JPS57108099A - Preparation of choline cytidine diphosphate - Google Patents

Preparation of choline cytidine diphosphate

Info

Publication number
JPS57108099A
JPS57108099A JP18288080A JP18288080A JPS57108099A JP S57108099 A JPS57108099 A JP S57108099A JP 18288080 A JP18288080 A JP 18288080A JP 18288080 A JP18288080 A JP 18288080A JP S57108099 A JPS57108099 A JP S57108099A
Authority
JP
Japan
Prior art keywords
halide
phosphorylcholine
chloride
metal salt
phosphoric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP18288080A
Other languages
Japanese (ja)
Inventor
Tadashi Sato
Osamu Maruyama
Takeshi Kawashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kohjin Holdings Co Ltd
Original Assignee
Kohjin Holdings Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kohjin Holdings Co Ltd filed Critical Kohjin Holdings Co Ltd
Priority to JP18288080A priority Critical patent/JPS57108099A/en
Publication of JPS57108099A publication Critical patent/JPS57108099A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled compound industrially advantageously useful as a recovering agent for consciousness and function disturbance in cerebral trauma, etc., by reacting cytidine-5'-phosphoric acid with a metal salt of phosphorylcholine halide in the presence of an excess amount of acyl halide.
CONSTITUTION: (A) Cytidine-5'-phosphoric acid is reacted with (B) a metal salt of phosphorylcholine halide (e.g., calcium phosphorylcholine chloride, etc.) in the presence of an excess molar amount (preferably 2W5 times the molar quantity) based on component B of an acyl halide (preferably acid halide having 1W10C alkyl or aryl residue, e.g., acetyl chloride, benzoyl chloride, etc.) in a solvent, preferably DMF, etc. at 0W50°C for 1Wseveral hours, to give the desired compound. The molar ratio of the starting substances A:B is preferably 1:2W4.
EFFECT: The reaction and the fractionation operation of the desired substance are simple, and the desired substance is obtained in high yield.
COPYRIGHT: (C)1982,JPO&Japio
JP18288080A 1980-12-25 1980-12-25 Preparation of choline cytidine diphosphate Pending JPS57108099A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18288080A JPS57108099A (en) 1980-12-25 1980-12-25 Preparation of choline cytidine diphosphate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18288080A JPS57108099A (en) 1980-12-25 1980-12-25 Preparation of choline cytidine diphosphate

Publications (1)

Publication Number Publication Date
JPS57108099A true JPS57108099A (en) 1982-07-05

Family

ID=16126024

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18288080A Pending JPS57108099A (en) 1980-12-25 1980-12-25 Preparation of choline cytidine diphosphate

Country Status (1)

Country Link
JP (1) JPS57108099A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004400A1 (en) * 1988-10-27 1990-05-03 Massachusetts Institute Of Technology PROCESS FOR INCREASING PHOSPHATIDYLCHOLINE $i(IN VIVO)
US5801160A (en) * 1995-03-06 1998-09-01 Interneuron Pharmaceuticals, Inc. Method of protecting brain tissue from cerebral infarction subsequent to ischemia

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004400A1 (en) * 1988-10-27 1990-05-03 Massachusetts Institute Of Technology PROCESS FOR INCREASING PHOSPHATIDYLCHOLINE $i(IN VIVO)
EP0408668A1 (en) * 1988-10-27 1991-01-23 Massachusetts Inst Technology Process for increasing phosphatidylcholine in vivo.
EP0408668B1 (en) * 1988-10-27 1994-05-11 Massachusetts Institute Of Technology Process for increasing phosphatidylcholine in vivo
US5801160A (en) * 1995-03-06 1998-09-01 Interneuron Pharmaceuticals, Inc. Method of protecting brain tissue from cerebral infarction subsequent to ischemia

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