Blood flowing from the blood sampling end 1 via the blood sampling pressure abnormality detector 2 and the body fluid pump 3 reaches the dripper 5 while being mixed with heparin from the heparin pump 4.
血液は、次ぎに血漿分離１６の流入口６ａから流入し、
該血漿分離器６内において血球成分と血漿成分とに分離
される。このうち血漿成分は前記血漿分離器６の分離口
６ｂから漏血検出器７を経てドリッパ−８に至る。また
該ドリッパ−８内の血漿成分は、流量制御ポンプ１１の
駆動を受けてＬＤＬ除去装置９を通過し、次ぎのドリッ
パ−１０に至る。The blood then flows in through the inlet 6a of the plasma separator 16,
The blood is separated into blood cell components and plasma components in the plasma separator 6. Among these, the plasma component reaches the dripper 8 from the separation port 6b of the plasma separator 6 via the blood leakage detector 7. Further, the plasma component in the dripper 8 passes through the LDL removal device 9 under the drive of the flow rate control pump 11, and reaches the next dripper 10.
そして再び前記血漿分離器６の混入口６ｃへ流入する。Then, it flows into the mixing port 6c of the plasma separator 6 again.
そして前記の如く血漿分ｊｌｌＳ内において分離され、
そのまま血漿分離器６内を通過している血球成分と混合
され、成分処理が完了した血液となる。該血液は、血漿
分離器６の流出口６ｄから血液ヒーター１２．ドリッパ
−１３及び気泡検出器１４を経て返血端１５から人体へ
返血される。Then, as mentioned above, it is separated in the plasma fraction jllS,
It is mixed with the blood cell components passing through the plasma separator 6 as it is, resulting in blood whose component processing has been completed. The blood is transferred from the outlet 6d of the plasma separator 6 to the blood heater 12. Blood is returned to the human body from a blood return end 15 via a dripper 13 and a bubble detector 14.
ところで、血液中に含まれるＬＤＬの量には、外見的に
同様な体型の人であっても、疾患の進捗状況や体質によ
る個人差がある。従ってときとして前記体液成分処理袋
Ｗ９のＬＤＬ＆着能力、即ち内容積に不満足な場合が発
生する。しかし、体液成分処理装置９におけるカラム１
６の内容積を増大させるということは、患者の体外へ持
ち出される血液量が増加することを意味する。従って、
処理中の患者には血圧低下環が起きるおそれがあり、む
やみに体液成分処理装置９のＬＤＬ吸着能力を増加させ
ることはできなかった。つまり、前記体液成分処理装置
９の内容量は、従来において既に限界量にまで達してい
るのである。Incidentally, the amount of LDL contained in the blood varies from person to person depending on the progress of the disease and constitution, even among people with similar body shapes. Therefore, the LDL and loading capacity of the body fluid component processing bag W9, that is, the internal volume may sometimes be unsatisfactory. However, column 1 in the body fluid component processing device 9
Increasing the internal volume of 6 means increasing the amount of blood taken out of the patient's body. Therefore,
The LDL adsorption capacity of the body fluid component processing device 9 could not be increased unnecessarily because there was a risk that a blood pressure drop would occur in the patient during the treatment. In other words, the internal capacity of the body fluid component processing device 9 has already reached its limit in the prior art.
そこで、上記の如き欠点を解決するため、第４図に示す
如き体液成分処理装置４１が開発された。Therefore, in order to solve the above-mentioned drawbacks, a body fluid component processing device 41 as shown in FIG. 4 was developed.
該体液処理装置４１は、小容量を有する複数の小処理装
置４２．４３が、前後択一して処理に供されるように並
列接続されてなる。つまり、処理開始時において図面左
側の小処理装置４２に血漿成分を流通させて、該小処理
装置４２のＬＤＬ吸着′＃！Ａ能が飽和状態となったと
きに図中右側の小処理装置４３へ交替的に血漿成分を流
通させるのである。この体液成分処理装置４１の開発に
よって、患者の体外へ持ち出される血液量を最少限に抑
えることができたばかりでなく、その処理能力も個々の
患者の症状に合わせて増大できるようになった。ところ
が、このことによって、カラム内に当初充填されている
多量の初期流通液が体内に注入されることになる。前記
初期流通液は、前述した如く人体に対して無害ではある
が、多量分が体内に注入されることによって体内の循環
血液を希釈し、血液の膠質浸透圧の低下を招くおそれが
あった。また、処理終了後において容器内に残留した体
液は、人体に帰されず廃棄させられていた。The body fluid processing device 41 is made up of a plurality of small processing devices 42 and 43 each having a small capacity connected in parallel so that front and rear processing can be selectively performed. That is, at the start of treatment, plasma components are passed through the small processing device 42 on the left side of the drawing, and the small processing device 42 adsorbs LDL. When the A capacity is saturated, plasma components are alternately distributed to the small processing device 43 on the right side of the figure. The development of this body fluid component processing device 41 has not only made it possible to minimize the amount of blood taken out of the patient's body, but also made it possible to increase its processing capacity in accordance with the symptoms of each individual patient. However, this results in a large amount of the initial flow fluid initially filled in the column being injected into the body. As mentioned above, the initial circulation liquid is harmless to the human body, but if a large amount is injected into the body, it may dilute the circulating blood in the body, leading to a decrease in the colloid osmotic pressure of the blood. Furthermore, body fluids remaining in the container after the treatment has been disposed of without being returned to the human body.
