JPS56110625A - Separating method of blood plasma and apparatus for the same - Google Patents

Separating method of blood plasma and apparatus for the same

Info

Publication number
JPS56110625A
JPS56110625A JP1842780A JP1842780A JPS56110625A JP S56110625 A JPS56110625 A JP S56110625A JP 1842780 A JP1842780 A JP 1842780A JP 1842780 A JP1842780 A JP 1842780A JP S56110625 A JPS56110625 A JP S56110625A
Authority
JP
Japan
Prior art keywords
blood plasma
separating
separating membranes
blood
membranes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1842780A
Other languages
Japanese (ja)
Other versions
JPH0212579B2 (en
Inventor
Yukihiko Nose
Esu Maruchiesukii Pooru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of JPS56110625A publication Critical patent/JPS56110625A/en
Publication of JPH0212579B2 publication Critical patent/JPH0212579B2/ja
Granted legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Water Supply & Treatment (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

PURPOSE: To separate a blood plasma effectively without destroying the plasmic cell, by keeping the positive pressure difference between separating membranes at a specific low pressure difference, and permeating the whole blood through the separating membranes.
CONSTITUTION: The whole blood is fed along one surface of separating membranes, e.g. filmlike or hollow fiber membranes made of cellulose acetate, consisting of a porous material having a pore size of 0.1W0.6μ under the conditions of a flow velocity 5W1,500cm/min and sufficient depth. The blood plasma contained in the blood is permeated through the separating membranes while keeping the positive pressure difference between the separating membranes at just below 50mmHg, preferably about 20W40mmHg, and the resultant separated blood plasma is recovered. The low permeation pressure between the separating membranes permits the separation of a large amount of blood plasma and increase in the sieve coefficient of various components of the blood plasma without clogging a filter. The method is useful for the so-called on-line blood plasma separating method with a permeating membrane.
COPYRIGHT: (C)1981,JPO&Japio
JP1842780A 1980-02-05 1980-02-16 Separating method of blood plasma and apparatus for the same Granted JPS56110625A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11867780A 1980-02-05 1980-02-05

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2417055A Division JPH0745407B2 (en) 1980-02-05 1990-12-28 Plasma separation method

Publications (2)

Publication Number Publication Date
JPS56110625A true JPS56110625A (en) 1981-09-01
JPH0212579B2 JPH0212579B2 (en) 1990-03-22

Family

ID=22380081

Family Applications (3)

Application Number Title Priority Date Filing Date
JP1842780A Granted JPS56110625A (en) 1980-02-05 1980-02-16 Separating method of blood plasma and apparatus for the same
JP2417055A Expired - Lifetime JPH0745407B2 (en) 1980-02-05 1990-12-28 Plasma separation method
JP8109468A Expired - Lifetime JP2928913B2 (en) 1980-02-05 1996-04-30 Plasma separation method

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2417055A Expired - Lifetime JPH0745407B2 (en) 1980-02-05 1990-12-28 Plasma separation method
JP8109468A Expired - Lifetime JP2928913B2 (en) 1980-02-05 1996-04-30 Plasma separation method

Country Status (3)

Country Link
JP (3) JPS56110625A (en)
CA (1) CA1158988A (en)
DE (1) DE3006455A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0096973A1 (en) 1982-05-28 1983-12-28 Kuraray Co., Ltd. Apparatus for plasma separation
US5443451A (en) * 1993-11-17 1995-08-22 Baxter International Inc. Peristaltic pumping assembly
US5460493A (en) * 1993-11-17 1995-10-24 Baxter International Inc. Organizer frame for holding an array of flexible tubing in alignment with one or more peristaltic pump rotors

