JPS56120639A - Biphenyl derivative - Google Patents

Biphenyl derivative

Info

Publication number
JPS56120639A
JPS56120639A JP2454380A JP2454380A JPS56120639A JP S56120639 A JPS56120639 A JP S56120639A JP 2454380 A JP2454380 A JP 2454380A JP 2454380 A JP2454380 A JP 2454380A JP S56120639 A JPS56120639 A JP S56120639A
Authority
JP
Japan
Prior art keywords
formula
biphenylylacetate
react
halogen
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2454380A
Other languages
Japanese (ja)
Other versions
JPS621380B2 (en
Inventor
Yasumitsu Tamura
Masao Murayama
Shingo Matsumura
Yoshihiko Yoshimoto
Shinichi Tanda
Katsutoshi Kunimoto
Hiroshi Enomoto
Yoshihisa Shibata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP2454380A priority Critical patent/JPS56120639A/en
Publication of JPS56120639A publication Critical patent/JPS56120639A/en
Publication of JPS621380B2 publication Critical patent/JPS621380B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:4',5-Di-substituted-3-biphenylylacetic acid ester of formula I (R1 is H, lower alkoxy, or halogen; R2 is H, halogen, or amino; R3 is lower alkyl).
EXAMPLE: Methyl 5-fluoro-3-biphenylylacetate.
USE: Intermediate of the synthetic pharmaceuticals having excellent antiinflammatory and lenitive activities, e.g. 4'5-di-substituted-3-bihenylylacetic acid.
PROCESS: For example, an aqueous solution of hydrogen borofluoride is added to a compound of formula II (R4 is group of formula III), e.g. methyl 5-amino-3-biphenylylacetate hydrochloride, and made to react at 0W5°C for 10min, and then an aqueous solution of sodium nitrite is added and made to react at the same temp. for 20min to give a compound of formula I wherein R1 is H and R2 is F.
COPYRIGHT: (C)1981,JPO&Japio
JP2454380A 1980-02-27 1980-02-27 Biphenyl derivative Granted JPS56120639A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2454380A JPS56120639A (en) 1980-02-27 1980-02-27 Biphenyl derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2454380A JPS56120639A (en) 1980-02-27 1980-02-27 Biphenyl derivative

Publications (2)

Publication Number Publication Date
JPS56120639A true JPS56120639A (en) 1981-09-22
JPS621380B2 JPS621380B2 (en) 1987-01-13

Family

ID=12141058

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2454380A Granted JPS56120639A (en) 1980-02-27 1980-02-27 Biphenyl derivative

Country Status (1)

Country Link
JP (1) JPS56120639A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06216593A (en) * 1993-01-18 1994-08-05 Nippon Dainapaato Kk Cut/clinch mechanism of automatic inserting device for axial component

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5126433A (en) * 1974-08-29 1976-03-04 Fujitsu Ltd JOHOSHORISHISUTEMUSEIGYOHOSHIKI
JPS5145584A (en) * 1974-10-16 1976-04-19 Hitachi Ltd
JPS5210859A (en) * 1975-07-16 1977-01-27 Matsushita Electric Ind Co Ltd Ion wind generator
JPS5218189A (en) * 1975-08-01 1977-02-10 Nippon Telegr & Teleph Corp <Ntt> Zinc selenide light emitting diode process

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5126433A (en) * 1974-08-29 1976-03-04 Fujitsu Ltd JOHOSHORISHISUTEMUSEIGYOHOSHIKI
JPS5145584A (en) * 1974-10-16 1976-04-19 Hitachi Ltd
JPS5210859A (en) * 1975-07-16 1977-01-27 Matsushita Electric Ind Co Ltd Ion wind generator
JPS5218189A (en) * 1975-08-01 1977-02-10 Nippon Telegr & Teleph Corp <Ntt> Zinc selenide light emitting diode process

Also Published As

Publication number Publication date
JPS621380B2 (en) 1987-01-13

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