JPS6088531A - Endoscope with inspector - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an endoscope with an inspection device for inspecting a lesion in a body cavity using photoacoustic effects.

Conventionally, endoscopes have optical fibers in both sides, 1 rij, and i part. It consists of a bundle (abbreviated as light guide), forceps, etc. This operation of the endoscope ('+:R) involves illuminating the inside of the body cavity with a light guide, observing the inside of this body cavity with an image guide, and using forceps once a month to remove a site that is recognized as a lesion inside the body cavity. 1J) I=-ko d1. Tetsubo JJ'V I-tal:f O1. Ic
d. In the method of analyzing the composition of an abnormal part of a subject based on the method of examining whether there is a lesion in that part, it is necessary to injure a part of the subject, which is not desirable. Since the tissue was collected from the subject, it was impossible to analyze the living tissue.

Recently, in order to detect the fourth stage of cancer, a specific drug solution is injected into the subject and absorbed into the subject's tissues, and then an optical fiber that guides laser light is passed through the forceps hole of the endoscope into the body cavity. By tilting the body, laser light from the outside is guided into the body cavity, and areas within the body cavity that are irradiated with this laser light, where cancer cells are located, emit fluorescence, and the absence of this fluorescence is observed. As a result, a method for diagnosing the presence of W child cells was proposed.
・Ru.

However, with this method, when the growth of the cancer cells themselves is incomplete, the lesion may not emit fluorescence or the fluorescence may be weak, so there is a possibility that the lesion may be overlooked.

The present invention has been made in view of the above points and to eliminate the above drawbacks, and is based on the realization that tissue analysis within body cavities using photoacoustic spectroscopy provides more important diagnostic information.
Inaugural celebration of inspection equipment using photoacoustic spectroscopy', j', i:
By applying it to the body cavity, it is possible to damage the internal tissue without being affected by the surface condition of the tissue within the body cavity. Many biological samples and biological substances have shapes and conditions that are difficult to measure using other spectroscopic methods. In addition, there is no need to perform any 1111 processing on the sample, and any information related to the absorption spectrum can be obtained as is.From this point, the photoacoustic spectrum Q' is considered to be an extremely powerful spectrum measurement method. The photophonic effect is a phenomenon in which a material absorbs light, causing a local temperature increase of 2111'1 degrees, which propagates through the material as pressure, resulting in an acoustic response.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS An embodiment of an endoscope placed on the side of an inspection device according to the present invention will be described in detail with reference to the drawings.

FIG. 7(a), Ib) is an embodiment of the present invention,
FIG. 7(a) is an explanatory diagram of the entire cross section of the endoscope with inspection device E1, and FIG. 1(b) is the light source section of FIG. 1(a). In the figure, / is the endoscope body, and the part inserted into the body cavity except the observation side is flexible. An image guide a with flexibility and a light guide 3 with flexibility are provided inside the endoscope body, and at the tip of the image guide is a prism for changing the optical path, and an imaging lens is attached to the tip of the image guide. Similarly, at the tip of the ride guide 3, a condenser lens B for condensing light and a prism 7 for changing the optical path are arranged. g is the observation glass window 711 provided at the tip of the endoscope body, through which the object 1 is observed through the imaging lens, the prism, and the image guide.
In addition, the light passing through the light guide 3 can illuminate the body wall of the subject/shio to be observed through the condenser lens O and the prism 7. l: Placed in an upright position at ℃・ru.

Reference numeral 9 denotes a piezoelectric element for detecting the light of the subject/S), which is fixedly installed on the outside of any glass window, preferably transparent, and located within the observation field of image guide a. preferable. /θ is the image // is a prism for changing the optical path provided on the side where light enters the light guide 3, /2
is the light source section /3 through the prism // and the light guide 3
(Incidence for directing light to) l Hakushu light guide, /g is the observing eye.

Incidentally, detection errors from the piezoelectric element 7 can occur from the transparent electrode (not shown) of the piezoelectric element 7 to the lead wire (not shown) embedded in the endoscope body or the lead wire (not shown) passing through the endoscope body. It is taken out of the endoscope from K (shown in the figure), and the magnitude of its output is measured and recorded using two external devices (not shown).

The end of the aforementioned light guide/2 for incident light is attached to the light source unit body 23 of the light source unit/3, and a light source/7 for illumination is arranged behind this via a condenser lens/B. C
There is. Further, 7g is a half mirror provided between the condenser lens/B and the light guide/2 for incident light so as to form an angle of 1I-30 with respect to its optical axis. 22 is the laser beam I source, and in front of it is a motor, which rotates 11 times by the rotation of 2/ and emits the laser beam A source, 2 forces) and others. −
'#shi ■ Oha, published by S - "4 no Jσ and 1 (Ha chopper sector plate 20 is provided, and the chopped laser beam is further focused in front of this chopper sector plate 20. A condenser lens /9 is arranged for reflecting the light from the half mirror 7g and making it incident on the incident light guide I/2.