「発明の目的」
本発明は、上記の如き事情に鑑みてなされたものであっ
て、体液成分処理中における体液の外部循環量を少なく
すると共に、人体にとって不要な初期流通液が、体内に
注入される量を可能な限り減少させ、体液の損失も少な
い新規な体液成分処理装置（以下、本発明処理装置とい
う）及び体液成分処理方法（以下、本発明処理方法とい
う）を提供することを目的とする。``Object of the Invention'' The present invention has been made in view of the above-mentioned circumstances, and aims to reduce the amount of external circulation of body fluid during treatment of body fluid components, and to reduce the amount of initially circulating fluid that is unnecessary for the human body by injecting it into the body. The purpose of the present invention is to provide a novel body fluid component treatment device (hereinafter referred to as the treatment device of the present invention) and a body fluid component treatment method (hereinafter referred to as the treatment method of the present invention) in which the amount of body fluids is reduced as much as possible and loss of body fluids is small. shall be.
「発明の構成」 （問題点を解決するための手段） 本発明処理装置の要旨とするところは、血液。"Structure of the invention" (Means for solving problems) The gist of the processing apparatus of the present invention is to treat blood.
リンパ液、腹水その他の体液に各種の処理を加走る体液
成分処理回路内に設けられ、複数の小処理装置が前後択
一して処理に供されるべく並列接続されてなり、前段と
なる小処理装置には停留体液の送出機構が備えられ、後
段となる小処理装置には初期流通液の排出機構が備えら
れていることである。It is installed in a body fluid component processing circuit that performs various processes on lymph fluid, ascites, and other body fluids, and multiple small processing devices are connected in parallel to selectively perform processing. The device is equipped with a mechanism for discharging the retained body fluid, and the subsequent small processing device is equipped with a mechanism for discharging the initial circulating fluid.
また、各小処理装置の上流側分岐部及び下流側合流部に
は自動制御装置を備えた流路切換弁が設けられているこ
とである。In addition, a flow path switching valve equipped with an automatic control device is provided at the upstream branch section and the downstream confluence section of each small processing device.
また、本発明処理方法の要旨とするところは、前段不処
理装置へ血液、リンパ液、腹水その他の採取体液を流通
させ、該前段不処理装置での処理が終了した時点で該前
段不処理装置と並列接続された後段不処理装置へ体液□
供給路を切り換えて該後段不処理装置へ採取体液・を供
給させ、該後段小処理装置内に予め充満された初期流通
液を前記採取体液によって回路外へ排出しつつ、前記前
段小処理装置内に飽和状態にある停留体液を適宜の手段
によって回路継続路へ送り出し、該前記小処理装置内の
停留体液及び後段小処理装置内の初期流通液が排出され
た後、前記回路継続路を後段小娼理装置へ切り換えて該
後段小処理装置内に採取体液を流通させることである。In addition, the gist of the processing method of the present invention is that blood, lymph fluid, ascites, and other collected body fluids are distributed to the pre-stage non-processing device, and when the processing in the pre-stage non-processing device is completed, the collected body fluids are transferred to the pre-stage non-processing device. Body fluids to parallel-connected downstream non-processing equipment□
The supply path is switched to supply the sampled body fluid to the second-stage non-processing device, and while the initial circulating fluid that has been filled in the second-stage small processing device is discharged from the circuit by the collected body fluid, the second-stage small processing device is The stagnant body fluid in a saturated state is sent to the circuit continuation path by appropriate means, and after the stagnant body fluid in the small processing device and the initial circulating fluid in the subsequent small processing device are discharged, the circuit continuation path is transferred to the subsequent small processing device. The procedure is to switch to the dispensing device and distribute the collected body fluid in the subsequent small processing device.
