JPS59142832A - Automatic medical liquid compounding apparatus - Google Patents

Abstract

PURPOSE:To compound rapidly and automatically a medical liquid with a high degree of accuracy by moving an electronic balance, and measuring automatically the weight of the medical liquid to be measured. CONSTITUTION:The medical liquid in a vessel 1 is flowed out through outflow tubes 4 having valves 3, and the effluent medical liquid is received by a receiving vessel 5. The change in weight of the received medical liquid is converted into an electrical signal through an electronic balance 11. In a controlling mechanism 18, the level of said electrical signal is compared with the previously set value to open or shut continuously or intermittently the valves 3. A conveyor 8 for carrying plural vessels 5, a motor 9 for driving the conveyor 8 and a lift 12 for lifting the balance 11 up and down are provided. In the controlling mechanism 18, a cycle, consisting of the setting of the regular position of the conveyor 8, the carrying of the vessel 5 by lifting up the balance 11, the compounding of the medical liquid and the releasing of the vessel 5 by lowering the balance 11 down is repeated continuously plural times.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an automatic chemical compounding device, and more particularly, it relates to an apparatus for automatically preparing a plurality of pears in sequence using several types of chemical solutions. By mixing dye stock solutions, you can make multiple dye solutions of the desired color.
This invention relates to an effective device for automatically adjusting the +Li order.

Conventionally, the preparation of a dye liquor involves empirically selecting several types of dyes that make up the color components of the desired color sample, mixing the dye liquor, and dyeing the object to be dyed to create the color sample. In contrast, this process was sometimes repeated several times to finally decide on the dye solution formulation. Recent spectrophotometer and digital computer
Color matching is generally done on the needle side using a computer.
A method called color masotink has been developed.

Using the computer colormanotinking method, it has become quick and easy to understand color samples and apply one-color combinations with dye concentrations centered on the three primary colors. But to power!
Select dyes from among the many commercially available dyes*1, taking into consideration quality such as fastness of the dyed material and cost, as well as economy lI4-. However, testing the complete match with the brown sample with the naked eye is an extremely difficult task in terms of color preparation, and the selected dye is then added to the middle layer. The work is done by hand at 'J! : 4rQ, and such work requires a great deal of skill and experience.

Reflecting this situation, in recent years, Tokufuna Application No. 75159 (1972) and Japanese Patent Application Laid-open No. 188577 (1972) have been proposed as devices for automatically operating the above-mentioned lJM machine, but both of them use dye raw materials. a+! Because the measurement is done by # quantity, it is easy to cause errors due to changes in volume due to temperature change, inclusion of air bubbles, etc., and although it contributes to speeding up work and saving labor, it does not improve measurement accuracy. Since then, there are still many issues that need to be resolved. Therefore, the present applicant et al.
In No. 77, we proposed a highly accurate and efficient chemical solution automatic dispensing device that can be measured using the measuring method, but as a result of further study, we found that We have discovered a more efficient current collecting automatic mixing device that can carry out weighing, rJJJ single operations, all operations multiple times in succession, and with this device, we have achieved a high level of automatic preparation of divine medicinal solutions without having to worry about the dye solution. It has been discovered that the method can be effectively carried out at 1+ degrees, and the present invention has been achieved.

In particular, it is an object of the present invention to provide an apparatus that can quickly and automatically perform drug atomization multiple times at HrM degrees.

The object of the present invention is to provide containers for storing the first number of chemical solutions, outflow pipes each having a valve for allowing the drug solutions in the containers to flow out, and for receiving the drug solutions flowing out from the outflow pipes in 111μ stages. The change in weight of the receiving container and the chemical solution received in the receiving container is determined by comparing the measurement device that converts it into a gas signal and the predetermined settings according to the level of the electrical signal. Rakuli automatic with a control mechanism to open and close the valves individually or sequentially? A transfer device on which the receiving container places several paddy grains, a motor for transferring the transfer device, and a lifting device for vertically moving the weighing device disposed below the receiving container are installed directly at the A-combining device. 4, and then the transfer device is set in a fixed position, the weighing device is raised, the receiving container is placed, the rack is adjusted, and the paper counting device is lowered to open the receiving container. This can be effectively achieved by an automatic drug solution dispensing device characterized by being equipped with a control mechanism for repeating the process multiple times.

According to the device of the present invention, various drugs 6k are placed in a container as a solution with multiple concentrations as necessary, and the designated amount is received by drawing a solenoid valve based on a pre-input prescription. Since the amount is measured using the droplet sif and #i' metering device, it is possible to measure with higher precision than the Tani M1111I constant.Also, it is possible to measure each drop separately from the container containing the chemical solution. Since it has an outflow pipe with 1 ffl of January's Semagaku Pulg [!], there is no contamination by other chemicals,
The same liquid can always pass through.