Next, I will explain the operation of Kaxuru Naranari's inspection device, the endoscope. The light from the light source/7 is guided to the end face of the incident light light guide/2 through the condenser lens/B and the half mirror 7g.
The object 15 is then passed through the prism//, the light guide 3, the condenser lens B, the prism 7, and the glass window g.
illuminates the body wall. In addition, this illumination light allows the observation eye to see the subject through the glass window, the prism, the image guide, and the eyepiece 10.
The body wall of S. can be observed. Through this observation, the body wall in a predetermined body cavity is seen, and the piezoelectric element 7 is applied to the body wall of the subject/shio as shown in the figure. On the other hand, the laser beam from the laser light source 2.2 is chopped by the chopper sector plate 20 which is rotated by the rotating motor 27), and the incident light is processed by the condenser lens /q and half mirror 7g. It is honored on the end face of the light guide/2.

Thereafter, this intermittent laser beam is emitted from the glass window g through the light guide 3 in the same manner as described above, and at least the piezoelectric element wa is in contact with the part 11 of the subject 7.
〒Irradiate the commander. Next, the light energy absorbed inside the subject 15 becomes heat, which is continuously transmitted as an elastic wave to the surface wall of the subject 15 and then to the piezoelectric element 7. The output signal of the piezoelectric element of this lli is transmitted to the inside of the inspection device 11 by one stage (not shown). (It will be guided to the outside of the mirror and recorded. Depending on the magnitude of this output signal, it is possible to diagnose whether there is an abnormality on the surface or inside of the subject.)

In the above embodiment, instead of the half mirror 7g, a guichroic mirror or a fully reversing mirror in the characteristic portion may be provided to change the optical path of the laser light source (laser 11t in 2.2). Furthermore, when the piezoelectric element 9 is transparent, at least a portion of the emitted light and the reflection from the body wall 1- passes through it.

Further, in the above embodiment, the laser light source 2.2 was used to measure only monochromatic light, but a white light source such as a tungsten lamp was used instead of the laser light source 22, and a monochromator was used between this light source and the chopper. 19 people change the wavelengths that are most likely to be chopped by changing the input and output signals as described above for each wavelength. ! By comparing this characteristic curve with the characteristic curve of the non-lesioned part of the subject or the general standard ←%shi1f curve based on the time curve, it is found that the characteristic curve in the figure and the characteristic curve for comparison do not match. In case, subject/S
It may be determined that there is a lesion in the area. In this case light over a wide wavelength range? Since it is possible to measure the effects of the Song Dynasty, it is possible to determine the effect of the Song Dynasty.In addition, several types of laser light sources can be used as the light source for the Chopper River. , a single laser beam 4jlj whose wavelength is changed by 〒I] may be used instead.

Further, when a semiconductor laser is used, the chopper of the above embodiment becomes unnecessary, and it goes without saying that the optical gap current of the semiconductor laser may be modulated instead.

FIG. 3 shows another embodiment of the present invention, in which a prism (C half mirror, 2
11 is arranged, and the light guide 3 reflects the chopped light of the half mirror 2'l to illuminate the object 15 from directly above the mold element 9. . In this case as well, the piezoelectric element is within the observation field of Image Gaitos, so is this piezoelectric element? Is it the subject/Ushio's body? (In this example, unlike the manual example, the 16 was re-chopped) was irradiated from the side, so it was inspected (
- Be able to efficiently irradiate light to the part of the subject 15.

FIG. 9 shows another embodiment of the present invention, in which the piezoelectric element 7 forms at least a part of the observation lens g, f, il, 1. In this case, the piezoelectric element 7 The element is [゛]'s lead wire a inside the endoscope body/inside the endoscope body.
ii.

FIG. S shows another embodiment of the present invention. In this case, the piezoelectric element 9 is formed into a ring shape, and the body wall of the subject 15 is irradiated with chopped light through the hole of the piezoelectric element 9. This embodiment is particularly effective when the piezoelectric element 9 is opaque. Furthermore, in order to check whether the piezoelectric element 7 is in close contact with the body wall, the light guide 3 is branched, and a condenser lens O and a prism 7 are installed on the other end surface side as shown in FIG.
Of course, it is also possible to arrange .

FIG. 4 shows an embodiment in which the inspection device-handed endoscope according to the present invention is applied to a direct-viewing endoscope. 27 is a light noid and an image noid, whose end is / in Fig. 7(a).
111<The center part, 27B is an image guide, and the light guide 27A surrounds it, or as shown in FIG. The composition is a mixture of. An objective lens and a glass window g for observation are provided on the 11th surface of the end thereof, and an excellent piezoelectric element wa is provided in the glass window g. In addition, the present invention has an image guide and a light guide.
It goes without saying that it is possible to use an endoscopic endoscope.

Fig. 3 shows a ring-shaped piezoelectric element 9 provided at the tip of the endoscope 4 and with the center hole 2g aligned with the button hole 2q, and a ring-shaped piezoelectric element 9 placed in the forceps hole 29. Internal viewing through the optical fiber 30 of the laser guide ≦): Take out the tip of the optical fiber 30, pass the chopped laser light through the optical fiber 30, and further pass this light through the center hole 2g of the piezoelectric element. It is also possible to irradiate the body wall of the specimen (・.) In the first embodiment, the side-viewing type examination device-dominant endoscope does not use a light guide as in the above embodiment. Chopped using optical fiber inside) 1
6 or a chopped laser)'ts may be guided through the 1.2 fibers provided separately from the lie guide.