（実施例）
以下本発明を、その実施例を示す図面に基づいて説明す
ると次のとおりである。(Example) The present invention will be described below based on drawings showing examples thereof.
第１図はミ本発明処理装置を示す正面図である。FIG. 1 is a front view showing the processing apparatus of the present invention.
同図に示すように本発明処理装置の最も特徴とするとこ
ろは、流路切換弁２２．２３によって並列接続された複
数の小処理装置（２０，２１）のうち、前段となる小処
理装置（例えば符号２０とし、以下前段小処理装置と仮
称する）には、停留体液の送出機構３８が備えられてい
ると共に、後段となる小処理装置（符号２１とし、以下
後段小処理装置と仮称する）には、初期流通液の排出機
構３９が備えられている点にある。尚、本実施例におい
て各小処理装置（２０，２１）夫々の内容積は、従来の
ものに比してその部分した内容積に等しくなっている。As shown in the figure, the most distinctive feature of the processing apparatus of the present invention is that among the plurality of small processing apparatuses (20, 21) connected in parallel by flow path switching valves 22, 23, the small processing apparatus ( For example, a small processing device 20 (hereinafter referred to as the front stage small processing device) is equipped with a mechanism 38 for discharging the retained body fluid, and a rear stage small processing device (hereinafter referred to as the number 21, tentatively called the second stage small processing device) is provided. is equipped with a discharge mechanism 39 for the initial circulating liquid. In this embodiment, the internal volume of each small processing device (20, 21) is equal to its partial internal volume, compared to the conventional one.
送出機構３８は、初期流通液の貯留袋２５と、送液ポン
プ２６と、流路開閉弁２７とからなり、前段不処理装置
２０の上流側に、分岐管３０を介して接続されている。The delivery mechanism 38 includes a storage bag 25 for the initial circulating liquid, a liquid feeding pump 26, and a channel opening/closing valve 27, and is connected to the upstream side of the pre-stage non-processing device 20 via a branch pipe 30.
排出機構３９は、流路開閉弁２８と、廃液管２９とから
なり、後段不処理装置２１の下流側に、分岐管３３を介
して接続されている。The discharge mechanism 39 includes a channel opening/closing valve 28 and a waste liquid pipe 29, and is connected to the downstream side of the subsequent non-processing device 21 via a branch pipe 33.
流路切換弁２２は前段不処理装置２０と後段不処理装置
２１との上流側分岐部に設けられ、体液供給路が前段不
処理装置２０又は後段不処理装置２１に択一的に連通ず
るように切り換わり、流路切換弁２３は前段不処理装置
２０と後段不処理装置２１との下流側合流部に設けられ
、回路継続路が前段不処理装置２０又は後段不処理装置
２１に択一的に連通するように切り換わる如く、各々、
独自に駆動可能に制御されている。The flow path switching valve 22 is provided at the upstream branch of the front-stage non-treatment device 20 and the second-stage non-treatment device 21, so that the body fluid supply path is selectively communicated with the first-stage non-treatment device 20 or the second-stage non-treatment device 21. , the flow path switching valve 23 is provided at the downstream confluence of the pre-stage non-processing device 20 and the post-stage non-processing device 21, and the circuit continuation path is selectively connected to the pre-stage non-processing device 20 or the post-stage non-processing device 21. As if switching to communicate with each other,
It is controlled so that it can be driven independently.
本発明処理装置は、例えば前記第３図に示す如き血液成
分処理回路内において、体液成分処理装置９が設置され
た同一箇所（点線で囲まれた部分）に組み込まれる。そ
して本発明処理装置は、第１図における図面上部の管端
３６が血漿成分の流入側となり、図面下部の管端３７が
血漿成分の流出側となるように接続される。The processing device of the present invention is installed, for example, in a blood component processing circuit as shown in FIG. 3, at the same location (the part surrounded by the dotted line) where the body fluid component processing device 9 is installed. The processing apparatus of the present invention is connected such that the tube end 36 at the top of the drawing in FIG. 1 becomes the inflow side of the plasma component, and the tube end 37 at the bottom of the drawing becomes the outflow side of the plasma component.
次ぎに本発明処理方法を、前述の如くしてなる本発明処
理装置の使用状況に沿って説明する。Next, the processing method of the present invention will be explained along with the usage situation of the processing apparatus of the present invention as described above.
