JPS5576859A - Novel preparation of 4-hydroxyindole - Google Patents

Novel preparation of 4-hydroxyindole

Info

Publication number
JPS5576859A
JPS5576859A JP14941478A JP14941478A JPS5576859A JP S5576859 A JPS5576859 A JP S5576859A JP 14941478 A JP14941478 A JP 14941478A JP 14941478 A JP14941478 A JP 14941478A JP S5576859 A JPS5576859 A JP S5576859A
Authority
JP
Japan
Prior art keywords
hydroxyindole
cyanomethyl
carboxylic acid
nitrobenzene
novel preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14941478A
Other languages
Japanese (ja)
Inventor
Dotaro Fujimoto
Toshimitsu Shigeari
Giichi Funatsukuri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujimoto Pharmaceutical Corp
Original Assignee
Fujimoto Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujimoto Pharmaceutical Corp filed Critical Fujimoto Pharmaceutical Corp
Priority to JP14941478A priority Critical patent/JPS5576859A/en
Publication of JPS5576859A publication Critical patent/JPS5576859A/en
Pending legal-status Critical Current

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  • Indole Compounds (AREA)

Abstract

PURPOSE: To obtain the title compound useful as a raw material for drugs, Pindolol or Psilocin, in one step, by catalytic reduction of a 2-cyanomethyl-3-substituted methoxy-nitrobenzene in the presence of an aromatic carboxylic acid.
CONSTITUTION: A 2-cyanomethyl-3-substituted methoxy nitrobenzene is subjected to catalytic reduction in the presence of an aromatic carboxylic acid and palladium carbon in a solvent in an autoclave through ring closure and benzylation to give 4-hydroxyindole in one step.
COPYRIGHT: (C)1980,JPO&Japio
JP14941478A 1978-12-01 1978-12-01 Novel preparation of 4-hydroxyindole Pending JPS5576859A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14941478A JPS5576859A (en) 1978-12-01 1978-12-01 Novel preparation of 4-hydroxyindole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14941478A JPS5576859A (en) 1978-12-01 1978-12-01 Novel preparation of 4-hydroxyindole

Publications (1)

Publication Number Publication Date
JPS5576859A true JPS5576859A (en) 1980-06-10

Family

ID=15474589

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14941478A Pending JPS5576859A (en) 1978-12-01 1978-12-01 Novel preparation of 4-hydroxyindole

Country Status (1)

Country Link
JP (1) JPS5576859A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1000762A5 (en) * 1986-11-07 1989-03-28 Oreal PROCESS FOR THE PREPARATION OF 5,6-DIHYDROXYINDOLE AND ITS 3-ALKYL DERIVATIVE AND INTERMEDIATE COMPOUNDS.
US10519175B2 (en) 2017-10-09 2019-12-31 Compass Pathways Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
US11564935B2 (en) 2019-04-17 2023-01-31 Compass Pathfinder Limited Method for treating anxiety disorders, headache disorders, and eating disorders with psilocybin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5289668A (en) * 1975-12-09 1977-07-27 Dumex Ltd As Production of heterocyclic compound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5289668A (en) * 1975-12-09 1977-07-27 Dumex Ltd As Production of heterocyclic compound

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1000762A5 (en) * 1986-11-07 1989-03-28 Oreal PROCESS FOR THE PREPARATION OF 5,6-DIHYDROXYINDOLE AND ITS 3-ALKYL DERIVATIVE AND INTERMEDIATE COMPOUNDS.
US10519175B2 (en) 2017-10-09 2019-12-31 Compass Pathways Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
US10947257B2 (en) 2017-10-09 2021-03-16 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
US10954259B1 (en) 2017-10-09 2021-03-23 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
US11149044B2 (en) 2017-10-09 2021-10-19 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
US11180517B2 (en) 2017-10-09 2021-11-23 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
US11447510B2 (en) 2017-10-09 2022-09-20 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
US11505564B2 (en) 2017-10-09 2022-11-22 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
US11629159B2 (en) 2017-10-09 2023-04-18 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
US11851451B2 (en) 2017-10-09 2023-12-26 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
US11939346B2 (en) 2017-10-09 2024-03-26 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
US11564935B2 (en) 2019-04-17 2023-01-31 Compass Pathfinder Limited Method for treating anxiety disorders, headache disorders, and eating disorders with psilocybin

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