FIG. 9 shows another embodiment of the present invention, in which the piezoelectric element is separated from the tip of the endoscope and closely attached to the body wall of the subject by using the tj1 hole of this single-side drawer type endoscope. It is used for measurement. In the figure, 2q is a forceps hole, 3/ is a wire extending inside the forceps hole 29, and a piezoelectric element is fixed to the tip thereof. The reference numeral 32 is a microphone, which is housed outside or inside the endoscope (IBI) with a piezoelectric element in close contact with the body wall, and which detects these sound waves.
The A sign detected by a lead wire (not shown) can be viewed internally and output +1y outside the boundary and recorded (
In one case of this embodiment, the microphone 3.2 is installed near the exit 1-1 of the hole 29 on either side of the glass window. ). When the endoscope 1.1 is inserted into the body cavity, the wire 3/ is pulled to the right to bring the piezoelectric element 7 as close to the glass window g as possible. After inserting this into the body cavity, operate the wire 29 to open the forceps hole 29.
Bring the piezoelectric element 7 into close contact with the body wall of the subject 15 from the tip of the endoscope. After this, in the same manner as in the embodiment shown in Fig. 1, the chopped light was irradiated to the part of the subject/S to be sound-diagnosed, and the piezoelectric element W, which received the future irises and emitted the sound waves, emitted the chopped light. The signal is received by the microphone 32 and measured.

In addition to this, the present invention also provides an insulating layer j'i'λ shown in FIG.
It is also possible to pass the lead wire through the wire which has been subjected to the above-mentioned process, and to take the lead wire from the contact pressure element without using the microphone 1-r phono.

In addition, a protrusion is provided on the piezoelectric element. It is also possible to pick it up with regular forceps and arrange the piezoelectric element as shown in FIG.

In addition to this invention, there is also an endoscope that uses a solid-state imaging device such as CCI instead of an optical fiber image guide. Needless to say, it is also applicable to semiconductor lasers or emitted light, rather than using a light guide to guide the chopped (1). ,', diodes, etc.)1i-elements of at least 7 types, including fiJ
Installed at the tip of the mirror, electrically chopping (II +
Of course, there are words that can be used.

As described above, by using an endoscope capable of carrying out 16 acoustic spectroscopic examinations, information about the contents of each piece of tissue inside the body can be obtained spectroscopically. It is possible to diagnose and judge the lesion site (1' 1
It is 11.

[Brief explanation of drawings]

FIG. 7(a) is a cross-sectional view of an endoscope with an inspection device according to the present invention.
! FIG. 1(b) is an explanatory diagram of the entire structure without showing the light source section of FIG. 1(a), FIG. 1 is an explanatory diagram of the state measured using the apparatus of FIG. 7, and FIGS. Explanatory diagrams showing other embodiments of the inspection device inspection endoscope according to the present invention, FIG. FIG. 2 is an explanatory diagram showing still other embodiments of the device inspection endoscope according to the invention. / is the endoscope body, 2 is the image guide, 3G.
・Guide, g is glass window, 9 is piezoelectric element, // is prism, /2 is light guide for incident light, /3 is light source part, /S
/9 ill: condenser lens; /7 is the light source; /g is the half mirror; 1 and 20 are the horizontal bar sector plates; 2/ is the motor. 22 is a laser light source, 2'l is a half mirror, 92 is a lead wire, 29 is a forceps hole, and 30 is an optical fiber assembly. 3/ is a wire. Figure 3 Figure 5 (a) (b) Figure 7 Figure 4 Figure 6 Figure 8

Claims (1)

[Scope of Claims] (1) The irradiation means for irradiating the subject with chopped light and the detection means for detecting the photoacoustic effect of the irradiated area of the subject are different from each other. An endoscope with inspection equipment. (2) The inspection device endoscope according to claim 1, wherein the irradiation means can change the wavelength of the irradiated target by 11". (3) From the irradiated area of the subject where the detection means is:
According to the patent claim set forth above, the detection means described in box No./(4) is an endoscope with a device.
71! An internal examination mirror with a throttling device according to claim 1, which contacts the irradiated site of a subject and captures the response of these lights. (5) - The piezoelectric element is translucent, and the 1
,, ``i:] d-+ ' l/ , lW & u+
＞+ Sl/-4= +I to I↓-If IX
u i41 ,, J-Y lkl Endoscopy with inspection device according to claim 9 (6) The piezoelectric element forms a part of the observation window of the endoscope. wound r1
Scope of crystallization Endoscopy 4E'λ with the inspection device described in Section G. (7) The endoscope with a sound detection device according to claim 7, wherein the piezoelectric element is ring-shaped, and the subject is irradiated with chopped light through a hole in the ring.