、本発明処理装置の使用前において、流路切換弁２２は
体液供給路を前段不処理装置２０へ連通し、流路切換弁
２３は回路継続路を前段不処理装置２０へ連通し、流路
開閉路２７及び２８は閉止状態にある。, before the treatment apparatus of the present invention is used, the flow path switching valve 22 connects the body fluid supply path to the pre-stage non-processing device 20, the flow path switching valve 23 connects the circuit continuation path to the pre-stage non-processing device 20, and the flow path The switching paths 27 and 28 are in a closed state.
まず、体内から採取された血漿成分は、流量制御ポンプ
１１によって前段不処理装置２０へ導かれる。First, plasma components collected from the body are guided to the pre-treatment device 20 by the flow rate control pump 11.
そして該前段不処理装置２０によってＬＤＬの吸着が行
われつつ、流路切換弁２３を介して回路継続路へと流通
する。Then, while LDL is adsorbed by the pre-stage non-processing device 20, it flows to the circuit continuation path via the flow path switching valve 23.
流通時間の経過又は視覚認識によって前段不処理装置２
０のＬＤＬ吸着効率が低下又は飽和したことを確認した
後、流路切換弁２２を切り換えて体液供給路を後段小処
理装置２１側へ連通させ、同時に前段不処理装置２０の
送出機構３８と、後段不処理装置２１の排出機構３９と
を駆動させる。送出機構３８の駆動は流路開閉弁２７が
開、送液ポンプ２６が回転駆動することによって行われ
、排出機構３９の駆動は流路開閉弁２８が開になること
によって行われる。Depending on the passage of distribution time or visual recognition, the first stage non-processing device 2
After confirming that the LDL adsorption efficiency of 0 is reduced or saturated, the flow path switching valve 22 is switched to connect the body fluid supply path to the downstream small processing device 21 side, and at the same time, the delivery mechanism 38 of the upstream non-processing device 20, The discharging mechanism 39 of the subsequent non-processing device 21 is driven. The delivery mechanism 38 is driven by opening the channel opening/closing valve 27 and rotating the liquid feeding pump 26, and the discharging mechanism 39 is driven by opening the channel opening/closing valve 28.
この一連の動作によって採取体液は後段不処理装置２１
へ供給され、該後段不処理装置２１内に予め充満されて
いた初期流通液が追い出されて廃液管２９へ排出される
。また、前段小処理装置２０内に残留する停留体液は貯
留袋２５からの初期流通液によって引続き回路継続路へ
送り出される。尚、このときの送液ポンプ２６の送液付
与力、即ち初期流通液の供給流量は、前段不処理装置２
０へ供給されていた血漿成分の流量と等しくしておくこ
とが好ましい。Through this series of operations, the collected body fluid is transferred to the subsequent non-processing device 21.
The initial circulating liquid that was previously filled in the latter non-processing device 21 is expelled and discharged to the waste liquid pipe 29. Further, the stagnant body fluid remaining in the pre-stage small processing device 20 is continuously sent out to the circuit continuation path by the initial distribution fluid from the storage bag 25. Note that the liquid feeding force of the liquid feeding pump 26 at this time, that is, the supply flow rate of the initial circulating liquid is
It is preferable to keep the flow rate equal to the flow rate of the plasma component that was being supplied to 0.
前段小処理装置２０内の殆どの停留体液が回路継続路へ
送り出され、後段不処理装置２１内の初期流通液が総て
廃液管２９へ排出された後は、流路切換弁２３を切り換
えて回路継続路を後段不処理装置２１へ連通させる。こ
のことによって体内から採取される血漿成分は、後段不
処理装置２１を流通するようになる。After most of the stagnant body fluid in the front-stage small treatment device 20 has been sent out to the circuit continuation path and all the initial circulating fluid in the rear-stage non-treatment device 21 has been discharged to the waste liquid pipe 29, the flow path switching valve 23 is switched. The circuit continuation path is communicated to the subsequent non-processing device 21. This allows the plasma components collected from the body to flow through the subsequent non-processing device 21.
