JPS5959605A - Emulsion-type cosmetic containing allantoin - Google Patents

Abstract

PURPOSE:To provide a cosmetic having excellent hydrolytic stability of allantoin having keratolytic activity, etc., and excellent stability and safety of the product, by compounding allantoin, a nonionic surface active agent, a water-soluble polysaccharide, an oily substance, and water. CONSTITUTION:The cosmetic contains 0.01-10wt% of allantoin, 0.1-5wt% of a nonionic surface active agent having an HLB of 5-18, 0.01-5wt% of a water- soluble polysaccharide (e.g. pectin, karaya gum, guar gum, xanthan gum, locust bean gum, etc.), 5-90wt% of an oily substance and 5-90wt% of water, and has a pH of 4-7. Allantoin has keratolytic activity, vulnerary promoting activity, cell proliferation activity, emollient activity, and sphacelus excretory activity, etc. The unstable property of allantoin caused by the high sensitivity to hydrolysis can be covered by making the above composition, and an excellent cosmetic can be provided.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an emulsified cosmetic containing allantoin, and particularly to a cosmetic that has excellent hydrolytic stability of allantoin and excellent product stability and safety.

Conventionally, the conditions required for emulsified skin cosmetics such as creams and emulsions are (11) they do not stimulate skin breakdown and are highly safe; (2) they have high emulsion stability and oral stability; (3) Good chemical stability such as hydrolysis resistance, and (4) Good appearance such as texture and gloss.

In order to satisfy these conditions, selection of appropriate emulsifiers, effective combinations of two or more types of emulsifiers, and blending of special ingredients are carried out. It's not easy.

On the other hand, allantoin has a keratin softening effect, a wound healing promoting effect, a cell proliferation effect, a skin softening effect, a necrotic tissue discharging effect, and the like, and is therefore widely used as an active ingredient in cosmetics. However, allantoin has unstable properties such that it is easily hydrolyzed in the presence of acids and alkalis. That is, allantoin is decomposed into glyogysaric acid and urea by acid hydrolysis, and is converted into allantoic acid in a strained alkaline aqueous solution.

Therefore, it is particularly difficult to improve the stability of cosmetics containing such allantoin.

Generally, allantoin is said to be axially stable in the range of P114 to 7. 11r, a commercially available product containing allantoin, also falls within this Pll range. However, when the present inventors prepared a mediocre allantoin-containing emulsified cosmetic and conducted a storage test on it, it was found that the allantoin-containing groups decreased over time, even though the pH was in the range of 4 to 9. In other words, it was found that allantoin was degraded. Therefore, as a result of further research, the present inventors found that allantoin's 4I
It was found that jf depends not only on the pH of the group E'2 but also on the polarity of the emulsifier.

Generally, as emulsifiers added to cosmetics, slag, anionic surfactants alone, or a combination of anionic surfactants and nonionic surfactants are used.
When such a surfactant is used as an emulsifier, allantoin cannot be stabilized (c) even if the Pll of cosmetic f) is set to 7 or less. On the other hand, when an emulsifier consisting of one or two non-polar nonionic surfactants is used, the stability of allantoin can be improved.

However, nonionic surfactants as emulsifiers have the following drawbacks. That is, polymexyethylene alkyl ether type nonionic surfactants are generally highly irritating to the skin layer and have poor emulsifying power. Furthermore, ester type nonionic surfactants such as polyoxyethylene higher fatty acid ester and polyoxyethylene sorbitan higher Jfi7 fatty acid ester have poor emulsifying power and deteriorate the stability of cosmetics. Furthermore, to increase the emulsifying power, if a large amount of nonionic surfactant is used, hydroxybenzene, which is commonly added to cosmetics as a preservative, can be used. This may reduce the effectiveness of rH.

The present invention was not made under these circumstances; +7. )
TC's mission is to provide an emulsified cosmetic containing allantoin that has excellent hydrolytic stability of plantin and is superior in product stability and safety.

That is, the allantoin-containing emulsified cosmetic of the present invention has 0.
01-10 Allantoin of Shigebe and HLB 5-1
8 or more of a nonionic 51゛-surfactant for at least 2 seconds, and at least one of the 14 water-soluble compounds selected from the group consisting of pectin, karaya gum, guaya gum, xanthan gum and paralytic locust bean gum. 9. It is characterized by containing No. 1a, an oily substance, and water.

