JPS5740479A - Preparation of benzofuran derivative and its acid addition salt - Google Patents
Preparation of benzofuran derivative and its acid addition saltInfo
- Publication number
- JPS5740479A JPS5740479A JP11563580A JP11563580A JPS5740479A JP S5740479 A JPS5740479 A JP S5740479A JP 11563580 A JP11563580 A JP 11563580A JP 11563580 A JP11563580 A JP 11563580A JP S5740479 A JPS5740479 A JP S5740479A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- addition salt
- acid addition
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
PURPOSE: To obtain a benzofuran derivative and an acid addition salt thereof useful as an adrenergic β-receptor blocking agent, by reacting a novel benzofuranylglycerol monosulfonate compound with a primary alkyl amine.
CONSTITUTION: A novel substance of formula I (R is 1W4C alkyl, 1W3C alkoxyl or phenyl; Y is aryl- or alkylsulfonyl; substituted propoxy group is substituted at an optional position of the 3- W 7-positions of the benzofuran ring) is reacted with an amine of formula II (R' is 1W4C alkyl) in a suitable solvent or in the amine of formula II itself as the solvent at normal or higher pressure at a temperature of 50W 150°C for several hours to give a compound of formula III or an acid addition salt thereof. The novel substance of formula I is obtained by reacting a compound of formula IV with a compound of formula V, hydrolyzing the reaction product with an acid, and reacting the resultant product with an aryl- or alkylsulfonyl halide.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11563580A JPS5740479A (en) | 1980-08-21 | 1980-08-21 | Preparation of benzofuran derivative and its acid addition salt |
ES494881A ES494881A0 (en) | 1980-08-21 | 1980-09-08 | A PROCEDURE FOR PREPARING A BENZOFURAN DERIVATIVE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11563580A JPS5740479A (en) | 1980-08-21 | 1980-08-21 | Preparation of benzofuran derivative and its acid addition salt |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5740479A true JPS5740479A (en) | 1982-03-06 |
Family
ID=14667518
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11563580A Pending JPS5740479A (en) | 1980-08-21 | 1980-08-21 | Preparation of benzofuran derivative and its acid addition salt |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS5740479A (en) |
ES (1) | ES494881A0 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4663347A (en) * | 1983-10-31 | 1987-05-05 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis |
US4822803A (en) * | 1983-10-31 | 1989-04-18 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis |
US4933351A (en) * | 1983-10-31 | 1990-06-12 | Merck Frosst Canada, Inc. | Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis |
WO2000037464A3 (en) * | 1998-12-18 | 2000-11-02 | Hoffmann La Roche | 4-(aminoalkoxy)benzofurans as n-myristoyltransferase inhibitors |
KR20180061289A (en) | 2015-09-30 | 2018-06-07 | 세키스이가세이힝코교가부시키가이샤 | Polymer particles and uses thereof |
-
1980
- 1980-08-21 JP JP11563580A patent/JPS5740479A/en active Pending
- 1980-09-08 ES ES494881A patent/ES494881A0/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4663347A (en) * | 1983-10-31 | 1987-05-05 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis |
US4822803A (en) * | 1983-10-31 | 1989-04-18 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis |
US4933351A (en) * | 1983-10-31 | 1990-06-12 | Merck Frosst Canada, Inc. | Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis |
WO2000037464A3 (en) * | 1998-12-18 | 2000-11-02 | Hoffmann La Roche | 4-(aminoalkoxy)benzofurans as n-myristoyltransferase inhibitors |
KR20180061289A (en) | 2015-09-30 | 2018-06-07 | 세키스이가세이힝코교가부시키가이샤 | Polymer particles and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
ES8106899A1 (en) | 1981-09-01 |
ES494881A0 (en) | 1981-09-01 |
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