JPS5759847A - 4-aminomethylcyclohexanecarboxylic acid derivative - Google Patents
4-aminomethylcyclohexanecarboxylic acid derivativeInfo
- Publication number
- JPS5759847A JPS5759847A JP13700880A JP13700880A JPS5759847A JP S5759847 A JPS5759847 A JP S5759847A JP 13700880 A JP13700880 A JP 13700880A JP 13700880 A JP13700880 A JP 13700880A JP S5759847 A JPS5759847 A JP S5759847A
- Authority
- JP
- Japan
- Prior art keywords
- compound expressed
- formula
- trans
- agent
- acid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NEW MATERIAL:A compound expressed by formulaI[R1 is H or lower alkyl; R2 is cycloalkyl or group of formula IV (X is OH or lower alkoxyl; n is an integer 1W3)].
EXAMPLE: trans-4-(trans-4-n-Pentylcyclohexylcarbonylaminomethyl)cyclohexanecar- boxylic acid.
USE: A remedy and preventing agent for allergic diseases, e.g. nephritis, rheumatism, collagen disease or autoimmune disease, having antiplasminic, antitumor and antithrombotic actions, and useful as a medicine.
PROCESS: A compound expressed by formula II is reacted with an equimolar amount or slight excess of a reactive derivative of a compound expressed by formula III, e.g. acid chloride or anhydride, in a solvent e.g. water or methanol, and if necessary in the presence of a dehydrating agent or deacidifying agent at room temperature or under refluxing to give the compound expressed by formlaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13700880A JPS5759847A (en) | 1980-09-29 | 1980-09-29 | 4-aminomethylcyclohexanecarboxylic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13700880A JPS5759847A (en) | 1980-09-29 | 1980-09-29 | 4-aminomethylcyclohexanecarboxylic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5759847A true JPS5759847A (en) | 1982-04-10 |
JPS648616B2 JPS648616B2 (en) | 1989-02-14 |
Family
ID=15188646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13700880A Granted JPS5759847A (en) | 1980-09-29 | 1980-09-29 | 4-aminomethylcyclohexanecarboxylic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5759847A (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6169816A (en) * | 1984-09-13 | 1986-04-10 | Mitsubishi Chem Ind Ltd | Production of porous copolymer |
EP0585130A2 (en) * | 1992-08-27 | 1994-03-02 | Shiseido Company Limited | External preparation for skin containing a depigmentation agent |
EP0647616A1 (en) * | 1992-06-23 | 1995-04-12 | Zaidan Hojin Seisan Kaihatsu Kagaku Kenkyusho | Zinc tranexamate compound |
EP1132083A3 (en) * | 2000-03-08 | 2002-10-23 | Hamari Chemicals Co., Ltd. | Use of zinc tranexamate in the treatment of diabetes |
WO2005011650A1 (en) * | 2003-07-31 | 2005-02-10 | Xanodyne Pharmaceuticals, Inc. | Tranexamic acid formulations with reduced adverse effects |
US7947739B2 (en) | 2004-03-04 | 2011-05-24 | Ferring B.V. | Tranexamic acid formulations |
US8487005B2 (en) | 2004-03-04 | 2013-07-16 | Ferring B.V. | Tranexamic acid formulations |
US8957113B2 (en) | 2004-03-04 | 2015-02-17 | Ferring B.V. | Tranexamic acid formulations |
CN108976146A (en) * | 2017-05-31 | 2018-12-11 | 首都医科大学 | The positive positive hexanoyl ArAA of hexanoyl ammonia first cyclic amide base of amino, synthesis, activity and application |
CN109081790A (en) * | 2017-06-13 | 2018-12-25 | 首都医科大学 | The positive positive hexanoyl basic amino acid of hexanoyl amino first cyclic amide base of amino, synthesis, activity and application |
-
1980
- 1980-09-29 JP JP13700880A patent/JPS5759847A/en active Granted
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6169816A (en) * | 1984-09-13 | 1986-04-10 | Mitsubishi Chem Ind Ltd | Production of porous copolymer |
EP0647616A1 (en) * | 1992-06-23 | 1995-04-12 | Zaidan Hojin Seisan Kaihatsu Kagaku Kenkyusho | Zinc tranexamate compound |
EP0647616A4 (en) * | 1992-06-23 | 1995-08-16 | Zaidan Hojin Seisan Kaihatsu K | Zinc tranexamate compound. |
US5506264A (en) * | 1992-06-23 | 1996-04-09 | Zaidan Hojin Seisan Kaihatsu Kaguki Kenkyusho | Zinc tranexamate compounds |
EP0585130A2 (en) * | 1992-08-27 | 1994-03-02 | Shiseido Company Limited | External preparation for skin containing a depigmentation agent |
EP0585130A3 (en) * | 1992-08-27 | 1994-06-08 | Shiseido Co Ltd | External preparation for skin containing a depigmentation agent |
US5690914A (en) * | 1992-08-27 | 1997-11-25 | Shiseido Co., Ltd | External preparation for skin |
EP1132083A3 (en) * | 2000-03-08 | 2002-10-23 | Hamari Chemicals Co., Ltd. | Use of zinc tranexamate in the treatment of diabetes |
WO2005011650A1 (en) * | 2003-07-31 | 2005-02-10 | Xanodyne Pharmaceuticals, Inc. | Tranexamic acid formulations with reduced adverse effects |
US8968777B2 (en) | 2003-07-31 | 2015-03-03 | Ferring B.V. | Tranexamic acid formulations with reduced adverse effects |
US8487005B2 (en) | 2004-03-04 | 2013-07-16 | Ferring B.V. | Tranexamic acid formulations |
US8791160B2 (en) | 2004-03-04 | 2014-07-29 | Ferring B.V. | Tranexamic acid formulations |
US8809394B2 (en) | 2004-03-04 | 2014-08-19 | Ferring B.V. | Tranexamic acid formulations |
US8957113B2 (en) | 2004-03-04 | 2015-02-17 | Ferring B.V. | Tranexamic acid formulations |
US7947739B2 (en) | 2004-03-04 | 2011-05-24 | Ferring B.V. | Tranexamic acid formulations |
US9060939B2 (en) | 2004-03-04 | 2015-06-23 | Ferring B.V. | Tranexamic acid formulations |
CN108976146A (en) * | 2017-05-31 | 2018-12-11 | 首都医科大学 | The positive positive hexanoyl ArAA of hexanoyl ammonia first cyclic amide base of amino, synthesis, activity and application |
CN108976146B (en) * | 2017-05-31 | 2020-11-27 | 首都医科大学 | Amino n-hexanoyl methyl cyclamido n-hexanoyl aromatic amino acid, synthesis, activity and application thereof |
CN109081790A (en) * | 2017-06-13 | 2018-12-25 | 首都医科大学 | The positive positive hexanoyl basic amino acid of hexanoyl amino first cyclic amide base of amino, synthesis, activity and application |
CN109081790B (en) * | 2017-06-13 | 2021-02-12 | 首都医科大学 | Amino n-hexanoyl amido methyl-n-hexanoyl basic amino acid, synthesis, activity and application thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS648616B2 (en) | 1989-02-14 |
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