（別態様の検討）
流量制御ポンプ１１と送液ポンプ２６とを釣合装置３４
（二点鎖線で示す）によって連動制御して、後段不処理
装置２１へ供給する採取体液の流量と、前段不処理装置
２０へ供給する初期流通液の流量とを等しく釣り合わせ
ておけば、前段小処理装置２０内の殆どの停留体液が回
路継続路へ送り出される完了タイミングと後段不処理装
置２１内の総ての初期流通液が排出される完了タイミン
グとを同期させることができる。また、前段不処理装置
２０の下流側に、流路開閉弁２Ｂに連通ずる回避管３５
（二点鎖線で示す）を設けておけば、前段小処理装置２
０内に充填されている初期流通液をも排出管２９へ追い
出すことが可能になり、本発明、に係る体液成分処理装
置のみに関していえば、全く初期流通液を体内へ注入す
ることはない。また、後段不処理装置２１の上流側に流
路制御弁２７に連通ずる回避路４０（二点鎖線で示す）
を設けておけば、処理終了後において貯留袋２５から後
段不処理装置２１へ初期流通液を供給し、該後段不処理
装置２１内に停留する血漿成分を回収することもできる
。更に、前記実施例においては図面左側、の小処理装置
２０を前段不処理装置とし、図面右側の小処理装置２１
を後段不処理装置として説明したが、回避管３５及び回
避管４０を備える回路構成としておくならば、いずれが
前段側又は後段側となっても構わない、勿論、これら小
処理装置の設置数に関しては全く限定されるものではな
い、このように、本発明に係る体液成分処理装置及び体
液成分処理方法の細部にわたる構成は、実施の態様に応
じて適宜変更可能なものである。(Study of another aspect) The flow rate control pump 11 and the liquid feeding pump 26 are connected to a balancing device 34.
(indicated by the two-dot chain line) to equalize the flow rate of the collected body fluid supplied to the post-stage non-processing device 21 and the flow rate of the initial circulating fluid supplied to the pre-stage non-processing device 20. It is possible to synchronize the completion timing at which most of the stagnant body fluid in the small processing device 20 is sent out to the circuit continuation path and the completion timing at which all the initial circulation fluid in the subsequent non-processing device 21 is discharged. Further, on the downstream side of the pre-stage non-processing device 20, an avoidance pipe 35 communicating with the flow path opening/closing valve 2B is provided.
(shown by the two-dot chain line), the front small processing device 2
It becomes possible to expel the initial circulating fluid filled in the body into the discharge pipe 29, and as far as the body fluid component processing device according to the present invention is concerned, no initial circulating fluid is injected into the body. Further, an avoidance path 40 (indicated by a two-dot chain line) communicating with the flow path control valve 27 is provided on the upstream side of the subsequent non-processing device 21.
If this is provided, it is also possible to supply the initial circulation liquid from the storage bag 25 to the subsequent non-processing device 21 after the completion of the treatment, and to collect the plasma components remaining in the subsequent non-processing device 21. Furthermore, in the above embodiment, the small processing device 20 on the left side of the drawing is used as a pre-stage non-processing device, and the small processing device 21 on the right side of the drawing
has been described as a post-stage non-processing device, but as long as the circuit configuration includes the avoidance pipe 35 and the avoidance pipe 40, it does not matter which one is on the front-stage side or the post-stage side.Of course, regarding the number of installations of these small processing devices As described above, the detailed structure of the body fluid component processing device and the body fluid component processing method according to the present invention can be changed as appropriate depending on the embodiment.
「発明の効果」
以上の説明で明らかなように、本発明に係る体液成分処
理装置及び体液成分処理方法によれば、患者の体外へ持
ち出す採取体液の量を、血圧低下に繋がらない範囲に抑
えることができると共に、初期流通液が人体に注入され
る量も可能な限り少なくすることができる。"Effects of the Invention" As is clear from the above explanation, according to the body fluid component processing device and the body fluid component processing method according to the present invention, the amount of collected body fluid taken out of the patient's body is suppressed to a range that does not lead to a drop in blood pressure. At the same time, the amount of the initial circulating fluid injected into the human body can be reduced as much as possible.
