JPS60168350A - Feed additive passing through rumen of ruminant - Google Patents

Abstract

PURPOSE:A feed additive, obtained by adding a specific material to a water-insoluble salt of an acid, more weakly acidic then hydrochloric acid, and acceptable by living bodies as a main agent, and granulating the resultant mixturre, and capable of passing through the rumen of ruminants and dissolving out satisfactorily in the abomasum or thereafter. CONSTITUTION:A feed additive containing a material effective for living bodies. The feed is obtained by adding (a) >=20wt%, based on the total amount of the feed additive, water-insoluble salt of an acid, more weakly acidic than hydrochloric acid, and acceptable by the living bodies to (b) >=10wt% at least one substance of a >=14C straight chain or branched saturated or unsaturated monocarboxylic acid or a salt thereof or a wax having >=40 deg.C melting point, and granulating the resultant mixture. The above-mentioned material effective for the living bodies is a nutriment or a feed or drug containing the same, and preferably absorbed throug the abomasum or thereafter effectively in the bodies of individual ruminants without consumption by microorganisms in the rumen. Calcium tertiary phosphate, magnesium tertiary phosphate, magnesium carbonated, etc. may be cited as the above-mentioned water-soluble salt.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to feed additives that pass through the rumen of ruminants. More specifically, the present invention relates to feed additives which have the characteristic of protecting substances effective for living organisms so that they pass through the rumen of ruminants and are eluted from the abomasum onwards.

Ruminants have a variety of microorganisms living symbiotically in their rumen, and with their help they are able to digest and utilize components such as cellulose that higher animals cannot normally use. The existence and function of the rumen is extremely important for ruminants. However, in recent years, physiological and nutritional research on ruminants has pointed out the existence of the rumen as one of the factors that restricts the productivity of ruminants. In other words, there is active research into using substances that are effective for living organisms more efficiently by allowing substances that are useful for living organisms that do not want to be broken down in the rumen to pass through the rumen, and then being broken down and absorbed in the abomasum and beyond. It has become.

In addition, the livestock industry, which is aiming for more efficient management, is hoping for the development of a technology that allows it to pass through the rumen, and several methods have been proposed, but none of them are sufficiently effective. do not have. For example, German patent no. It is shown in particle form coated with a coating consisting of a salt of such an acid mixture.

Japanese Patent Publication No. 56-1057 also describes biologically active substances as saturated linear or branched substituted or unsubstituted aliphatic monocarboxylic acids or their salts having a small number of carbon atoms (both 14). or coated with a matrix consisting of a mixture of the saturated acid or its salt and an unsaturated linear or branched substituted or unsubstituted aliphatic monocarboxylic acid having a small number of carbon atoms (both 14) or its salt. It shows what is happening.

Furthermore, JP-A-56-154956 discloses that a biologically effective substance is provided with a coating containing a salt of an aliphatic monocarboxylic acid having 14 to 22 carbon atoms or a mixture of several of said acids. It shows something in the form of particles.

Furthermore, JP-A-58-175449 describes biologically active substances as linear or branched saturated or unsaturated monocarboxylic acids having 14 to 22 carbon atoms, hydrogenated vegetable fats and hydrogenated animal fats. This figure shows one surrounded by a protective substance coating containing one or more substances selected from sexual fats and chitosan.

However, in German Patent No. 22125<S8 and Japanese Patent Publication No. 56-1057, it is expected that the disintegration of the membrane substance will occur after the small intestine, so there are restrictions on the time available for digestion and absorption. However, it has the disadvantage that it is not sufficiently digested and absorbed. Also, JP-A-56-1549
No. 56 and JP-A No. 58-175449 use a coating material that disintegrates in the abomasum and elutes substances effective for living organisms in order to overcome the above-mentioned drawbacks.
The disintegration effect of the coating material within the abomasum is insufficient, and its effect cannot be said to be stable. That is, the reality is that there is still no satisfactory feed additive that passes through the rumen and dissolves from the abomasum onwards.

As a result of various studies under the circumstances described above, the present inventors have found that a feed additive based on a water-insoluble salt of an acid that is weakly acidic and acceptable to the living body compared to hydrochloric acid is superior without the above-mentioned disadvantages. The present invention was completed by discovering that the feed additive is a feed additive.

The present invention will be explained in more detail below.

The animals targeted by the feed additive of the present invention are ruminants, typical examples of which are beef cattle, dairy cattle, calves, sheep, and goats.

In the present invention, substances that are effective for living organisms include nutrients, feeds containing nutrients, and drugs such as rumin, enzymes, Carbohydrates, veterinary drugs, hormones, etc. Typical examples are amino acids such as methionine, lysine, threonine, leucine, inleucine, tryptophan, phenylalanine, valine, chrysine, and amino acid derivatives such as N-acyl amino acids. , for example N-stearoylmethionine or N-oleoylmethionine, N-
Calcium salt of hydroxymethylmethionine, lysine hydrochloride, and vitamins such as vitamin AI, vitamin A palmitate, vitamin A acetate, β-carotene, vitamin D2, vitamin D8, pitami 7E, menadiol/sodium bisulfite. , vitamin B group (thiamine, thiamine hydrochloride, riboflavin, nicotinic acid, nicotinamide, calcium pantothenate, choline pantothenate, pyridoxine hydrochloride, choline chloride, dianocobalamin, pyotin, folic acid, paraaminobenzoic acid) enzymes include: Protease agents, amylase agents, mixed enzyme agents, lipase agents; Carbohydrates include starch, glucose, and sucrose; Veterinary drugs include tetracyclines, aminoglycosides, macrolides, polypeptides, polysaccharides, and polyethers. Examples of the hormones include estrous hormones such as nystrodiene, stilbestrol, and hexestrol, and thyroid hormones such as thyroprotein and goitrogens.