A plurality of receiving containers are placed on the transfer device ffK, and the chemical solution is measured and mixed into the specified receiving container. When the mixing is completed, the transfer device automatically moves to specify the next receiving container, measure the chemical solution, It is possible to carry out compounding, thereby making it possible to carry out a plurality of cases 18- consecutively in i-orders with high precision. In particular, when measuring the mixed liquid, the measuring device, which has a receiving container located below the tip of the outflow tube of drug R+, moves up a certain distance and touches the receiving #1 meter by 1 m, and then the drug solution 1i is measured.
111, and when the mixing is completed, the measuring device is lowered to the original position 1 to open the receiving container, so the meter T' device is fixed and the transfer device is moved up and down. This method is simpler in structure and more efficient in terms of speeding up weighing compared to the method of moving the container or the method of automatically placing only the designated receiving container on the weighing device.

The chemical solution of the present invention #I: The chemical solution that can be used for JJ Katsou↑Pt includes any common liquid substance, such as water; acid and alkaline water baths; ether,
Organic liquids such as alcohol and petroleum; (aqueous) bath solutions of organic and inorganic substances such as dyestuffs, dyestuffs, pharmaceuticals, and agricultural chemicals; metallic liquids such as mercury, etc., depending on the purpose of preparation. It can be used for mixing and mixing, but especially when the chemical solution is an undiluted dye solution, problems such as complicated processes, high precision, and the need for skilled personnel are solved and it is effective. This is desirable because it allows you to fully demonstrate your abilities.

Next, as an embodiment of the apparatus of the present invention, preparation of a dye stock solution will be described in detail with reference to the drawings. Figure 1 shows the outline of the device of the present invention, in which a plurality of chemical liquid containers are arranged, and a desired dye stock solution (2), that is, a stock solution of several kinds of dyes and auxiliary agents, or water as required is stored in advance. As a dye stock solution, dyes of several colors are used at different concentrations, for example, 1rA.
If you store dyes with three or more concentrations, such as 2 types of light and 7 types of dyes, medium and light, you can specify one of them to use in the dust room at the input stage of the compounding recipe depending on the amount of dye used. can.

For dye stock solutions, such as frozen disperse dyes, where the dye may settle if left for a long time, it is also possible to search and stir with a Makunechi Isoxterfu or the like.

The dye stock solution (2) flows out through the outflow tube (4) into the receiving container (5) by the siphon effect. Outflow pipe (4)
A solenoid valve (3) is self-installed. 'Solenoid valve (3
) is opened and closed by electrical signals from the control device (18) based on the dye formulation input into the input device (17) to flow out a desired amount of the dye stock solution (2).

As for the opening and closing of the electromagnetic valve (3), 95% of the required volume of one color of selected dye, for example, 95% of the required quantity of one color of dye, is 'P11. m bulk (3) open position 1
．． Then, the remaining 5% is drained out to 100% of the required amount by repeating instantaneous opening and closing of the electromagnetic valve, that is, repeating the drop-to-thorn 1' amount adjustment process frequently.

In this method, it is of course possible to improve the outflow speed or accuracy by appropriately determining the inner diameter and length of the fA outlet tube, or the ease of the flow from the Sogan container to the tip of the tube. For example, by increasing the inner diameter of the outflowing bone of the drug solution and making it longer, M/J! 'improvement,
It is possible to improve the metering speed by widening and shortening the inner diameter of the outflow tube for the concentrated chemical solution. On the other hand, the phase properties of the outflow tube (4) are preferably made of fluorine to 1JJii from the viewpoints of bending 1, 111ri benign, quasi-grain 1, prevention of internal f'j and clogging, and the tip of the outflow tube. In order to completely separate the surfaces, it is preferable to use a material with a pore size only at the tip.

The distal end of each ML outlet tube is arranged in a concentrated manner above one receiving container (5) that is placed in a fixed position, with a constant interval therebetween.

A plurality of receiving containers (5) are respectively placed on a plurality of saucers (7) on a rotating chiffle (8). The rotary table (8) is shown as an example of a transfer device angle, but it may be of any type as long as it can place and transfer a plurality of receiving containers on one side. 'I do not hit σ even on the i-circuit conveyor.

