JPS58128141A - Production of soft capsule agent containing self- emulsifiable and dispersible type carotenoid - Google Patents

Abstract

PURPOSE:To develop soft capsules contg. self-emulsifiable and dispersible type carotenoids having high stability and a wide range of uses by dissolving or suspending carotenoids into a system consisting of a fat or oil, surfactant and of polyhydric alcohol then forming the same into soft capsules. CONSTITUTION:Soft capsule agents which contain in high concn. carotenoids insolube in water and poorly stable and contain self-emulsifiable and dispersible type carotenoids usable in a highly stable state over a wide range are prepd. Such capsules are prepd. by dissolving or suspending carotenoids such as alpha, beta, gamma-carotenes, xanthophyll, lycopene, canthaxantine, or the like into a system consisting of animal or vegetable fat or oil, surfactant such as hydrophilic glycerol, fatty acid ester or the like of 0.02-1 based on of one fat or oil and >6 HLB, contg. also polyhydric alochols such as glycerol, propylene glycol or the like of likewise 0.02-1 based on one fat or oil, then forming the mixture into soft capsules.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention involves dissolving carotenoid IF@ into a monomer component from a system of oil III, a water-retaining agent, and a polyhydric alcohol, and converting it into soft capsules. The method for manufacturing capsules of self-emulsifying and dispersing type V-type capsules has been expanded.

Carotenoid FIIll is excellent as a natural coloring agent and a vitamin precursor**.Furthermore, the wrinkle substance has poor stability and is soluble in water, making it difficult to use oil. It is abnormal that the animal is being slaughtered. Therefore, the current Toniro Carotinoi I# is a water-soluble 01. The shavings are simply due to the fact that the powder that has been turned into a powder has become crystallized, and crystal powder and oil-based suspensions are unstable due to the nature of the powder and cannot be easily opened. IFIIO is selected for use with threat gas replacement, or is it obvious that it is in water?There are some restrictions on use.*H%. Water-soluble emulsions and powders are more easily dispersed in water than crystalline powders and oil-based suspensions, and have better adhesion stability (T40) and (medium) stability (T40) for formulation processing. It is unavoidable that %Atk, which increases the am of upper carotenoids, is subject to restrictions in use.

For these reasons, there has been a strong desire to develop a formulation method that takes advantage of the excellent properties of carotenoids.
As a result of various studies on the formulation of Ill-containing f A II agent o H, we found that 1ml of carotenoid was dissolved or layered in the e4 component from a system of oil msi, surfactant, and polyhydric alfur, and then this was made into soft capsules. By doing so, it is possible to obtain a good preparation without any drawbacks, and it is easy to understand the cause and effect of the present invention.

That is, the present invention is based on the above-mentioned knowledge, and involves dissolving carotenoids in a component consisting of oils and fats, a surfactant, and a polyhydric alcohol, and then suspending the carotenoids in a composition consisting of a system of oils and fats, a surfactant, and a polyhydric alcohol, and then encapsulating the carotenoids into soft capsules. Become.

By using the timed melting or II suspension of the present invention, it is possible to make soft capsules, and when the soft capsules of the present invention are thrown into water, the outer shell dissolves and fats and oils containing carotenoids are mixed with surfactants and polyvalent Self-emulsifying due to aluminum action.

It can be dispersed and colored as desired.

In other words, practical soft capsules cannot be produced using other solutions or suspensions, but soft capsules can be made for the first time using a specific solution or suspension.
In addition, the soft capsules have a high self-emulsifying and dispersing property, so even in pigeon lofts in which pigeonholes have been administered for animals, craftsmen promote them as a nutritional source. Moreover, it has many advantages that have not been seen before, such as ease of handling, improved stability, etc., and greatly expanding OIi@ in use.

The Kfi carotenoids used in the present invention can be dissolved or suspended in a component consisting of fats and oils, a surfactant, and a polyhydric alcohol, and then soft encapsulated. It contains electron-1et-carotene, medium-weight monofilament, lycobin, canthaxanthin, and other synthetically produced as well as naturally produced products at the desired concentration! J) is used as appropriate. Fats and oils that dissolve or suspend these include animal and vegetable oils, such as cottonseed oil, wet oil, soybean oil, coconut oil, and pork oil.
, beef $tk and esters such as dioctyldecylglyceride.

