JPS572279A - Dibenzoxazepin derivative - Google Patents

Dibenzoxazepin derivative

Info

Publication number
JPS572279A
JPS572279A JP7417780A JP7417780A JPS572279A JP S572279 A JPS572279 A JP S572279A JP 7417780 A JP7417780 A JP 7417780A JP 7417780 A JP7417780 A JP 7417780A JP S572279 A JPS572279 A JP S572279A
Authority
JP
Japan
Prior art keywords
formula
compound
dibenzoxazepin
derivative
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7417780A
Other languages
Japanese (ja)
Other versions
JPH0220638B2 (en
Inventor
Kazuo Sasahara
Narimitsu Honda
Masuo Koizumi
Yasushi Murakami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP7417780A priority Critical patent/JPS572279A/en
Publication of JPS572279A publication Critical patent/JPS572279A/en
Publication of JPH0220638B2 publication Critical patent/JPH0220638B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A dibenzoxazepin derivative of formula I (R1 is H, lower alkyl, or lower alkoxy; R2 is lower alkoxycarbonyl; R3 is lower alkyl or phenyl).
EXAMPLE: 10, 11-Dihydro-2, 4-dimethoxy-11-phenyldibenzo[ b,f ][ 1,4 ]oxazepin-8- carboxylic acid ethyl ester.
USE: It has antilipemic activity and blood platelet coagulation inhibiting activity, and is useful as a medicine.
PROCESS: The compound of formula I can be prepared by the catalytic reduction of the compound of formula II in a solvent such as methanol, tetrahydrofuran, etc. in the presence of a catalyst such as 5W10% Raney nickel or palladium-carbon. The compound of formula II is also new, and can be prepared by heating e.g. the compound of formula III in a solvent such as benzene in the presence of a dehydrating agent such as phosphorus oxychloride.
COPYRIGHT: (C)1982,JPO&Japio
JP7417780A 1980-06-04 1980-06-04 Dibenzoxazepin derivative Granted JPS572279A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7417780A JPS572279A (en) 1980-06-04 1980-06-04 Dibenzoxazepin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7417780A JPS572279A (en) 1980-06-04 1980-06-04 Dibenzoxazepin derivative

Publications (2)

Publication Number Publication Date
JPS572279A true JPS572279A (en) 1982-01-07
JPH0220638B2 JPH0220638B2 (en) 1990-05-10

Family

ID=13539615

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7417780A Granted JPS572279A (en) 1980-06-04 1980-06-04 Dibenzoxazepin derivative

Country Status (1)

Country Link
JP (1) JPS572279A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886815A (en) * 1984-06-20 1989-12-12 Schachar Ronald A Treatment and prevention of retinal edema with dopaminergic antagonists
US4886795A (en) * 1984-06-20 1989-12-12 Schachar Ronald A Treatment and prevention of retinal edema with dopaminergic antagonists
JPH0452600U (en) * 1990-09-10 1992-05-06
US11649218B2 (en) * 2018-03-09 2023-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886815A (en) * 1984-06-20 1989-12-12 Schachar Ronald A Treatment and prevention of retinal edema with dopaminergic antagonists
US4886795A (en) * 1984-06-20 1989-12-12 Schachar Ronald A Treatment and prevention of retinal edema with dopaminergic antagonists
JPH0452600U (en) * 1990-09-10 1992-05-06
US11649218B2 (en) * 2018-03-09 2023-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same

Also Published As

Publication number Publication date
JPH0220638B2 (en) 1990-05-10

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