Below, the four types of emulsification type cutting of the present invention will be explained in more detail.
I will clarify.

The blending amount of allantoin, which is an essential rumbling component of the cosmetics of the present invention, is 0.01% depending on the desired effect of allantoin.
It is used as appropriate within the range of 10 to 10 times.

In the cosmetic of the present invention, the nonionic surfactant used as an emulsifier is one in which 5 to 150 moles of ethylene oxide is added to a lipophilic group having 8 to 30 carbon atoms, and HLB (hydrophilic-lipophilic balance). 5 to 18 is suitable. Further, glycerin fatty acid ester or the like may be used together with these surfactants. As a lipophilic group,
There are alkane groups, alkene groups, aryl groups, steroid groups, etc., and these lipophilic groups form ether bonds or ester bonds f-f with ethylene oxide.

The specific list of nonionic surfactants to be incorporated into the cosmetics of the present invention is as follows: 100 polyoxyethylene higher alcohol ether (2) polyoxyethylene fatty acid ester with suderic acid, olein, etc. as fatty acid part and ethylene oxide addition mole number from 5 to 100 (3) alkyl group, alkenyl group , a surfactant prepared by adding 10 to 150 moles of ethylene oxide to an ester of a fatty acid and a polyhydric alcohol having all hydroxyalkyl groups.For example, ld', polyoxyethylene castor oil,
Polyquine ethylene hydrogenated castor oil and polymexyethylene sorbicun fatty acid ester.

1. Is it possible that the acid or alkali used during production remains in the nonionic surfactant used in I+'4 production? - Like I Niji'1'
-Mountain i right (11〆1・Sari Rike Ir is not small.

The nonionic surfactants may be used alone or in combinations of one or more. In addition, in history, lipophilic surfactants such as glycerin monostearate and sorbitan monostearate are used together with all the nonionic surfactants mentioned above.
It is also possible to speak.

Distribution of nonionic surfactant M1. It is -'ct% for 01~5() for one whole bottle, and Q4 size or 1~
3 is in charge of city volume. O. ], ii, i If it is less than 5%, the emulsifying power tends to decrease, and if it exceeds 5(17rrh), the skin irritation level increases, and the preservative power of the hydroxybenzoic acid ester decreases (2%). .

Water-soluble poly-HLH compounds used in the awns of Kinoe 1414 (such as karaya gum, guaya gum, xanthan gum, and locust bean gum).
Zhong Yiju. The blending amount is 001 to 5N to the entire compound, and lf3'! ! Niji < is 01-2 Bishitari. If the concentration is 001, the storage quality will deteriorate, and if it exceeds 5 +Ir m%, the usability will be poor.

As the oily substance P↓ to be blended in the cosmetic composition of the present invention, a known oily substance for skin cosmetics may be used.

Such items include hydrocarbons and animal fats and oils.

Seed oils, fats and oils, higher alcohols, higher fatty acids,
There are ester oils, etc. Among them, hydrocarbons include liquid rough fin, squalane, and petrolatum IJ 7, paraffin, wax, animal fats and oils such as beef tallow, whale fat, cod liver oil, and mink oil, and vegetable oils and fats such as olive oil and almond oil. Oil, avocado oil, castor oil, cacao butter, A-
Mu oil.

Waxes include miso wax, carna wax, spermaceti wax, lanolin, and higher alcohols include Rau I (rual alcohol, stearyl alcohol, cetanol, oleyl alcohol, incetanol/l, etc.).

Higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, olefin, behenic acid,
Lanolin fatty acid, isomeric acid.

Ester oil and [2 is Inpropi" Lumiliscar-1.
, straight chain esters such as butyl stearate, hexyl laurate, octyldodecyl myristate, fin')olopyl adipate, branched chain caustyl, and the like.

These oily substances can be used alone or in combination. The formulation h1 of 7 is usually 5 to 90% by weight, preferably io to 70% by weight based on the entire cosmetic.

The amount of water σ) used in the cosmetics of the present invention is usually 5 to 90 M, or 30 to 80 M by weight.

For the 1-nome-like or emulsion-like cosmetics containing each of the essential ingredients described above, optional ingredients commonly used in cosmetics such as jjy, IIFIJ glycerin, zoropylene glycol, and pyropylene glycol can be added. Moisturizers such as sodium IJtone carboxylate and 1,3-butylene gel 1-nocol;
The allantoin-containing emulsified cosmetic of the present invention may contain preservatives such as hydroxybenzoic acid esters, other antioxidants, ultraviolet rays 11 and absorbers, various medicinal compounds, fragrances, coloring agents, etc. Applicable to various creamy or milky cosmetics such as nourishing creams, massage creams, cleansing creams, cleansing creams, milky lotions, and hair creams.