Isopropyl olistate, cetyl isootatanoide, etc., avian grade arsuls, such as cetyl alcohol, penyl alcohol tz, x-class fatty acids, such as stearin II, palmitic acid hydrocarbons, such as liquid Zl fine, Ektalan, etc. One or more of them may be used as appropriate, but animal and vegetable oils and esters that can easily dissolve or suspend light and heavy carotenoids are convenient, and as surfactants, HLb 4
Preferably /- or more O1f aqueous ones are convenient, such as polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, polysilicon Fatty esters, esters, and other metal forming agents or glues
Two or more types of natural surfactants such as lipids may be used as appropriate.The amount of surfactant added depends on the amount of carotenoid, and the amount of fat and oil depends on the type of surfactant. -1
BLBKJ Rij & Kameru is normal oils/fats/O1 grade ~ 1
Just add it in the 0 range.

In the present invention, the polyvalent fluor acts as a bridge between the fats and oils in which carotenoid is dissolved or suspended and the hydrophilic surfactant. When submerged in water, it enhances the self-emulsification and dispersion of oils and fats in which carotenoids are dissolved or suspended and a hydrophilic surfactant, and is the most important type in carrying out the present invention.
1 kg of glycerin or probirecidal l-ol is used as eToh and polyhydric alfur, and the amount added is as follows:
It varies depending on the type of surfactant used, but usually all oils and fats are used.
/ to 0. It is sufficient to add in the range of a to no. In addition, antioxidants, flavoring agents, fragrances, etc. can also be added to these component systems as necessary.

Carotenoid F@ is dissolved or llm1lJt into a component consisting of oils and fats, surfactants, and polyhydric alcohol O system.
&Method Objectives*, Ingredients.

All you have to do is stir the pot using the usual method until the amount reaches Km, and you can heat it if necessary to dissolve it, so it's basically a one-component system, so all you have to do is stir it up.

In order to make soft capsules from the above-mentioned component system, the conventional technique using gelatin and polyvinyl alcohol as a shell is used to fill the capsules to any size of 7-10 capsules.
Ami with good things.

As explained in detail above, KtJ rotinoid is contained in a component consisting of oil, fat, surfactant, and polyhydric alcohol.
ll solution or II Mlt firefly, this is soft encapsulated.

The manufacturing method of the self-emulsifying and dispersing carotenoid VIII-containing shaved soft capsules of the present invention greatly improves various problems in the use of carotenoids 111O, which have been problems in the past, and makes the most of the excellent properties of carotenoids. . Examples will be shown below to specifically explain the invention.

Example / 11 carotene/θl was dissolved with heating and stirring in cottonseed oil 4Ioo I and common fatty acid ester <IILII/J) 4101-naturally #kamen]CJg and glycerinda 0ρg, When filled with Denki Jll's soft capsules, this product self-emulsifies and disperses by stirring gently when dropped into water, and is then mixed with yellow homogeneous emulsion soda.

Example 1 P-carotene 101 was heated and stirred in dioctyldisyldaricetoid daooti and polysaccharide in ethylene sorbitase fatty acid ester (ar, nzj) θI% natural vitamin xsg and propylecidalyl θ01. This product is dissolved and filled into a gelatin shell to form a soft capsule of Nao II &/θ Kasumi.When thrown into water, it self-emulsifies and disperses with just gentle stirring, resulting in a yellow, evenly-constructed mulch capsule. I lost weight.

Example 3 11 carotene/θg was dissolved in coconut oil qρθg, polyglycerin fat ester ('HI,B/J) 10θI and glycerin 1001 with heating and stirring, and the solution was filled into a gelatin shell and made into a gelatin shell with a diameter of J. It was made into soft capsules. When crystals are dropped into water, they self-emulsify and disperse by stirring gently.

A uniform yellow emulsion was obtained.

Claims (1)

[Scope of Claims] H) A self-emulsifying dispersion characterized in that carotenoid Fll is dissolved or layered in a component consisting of oils and fats, an interfacial frI agent, and a polyhydric alcohol, and then soft encapsulated. Soft capsules containing type carotenoids Oa
t method. - Fats and oils include animal and vegetable oils, esters, higher alcohols,
The method for producing higher fats and hydrocarbons of type ○ or two or more according to item (1) of the patent application. (J) The manufacturing method according to claim 1), when the surfactant has a hydrophilicity of B114 or higher.