JPS57156467A - 2,4-disubstituted-6-quinazolinesulfonamide derivative - Google Patents
2,4-disubstituted-6-quinazolinesulfonamide derivativeInfo
- Publication number
- JPS57156467A JPS57156467A JP56039551A JP3955181A JPS57156467A JP S57156467 A JPS57156467 A JP S57156467A JP 56039551 A JP56039551 A JP 56039551A JP 3955181 A JP3955181 A JP 3955181A JP S57156467 A JPS57156467 A JP S57156467A
- Authority
- JP
- Japan
- Prior art keywords
- amino
- formula
- expressed
- compound expressed
- quinazolinesulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A compound expressed by formulaI[R1 is Cl, amino, alkoxyl or piperidino; R2 is amino or piperidino; R2 is formula IV (R4 is lower alkyl), -NH(CH2)nNH2 (n is an integer 4W10) or formula V]and an acid addition salt thereof.
EXAMPLE: 1-( 4-Amino-2-chloro-6-quinazolinesulfonyl )-4-( 2-ethoxy-2-phenylethyl ) piperazine.
USE: A vasodilator, ameliorant of cerebral circulation, remedy for angina pectoris and a preventing agent and remedy for the cerebral and cardiovascular thrombosis having powerful smooth muscle relaxing action and inhibitory action on blood platelet aggregation.
PROCESS: A 4-amino-2-chloroquinazoline expressed by formula II is sulfonated and converted into an acid chloride. The resultant 4-amino-2-chloro-6-quinazolinesulfonyl chloride expressed by formula III is then reacted with a compound expressed by the formula R3H, e.g. 1-(2-ethoxy-2-phenylethyl)piperazine, to give the compound expressed by formulaI(R1 is Cl).
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56039551A JPS57156467A (en) | 1981-03-20 | 1981-03-20 | 2,4-disubstituted-6-quinazolinesulfonamide derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56039551A JPS57156467A (en) | 1981-03-20 | 1981-03-20 | 2,4-disubstituted-6-quinazolinesulfonamide derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57156467A true JPS57156467A (en) | 1982-09-27 |
JPH0254344B2 JPH0254344B2 (en) | 1990-11-21 |
Family
ID=12556192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56039551A Granted JPS57156467A (en) | 1981-03-20 | 1981-03-20 | 2,4-disubstituted-6-quinazolinesulfonamide derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57156467A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4502880A (en) * | 1983-02-03 | 1985-03-05 | E. I. Du Pont De Nemours And Company | 4-Pyridinium quinazoline derivatives |
US4607034A (en) * | 1979-10-29 | 1986-08-19 | Mitsubishi Yuka Pharmaceutical Co., Ltd. | Quinazoline derivatives and pharmaceutical composition thereof |
US5430148A (en) * | 1992-03-31 | 1995-07-04 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5050390A (en) * | 1973-09-06 | 1975-05-06 | Ciba Geigy |
-
1981
- 1981-03-20 JP JP56039551A patent/JPS57156467A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5050390A (en) * | 1973-09-06 | 1975-05-06 | Ciba Geigy |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4607034A (en) * | 1979-10-29 | 1986-08-19 | Mitsubishi Yuka Pharmaceutical Co., Ltd. | Quinazoline derivatives and pharmaceutical composition thereof |
US4502880A (en) * | 1983-02-03 | 1985-03-05 | E. I. Du Pont De Nemours And Company | 4-Pyridinium quinazoline derivatives |
US5430148A (en) * | 1992-03-31 | 1995-07-04 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
US5707992A (en) * | 1992-03-31 | 1998-01-13 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
US5885996A (en) * | 1992-03-31 | 1999-03-23 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
Also Published As
Publication number | Publication date |
---|---|
JPH0254344B2 (en) | 1990-11-21 |
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