JPS5759847A - 4-aminomethylcyclohexanecarboxylic acid derivative - Google Patents

4-aminomethylcyclohexanecarboxylic acid derivative

Info

Publication number
JPS5759847A
JPS5759847A JP13700880A JP13700880A JPS5759847A JP S5759847 A JPS5759847 A JP S5759847A JP 13700880 A JP13700880 A JP 13700880A JP 13700880 A JP13700880 A JP 13700880A JP S5759847 A JPS5759847 A JP S5759847A
Authority
JP
Japan
Prior art keywords
compound expressed
formula
trans
agent
acid derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13700880A
Other languages
Japanese (ja)
Other versions
JPS648616B2 (en
Inventor
Kanji Noda
Akira Nakagawa
Toshiharu Motomura
Satoru Miyata
Toshitaka Inoue
Hiroyuki Ide
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Priority to JP13700880A priority Critical patent/JPS5759847A/en
Publication of JPS5759847A publication Critical patent/JPS5759847A/en
Publication of JPS648616B2 publication Critical patent/JPS648616B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

NEW MATERIAL:A compound expressed by formulaI[R1 is H or lower alkyl; R2 is cycloalkyl or group of formula IV (X is OH or lower alkoxyl; n is an integer 1W3)].
EXAMPLE: trans-4-(trans-4-n-Pentylcyclohexylcarbonylaminomethyl)cyclohexanecar- boxylic acid.
USE: A remedy and preventing agent for allergic diseases, e.g. nephritis, rheumatism, collagen disease or autoimmune disease, having antiplasminic, antitumor and antithrombotic actions, and useful as a medicine.
PROCESS: A compound expressed by formula II is reacted with an equimolar amount or slight excess of a reactive derivative of a compound expressed by formula III, e.g. acid chloride or anhydride, in a solvent e.g. water or methanol, and if necessary in the presence of a dehydrating agent or deacidifying agent at room temperature or under refluxing to give the compound expressed by formlaI.
COPYRIGHT: (C)1982,JPO&Japio
JP13700880A 1980-09-29 1980-09-29 4-aminomethylcyclohexanecarboxylic acid derivative Granted JPS5759847A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13700880A JPS5759847A (en) 1980-09-29 1980-09-29 4-aminomethylcyclohexanecarboxylic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13700880A JPS5759847A (en) 1980-09-29 1980-09-29 4-aminomethylcyclohexanecarboxylic acid derivative

Publications (2)

Publication Number Publication Date
JPS5759847A true JPS5759847A (en) 1982-04-10
JPS648616B2 JPS648616B2 (en) 1989-02-14

Family

ID=15188646

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13700880A Granted JPS5759847A (en) 1980-09-29 1980-09-29 4-aminomethylcyclohexanecarboxylic acid derivative

Country Status (1)

Country Link
JP (1) JPS5759847A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6169816A (en) * 1984-09-13 1986-04-10 Mitsubishi Chem Ind Ltd Production of porous copolymer
EP0585130A2 (en) * 1992-08-27 1994-03-02 Shiseido Company Limited External preparation for skin containing a depigmentation agent
EP0647616A1 (en) * 1992-06-23 1995-04-12 Zaidan Hojin Seisan Kaihatsu Kagaku Kenkyusho Zinc tranexamate compound
EP1132083A3 (en) * 2000-03-08 2002-10-23 Hamari Chemicals Co., Ltd. Use of zinc tranexamate in the treatment of diabetes
WO2005011650A1 (en) * 2003-07-31 2005-02-10 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations with reduced adverse effects
US7947739B2 (en) 2004-03-04 2011-05-24 Ferring B.V. Tranexamic acid formulations
US8487005B2 (en) 2004-03-04 2013-07-16 Ferring B.V. Tranexamic acid formulations
US8957113B2 (en) 2004-03-04 2015-02-17 Ferring B.V. Tranexamic acid formulations
CN108976146A (en) * 2017-05-31 2018-12-11 首都医科大学 The positive positive hexanoyl ArAA of hexanoyl ammonia first cyclic amide base of amino, synthesis, activity and application
CN109081790A (en) * 2017-06-13 2018-12-25 首都医科大学 The positive positive hexanoyl basic amino acid of hexanoyl amino first cyclic amide base of amino, synthesis, activity and application

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6169816A (en) * 1984-09-13 1986-04-10 Mitsubishi Chem Ind Ltd Production of porous copolymer
EP0647616A1 (en) * 1992-06-23 1995-04-12 Zaidan Hojin Seisan Kaihatsu Kagaku Kenkyusho Zinc tranexamate compound
EP0647616A4 (en) * 1992-06-23 1995-08-16 Zaidan Hojin Seisan Kaihatsu K Zinc tranexamate compound.
US5506264A (en) * 1992-06-23 1996-04-09 Zaidan Hojin Seisan Kaihatsu Kaguki Kenkyusho Zinc tranexamate compounds
EP0585130A2 (en) * 1992-08-27 1994-03-02 Shiseido Company Limited External preparation for skin containing a depigmentation agent
EP0585130A3 (en) * 1992-08-27 1994-06-08 Shiseido Co Ltd External preparation for skin containing a depigmentation agent
US5690914A (en) * 1992-08-27 1997-11-25 Shiseido Co., Ltd External preparation for skin
EP1132083A3 (en) * 2000-03-08 2002-10-23 Hamari Chemicals Co., Ltd. Use of zinc tranexamate in the treatment of diabetes
WO2005011650A1 (en) * 2003-07-31 2005-02-10 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations with reduced adverse effects
US8968777B2 (en) 2003-07-31 2015-03-03 Ferring B.V. Tranexamic acid formulations with reduced adverse effects
US8487005B2 (en) 2004-03-04 2013-07-16 Ferring B.V. Tranexamic acid formulations
US8791160B2 (en) 2004-03-04 2014-07-29 Ferring B.V. Tranexamic acid formulations
US8809394B2 (en) 2004-03-04 2014-08-19 Ferring B.V. Tranexamic acid formulations
US8957113B2 (en) 2004-03-04 2015-02-17 Ferring B.V. Tranexamic acid formulations
US7947739B2 (en) 2004-03-04 2011-05-24 Ferring B.V. Tranexamic acid formulations
US9060939B2 (en) 2004-03-04 2015-06-23 Ferring B.V. Tranexamic acid formulations
CN108976146A (en) * 2017-05-31 2018-12-11 首都医科大学 The positive positive hexanoyl ArAA of hexanoyl ammonia first cyclic amide base of amino, synthesis, activity and application
CN108976146B (en) * 2017-05-31 2020-11-27 首都医科大学 Amino n-hexanoyl methyl cyclamido n-hexanoyl aromatic amino acid, synthesis, activity and application thereof
CN109081790A (en) * 2017-06-13 2018-12-25 首都医科大学 The positive positive hexanoyl basic amino acid of hexanoyl amino first cyclic amide base of amino, synthesis, activity and application
CN109081790B (en) * 2017-06-13 2021-02-12 首都医科大学 Amino n-hexanoyl amido methyl-n-hexanoyl basic amino acid, synthesis, activity and application thereof

Also Published As

Publication number Publication date
JPS648616B2 (en) 1989-02-14

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