【図面の簡単な説明】
第１図は本発明処理装置を示す正面図、第２図は従来の
体液成分処理装置を正面視して示す半断面図、第３図は
前記従来の体液成分処理装置を使用した一例を示す血液
成分処理用の回路図、第４図は従来の別の体液成分処理
装置を示す正面図である。
９・・・体液成分処理装置（従来）
２０・・・（前段）小処理装置
２１・・・（後段）小処理装置
２２、２３・・・流路切換弁 ３６・・・送液機構特
許出願人 鐘淵化学工業株式会社
出願代理人 弁理士 内１）敏彦
第２図
９ｂ[BRIEF DESCRIPTION OF THE DRAWINGS] Fig. 1 is a front view showing the processing device of the present invention, Fig. 2 is a half sectional view showing the conventional body fluid component processing device as seen from the front, and Fig. 3 is the conventional body fluid processing device. A circuit diagram for blood component processing showing an example of the use of the device, and FIG. 4 is a front view showing another conventional body fluid component processing device. 9... Body fluid component processing device (conventional) 20... (first stage) small processing device 21... (second stage) small processing device 22, 23... flow path switching valve 36... liquid feeding mechanism patent application Person Kanebuchi Chemical Industry Co., Ltd. Application agent Patent attorney 1) Toshihiko Figure 2 9b
Claims (1)
加える体液成分処理回路内に設けられ、複数の小処理装
置が前後択一して処理に供されるべく並列接続されてな
り、前段となる小処理装置には停留体液の送出機構が備
えられ、後段となる小処理装置には初期流通液の排出機
構が備えられていることを特徴とする体液成分処理装置
。 ２、各小処理装置の上流側分岐部及び下流側合流部には
自動制御装置を備えた流路切換弁が設けられている特許
請求の範囲第１項記載の体液成分処理装置。 ３、前段小処理装置へ血液、リンパ液、腹水その他の採
取体液を流通させ、該前段小処理装置での処理が終了し
た時点で該前段小処理装置と並列接続された後段小処理
装置へ体液供給路を切り換えて該後段小処理装置へ採取
体液を供給させ、該後段小処理装置内に予め充満された
初期流通液を前記採取体液によって回路外へ排出しつつ
、前記前段小処理装置内に飽和状態にある停留体液を適
宜の手段によって回路継続路へ送り出し、該前記小処理
装置内の停留体液及び後段小処理装置内の初期流通液が
排出された後、前記回路継続路を後段小処理装置へ切り
換えて該後段小処理装置内に採取体液を流通させること
を特徴とする体液成分処理方法。[Scope of Claims] 1. Provided within a body fluid component processing circuit that performs various processes on blood, lymph fluid, ascites, and other body fluids, and a plurality of small processing devices are connected in parallel so that processing can be performed selectively. What is claimed is: 1. A body fluid component processing device characterized in that the first stage small processing device is equipped with a mechanism for discharging retained body fluid, and the second stage small processing device is equipped with a discharge mechanism for initially circulating fluid. 2. The body fluid component processing device according to claim 1, wherein a flow path switching valve equipped with an automatic control device is provided at the upstream branch section and the downstream confluence section of each small processing device. 3. Flow blood, lymph, ascites, and other collected body fluids to the front small processing device, and when the processing in the front small processing device is completed, supplying the body fluid to the second small processing device connected in parallel with the first small processing device. The route is switched to supply the collected body fluid to the downstream small processing device, and while the initial circulating fluid that has been filled in the downstream small processing device is discharged out of the circuit by the collected body fluid, the upstream small processing device is saturated. After the stagnant body fluid in the state is sent to the circuit continuation path by an appropriate means, and the stagnant body fluid in the small processing device and the initial circulating fluid in the subsequent small processing device are discharged, the circuit continuation path is transferred to the subsequent small processing device. A method for processing body fluid components, characterized in that the collected body fluid is circulated through the subsequent small processing device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60006341A JPS61164562A (en) | 1985-01-16 | 1985-01-16 | Apparatus and method for treatment of body fluid component |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60006341A JPS61164562A (en) | 1985-01-16 | 1985-01-16 | Apparatus and method for treatment of body fluid component |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS61164562A true JPS61164562A (en) | 1986-07-25 |
Family
ID=11635661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60006341A Pending JPS61164562A (en) | 1985-01-16 | 1985-01-16 | Apparatus and method for treatment of body fluid component |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61164562A (en) |