The rotary cheagle is provided with a plurality of notched holes concentrically arranged on which the saucers (7) are placed. For example, by using a receiving container whose body has an outer diameter smaller than the notch hole diameter, it is not necessarily necessary to use the saucer (7), but by using the saucer (7), the dyeing pot can be used as a receiving container. Beaker etc. f! : Desirable as it can be used as appropriate;
In order for the saucer (7) to be easily separated from the rotary cheagle, it is desirable that the outer diameter of the saucer body be smaller than the diameter of the cutout hole of the rotary cheagle and be tapered. Moreover, the jealous saucer described later is also Rjit, 1t(
Since the i+ is constant, it is preferable to use a resin-based material, which has a lower stiffness, than a metal material.

The material of the 1st Hiro Cheagle (8) is a metal plate or skein 7
Is it + for any of the April items? I don't know, but the rotating tape'
Structure 6 from the point of view of power load to drive the cell, blood phagocytosis, etc.
Ribosu is preferred.

The rotating gear (8) is fitted with a rotating gear (11) fitted into a bearing (5) and a brake motor (9).
The motor (9) with a brake is rotated by a gear fixed to the rotating shaft, and the motor (9) with a brake is produced by a command from the control device (18).

On the other hand, a plurality of extraction ends for position 1d sensors are attached to the outer periphery of the turning table tag (8), and in response to the position 1^ sensor (lO), an E completion signal is sent to the control device (18). (1) Controls the operation of the motor (9) and instructs the rotating cheagle (8) to stop at the specified position 1g.

Among the first few receiving containers, there is a receiving container (
5) is placed at the 1: side of the collecting part of the outflow pipe (4), and an electronic balance (11) as a scale stitching device 1' is arranged at a constant interval below the K-receiving container. It is set up. The electronic balance (
l1) sends the weight of the object to be weighed i, 4AfL to the control device (18) by electrical signals, and displays the attached digital display device (19) or printer (2) as necessary.
0), it is output at the same time as the measurement, and it is possible to confirm or record the measurement result.

61J Note: The scale (11) is a rank binion (4 scales (11)) as a lifting device, which will be explained below when determining the receiving container (5) and the amount of water flowing into the container.
According to 2), the upper case I-L places the acceptance capacity % on the electronic balance table, and when the weight measurement and adjustment are completed, it is lowered to the original position. In this way, the device of the present invention is a weighing device without moving the object to be weighed. Compared to methods that move the f'c transfer device up and down, or mechanically move the receiving container and place it on a large scale table, the structure is more simple, and the vibration of the object to be weighed is reduced. It is an efficient weighing method because it does not cause leakage due to etc. and can speed up the weighing process.

Next, the rank-binion mechanism 4 will be explained in detail as an elevating device for the electronic balance (11). City: Kodaibin (the river is
It is fixed to a stand (13) that moves up and down by a rank-binion machine (1□4 (12). In this example, the
・Although the Rank-Vinioff machine 1i4'e is shown as an example of a lowering device, any mechanism that moves the electronic balance up and down a certain distance can be used; for example, a hydraulic mechanism, a pneumatic mechanism, or a screw mechanism can also be used. It is not surprising that it is ijj noh that is adopted.

The rack and binion machine m (12) is combined with a motor (14) with seven rake and rotates the binion by an electric signal from a control device (18). The pinion meshes with a hook having a pedestal (13) fixed to its upper end, and the hook moves by the rotation of the pinion. Here, the electronic balance (
11) In order to control the upper F movement distance, a detection end of a distance sensor is provided at the lower end of the rack, and in response to the i[lLj distance sensor (16)? An example of the liquid preparation operation of the device of the present invention having the above-described configuration will be described in more detail.

The electronic balance (saucer (7) and receiving container (5) placed on a rotating cheagle (8) with a certain distance from the top of the river and the child balance are rack-binion mW (+2) K
Therefore, it is placed on the ascending electronic balance (ll) stand, released from the rotary table (8), and the heavy liquid (tare measurement is performed).Next, the first chemical liquid input into the input device (17) Based on the compounding prescription, one of the multiple medicinal solutions that must be included in the i'tI piece is opened and closed by the ν magnetic valve (3) to receive the container (s) K 1m Use the same method for other straw waste and water to complete the first mixture.

After that, the child balance (If) L/i descends to ), and the saucer (7
) and the receiving container (5) are placed in the first position on the rotary table (8). ” “Kaiko Daibain (11) is cut off and Fi4id.

On the other hand, the second medicine (4f) inputted into the input device (17)
, the designated receiving container (5) is placed in the upper part of the electronic balance (11) (outflow tube (4)) to add the compound based on the compounding recipe.
) The rotating cheagle (8) rotates so that it is located at the lower part of the collecting part, stops at the designated position, and performs the same operation as described above to complete the second blending.

Thereafter, in the same manner, the third, fourth, middle, third, third, third, and several third prescriptions are completed based on the prescriptions previously entered into the input device +Ffj (17).