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668399A (en) * 1982-02-16 1987-05-26 E. I. Du Pont De Nemours And Company Hollow fiber plasmapheresis process
EP0118473A4 (en) * 1982-08-24 1985-09-16 Baxter Travenol Lab Increased yield blood component collection systems and methods.
DE3302383C2 (en) * 1983-01-25 1985-08-29 Michael J. 8000 München Lysaght Method and device for obtaining blood plasma
EP0168407A4 (en) * 1983-12-09 1987-04-29 Baxter Travenol Lab Controlling transmembrane pressure in membrane plasma filtration.
US5217627A (en) * 1990-11-06 1993-06-08 Pall Corporation System and method for processing biological fluid
CA2074671A1 (en) * 1991-11-04 1993-05-05 Thomas Bormann Device and method for separating plasma from a biological fluid
GB9311988D0 (en) * 1993-06-10 1993-07-28 Pall Corp Device and method for separating plasma from a blood product
DE4338858C1 (en) * 1993-11-13 1995-04-13 Alois Kastl Apparatus for eliminating substances from the blood of a patient
AU3273101A (en) 1997-02-14 2001-06-04 Nxstage Medical, Inc. Extracorporeal circuits for performing hemofiltration employing pressure sensingwithout an air interface
US7780619B2 (en) 1999-11-29 2010-08-24 Nxstage Medical, Inc. Blood treatment apparatus
WO2008114998A1 (en) * 2007-03-21 2008-09-25 Korea Institute Of Machinery & Materials Blood separator using dissolved air flotation
KR100808924B1 (en) * 2007-03-21 2008-03-03 한국기계연구원 Blood separator using dissolved air flotation
KR100836272B1 (en) * 2007-03-21 2008-06-10 한국기계연구원 Blood separator using vacuum flotation
AU2009288234B2 (en) 2008-09-02 2014-08-21 Merck Millipore Ltd. Chromatography membranes, devices containing them, and methods of use thereof
JP2012210187A (en) * 2011-03-31 2012-11-01 Kaneka Corp Method for condensing cell suspension
KR101920905B1 (en) 2011-05-17 2019-02-13 나트릭스 세퍼레이션즈, 인코포레이티드 Layered tubular membranes for chromatography, and methods of use thereof
JP6204193B2 (en) 2011-10-24 2017-09-27 株式会社カネカ Method for producing cell concentrate
JP6196222B2 (en) 2012-08-30 2017-09-13 株式会社カネカ Method for producing cell concentrate
CN103263705A (en) * 2013-05-09 2013-08-28 浙江大学 Plasma exchange absorption filter purifying system with square plasma storage tank
SG11201608046UA (en) * 2014-03-28 2016-11-29 Hitachi Chemical Co Ltd Cell capturing apparatus, cell capturing device provided with pre-processing part, and pre-processing part

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51116096A (en) * 1975-03-17 1976-10-13 Takeda Chemical Industries Ltd Blood processor
JPS54100197A (en) * 1978-01-24 1979-08-07 Medekusu Kk Device for fractioning* separating and purifying blood

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3541005A (en) * 1969-02-05 1970-11-17 Amicon Corp Continuous ultrafiltration of macromolecular solutions
JPS52155888A (en) * 1976-06-22 1977-12-24 Mitsui Toatsu Chemicals Device for continuously removing material in blood flow
JPS5837037B2 (en) * 1977-09-05 1983-08-13 株式会社クラレ Purified water production method
JPS54118699A (en) * 1978-03-06 1979-09-14 Kuraray Co Device for treating abdominal dropsy
JPS55500370A (en) * 1978-05-25 1980-06-26

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51116096A (en) * 1975-03-17 1976-10-13 Takeda Chemical Industries Ltd Blood processor
JPS54100197A (en) * 1978-01-24 1979-08-07 Medekusu Kk Device for fractioning* separating and purifying blood

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0096973A1 (en) 1982-05-28 1983-12-28 Kuraray Co., Ltd. Apparatus for plasma separation
US5443451A (en) * 1993-11-17 1995-08-22 Baxter International Inc. Peristaltic pumping assembly
US5460493A (en) * 1993-11-17 1995-10-24 Baxter International Inc. Organizer frame for holding an array of flexible tubing in alignment with one or more peristaltic pump rotors
US6186752B1 (en) 1993-11-17 2001-02-13 Baxter International Inc. Peristaltic pumping apparatus with tubing organizer

Also Published As

Publication number Publication date
JPH0212579B2 (en) 1990-03-22
JPH04230853A (en) 1992-08-19
CA1158988A (en) 1983-12-20
DE3006455C2 (en) 1991-07-04
JP2928913B2 (en) 1999-08-03
JPH08295630A (en) 1996-11-12
DE3006455A1 (en) 1981-08-13
JPH0745407B2 (en) 1995-05-17

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