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS645563A (en) * | 1987-06-30 | 1989-01-10 | Terumo Corp | Apparatus for removing unnecessary substance in blood |
| JPH01121062A (en) * | 1987-11-05 | 1989-05-12 | Kanegafuchi Chem Ind Co Ltd | Operational process and device for adsorption system composed of a plurality of adsorbers |
| US4855057A (en) * | 1986-09-30 | 1989-08-08 | Yokogawa Electric Corporation | Regeneration type body fluid treating circuit and method for treating body fluid |
| JP2006223723A (en) * | 2005-02-21 | 2006-08-31 | Hitachi Ltd | Blood purifying apparatus and blood purifying method |
| JP2017511168A (en) * | 2014-02-19 | 2017-04-20 | メドトロニック，インコーポレイテッド | Module for refilling adsorbent material inline with optional bypass |
| JP2017511167A (en) * | 2014-02-19 | 2017-04-20 | メドトロニック，インコーポレイテッド | Parallel module for refilling adsorbents inline using alternating duty cycles |
| US10052612B2 (en) | 2013-11-26 | 2018-08-21 | Medtronic, Inc. | Zirconium phosphate recharging method and apparatus |
| US10052624B2 (en) | 2013-11-26 | 2018-08-21 | Medtronic, Inc. | Zirconium phosphate and zirconium oxide recharging flow paths |
| US10064986B2 (en) | 2013-11-26 | 2018-09-04 | Medtronic, Inc. | Recharger for recharging zirconium phosphate and zirconium oxide modules |
| US10071323B2 (en) | 2013-11-26 | 2018-09-11 | Medtronic, Inc | Module for in-line recharging of sorbent materials with optional bypass |
| US10099214B2 (en) | 2013-11-26 | 2018-10-16 | Medtronic, Inc. | Zirconium phosphate and zirconium oxide recharger control logic and operational process algorithms |
| US10099215B2 (en) | 2013-11-26 | 2018-10-16 | Medtronic, Inc. | Management of recharger effluent pH |
| US10159957B2 (en) | 2013-11-26 | 2018-12-25 | Medtronic, Inc. | Zirconium phosphate recharging customization |
| US10245365B2 (en) | 2014-06-24 | 2019-04-02 | Medtronic, Inc. | Replenisihing urease in dialysis systems using a urease introducer |
| US10478545B2 (en) | 2013-11-26 | 2019-11-19 | Medtronic, Inc. | Parallel modules for in-line recharging of sorbents using alternate duty cycles |
| US10537875B2 (en) | 2013-11-26 | 2020-01-21 | Medtronic, Inc. | Precision recharging of sorbent materials using patient and session data |
| US10807068B2 (en) | 2014-06-24 | 2020-10-20 | Medtronic, Inc. | Sorbent pouch |
| US10821214B2 (en) | 2014-06-24 | 2020-11-03 | Medtronic, Inc. | Urease introduction system for replenishing urease in a sorbent cartridge |
| US10888800B2 (en) | 2014-06-24 | 2021-01-12 | Medtronic, Inc | Replenishing urease in dialysis systems using urease pouches |
| US10926017B2 (en) | 2014-06-24 | 2021-02-23 | Medtronic, Inc. | Modular dialysate regeneration assembly |
| US10960381B2 (en) | 2017-06-15 | 2021-03-30 | Medtronic, Inc. | Zirconium phosphate disinfection recharging and conditioning |
| US10981148B2 (en) | 2016-11-29 | 2021-04-20 | Medtronic, Inc. | Zirconium oxide module conditioning |
| US11045790B2 (en) | 2014-06-24 | 2021-06-29 | Medtronic, Inc. | Stacked sorbent assembly |
| US11167070B2 (en) | 2017-01-30 | 2021-11-09 | Medtronic, Inc. | Ganged modular recharging system |
| US11213616B2 (en) | 2018-08-24 | 2022-01-04 | Medtronic, Inc. | Recharge solution for zirconium phosphate |
| US11857712B2 (en) | 2013-01-09 | 2024-01-02 | Mozarc Medical Us Llc | Recirculating dialysate fluid circuit for measurement of blood solute species |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5450172A (en) * | 1977-09-27 | 1979-04-19 | Toshimitsu Niwa | Artificial retina internal system device that can continuously be used |
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1985
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5450172A (en) * | 1977-09-27 | 1979-04-19 | Toshimitsu Niwa | Artificial retina internal system device that can continuously be used |
Cited By (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855057A (en) * | 1986-09-30 | 1989-08-08 | Yokogawa Electric Corporation | Regeneration type body fluid treating circuit and method for treating body fluid |