Examples of the embodiments of the present invention are shown below, but these embodiments are not intended to limit the invention in any way.

In addition, all the percentages in the examples indicate the amount of M.

Example 1 Nutrient Cream 1, which is an embodiment of the present invention, and Nutrient Cream 2, which is a comparative example, were prepared by the following method. That is, for both nutritional cream 1.2, the oil phase [A) and water phase [B) shown below were heated to 70°C and dissolved. Next, the aqueous phase [B) was stirred with a homomixer, and then the oil phase [lk] was added, and the emulsified mixture was cooled. During this time, the abduction and agitation continued, and 30
Stirring was completely stopped at ℃ to obtain nutritional cream 1.2.

[A] Oil 0 [A] Oil phase fluid/rough-in 25.0 liquid paraffin 25.0% petrolatum 3.0 petrolatum
30 Setanol 25 Setanol
25 Stearin 12 3.0 Stearic acid 30 Preservative 0.2 [B] Water Socense Sting 05 Allantoin o5
[B] Aqueous phase Caustic soda o3
Allantoin 05 Purified water 645
Karaya gum 05 Purified water 618 Example Emulsion 1, which is an example of the present invention, and Emulsion 2, which is a comparative example, were prepared in the same manner as in Example 1.

Emulsion 1 Emulsion 2 [A
] Oil phase CA] Oil phase liquid paraffin 10. (l section fluid/grafine
10.0 Knorr 15 Setanol 15 Stearic acid 30 Stearic acid 3.0 Glycerin mono Glycerin monostearate o, 3 Stearate
0.3 Preservative 0.3 (B) Water phase Incense stick 05 Allantoin 1° [B, l] Water phase Triethanolamine
05 Allantoin 10 Purified water 829 Xanthan gum OIN Seisui 813 Seven PH and allantoin stability were tested for the four cosmetics in Example 1.2 above. That is, the temperature is 40℃
Allantoin was analyzed after being stored for 6 months, and the stability of allantoin was determined by the residual heavy metal of 7. The analysis of allantoin was conducted in accordance with the quantitative method of cosmetic raw material standards. The results are shown in the table below.

As is clear from the above table, both the nutritional cream 1.1=- and the milky lotion IL1', which are cosmetics of the present invention, exhibit vague allantoin stability. Further, when the emulsification state, texture, and gloss were visually judged after storage for 6 months, no changes were observed.

Example Example Row I and four-stroke operation resulted in allanto-in stability with 1. I got some hand cream.

[A] Oil phase liquid breadfin 30.0 solid paraffin 3.0 stearin
3.0 inpropyl myristate
4,0 methyl silicone [
) 5 Sorbitan monostearate 08 Polyoxyethylene rubitan monooleate (20 moles EO) 1.8 Preservative 0.3 CB,) Water phase allantoin O2 Locust bean gum 0.5 Sheath water
55゜9 fruits/1 can [Row 4 A hair cream with ambiguous allantoin stability was obtained by the same operation as in Example 1.

[A] Oil phase liquid paraffin 500 Sorbitan monosderate 08 Polyoxyethylenes dearyl ether (25 moles EO) 2.0 Preservative
03 Kosashi
05 [B] Water phase

Claims (1)

[Scope of Claims] <11 In an emulsified cosmetic containing 0.01 to 10% by weight of allantoin, one or more nonionic surfactants with HLf35 to 18, pectin, karaya gum, guaya gum, An emulsified cosmetic, further comprising at least one water-soluble polysaccharide selected from the group consisting of xanthan gum and locust bean gum, an oily substance, and water. (2) The cosmetic composition according to claim 1, wherein the nonionic surfactant is blended in an amount of 0.1 to 5% based on the entire cosmetic composition. (3) The cosmetic according to claim 1, wherein the water-soluble polysaccharide is blended in an amount of 0.01 to 5% by weight based on the entire cosmetic. (4) The cosmetic according to claim 1, wherein the blending amount of the oily substance is 5 to 90M. (5) The cosmetic according to claim 1, wherein the water content is 5 to 90% by weight. (6) The cosmetic according to claim 1, which has a pH of 4 to 7.