In automatic blending, the above input device may be directly linked to a cuff matching device (not shown), or it may be used to input data from a color matching device to a recording medium such as paper tape or magnetic tape: magnetic disk, f disk, etc. You can record it manually, or you can record it manually. input device i&
Directly input l: on the keyboard 7r board installed in
-The end is also on the river surface.

Figure 2 shows the microprocessor (18) & control ml
Dye liquor automatic A1. ', 1
It is an example of a data processing for the stand and a control diagram of each mechanism. In this embodiment, as shown in Fig. 2, a microprocessor, which has become very inexpensive these days, is used as a control device, and input device N (17), Gibaud 1-, inputs h~ C samurai name, dye, etc. Microprocessor (+8) selects the dye stock solution based on input information such as coal dust and vehicle to be dyed, sets δtX and setting of the dye stock solution flowing out or under the dye, and sets the music when opening and closing the electric valve. At the same time, the electronic balance (from the river (N)
The data is taken in from time to time, compared with the set value for the outflow or 7-height dye original surface retention, and an instruction to open the electromagnetic tube f(3) is also given. Further, the value of the measured vehicle amount near the center is immediately outputted and recorded by a printer (2o), a controller such as a digital vehicle display device (19), and a microprocessor (18).

In addition, there is also a motor (9) with a latch that drives and controls the rotation of the rotary cheagle (8), and a positioner: i-LJ--
(10), a motor with a brake (14) that drives and controls the electronic balance (11) to move it up and down, commands such as a position sensor (1), and a micro-pro sensor (18) to control the lever 1. It is something that I am proud of.

Such a microprocessor (18) k Honraku f4
* By using it as the control mechanism of the automatic compounding device N and controlling the entire system using software, the scope of application of this device a can be extended to every type of chemical solution, and the design of the mechanical part is fixed. This prevents things from happening.

In addition, this device fully demonstrates its function when preparing the first few medicines ak, but it can also be used to weigh the first few 5-liquid 1-11 items and prepare multiple tablets individually. It is not a good idea that it can be used for purposes such as sequentially weighing into separate receiving containers.

In the device of the present invention that uses lead as described above, the electronic balance is transferred. In January, we adopted a weighing method that automatically measures the rectangular area of the object to be measured using IU+. It has great special enemies such as being able to dynamically adjust 11 pieces, improving the mixing depth IW, shortening the A-piece time, and even becoming self-bladed.In addition, it has great advantages such as the ability to adjust the temperature of the liquid (there is no difference, Since anyone can mix the mixture with high precision without the need for experience or skill as would be the case with manual preparation, there is no difference in human performance, and the IhM g
Another notable effect of the present invention is that it is easy.

[Brief explanation of the drawing]

Fig. 1 shows an overall diagram of the equipment 1 with Glock diagrams showing the bodies of the various machines, and Fig. 2 shows a diagram of the system using a micro-boiler as a control device. 1... ≧1ρ2 liquid
2...Medicine n'fse3-・
・? [4j3; F pal)゛ 4...d also delivered 5...
・Receiving container 6・-・Tone is liquid 7... Receiving container
Dish 8... Rotating cheagle 9... Motor with brake 1o... Position sensor 11 ・
...' Yuichiko large scale 12... Rack/binion machine IM13... Frame 14.
・-Slip key・]Moke 15-... Bearing
16... Amber sensor 17... Input device 18... Control device surface 19... Digital display device 20... Printer center 1 diagram 1゛11 20 Back Z diagram

Claims (4)

[Claims] (1) a container each accommodating the first few mulberry rff;
An outflow pipe each having a valve cut out to allow the drug I(k) in the container to flow out, a receiving container that sequentially receives the drug I (k) flowing out from the outflow pipe, and the drug received into the receiving valley HH 1]
A measuring device that converts the change in vehicle volume of IJ Kishiba ak into electricity (no. In the Rakuju automatic adjustment device 8- equipped with a control device m for opening and closing, the receiving container is loaded with the first number ii't
a transfer device, a motor for transferring the transfer device, and an elevating device hood for vertically moving the front-loading device disposed below the receiving container; -Weighing equipment! A control mechanism is provided for performing the operation of placing the receiving container by raising the volume 1'i--opening the receiving container by the lower part of the liquid mixing device 11 in 1 cycle multiple times. An automatic chemical compounding device characterized by: (2) Medicine a (self-iJr adjustment device) according to claim 1, wherein the measuring device is an electronic balance. (3) The liquid medicine automatic compounding device according to claim 1, wherein the transfer device is a rotary Cheagle or a circulating conveyor. (4) A special fl- characterized in that the chemical solution is a dye stock solution.
Pharmaceutical solution automatic blending device 0 according to claim 1