JPS57108099A - Preparation of choline cytidine diphosphate - Google Patents
Preparation of choline cytidine diphosphateInfo
- Publication number
- JPS57108099A JPS57108099A JP18288080A JP18288080A JPS57108099A JP S57108099 A JPS57108099 A JP S57108099A JP 18288080 A JP18288080 A JP 18288080A JP 18288080 A JP18288080 A JP 18288080A JP S57108099 A JPS57108099 A JP S57108099A
- Authority
- JP
- Japan
- Prior art keywords
- halide
- phosphorylcholine
- chloride
- metal salt
- phosphoric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the titled compound industrially advantageously useful as a recovering agent for consciousness and function disturbance in cerebral trauma, etc., by reacting cytidine-5'-phosphoric acid with a metal salt of phosphorylcholine halide in the presence of an excess amount of acyl halide.
CONSTITUTION: (A) Cytidine-5'-phosphoric acid is reacted with (B) a metal salt of phosphorylcholine halide (e.g., calcium phosphorylcholine chloride, etc.) in the presence of an excess molar amount (preferably 2W5 times the molar quantity) based on component B of an acyl halide (preferably acid halide having 1W10C alkyl or aryl residue, e.g., acetyl chloride, benzoyl chloride, etc.) in a solvent, preferably DMF, etc. at 0W50°C for 1Wseveral hours, to give the desired compound. The molar ratio of the starting substances A:B is preferably 1:2W4.
EFFECT: The reaction and the fractionation operation of the desired substance are simple, and the desired substance is obtained in high yield.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18288080A JPS57108099A (en) | 1980-12-25 | 1980-12-25 | Preparation of choline cytidine diphosphate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18288080A JPS57108099A (en) | 1980-12-25 | 1980-12-25 | Preparation of choline cytidine diphosphate |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57108099A true JPS57108099A (en) | 1982-07-05 |
Family
ID=16126024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP18288080A Pending JPS57108099A (en) | 1980-12-25 | 1980-12-25 | Preparation of choline cytidine diphosphate |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57108099A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990004400A1 (en) * | 1988-10-27 | 1990-05-03 | Massachusetts Institute Of Technology | PROCESS FOR INCREASING PHOSPHATIDYLCHOLINE $i(IN VIVO) |
US5801160A (en) * | 1995-03-06 | 1998-09-01 | Interneuron Pharmaceuticals, Inc. | Method of protecting brain tissue from cerebral infarction subsequent to ischemia |
-
1980
- 1980-12-25 JP JP18288080A patent/JPS57108099A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990004400A1 (en) * | 1988-10-27 | 1990-05-03 | Massachusetts Institute Of Technology | PROCESS FOR INCREASING PHOSPHATIDYLCHOLINE $i(IN VIVO) |
EP0408668A1 (en) * | 1988-10-27 | 1991-01-23 | Massachusetts Inst Technology | Process for increasing phosphatidylcholine in vivo. |
EP0408668B1 (en) * | 1988-10-27 | 1994-05-11 | Massachusetts Institute Of Technology | Process for increasing phosphatidylcholine in vivo |
US5801160A (en) * | 1995-03-06 | 1998-09-01 | Interneuron Pharmaceuticals, Inc. | Method of protecting brain tissue from cerebral infarction subsequent to ischemia |
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