JPS5740479A - Preparation of benzofuran derivative and its acid addition salt - Google Patents

Preparation of benzofuran derivative and its acid addition salt

Info

Publication number
JPS5740479A
JPS5740479A JP11563580A JP11563580A JPS5740479A JP S5740479 A JPS5740479 A JP S5740479A JP 11563580 A JP11563580 A JP 11563580A JP 11563580 A JP11563580 A JP 11563580A JP S5740479 A JPS5740479 A JP S5740479A
Authority
JP
Japan
Prior art keywords
formula
compound
addition salt
acid addition
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11563580A
Other languages
Japanese (ja)
Inventor
Katsuhiro Uchida
Kazuhiko Kimura
Teruo Nakanishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Original Assignee
Kaken Pharmaceutical Co Ltd
Kakenyaku Kako KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharmaceutical Co Ltd, Kakenyaku Kako KK filed Critical Kaken Pharmaceutical Co Ltd
Priority to JP11563580A priority Critical patent/JPS5740479A/en
Priority to ES494881A priority patent/ES494881A0/en
Publication of JPS5740479A publication Critical patent/JPS5740479A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

PURPOSE: To obtain a benzofuran derivative and an acid addition salt thereof useful as an adrenergic β-receptor blocking agent, by reacting a novel benzofuranylglycerol monosulfonate compound with a primary alkyl amine.
CONSTITUTION: A novel substance of formula I (R is 1W4C alkyl, 1W3C alkoxyl or phenyl; Y is aryl- or alkylsulfonyl; substituted propoxy group is substituted at an optional position of the 3- W 7-positions of the benzofuran ring) is reacted with an amine of formula II (R' is 1W4C alkyl) in a suitable solvent or in the amine of formula II itself as the solvent at normal or higher pressure at a temperature of 50W 150°C for several hours to give a compound of formula III or an acid addition salt thereof. The novel substance of formula I is obtained by reacting a compound of formula IV with a compound of formula V, hydrolyzing the reaction product with an acid, and reacting the resultant product with an aryl- or alkylsulfonyl halide.
COPYRIGHT: (C)1982,JPO&Japio
JP11563580A 1980-08-21 1980-08-21 Preparation of benzofuran derivative and its acid addition salt Pending JPS5740479A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP11563580A JPS5740479A (en) 1980-08-21 1980-08-21 Preparation of benzofuran derivative and its acid addition salt
ES494881A ES494881A0 (en) 1980-08-21 1980-09-08 A PROCEDURE FOR PREPARING A BENZOFURAN DERIVATIVE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11563580A JPS5740479A (en) 1980-08-21 1980-08-21 Preparation of benzofuran derivative and its acid addition salt

Publications (1)

Publication Number Publication Date
JPS5740479A true JPS5740479A (en) 1982-03-06

Family

ID=14667518

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11563580A Pending JPS5740479A (en) 1980-08-21 1980-08-21 Preparation of benzofuran derivative and its acid addition salt

Country Status (2)

Country Link
JP (1) JPS5740479A (en)
ES (1) ES494881A0 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663347A (en) * 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US4822803A (en) * 1983-10-31 1989-04-18 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
US4933351A (en) * 1983-10-31 1990-06-12 Merck Frosst Canada, Inc. Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis
WO2000037464A3 (en) * 1998-12-18 2000-11-02 Hoffmann La Roche 4-(aminoalkoxy)benzofurans as n-myristoyltransferase inhibitors
KR20180061289A (en) 2015-09-30 2018-06-07 세키스이가세이힝코교가부시키가이샤 Polymer particles and uses thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663347A (en) * 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US4822803A (en) * 1983-10-31 1989-04-18 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
US4933351A (en) * 1983-10-31 1990-06-12 Merck Frosst Canada, Inc. Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis
WO2000037464A3 (en) * 1998-12-18 2000-11-02 Hoffmann La Roche 4-(aminoalkoxy)benzofurans as n-myristoyltransferase inhibitors
KR20180061289A (en) 2015-09-30 2018-06-07 세키스이가세이힝코교가부시키가이샤 Polymer particles and uses thereof

Also Published As

Publication number Publication date
ES8106899A1 (en) 1981-09-01
ES494881A0 (en) 1981-09-01

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