| US4863590A (en) * | 1986-09-30 | 1989-09-05 | Yokogawa Electric Corp. | Regeneration type body fluid treating circuit and method for treating body fluid |
| JPS645563A (en) * | 1987-06-30 | 1989-01-10 | Terumo Corp | Apparatus for removing unnecessary substance in blood |
| JPH0580909B2 (en) * | 1987-06-30 | 1993-11-10 | Terumo Corp | |
| JPH01121062A (en) * | 1987-11-05 | 1989-05-12 | Kanegafuchi Chem Ind Co Ltd | Operational process and device for adsorption system composed of a plurality of adsorbers |
| JP2006223723A (en) * | 2005-02-21 | 2006-08-31 | Hitachi Ltd | Blood purifying apparatus and blood purifying method |
| US11857712B2 (en) | 2013-01-09 | 2024-01-02 | Mozarc Medical Us Llc | Recirculating dialysate fluid circuit for measurement of blood solute species |
| US10343145B2 (en) | 2013-11-26 | 2019-07-09 | Medtronic, Inc. | Zirconium phosphate recharging method and apparatus |
| US10159957B2 (en) | 2013-11-26 | 2018-12-25 | Medtronic, Inc. | Zirconium phosphate recharging customization |
| US10052624B2 (en) | 2013-11-26 | 2018-08-21 | Medtronic, Inc. | Zirconium phosphate and zirconium oxide recharging flow paths |
| US10064986B2 (en) | 2013-11-26 | 2018-09-04 | Medtronic, Inc. | Recharger for recharging zirconium phosphate and zirconium oxide modules |
| US10071323B2 (en) | 2013-11-26 | 2018-09-11 | Medtronic, Inc | Module for in-line recharging of sorbent materials with optional bypass |
| US10099214B2 (en) | 2013-11-26 | 2018-10-16 | Medtronic, Inc. | Zirconium phosphate and zirconium oxide recharger control logic and operational process algorithms |
| US10099215B2 (en) | 2013-11-26 | 2018-10-16 | Medtronic, Inc. | Management of recharger effluent pH |
| US11219880B2 (en) | 2013-11-26 | 2022-01-11 | Medtronic, Inc | System for precision recharging of sorbent materials using patient and session data |
| US10052612B2 (en) | 2013-11-26 | 2018-08-21 | Medtronic, Inc. | Zirconium phosphate recharging method and apparatus |
| US10668202B2 (en) | 2013-11-26 | 2020-06-02 | Medtronic, Inc. | Parallel modules for in-line recharging of sorbents using alternate duty cycles |
| US10478545B2 (en) | 2013-11-26 | 2019-11-19 | Medtronic, Inc. | Parallel modules for in-line recharging of sorbents using alternate duty cycles |
| US10537875B2 (en) | 2013-11-26 | 2020-01-21 | Medtronic, Inc. | Precision recharging of sorbent materials using patient and session data |
| JP2017511167A (en) * | 2014-02-19 | 2017-04-20 | メドトロニック，インコーポレイテッド | Parallel module for refilling adsorbents inline using alternating duty cycles |
| JP2017511168A (en) * | 2014-02-19 | 2017-04-20 | メドトロニック，インコーポレイテッド | Module for refilling adsorbent material inline with optional bypass |
| US10807068B2 (en) | 2014-06-24 | 2020-10-20 | Medtronic, Inc. | Sorbent pouch |
| US10888800B2 (en) | 2014-06-24 | 2021-01-12 | Medtronic, Inc | Replenishing urease in dialysis systems using urease pouches |
| US10926017B2 (en) | 2014-06-24 | 2021-02-23 | Medtronic, Inc. | Modular dialysate regeneration assembly |
| US11045790B2 (en) | 2014-06-24 | 2021-06-29 | Medtronic, Inc. | Stacked sorbent assembly |
| US10821214B2 (en) | 2014-06-24 | 2020-11-03 | Medtronic, Inc. | Urease introduction system for replenishing urease in a sorbent cartridge |
| US11673118B2 (en) | 2014-06-24 | 2023-06-13 | Mozarc Medical Us Llc | Stacked sorbent assembly |
| US10245365B2 (en) | 2014-06-24 | 2019-04-02 | Medtronic, Inc. | Replenisihing urease in dialysis systems using a urease introducer |
| US10981148B2 (en) | 2016-11-29 | 2021-04-20 | Medtronic, Inc. | Zirconium oxide module conditioning |
| US11642654B2 (en) | 2016-11-29 | 2023-05-09 | Medtronic, Inc | Zirconium oxide module conditioning |
| US11167070B2 (en) | 2017-01-30 | 2021-11-09 | Medtronic, Inc. | Ganged modular recharging system |
| US10960381B2 (en) | 2017-06-15 | 2021-03-30 | Medtronic, Inc. | Zirconium phosphate disinfection recharging and conditioning |
| US11883794B2 (en) | 2017-06-15 | 2024-01-30 | Mozarc Medical Us Llc | Zirconium phosphate disinfection recharging and conditioning |
| US11213616B2 (en) | 2018-08-24 | 2022-01-04 | Medtronic, Inc. | Recharge solution for zirconium phosphate |
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