Generally, one type of these is used, but a mixture of two or more types can also be used.

Examples of water-insoluble salts of acids that are weaker than hydrochloric acid and acceptable to the living body used in the present invention include hexacalcium phosphate, dibasic calcium phosphate, magnesium tertiary phosphate, zinc phosphate, and phosphoric acid. These include aluminum, calcium silicate, calcium birophosphate, magnesium carbonate, lead carbonate, and cobalt carbonate. Generally, one type of these is used, but a mixture of two or more types can also be used.

In the present invention, the amount of these water-insoluble salts is 20% by weight or more based on the total amount of feed additives. If it is less than 20% by weight,
Substances that are effective for living organisms become difficult to dissolve in the abomasum, resulting in less effectiveness.If the amount exceeds the upper limit, the amount of active ingredients decreases and sufficient effects cannot be obtained. Also carbon number 14
Selected from the above linear or branched saturated or unsaturated monocarboxylic acids or salts thereof, animal fats and oils with a melting point of 40℃ or higher, vegetable oils and fats with a melting point of 40℃ or higher, or waxes with a melting point of 40℃ or higher. At least one kind of substance (hereinafter referred to as “protective substance”)
) is 10% by weight or more based on the total amount of the feed additive of the present invention. If the amount is less than 10% by weight, there is a problem with the stability of the substance effective for living organisms in the rumen, and if it is less than the upper limit, the amount of the active ingredient will be too small to obtain sufficient effects.

The feed additive of the present invention can be produced in the form of pellets, spherical particles, tablets, etc. using granulation techniques such as transfer granulation, extrusion granulation, compression granulation, and spray granulation. One example is a method of molding. Further, a binder may be added depending on the case.

The feed additive of the present invention is directly added to normal feed and administered to the target animal, but it is also possible to add and mix it in advance, for example, during the production of compound feed.

As described above, the feed additive of the present invention has an excellent property of allowing the necessary components to pass through the rumen of ruminants and elute from the abomasum onwards, and is therefore extremely useful industrially.

The present invention will be explained in more detail with reference to Examples below.

In addition, parts in the examples are parts by weight, and % is weight %.

Examples 1 to 4 Comparative Examples DL-methionine and substances having the compositions shown in Table 1 were uniformly mixed in advance using a ribbon mixer, and then pellets with a diameter of 2 mm and a length of 311 m were produced using a pelletizer.

Using the obtained pelleted feed additive composition, a DL-methionine elution test was conducted under artificial ruminal fluid and artificial abomasal fluid. The artificial ruminal fluid is 0.1M sodium phosphate buffer, and the artificial abomasal fluid is 0.1M sodium phosphate buffer. IN hydrochloric acid was used. For the dissolution test, the pellets prepared above were immersed in an Erlenmeyer flask containing 100% of artificial ruminal fluid or artificial abomasal fluid, kept at 69°C using a shaking device, and after shaking for a predetermined period of time, the pellets were immersed in each solution. DL-methionine eluted from the pellet was measured by iodometry. The shaking period of 5 hours was 10 hours for the artificial ruminal fluid and 6 hours for the artificial abomasal fluid.

Table 1 shows the blending ratios and dissolution test results for each Example and each Comparative Example.

Example 5.6 Pellets containing nicotinic acid amide were produced in the same manner as in Examples 1-4. The N content of the eluted nicotinic acid amide was measured by the Kjeldahl method. The blending ratios and results are shown in Table 2.

=9- Procedural amendment June 20, 1985 Manabu Shiga, Commissioner of the Patent Office1, Indication of the case, Patent Application No. 10327 of 19822, Name of the invention Feed additive that passes through the rumen of ruminants 6. Relationship with the case of the person making the amendment Patent applicant address: 3-2-5-4 Kasumigaseki, Chiyoda-ku, Tokyo, Column 5 of the detailed description of the invention in the specification subject to the amendment, Contents of the amendment

Claims (1)

[Claims] A feed additive that contains a substance that is effective for living organisms, containing 20% by weight or more of a water-insoluble salt of an acid that is weaker than hydrochloric acid and acceptable to living organisms, based on the total amount of the feed additive, and Straight chain or branched saturated or unsaturated monocarboxylic acid or salt thereof having 14 or more carbon atoms, or melting point 40
Cumulus containing 10% by weight or more of one kind of substance selected from animal fats and oils with a melting point of 40°C or higher, vegetable oils and fats with a melting point of 40°C or higher, and granulated. Feed additives that pass through the animal's rumen.