JPS57169424A - Preparation of erythropoietin - Google Patents

Preparation of erythropoietin

Info

Publication number
JPS57169424A
JPS57169424A JP56054171A JP5417181A JPS57169424A JP S57169424 A JPS57169424 A JP S57169424A JP 56054171 A JP56054171 A JP 56054171A JP 5417181 A JP5417181 A JP 5417181A JP S57169424 A JPS57169424 A JP S57169424A
Authority
JP
Japan
Prior art keywords
erythropoietin
animal
urine
cells
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56054171A
Other languages
Japanese (ja)
Inventor
Morio Handa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TOUYOU SHINYAKU KK
Toyo Shinyaku Co Ltd
Original Assignee
TOUYOU SHINYAKU KK
Toyo Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TOUYOU SHINYAKU KK, Toyo Shinyaku Co Ltd filed Critical TOUYOU SHINYAKU KK
Priority to JP56054171A priority Critical patent/JPS57169424A/en
Publication of JPS57169424A publication Critical patent/JPS57169424A/en
Pending legal-status Critical Current

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE: To prepare erythropoietin useful as a remedy for the inveterate anemia of the patient of renal insufficiency, economically in an industrial scale, by implanting an erythropoietin-producing tumor to an immunodeficient animal, and separating the objective substance from the urine of the animal.
CONSTITUTION: An erythropoietin-producing tumor is implanted to an immunodeficient animal, e.g. a genetic thymoprival animal such as nude mouse, and the erythropoietin is separated from the urine of the animal. Erythropoietin is an important hormonelike substance which is produced or activated in the kindney, and acts to the stem cells existing in the hematopoietic organs to cause the differentiation of erythroblast cells and the acceleration of the production of erythrocytes. After the hypodermic implantation of the tumor cells to the above animal, the erythropoietin concentration in the urine of the animal having proliferated tumor cells is determined. When the increase in the amount of erythropoietin in the urine is observed, the urine is collected, and the erythropoietin is separated and purified by the combined use of dialysis, various chromatographic processes, etc.
COPYRIGHT: (C)1982,JPO&Japio
JP56054171A 1981-04-10 1981-04-10 Preparation of erythropoietin Pending JPS57169424A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56054171A JPS57169424A (en) 1981-04-10 1981-04-10 Preparation of erythropoietin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56054171A JPS57169424A (en) 1981-04-10 1981-04-10 Preparation of erythropoietin

Publications (1)

Publication Number Publication Date
JPS57169424A true JPS57169424A (en) 1982-10-19

Family

ID=12963089

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56054171A Pending JPS57169424A (en) 1981-04-10 1981-04-10 Preparation of erythropoietin

Country Status (1)

Country Link
JP (1) JPS57169424A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1063969C (en) * 1984-11-30 2001-04-04 柯瑞英-艾格公司 Process for preparing pharmaceutically composition containing polypeptides
US8193415B2 (en) 1999-10-26 2012-06-05 Stichting Dienst Landbouwkundig Onderzock Plant expressing mammalian β1,4-galactosyltransferase and β1,3-glucuronyltransferase
US8309795B2 (en) 2001-01-19 2012-11-13 Phyton Holdings, Llc Method for secretory production of glycoprotein having human-type sugar chain using plant cell
US8492613B2 (en) 2002-03-19 2013-07-23 Stichting Dienst Landbouwkundig Onderzoek GNTIII expression in plants
US8853370B2 (en) 1998-12-09 2014-10-07 Phyton Holdings, Llc Plant-produced glycoprotein comprising human-type sugar chain
US8927810B2 (en) 2002-03-19 2015-01-06 Stichting Dienst Landbouwkundig Onderzoek Optimizing glycan processing in plants
US9745594B2 (en) 2007-04-17 2017-08-29 Stichting Dienst Landbouwkundig Onderzoek Mammalian-type glycosylation in plants by expression of a zebrafish glycosyltransferase

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1063969C (en) * 1984-11-30 2001-04-04 柯瑞英-艾格公司 Process for preparing pharmaceutically composition containing polypeptides
US8853370B2 (en) 1998-12-09 2014-10-07 Phyton Holdings, Llc Plant-produced glycoprotein comprising human-type sugar chain
US8193415B2 (en) 1999-10-26 2012-06-05 Stichting Dienst Landbouwkundig Onderzock Plant expressing mammalian β1,4-galactosyltransferase and β1,3-glucuronyltransferase
US8907163B2 (en) 1999-10-26 2014-12-09 Stichting Dienst Landbouwkundig Onderzoek Transgenic plants expressing galactosyltransferase and sialyl transferase
US8309795B2 (en) 2001-01-19 2012-11-13 Phyton Holdings, Llc Method for secretory production of glycoprotein having human-type sugar chain using plant cell
US8735656B2 (en) 2001-01-19 2014-05-27 Phyton Holdings, Llc Method of expressing galactosyltransferase and inhibiting xylosyltransferase or fucosyltransferase in a transgenic plant cell for secretory production of glycoproteins having human-type sugar chains
US9574218B2 (en) 2001-01-19 2017-02-21 Phyton Holdings, Llc Method of co-expressing galactosyltransferase and a glycoprotein in a transgenic plant cell and sialylating the glycoprotein for production of glycoprotein having human-type sugar chain
US8492613B2 (en) 2002-03-19 2013-07-23 Stichting Dienst Landbouwkundig Onderzoek GNTIII expression in plants
US8927810B2 (en) 2002-03-19 2015-01-06 Stichting Dienst Landbouwkundig Onderzoek Optimizing glycan processing in plants
US9255277B2 (en) 2002-03-19 2016-02-09 Stichting Dienst Landbouwkundig Onderzoek GNTIII expression in plants
US9745594B2 (en) 2007-04-17 2017-08-29 Stichting Dienst Landbouwkundig Onderzoek Mammalian-type glycosylation in plants by expression of a zebrafish glycosyltransferase

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