JPS5576859A - Novel preparation of 4-hydroxyindole - Google Patents
Novel preparation of 4-hydroxyindoleInfo
- Publication number
- JPS5576859A JPS5576859A JP14941478A JP14941478A JPS5576859A JP S5576859 A JPS5576859 A JP S5576859A JP 14941478 A JP14941478 A JP 14941478A JP 14941478 A JP14941478 A JP 14941478A JP S5576859 A JPS5576859 A JP S5576859A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxyindole
- cyanomethyl
- carboxylic acid
- nitrobenzene
- novel preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Indole Compounds (AREA)
Abstract
PURPOSE: To obtain the title compound useful as a raw material for drugs, Pindolol or Psilocin, in one step, by catalytic reduction of a 2-cyanomethyl-3-substituted methoxy-nitrobenzene in the presence of an aromatic carboxylic acid.
CONSTITUTION: A 2-cyanomethyl-3-substituted methoxy nitrobenzene is subjected to catalytic reduction in the presence of an aromatic carboxylic acid and palladium carbon in a solvent in an autoclave through ring closure and benzylation to give 4-hydroxyindole in one step.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14941478A JPS5576859A (en) | 1978-12-01 | 1978-12-01 | Novel preparation of 4-hydroxyindole |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14941478A JPS5576859A (en) | 1978-12-01 | 1978-12-01 | Novel preparation of 4-hydroxyindole |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5576859A true JPS5576859A (en) | 1980-06-10 |
Family
ID=15474589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14941478A Pending JPS5576859A (en) | 1978-12-01 | 1978-12-01 | Novel preparation of 4-hydroxyindole |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5576859A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE1000762A5 (en) * | 1986-11-07 | 1989-03-28 | Oreal | PROCESS FOR THE PREPARATION OF 5,6-DIHYDROXYINDOLE AND ITS 3-ALKYL DERIVATIVE AND INTERMEDIATE COMPOUNDS. |
US10519175B2 (en) | 2017-10-09 | 2019-12-31 | Compass Pathways Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11564935B2 (en) | 2019-04-17 | 2023-01-31 | Compass Pathfinder Limited | Method for treating anxiety disorders, headache disorders, and eating disorders with psilocybin |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5289668A (en) * | 1975-12-09 | 1977-07-27 | Dumex Ltd As | Production of heterocyclic compound |
-
1978
- 1978-12-01 JP JP14941478A patent/JPS5576859A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5289668A (en) * | 1975-12-09 | 1977-07-27 | Dumex Ltd As | Production of heterocyclic compound |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE1000762A5 (en) * | 1986-11-07 | 1989-03-28 | Oreal | PROCESS FOR THE PREPARATION OF 5,6-DIHYDROXYINDOLE AND ITS 3-ALKYL DERIVATIVE AND INTERMEDIATE COMPOUNDS. |
US10519175B2 (en) | 2017-10-09 | 2019-12-31 | Compass Pathways Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US10947257B2 (en) | 2017-10-09 | 2021-03-16 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US10954259B1 (en) | 2017-10-09 | 2021-03-23 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11149044B2 (en) | 2017-10-09 | 2021-10-19 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11180517B2 (en) | 2017-10-09 | 2021-11-23 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11447510B2 (en) | 2017-10-09 | 2022-09-20 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11505564B2 (en) | 2017-10-09 | 2022-11-22 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11629159B2 (en) | 2017-10-09 | 2023-04-18 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11851451B2 (en) | 2017-10-09 | 2023-12-26 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11939346B2 (en) | 2017-10-09 | 2024-03-26 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11564935B2 (en) | 2019-04-17 | 2023-01-31 | Compass Pathfinder Limited | Method for treating anxiety disorders, headache disorders, and eating disorders with psilocybin |
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