JPS5772913A - Remedy for cardiac infraction - Google Patents
Remedy for cardiac infractionInfo
- Publication number
- JPS5772913A JPS5772913A JP14690980A JP14690980A JPS5772913A JP S5772913 A JPS5772913 A JP S5772913A JP 14690980 A JP14690980 A JP 14690980A JP 14690980 A JP14690980 A JP 14690980A JP S5772913 A JPS5772913 A JP S5772913A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- expressed
- alkyl
- remedy
- trans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To remedy for cardiac infarction with high safety containing a trans- epoxysuccinamic acid derivative as an active contituent.
CONSTITUTION: A remedy for cardiac infarctin containing a trans-epoxysuccinamic acid derivative expressed by formulaI(R1 is H or 1W4C alkyl; R2 and R3 are H or 1W4C alkyl, phenyl, etc., except when R2 and R3 are H at the same time; R4 is 1W5C alkyl) or a nontoxic salt thereof as an active constituent. In the case of the compound expressed by formulaIin which R1 is not H, an amine derivative expressed by formula II is reacted with a trans-epoxysuccinic monoester expressed by formula III (R5 is 1W4C alkyl) to give a compound expressed by formula IV. The compound expressed by formula V in which R1 is H is obtained by hydrolyzing or removing the ester residue of the compound expressed by formula IV. The dose of the emedy is 100mgW1g/day, and has improved effects on the prevention and treatment of the cardiac infarction.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14690980A JPS5772913A (en) | 1980-10-22 | 1980-10-22 | Remedy for cardiac infraction |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14690980A JPS5772913A (en) | 1980-10-22 | 1980-10-22 | Remedy for cardiac infraction |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5772913A true JPS5772913A (en) | 1982-05-07 |
JPH0121129B2 JPH0121129B2 (en) | 1989-04-19 |
Family
ID=15418304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14690980A Granted JPS5772913A (en) | 1980-10-22 | 1980-10-22 | Remedy for cardiac infraction |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5772913A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992006090A1 (en) * | 1990-09-29 | 1992-04-16 | Taisho Pharmaceutical Co., Ltd. | Epoxysuccinamic acid derivative |
US5556853A (en) * | 1993-10-29 | 1996-09-17 | Takeda Chemical Industries, Ltd. | Epoxysuccinic acid derivatives |
WO1999011640A1 (en) * | 1997-09-04 | 1999-03-11 | Nippon Chemiphar Co., Ltd. | Epoxysuccinamide derivatives |
-
1980
- 1980-10-22 JP JP14690980A patent/JPS5772913A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992006090A1 (en) * | 1990-09-29 | 1992-04-16 | Taisho Pharmaceutical Co., Ltd. | Epoxysuccinamic acid derivative |
US5281717A (en) * | 1990-09-29 | 1994-01-25 | Taisho Pharmaceutical Co., Ltd. | Epoxysuccinamic acid derivatives |
US5556853A (en) * | 1993-10-29 | 1996-09-17 | Takeda Chemical Industries, Ltd. | Epoxysuccinic acid derivatives |
WO1999011640A1 (en) * | 1997-09-04 | 1999-03-11 | Nippon Chemiphar Co., Ltd. | Epoxysuccinamide derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPH0121129B2 (en) | 1989-04-19 |
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